Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7G7_LEIIN

TriTrypDb:

LINF_320005400

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7G7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.645
CLV_MEL_PAP_1	100	106	PF00089	0.422
CLV_NRD_NRD_1	121	123	PF00675	0.442
CLV_NRD_NRD_1	253	255	PF00675	0.800
CLV_NRD_NRD_1	59	61	PF00675	0.452
CLV_NRD_NRD_1	68	70	PF00675	0.467
CLV_NRD_NRD_1	84	86	PF00675	0.405
CLV_PCSK_KEX2_1	121	123	PF00082	0.477
CLV_PCSK_KEX2_1	253	255	PF00082	0.636
CLV_PCSK_KEX2_1	68	70	PF00082	0.509
CLV_PCSK_KEX2_1	84	86	PF00082	0.408
CLV_PCSK_SKI1_1	122	126	PF00082	0.482
CLV_PCSK_SKI1_1	21	25	PF00082	0.521
CLV_PCSK_SKI1_1	233	237	PF00082	0.719
CLV_PCSK_SKI1_1	68	72	PF00082	0.483
CLV_PCSK_SKI1_1	73	77	PF00082	0.458
CLV_PCSK_SKI1_1	84	88	PF00082	0.390
CLV_PCSK_SKI1_1	93	97	PF00082	0.256
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_CYCLIN_RxL_1	119	129	PF00134	0.490
DOC_MAPK_gen_1	18	28	PF00069	0.517
DOC_MAPK_MEF2A_6	18	26	PF00069	0.482
DOC_WW_Pin1_4	77	82	PF00397	0.445
LIG_14-3-3_CanoR_1	103	109	PF00244	0.579
LIG_APCC_ABBAyCdc20_2	121	127	PF00400	0.465
LIG_BRCT_BRCA1_1	104	108	PF00533	0.442
LIG_FHA_1	109	115	PF00498	0.396
LIG_FHA_1	134	140	PF00498	0.457
LIG_FHA_1	183	189	PF00498	0.620
LIG_FHA_1	274	280	PF00498	0.777
LIG_FHA_1	70	76	PF00498	0.464
LIG_FHA_2	127	133	PF00498	0.537
LIG_FHA_2	214	220	PF00498	0.661
LIG_FHA_2	242	248	PF00498	0.586
LIG_LIR_Gen_1	211	221	PF02991	0.706
LIG_LIR_Gen_1	234	243	PF02991	0.711
LIG_LIR_Nem_3	211	217	PF02991	0.720
LIG_LIR_Nem_3	234	238	PF02991	0.691
LIG_MYND_1	196	200	PF01753	0.648
LIG_NRBOX	82	88	PF00104	0.494
LIG_Pex14_2	28	32	PF04695	0.486
LIG_REV1ctd_RIR_1	68	77	PF16727	0.478
LIG_SH2_CRK	214	218	PF00017	0.785
LIG_SH2_CRK	63	67	PF00017	0.478
LIG_SH2_GRB2like	63	66	PF00017	0.571
LIG_SH2_NCK_1	116	120	PF00017	0.442
LIG_SH2_NCK_1	63	67	PF00017	0.466
LIG_SH2_SRC	159	162	PF00017	0.447
LIG_SH2_STAP1	116	120	PF00017	0.400
LIG_SH2_STAT5	159	162	PF00017	0.447
LIG_SH2_STAT5	63	66	PF00017	0.497
LIG_SH2_STAT5	99	102	PF00017	0.388
LIG_SH3_2	189	194	PF14604	0.539
LIG_SH3_3	186	192	PF00018	0.626
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.446
LIG_UBA3_1	86	93	PF00899	0.512
LIG_WRC_WIRS_1	29	34	PF05994	0.493
MOD_CDK_SPxxK_3	77	84	PF00069	0.446
MOD_CK1_1	126	132	PF00069	0.529
MOD_CK1_1	150	156	PF00069	0.486
MOD_CK1_1	182	188	PF00069	0.532
MOD_CK1_1	264	270	PF00069	0.786
MOD_CK1_1	280	286	PF00069	0.571
MOD_CK1_1	303	309	PF00069	0.627
MOD_CK1_1	336	342	PF00069	0.762
MOD_CK2_1	126	132	PF00069	0.603
MOD_CK2_1	241	247	PF00069	0.581
MOD_CK2_1	319	325	PF00069	0.656
MOD_CK2_1	336	342	PF00069	0.675
MOD_Cter_Amidation	251	254	PF01082	0.629
MOD_GlcNHglycan	224	227	PF01048	0.825
MOD_GlcNHglycan	249	252	PF01048	0.767
MOD_GlcNHglycan	267	270	PF01048	0.555
MOD_GlcNHglycan	302	305	PF01048	0.680
MOD_GlcNHglycan	314	317	PF01048	0.607
MOD_GlcNHglycan	338	341	PF01048	0.721
MOD_GSK3_1	143	150	PF00069	0.485
MOD_GSK3_1	222	229	PF00069	0.751
MOD_GSK3_1	261	268	PF00069	0.723
MOD_GSK3_1	273	280	PF00069	0.679
MOD_GSK3_1	296	303	PF00069	0.728
MOD_GSK3_1	327	334	PF00069	0.664
MOD_GSK3_1	38	45	PF00069	0.540
MOD_LATS_1	260	266	PF00433	0.709
MOD_N-GLC_1	273	278	PF02516	0.708
MOD_N-GLC_1	320	325	PF02516	0.823
MOD_N-GLC_1	331	336	PF02516	0.598
MOD_NEK2_1	143	148	PF00069	0.438
MOD_NEK2_1	241	246	PF00069	0.752
MOD_NEK2_1	28	33	PF00069	0.489
MOD_NEK2_1	327	332	PF00069	0.622
MOD_NEK2_1	71	76	PF00069	0.426
MOD_PIKK_1	182	188	PF00454	0.532
MOD_PKA_2	102	108	PF00069	0.506
MOD_PKA_2	261	267	PF00069	0.709
MOD_PKA_2	37	43	PF00069	0.533
MOD_Plk_1	210	216	PF00069	0.672
MOD_Plk_1	239	245	PF00069	0.582
MOD_Plk_2-3	307	313	PF00069	0.813
MOD_Plk_4	280	286	PF00069	0.692
MOD_ProDKin_1	77	83	PF00069	0.441
MOD_SUMO_rev_2	306	315	PF00179	0.636
TRG_DiLeu_BaEn_1	82	87	PF01217	0.515
TRG_DiLeu_LyEn_5	19	24	PF01217	0.527
TRG_DiLeu_LyEn_5	82	87	PF01217	0.451
TRG_ENDOCYTIC_2	214	217	PF00928	0.773
TRG_ER_diArg_1	120	122	PF00400	0.472
TRG_ER_diArg_1	253	255	PF00400	0.817
TRG_ER_diArg_1	68	70	PF00400	0.523
TRG_ER_diArg_1	83	85	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H1	Leptomonas seymouri	35%	95%
A0A0N1I963	Leptomonas seymouri	60%	90%
A0A3S7X526	Leishmania donovani	97%	100%
A4HJY4	Leishmania braziliensis	70%	100%
E9B2C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5T2	Leishmania major	91%	100%