Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nodulin-like/Major Facilitator Superfamily - putative

Species:

Leishmania infantum

UniProt:

A4I7C5_LEIIN

TriTrypDb:

LINF_310040800

Length:

635

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 121
NetGPI	no	yes: 0, no: 121

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	114
GO:0110165	cellular anatomical entity	1	114
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A4I7C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7C5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	55
GO:0022857	transmembrane transporter activity	2	55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.512
CLV_NRD_NRD_1	256	258	PF00675	0.264
CLV_NRD_NRD_1	341	343	PF00675	0.510
CLV_NRD_NRD_1	459	461	PF00675	0.381
CLV_PCSK_KEX2_1	12	14	PF00082	0.502
CLV_PCSK_KEX2_1	256	258	PF00082	0.277
CLV_PCSK_KEX2_1	341	343	PF00082	0.510
CLV_PCSK_KEX2_1	38	40	PF00082	0.296
CLV_PCSK_KEX2_1	459	461	PF00082	0.366
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.337
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.369
CLV_PCSK_SKI1_1	104	108	PF00082	0.232
CLV_PCSK_SKI1_1	231	235	PF00082	0.304
CLV_PCSK_SKI1_1	256	260	PF00082	0.242
CLV_PCSK_SKI1_1	289	293	PF00082	0.327
CLV_PCSK_SKI1_1	30	34	PF00082	0.392
CLV_PCSK_SKI1_1	341	345	PF00082	0.335
CLV_PCSK_SKI1_1	363	367	PF00082	0.462
CLV_PCSK_SKI1_1	38	42	PF00082	0.261
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.298
DOC_MAPK_gen_1	256	265	PF00069	0.453
DOC_MAPK_gen_1	38	45	PF00069	0.456
DOC_MAPK_gen_1	459	468	PF00069	0.544
DOC_MAPK_MEF2A_6	259	267	PF00069	0.330
DOC_MAPK_MEF2A_6	38	47	PF00069	0.488
DOC_MAPK_MEF2A_6	461	470	PF00069	0.542
DOC_MAPK_MEF2A_6	491	498	PF00069	0.340
DOC_MAPK_MEF2A_6	566	573	PF00069	0.297
DOC_PP1_RVXF_1	287	293	PF00149	0.271
DOC_PP2B_LxvP_1	472	475	PF13499	0.307
DOC_SPAK_OSR1_1	135	139	PF12202	0.310
DOC_USP7_MATH_1	273	277	PF00917	0.358
DOC_USP7_MATH_1	336	340	PF00917	0.766
DOC_USP7_MATH_1	420	424	PF00917	0.402
DOC_USP7_MATH_1	574	578	PF00917	0.416
DOC_USP7_MATH_1	611	615	PF00917	0.683
DOC_USP7_UBL2_3	241	245	PF12436	0.374
DOC_USP7_UBL2_3	553	557	PF12436	0.406
DOC_WW_Pin1_4	251	256	PF00397	0.514
DOC_WW_Pin1_4	425	430	PF00397	0.372
DOC_WW_Pin1_4	612	617	PF00397	0.693
LIG_14-3-3_CanoR_1	19	26	PF00244	0.660
LIG_14-3-3_CanoR_1	341	349	PF00244	0.746
LIG_14-3-3_CanoR_1	352	360	PF00244	0.705
LIG_14-3-3_CanoR_1	612	616	PF00244	0.680
LIG_Actin_WH2_2	594	611	PF00022	0.635
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BIR_III_4	127	131	PF00653	0.160
LIG_BRCT_BRCA1_1	180	184	PF00533	0.460
LIG_deltaCOP1_diTrp_1	492	498	PF00928	0.206
LIG_EH1_1	106	114	PF00400	0.372
LIG_EH1_1	149	157	PF00400	0.311
LIG_eIF4E_1	101	107	PF01652	0.521
LIG_FHA_1	29	35	PF00498	0.649
LIG_FHA_1	294	300	PF00498	0.376
LIG_FHA_1	389	395	PF00498	0.494
LIG_FHA_1	405	411	PF00498	0.294
LIG_FHA_1	426	432	PF00498	0.354
LIG_FHA_1	467	473	PF00498	0.468
LIG_FHA_2	224	230	PF00498	0.428
LIG_FHA_2	232	238	PF00498	0.422
LIG_FHA_2	31	37	PF00498	0.624
LIG_GBD_Chelix_1	264	272	PF00786	0.309
LIG_IRF3_LxIS_1	466	471	PF10401	0.375
LIG_LIR_Apic_2	99	103	PF02991	0.475
LIG_LIR_Gen_1	137	145	PF02991	0.336
LIG_LIR_Gen_1	204	213	PF02991	0.333
LIG_LIR_Gen_1	383	394	PF02991	0.508
LIG_LIR_Gen_1	492	500	PF02991	0.299
LIG_LIR_Gen_1	56	66	PF02991	0.336
LIG_LIR_Gen_1	582	592	PF02991	0.336
LIG_LIR_Nem_3	137	142	PF02991	0.298
LIG_LIR_Nem_3	175	179	PF02991	0.346
LIG_LIR_Nem_3	181	187	PF02991	0.338
LIG_LIR_Nem_3	197	203	PF02991	0.261
LIG_LIR_Nem_3	204	209	PF02991	0.302
LIG_LIR_Nem_3	383	389	PF02991	0.512
LIG_LIR_Nem_3	492	496	PF02991	0.341
LIG_LIR_Nem_3	56	62	PF02991	0.347
LIG_LIR_Nem_3	582	588	PF02991	0.345
LIG_PCNA_yPIPBox_3	275	289	PF02747	0.241
LIG_Pex14_1	395	399	PF04695	0.342
LIG_Pex14_2	121	125	PF04695	0.241
LIG_Pex14_2	202	206	PF04695	0.359
LIG_Pex14_2	258	262	PF04695	0.331
LIG_Pex14_2	581	585	PF04695	0.354
LIG_PTB_Apo_2	411	418	PF02174	0.350
LIG_Rb_pABgroove_1	92	100	PF01858	0.388
LIG_RPA_C_Fungi	337	349	PF08784	0.657
LIG_SH2_CRK	260	264	PF00017	0.384
LIG_SH2_CRK	281	285	PF00017	0.387
LIG_SH2_CRK	303	307	PF00017	0.474
LIG_SH2_CRK	48	52	PF00017	0.282
LIG_SH2_NCK_1	419	423	PF00017	0.400
LIG_SH2_PTP2	589	592	PF00017	0.332
LIG_SH2_SRC	8	11	PF00017	0.668
LIG_SH2_STAP1	228	232	PF00017	0.396
LIG_SH2_STAP1	520	524	PF00017	0.327
LIG_SH2_STAP1	551	555	PF00017	0.354
LIG_SH2_STAT5	201	204	PF00017	0.313
LIG_SH2_STAT5	232	235	PF00017	0.322
LIG_SH2_STAT5	248	251	PF00017	0.322
LIG_SH2_STAT5	303	306	PF00017	0.356
LIG_SH2_STAT5	551	554	PF00017	0.385
LIG_SH2_STAT5	57	60	PF00017	0.325
LIG_SH2_STAT5	589	592	PF00017	0.327
LIG_SH3_3	215	221	PF00018	0.295
LIG_SH3_3	249	255	PF00018	0.328
LIG_SH3_3	267	273	PF00018	0.307
LIG_SH3_3	87	93	PF00018	0.384
LIG_SUMO_SIM_anti_2	476	481	PF11976	0.302
LIG_SUMO_SIM_anti_2	483	488	PF11976	0.280
LIG_SUMO_SIM_anti_2	511	518	PF11976	0.314
LIG_SUMO_SIM_par_1	29	36	PF11976	0.524
LIG_SUMO_SIM_par_1	466	471	PF11976	0.240
LIG_TRAF2_1	14	17	PF00917	0.679
LIG_TYR_ITIM	279	284	PF00017	0.341
LIG_UBA3_1	484	491	PF00899	0.378
LIG_WRC_WIRS_1	173	178	PF05994	0.355
LIG_WRC_WIRS_1	495	500	PF05994	0.400
MOD_CDC14_SPxK_1	254	257	PF00782	0.390
MOD_CDK_SPK_2	251	256	PF00069	0.435
MOD_CDK_SPxK_1	251	257	PF00069	0.390
MOD_CK1_1	388	394	PF00069	0.359
MOD_CK1_1	400	406	PF00069	0.369
MOD_CK1_1	433	439	PF00069	0.345
MOD_CK1_1	508	514	PF00069	0.376
MOD_CK1_1	532	538	PF00069	0.353
MOD_CK1_1	583	589	PF00069	0.364
MOD_CK1_1	78	84	PF00069	0.330
MOD_CK2_1	11	17	PF00069	0.595
MOD_CK2_1	223	229	PF00069	0.274
MOD_CK2_1	231	237	PF00069	0.267
MOD_CK2_1	30	36	PF00069	0.449
MOD_CK2_1	356	362	PF00069	0.561
MOD_CK2_1	367	373	PF00069	0.508
MOD_CK2_1	381	387	PF00069	0.359
MOD_CK2_1	448	454	PF00069	0.367
MOD_Cter_Amidation	10	13	PF01082	0.664
MOD_DYRK1A_RPxSP_1	612	616	PF00069	0.406
MOD_GlcNHglycan	139	142	PF01048	0.364
MOD_GlcNHglycan	180	183	PF01048	0.320
MOD_GlcNHglycan	203	206	PF01048	0.328
MOD_GlcNHglycan	275	278	PF01048	0.337
MOD_GlcNHglycan	316	319	PF01048	0.457
MOD_GlcNHglycan	372	376	PF01048	0.470
MOD_GlcNHglycan	442	445	PF01048	0.305
MOD_GlcNHglycan	507	510	PF01048	0.296
MOD_GlcNHglycan	576	579	PF01048	0.366
MOD_GlcNHglycan	62	65	PF01048	0.304
MOD_GSK3_1	11	18	PF00069	0.617
MOD_GSK3_1	157	164	PF00069	0.339
MOD_GSK3_1	26	33	PF00069	0.592
MOD_GSK3_1	352	359	PF00069	0.658
MOD_GSK3_1	367	374	PF00069	0.552
MOD_GSK3_1	381	388	PF00069	0.430
MOD_GSK3_1	400	407	PF00069	0.371
MOD_GSK3_1	494	501	PF00069	0.379
MOD_GSK3_1	531	538	PF00069	0.319
MOD_GSK3_1	579	586	PF00069	0.369
MOD_GSK3_1	611	618	PF00069	0.557
MOD_GSK3_1	75	82	PF00069	0.320
MOD_N-GLC_1	194	199	PF02516	0.310
MOD_N-GLC_1	327	332	PF02516	0.614
MOD_N-GLC_1	353	358	PF02516	0.645
MOD_N-GLC_1	70	75	PF02516	0.369
MOD_N-GLC_2	561	563	PF02516	0.478
MOD_NEK2_1	371	376	PF00069	0.460
MOD_NEK2_1	385	390	PF00069	0.389
MOD_NEK2_1	397	402	PF00069	0.303
MOD_NEK2_1	468	473	PF00069	0.355
MOD_NEK2_1	480	485	PF00069	0.295
MOD_NEK2_1	494	499	PF00069	0.295
MOD_NEK2_1	531	536	PF00069	0.291
MOD_NEK2_1	579	584	PF00069	0.318
MOD_NEK2_1	630	635	PF00069	0.697
MOD_NEK2_2	134	139	PF00069	0.342
MOD_NEK2_2	381	386	PF00069	0.464
MOD_PIKK_1	18	24	PF00454	0.670
MOD_PIKK_1	404	410	PF00454	0.359
MOD_PIKK_1	454	460	PF00454	0.398
MOD_PIKK_1	70	76	PF00454	0.296
MOD_PK_1	75	81	PF00069	0.383
MOD_PKA_1	240	246	PF00069	0.400
MOD_PKA_1	341	347	PF00069	0.400
MOD_PKA_2	11	17	PF00069	0.626
MOD_PKA_2	134	140	PF00069	0.285
MOD_PKA_2	18	24	PF00069	0.454
MOD_PKA_2	341	347	PF00069	0.659
MOD_PKA_2	356	362	PF00069	0.609
MOD_PKA_2	611	617	PF00069	0.569
MOD_Plk_4	154	160	PF00069	0.331
MOD_Plk_4	172	178	PF00069	0.370
MOD_Plk_4	381	387	PF00069	0.398
MOD_Plk_4	397	403	PF00069	0.352
MOD_Plk_4	430	436	PF00069	0.320
MOD_Plk_4	448	454	PF00069	0.345
MOD_Plk_4	473	479	PF00069	0.319
MOD_Plk_4	480	486	PF00069	0.308
MOD_Plk_4	508	514	PF00069	0.335
MOD_Plk_4	536	542	PF00069	0.303
MOD_Plk_4	580	586	PF00069	0.281
MOD_Plk_4	75	81	PF00069	0.387
MOD_ProDKin_1	251	257	PF00069	0.378
MOD_ProDKin_1	425	431	PF00069	0.454
MOD_ProDKin_1	612	618	PF00069	0.634
TRG_DiLeu_BaEn_1	430	435	PF01217	0.311
TRG_DiLeu_BaEn_4	463	469	PF01217	0.249
TRG_DiLeu_LyEn_5	626	631	PF01217	0.724
TRG_ENDOCYTIC_2	260	263	PF00928	0.366
TRG_ENDOCYTIC_2	281	284	PF00928	0.306
TRG_ENDOCYTIC_2	303	306	PF00928	0.317
TRG_ENDOCYTIC_2	399	402	PF00928	0.345
TRG_ENDOCYTIC_2	48	51	PF00928	0.288
TRG_ENDOCYTIC_2	528	531	PF00928	0.335
TRG_ENDOCYTIC_2	589	592	PF00928	0.386
TRG_ENDOCYTIC_2	59	62	PF00928	0.291
TRG_ENDOCYTIC_2	594	597	PF00928	0.404
TRG_ER_diArg_1	255	257	PF00400	0.308
TRG_ER_diArg_1	341	343	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.703
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	75%	100%
A0A0N1HT40	Leptomonas seymouri	40%	100%
A0A0N1HZC2	Leptomonas seymouri	26%	100%
A0A0N1IKC5	Leptomonas seymouri	40%	100%
A0A0N1PB63	Leptomonas seymouri	25%	96%
A0A0N1PFR4	Leptomonas seymouri	28%	96%
A0A0S4IIJ4	Bodo saltans	22%	100%
A0A0S4JR45	Bodo saltans	28%	100%
A0A1X0NKK0	Trypanosomatidae	27%	100%
A0A1X0NL32	Trypanosomatidae	30%	100%
A0A1X0NM09	Trypanosomatidae	25%	100%
A0A1X0NRW5	Trypanosomatidae	41%	91%
A0A1X0NV13	Trypanosomatidae	43%	98%
A0A1X0NV19	Trypanosomatidae	40%	100%
A0A1X0NV27	Trypanosomatidae	39%	100%
A0A1X0NVH8	Trypanosomatidae	39%	96%
A0A1X0NVM7	Trypanosomatidae	41%	98%
A0A1X0NWQ1	Trypanosomatidae	42%	99%
A0A1X0NZE6	Trypanosomatidae	31%	100%
A0A1X0NZU2	Trypanosomatidae	29%	98%
A0A1X0NZU5	Trypanosomatidae	31%	100%
A0A1X0NZW1	Trypanosomatidae	29%	100%
A0A1X0P0M7	Trypanosomatidae	29%	100%
A0A381MMW5	Leishmania infantum	27%	100%
A0A3Q8I7Y9	Leishmania donovani	38%	100%
A0A3Q8IEC4	Leishmania donovani	28%	98%
A0A3Q8IF95	Leishmania donovani	26%	100%
A0A3Q8IIT5	Leishmania donovani	28%	94%
A0A3Q8ISY9	Leishmania donovani	100%	100%
A0A3R7JSQ9	Trypanosoma rangeli	26%	100%
A0A3R7KKN8	Trypanosoma rangeli	29%	100%
A0A3R7MAQ7	Trypanosoma rangeli	39%	90%
A0A3R7N415	Trypanosoma rangeli	28%	100%
A0A3R7N921	Trypanosoma rangeli	29%	100%
A0A3R7R443	Trypanosoma rangeli	27%	100%
A0A3S7WRJ4	Leishmania donovani	40%	99%
A0A3S7WRJ5	Leishmania donovani	37%	91%
A0A3S7WRL4	Leishmania donovani	38%	100%
A0A3S7WRS3	Leishmania donovani	23%	100%
A0A3S7WSR4	Leishmania donovani	41%	100%
A0A3S7WWU1	Leishmania donovani	25%	96%
A0A3S7X2G0	Leishmania donovani	28%	97%
A0A3S7X2K5	Leishmania donovani	27%	100%
A0A3S7XB11	Leishmania donovani	27%	100%
A0A422MSE4	Trypanosoma rangeli	41%	100%
A0A422MSP6	Trypanosoma rangeli	30%	100%
A0A422MST9	Trypanosoma rangeli	26%	100%
A0A422MU68	Trypanosoma rangeli	24%	100%
A4H6J0	Leishmania braziliensis	40%	100%
A4H6J1	Leishmania braziliensis	38%	100%
A4H6J3	Leishmania braziliensis	37%	98%
A4H6Q5	Leishmania braziliensis	23%	100%
A4HC19	Leishmania braziliensis	25%	100%
A4HHG2	Leishmania braziliensis	27%	100%
A4HHG3	Leishmania braziliensis	27%	99%
A4HHG4	Leishmania braziliensis	26%	99%
A4HJW3	Leishmania braziliensis	84%	100%
A4HPE2	Leishmania braziliensis	27%	100%
A4HUX5	Leishmania infantum	40%	100%
A4HUX6	Leishmania infantum	38%	100%
A4HUX7	Leishmania infantum	38%	100%
A4HUX8	Leishmania infantum	38%	100%
A4HV40	Leishmania infantum	23%	100%
A4HZF5	Leishmania infantum	26%	100%
A4HZJ4	Leishmania infantum	25%	100%
A4I4L2	Leishmania infantum	27%	94%
A4ICI3	Leishmania infantum	27%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	99%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	93%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AE01	Leishmania major	27%	100%
E9AE09	Leishmania major	27%	94%
E9AE10	Leishmania major	27%	94%
E9AE11	Leishmania major	28%	100%
E9AGK5	Leishmania infantum	41%	100%
E9AHJ0	Leishmania infantum	28%	98%
E9AHJ1	Leishmania infantum	27%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	94%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	99%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1E4	Leishmania major	27%	100%
Q4Q5T8	Leishmania major	94%	100%
Q4QC27	Leishmania major	25%	100%
Q4QC28	Leishmania major	25%	100%
Q4QFY5	Leishmania major	40%	100%
Q4QGU8	Leishmania major	23%	100%
Q4QH10	Leishmania major	36%	98%
Q4QH11	Leishmania major	37%	95%
Q4QH12	Leishmania major	37%	95%
Q4QH13	Leishmania major	38%	95%
Q4QH14	Leishmania major	36%	100%
Q4QH15	Leishmania major	41%	100%
V5B647	Trypanosoma cruzi	42%	100%
V5B983	Trypanosoma cruzi	31%	100%
V5BBB1	Trypanosoma cruzi	42%	100%
V5BFV8	Trypanosoma cruzi	30%	95%
V5BQY6	Trypanosoma cruzi	39%	90%
V5BVP0	Trypanosoma cruzi	42%	100%
V5DT25	Trypanosoma cruzi	41%	100%