Nuclear segregation protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear segregation protein - putative

Species:

Leishmania infantum

UniProt:

A4I7G5_LEIIN

TriTrypDb:

LINF_320005100

Length:

494

Annotations

Annotations by Jardim et al.

Nuclear proteins, nuclear segregation Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	1
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Phosphorylation

Promastigote: 2, 7

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I7G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7G5

Function

Biological processes
Term	Name	Level	Count
GO:0006403	RNA localization	3	1
GO:0008298	intracellular mRNA localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	237	243	PF00089	0.451
CLV_NRD_NRD_1	103	105	PF00675	0.325
CLV_NRD_NRD_1	138	140	PF00675	0.416
CLV_NRD_NRD_1	152	154	PF00675	0.425
CLV_NRD_NRD_1	269	271	PF00675	0.426
CLV_NRD_NRD_1	284	286	PF00675	0.314
CLV_NRD_NRD_1	291	293	PF00675	0.434
CLV_NRD_NRD_1	338	340	PF00675	0.449
CLV_NRD_NRD_1	341	343	PF00675	0.460
CLV_NRD_NRD_1	45	47	PF00675	0.457
CLV_NRD_NRD_1	85	87	PF00675	0.378
CLV_NRD_NRD_1	92	94	PF00675	0.379
CLV_PCSK_FUR_1	281	285	PF00082	0.387
CLV_PCSK_FUR_1	339	343	PF00082	0.501
CLV_PCSK_FUR_1	90	94	PF00082	0.494
CLV_PCSK_KEX2_1	152	154	PF00082	0.426
CLV_PCSK_KEX2_1	213	215	PF00082	0.516
CLV_PCSK_KEX2_1	283	285	PF00082	0.407
CLV_PCSK_KEX2_1	291	293	PF00082	0.396
CLV_PCSK_KEX2_1	300	302	PF00082	0.379
CLV_PCSK_KEX2_1	306	308	PF00082	0.391
CLV_PCSK_KEX2_1	340	342	PF00082	0.487
CLV_PCSK_KEX2_1	45	47	PF00082	0.402
CLV_PCSK_KEX2_1	85	87	PF00082	0.402
CLV_PCSK_KEX2_1	92	94	PF00082	0.443
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.516
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.543
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.358
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.400
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.478
CLV_PCSK_SKI1_1	179	183	PF00082	0.448
CLV_PCSK_SKI1_1	213	217	PF00082	0.462
CLV_PCSK_SKI1_1	303	307	PF00082	0.454
CLV_PCSK_SKI1_1	374	378	PF00082	0.636
CLV_PCSK_SKI1_1	72	76	PF00082	0.527
DEG_APCC_KENBOX_2	386	390	PF00400	0.562
DOC_MAPK_gen_1	326	334	PF00069	0.498
DOC_MAPK_gen_1	413	422	PF00069	0.454
DOC_MAPK_MEF2A_6	326	334	PF00069	0.415
DOC_USP7_MATH_1	18	22	PF00917	0.562
DOC_USP7_MATH_1	393	397	PF00917	0.713
DOC_USP7_MATH_1	467	471	PF00917	0.494
DOC_USP7_UBL2_3	209	213	PF12436	0.519
DOC_USP7_UBL2_3	267	271	PF12436	0.385
DOC_USP7_UBL2_3	296	300	PF12436	0.413
DOC_USP7_UBL2_3	370	374	PF12436	0.629
DOC_USP7_UBL2_3	377	381	PF12436	0.622
DOC_WW_Pin1_4	470	475	PF00397	0.596
DOC_WW_Pin1_4	5	10	PF00397	0.578
LIG_14-3-3_CanoR_1	238	248	PF00244	0.453
LIG_14-3-3_CanoR_1	45	49	PF00244	0.348
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_deltaCOP1_diTrp_1	261	265	PF00928	0.372
LIG_FHA_1	164	170	PF00498	0.442
LIG_FHA_1	449	455	PF00498	0.487
LIG_FHA_1	482	488	PF00498	0.703
LIG_FHA_2	180	186	PF00498	0.431
LIG_FHA_2	428	434	PF00498	0.472
LIG_FHA_2	45	51	PF00498	0.527
LIG_IBAR_NPY_1	309	311	PF08397	0.398
LIG_LIR_Gen_1	191	199	PF02991	0.357
LIG_LIR_Nem_3	191	195	PF02991	0.336
LIG_PDZ_Class_3	489	494	PF00595	0.726
LIG_PTB_Apo_2	200	207	PF02174	0.469
LIG_PTB_Phospho_1	200	206	PF10480	0.467
LIG_SH2_CRK	192	196	PF00017	0.429
LIG_SH2_STAP1	206	210	PF00017	0.435
LIG_SH2_STAP1	445	449	PF00017	0.386
LIG_SH2_STAT3	273	276	PF00017	0.410
LIG_SH2_STAT3	324	327	PF00017	0.480
LIG_SH2_STAT5	273	276	PF00017	0.418
LIG_SH2_STAT5	311	314	PF00017	0.404
LIG_SH2_STAT5	324	327	PF00017	0.366
LIG_SH3_2	23	28	PF14604	0.539
LIG_SH3_3	20	26	PF00018	0.386
LIG_SH3_3	473	479	PF00018	0.521
LIG_SH3_3	6	12	PF00018	0.604
LIG_SUMO_SIM_par_1	418	423	PF11976	0.441
LIG_TRAF2_1	182	185	PF00917	0.444
LIG_TRAF2_1	2	5	PF00917	0.656
LIG_TRAF2_1	489	492	PF00917	0.652
LIG_UBA3_1	321	329	PF00899	0.402
LIG_UBA3_1	48	54	PF00899	0.447
MOD_CDK_SPxK_1	5	11	PF00069	0.476
MOD_CDK_SPxxK_3	470	477	PF00069	0.596
MOD_CK1_1	242	248	PF00069	0.371
MOD_CK1_1	316	322	PF00069	0.407
MOD_CK1_1	364	370	PF00069	0.670
MOD_CK1_1	427	433	PF00069	0.503
MOD_CK1_1	470	476	PF00069	0.576
MOD_CK2_1	179	185	PF00069	0.471
MOD_CK2_1	440	446	PF00069	0.471
MOD_CMANNOS	262	265	PF00535	0.360
MOD_GlcNHglycan	1	4	PF01048	0.603
MOD_GlcNHglycan	142	146	PF01048	0.423
MOD_GlcNHglycan	314	318	PF01048	0.361
MOD_GlcNHglycan	390	393	PF01048	0.612
MOD_GlcNHglycan	457	460	PF01048	0.625
MOD_GlcNHglycan	468	472	PF01048	0.689
MOD_GSK3_1	313	320	PF00069	0.303
MOD_GSK3_1	364	371	PF00069	0.638
MOD_GSK3_1	440	447	PF00069	0.401
MOD_N-GLC_1	368	373	PF02516	0.625
MOD_N-GLC_1	388	393	PF02516	0.423
MOD_NEK2_1	141	146	PF00069	0.413
MOD_NEK2_1	372	377	PF00069	0.696
MOD_NEK2_1	454	459	PF00069	0.625
MOD_NEK2_1	55	60	PF00069	0.409
MOD_NEK2_2	247	252	PF00069	0.363
MOD_PIKK_1	242	248	PF00454	0.371
MOD_PIKK_1	348	354	PF00454	0.573
MOD_PIKK_1	440	446	PF00454	0.406
MOD_PIKK_1	62	68	PF00454	0.516
MOD_PKA_2	239	245	PF00069	0.523
MOD_PKA_2	44	50	PF00069	0.389
MOD_Plk_1	368	374	PF00069	0.468
MOD_Plk_4	317	323	PF00069	0.343
MOD_ProDKin_1	470	476	PF00069	0.595
MOD_ProDKin_1	5	11	PF00069	0.580
MOD_SUMO_rev_2	162	166	PF00179	0.439
MOD_SUMO_rev_2	205	210	PF00179	0.494
MOD_SUMO_rev_2	362	372	PF00179	0.629
MOD_SUMO_rev_2	427	435	PF00179	0.517
TRG_ENDOCYTIC_2	192	195	PF00928	0.451
TRG_ER_diArg_1	237	240	PF00400	0.450
TRG_ER_diArg_1	339	342	PF00400	0.537
TRG_NLS_Bipartite_1	283	304	PF00514	0.524
TRG_NLS_Bipartite_1	86	108	PF00514	0.490
TRG_NLS_MonoExtC_3	103	109	PF00514	0.493
TRG_NLS_MonoExtC_3	211	216	PF00514	0.497
TRG_NLS_MonoExtC_3	269	275	PF00514	0.318
TRG_NLS_MonoExtN_4	102	108	PF00514	0.499
TRG_NLS_MonoExtN_4	209	216	PF00514	0.402
TRG_NLS_MonoExtN_4	267	274	PF00514	0.405
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD36	Leptomonas seymouri	56%	98%
A0A0S4J925	Bodo saltans	38%	100%
A0A1X0P6U5	Trypanosomatidae	41%	100%
A0A3R7KQ83	Trypanosoma rangeli	40%	98%
A0A3S7X525	Leishmania donovani	100%	100%
A4HJX8	Leishmania braziliensis	75%	99%
A4HJY1	Leishmania braziliensis	75%	99%
C9ZZZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B2C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5T4	Leishmania major	91%	100%
V5BS50	Trypanosoma cruzi	41%	98%