Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7G4_LEIIN

TriTrypDb:

LINF_320005000

Length:

134

Annotations

LeishMANIAdb annotations

A protein with unclear topology, conserved but entirely restricted to Kinetoplastida.

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase (SDH9)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I7G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7G4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.621
CLV_NRD_NRD_1	36	38	PF00675	0.418
CLV_NRD_NRD_1	8	10	PF00675	0.491
CLV_PCSK_KEX2_1	36	38	PF00082	0.418
CLV_PCSK_KEX2_1	8	10	PF00082	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.639
DOC_USP7_MATH_1	126	130	PF00917	0.366
DOC_USP7_MATH_1	19	23	PF00917	0.693
DOC_USP7_UBL2_3	121	125	PF12436	0.419
DOC_WW_Pin1_4	9	14	PF00397	0.674
LIG_14-3-3_CanoR_1	3	10	PF00244	0.626
LIG_14-3-3_CanoR_1	71	76	PF00244	0.391
LIG_BRCT_BRCA1_1	128	132	PF00533	0.371
LIG_FHA_2	110	116	PF00498	0.378
LIG_LIR_Apic_2	17	21	PF02991	0.682
LIG_LIR_Gen_1	52	61	PF02991	0.347
LIG_LIR_Gen_1	93	104	PF02991	0.397
LIG_LIR_Nem_3	29	34	PF02991	0.648
LIG_LIR_Nem_3	52	56	PF02991	0.347
LIG_LIR_Nem_3	60	64	PF02991	0.422
LIG_Pex14_2	53	57	PF04695	0.337
LIG_SH2_CRK	47	51	PF00017	0.391
LIG_SH2_STAT5	67	70	PF00017	0.355
LIG_SH3_3	80	86	PF00018	0.522
LIG_UBA3_1	23	28	PF00899	0.372
LIG_WRC_WIRS_1	58	63	PF05994	0.323
MOD_CK1_1	74	80	PF00069	0.511
MOD_CK2_1	109	115	PF00069	0.530
MOD_CK2_1	32	38	PF00069	0.484
MOD_GlcNHglycan	122	125	PF01048	0.537
MOD_GlcNHglycan	98	102	PF01048	0.608
MOD_GSK3_1	116	123	PF00069	0.464
MOD_GSK3_1	32	39	PF00069	0.499
MOD_N-GLC_1	69	74	PF02516	0.545
MOD_NEK2_1	2	7	PF00069	0.503
MOD_NEK2_1	57	62	PF00069	0.333
MOD_NEK2_1	69	74	PF00069	0.484
MOD_PK_1	36	42	PF00069	0.457
MOD_PKA_1	36	42	PF00069	0.517
MOD_PKA_2	2	8	PF00069	0.591
MOD_PKA_2	32	38	PF00069	0.545
MOD_Plk_2-3	109	115	PF00069	0.513
MOD_Plk_4	126	132	PF00069	0.449
MOD_Plk_4	19	25	PF00069	0.612
MOD_ProDKin_1	9	15	PF00069	0.603
MOD_SUMO_rev_2	100	110	PF00179	0.498
TRG_ENDOCYTIC_2	31	34	PF00928	0.573
TRG_ENDOCYTIC_2	47	50	PF00928	0.267
TRG_ER_diArg_1	7	9	PF00400	0.622
TRG_NES_CRM1_1	38	52	PF08389	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P8	Leptomonas seymouri	73%	100%
A0A0S4J967	Bodo saltans	44%	100%
A0A1X0PA05	Trypanosomatidae	59%	99%
A0A3S7X509	Leishmania donovani	97%	100%
A4HJY0	Leishmania braziliensis	78%	100%
D0A202	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9B2C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5T5	Leishmania major	94%	100%