LeishMANIAdb
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Phosphatidylethanolaminen-methyltransferase-lik e protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidylethanolaminen-methyltransferase-lik e protein
Gene product:
phosphatidylethanolaminen-methyltransferase-lik e protein
Species:
Leishmania infantum
UniProt:
A4I7B9_LEIIN
TriTrypDb:
LINF_310040200
Length:
582

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, Phosphatidylethanolaminen-methyltransferase-lik e

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4I7B9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7B9

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 9
GO:0006644 phospholipid metabolic process 4 9
GO:0006650 glycerophospholipid metabolic process 5 9
GO:0006656 phosphatidylcholine biosynthetic process 5 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0008610 lipid biosynthetic process 4 9
GO:0008654 phospholipid biosynthetic process 5 9
GO:0009058 biosynthetic process 2 9
GO:0009987 cellular process 1 9
GO:0019637 organophosphate metabolic process 3 9
GO:0032259 methylation 2 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044249 cellular biosynthetic process 3 9
GO:0044255 cellular lipid metabolic process 3 9
GO:0045017 glycerolipid biosynthetic process 4 9
GO:0046470 phosphatidylcholine metabolic process 4 9
GO:0046474 glycerophospholipid biosynthetic process 5 9
GO:0046486 glycerolipid metabolic process 4 9
GO:0071704 organic substance metabolic process 2 9
GO:0090407 organophosphate biosynthetic process 4 9
GO:1901564 organonitrogen compound metabolic process 3 9
GO:1901566 organonitrogen compound biosynthetic process 4 9
GO:1901576 organic substance biosynthetic process 3 9
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0004608 phosphatidylethanolamine N-methyltransferase activity 6 6
GO:0008168 methyltransferase activity 4 9
GO:0008170 N-methyltransferase activity 5 6
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 6
GO:0016740 transferase activity 2 9
GO:0016741 transferase activity, transferring one-carbon groups 3 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 39 43 PF00656 0.635
CLV_NRD_NRD_1 115 117 PF00675 0.344
CLV_NRD_NRD_1 125 127 PF00675 0.359
CLV_NRD_NRD_1 536 538 PF00675 0.262
CLV_NRD_NRD_1 556 558 PF00675 0.370
CLV_NRD_NRD_1 578 580 PF00675 0.411
CLV_PCSK_KEX2_1 115 117 PF00082 0.344
CLV_PCSK_KEX2_1 125 127 PF00082 0.359
CLV_PCSK_KEX2_1 378 380 PF00082 0.400
CLV_PCSK_KEX2_1 401 403 PF00082 0.333
CLV_PCSK_KEX2_1 538 540 PF00082 0.264
CLV_PCSK_KEX2_1 556 558 PF00082 0.377
CLV_PCSK_PC1ET2_1 378 380 PF00082 0.400
CLV_PCSK_PC1ET2_1 401 403 PF00082 0.333
CLV_PCSK_PC1ET2_1 538 540 PF00082 0.313
CLV_PCSK_SKI1_1 125 129 PF00082 0.350
CLV_PCSK_SKI1_1 229 233 PF00082 0.530
CLV_PCSK_SKI1_1 421 425 PF00082 0.409
CLV_PCSK_SKI1_1 556 560 PF00082 0.387
CLV_PCSK_SKI1_1 570 574 PF00082 0.359
DOC_CKS1_1 44 49 PF01111 0.643
DOC_CYCLIN_RxL_1 122 131 PF00134 0.566
DOC_CYCLIN_yClb5_NLxxxL_5 408 417 PF00134 0.409
DOC_CYCLIN_yCln2_LP_2 183 189 PF00134 0.530
DOC_CYCLIN_yCln2_LP_2 349 355 PF00134 0.366
DOC_MAPK_gen_1 31 40 PF00069 0.576
DOC_MAPK_MEF2A_6 332 340 PF00069 0.495
DOC_PIKK_1 159 167 PF02985 0.553
DOC_PP1_RVXF_1 227 234 PF00149 0.272
DOC_PP2B_LxvP_1 349 352 PF13499 0.366
DOC_PP4_FxxP_1 240 243 PF00568 0.272
DOC_PP4_FxxP_1 32 35 PF00568 0.539
DOC_SPAK_OSR1_1 31 35 PF12202 0.544
DOC_USP7_MATH_1 451 455 PF00917 0.392
DOC_USP7_MATH_1 492 496 PF00917 0.479
DOC_USP7_MATH_1 517 521 PF00917 0.407
DOC_USP7_MATH_1 6 10 PF00917 0.606
DOC_WW_Pin1_4 182 187 PF00397 0.560
DOC_WW_Pin1_4 293 298 PF00397 0.660
DOC_WW_Pin1_4 389 394 PF00397 0.590
DOC_WW_Pin1_4 43 48 PF00397 0.570
DOC_WW_Pin1_4 49 54 PF00397 0.499
DOC_WW_Pin1_4 507 512 PF00397 0.361
LIG_14-3-3_CanoR_1 332 340 PF00244 0.496
LIG_14-3-3_CanoR_1 51 57 PF00244 0.551
LIG_AP2alpha_1 145 149 PF02296 0.501
LIG_APCC_ABBA_1 324 329 PF00400 0.563
LIG_BIR_II_1 1 5 PF00653 0.710
LIG_BRCT_BRCA1_1 130 134 PF00533 0.535
LIG_BRCT_BRCA1_1 197 201 PF00533 0.409
LIG_Clathr_ClatBox_1 325 329 PF01394 0.539
LIG_deltaCOP1_diTrp_1 215 225 PF00928 0.272
LIG_eIF4E_1 344 350 PF01652 0.406
LIG_eIF4E_1 501 507 PF01652 0.328
LIG_FHA_1 122 128 PF00498 0.591
LIG_FHA_1 288 294 PF00498 0.472
LIG_FHA_1 346 352 PF00498 0.409
LIG_FHA_1 35 41 PF00498 0.554
LIG_FHA_1 442 448 PF00498 0.385
LIG_FHA_1 66 72 PF00498 0.336
LIG_FHA_2 13 19 PF00498 0.743
LIG_FHA_2 296 302 PF00498 0.594
LIG_GBD_Chelix_1 338 346 PF00786 0.409
LIG_LIR_Apic_2 30 35 PF02991 0.546
LIG_LIR_Apic_2 387 393 PF02991 0.590
LIG_LIR_Apic_2 424 428 PF02991 0.500
LIG_LIR_Apic_2 49 53 PF02991 0.423
LIG_LIR_Gen_1 109 118 PF02991 0.535
LIG_LIR_Gen_1 169 176 PF02991 0.459
LIG_LIR_Gen_1 234 245 PF02991 0.272
LIG_LIR_Gen_1 246 257 PF02991 0.272
LIG_LIR_Gen_1 261 270 PF02991 0.328
LIG_LIR_Gen_1 288 299 PF02991 0.599
LIG_LIR_Gen_1 456 466 PF02991 0.488
LIG_LIR_LC3C_4 321 324 PF02991 0.523
LIG_LIR_Nem_3 105 110 PF02991 0.521
LIG_LIR_Nem_3 169 173 PF02991 0.487
LIG_LIR_Nem_3 21 26 PF02991 0.589
LIG_LIR_Nem_3 215 219 PF02991 0.272
LIG_LIR_Nem_3 222 227 PF02991 0.272
LIG_LIR_Nem_3 232 236 PF02991 0.272
LIG_LIR_Nem_3 261 265 PF02991 0.327
LIG_LIR_Nem_3 268 273 PF02991 0.327
LIG_LIR_Nem_3 288 294 PF02991 0.388
LIG_LIR_Nem_3 454 458 PF02991 0.366
LIG_LIR_Nem_3 463 467 PF02991 0.462
LIG_LIR_Nem_3 483 489 PF02991 0.333
LIG_LIR_Nem_3 499 504 PF02991 0.343
LIG_LIR_Nem_3 61 65 PF02991 0.388
LIG_NRBOX 345 351 PF00104 0.376
LIG_NRBOX 372 378 PF00104 0.463
LIG_Pex14_1 220 224 PF04695 0.272
LIG_Pex14_1 400 404 PF04695 0.499
LIG_Pex14_1 89 93 PF04695 0.328
LIG_Pex14_2 145 149 PF04695 0.501
LIG_Pex14_2 216 220 PF04695 0.319
LIG_Pex14_2 233 237 PF04695 0.185
LIG_Pex14_2 368 372 PF04695 0.370
LIG_Pex14_2 467 471 PF04695 0.475
LIG_Pex14_2 82 86 PF04695 0.343
LIG_PTB_Apo_2 409 416 PF02174 0.328
LIG_PTB_Phospho_1 409 415 PF10480 0.328
LIG_SH2_CRK 114 118 PF00017 0.591
LIG_SH2_CRK 170 174 PF00017 0.541
LIG_SH2_CRK 23 27 PF00017 0.594
LIG_SH2_CRK 253 257 PF00017 0.272
LIG_SH2_CRK 266 270 PF00017 0.328
LIG_SH2_CRK 291 295 PF00017 0.653
LIG_SH2_CRK 390 394 PF00017 0.513
LIG_SH2_CRK 482 486 PF00017 0.472
LIG_SH2_GRB2like 488 491 PF00017 0.472
LIG_SH2_NCK_1 390 394 PF00017 0.576
LIG_SH2_NCK_1 458 462 PF00017 0.480
LIG_SH2_SRC 316 319 PF00017 0.587
LIG_SH2_STAP1 249 253 PF00017 0.272
LIG_SH2_STAP1 262 266 PF00017 0.328
LIG_SH2_STAP1 358 362 PF00017 0.377
LIG_SH2_STAP1 565 569 PF00017 0.553
LIG_SH2_STAT3 540 543 PF00017 0.530
LIG_SH2_STAT5 170 173 PF00017 0.456
LIG_SH2_STAT5 245 248 PF00017 0.272
LIG_SH2_STAT5 262 265 PF00017 0.328
LIG_SH2_STAT5 316 319 PF00017 0.543
LIG_SH2_STAT5 344 347 PF00017 0.361
LIG_SH2_STAT5 375 378 PF00017 0.417
LIG_SH2_STAT5 415 418 PF00017 0.361
LIG_SH2_STAT5 422 425 PF00017 0.361
LIG_SH2_STAT5 452 455 PF00017 0.328
LIG_SH2_STAT5 466 469 PF00017 0.454
LIG_SH2_STAT5 488 491 PF00017 0.481
LIG_SH2_STAT5 72 75 PF00017 0.346
LIG_SH3_3 279 285 PF00018 0.472
LIG_SH3_3 528 534 PF00018 0.472
LIG_SUMO_SIM_anti_2 321 327 PF11976 0.535
LIG_SUMO_SIM_anti_2 510 516 PF11976 0.335
LIG_SUMO_SIM_par_1 334 341 PF11976 0.372
LIG_TRAF2_1 298 301 PF00917 0.586
LIG_TYR_ITIM 168 173 PF00017 0.511
LIG_TYR_ITIM 264 269 PF00017 0.328
LIG_TYR_ITIM 480 485 PF00017 0.472
LIG_WRC_WIRS_1 107 112 PF05994 0.539
MOD_CDK_SPK_2 43 48 PF00069 0.646
MOD_CK1_1 13 19 PF00069 0.627
MOD_CK1_1 182 188 PF00069 0.530
MOD_CK1_1 2 8 PF00069 0.689
MOD_CK1_1 295 301 PF00069 0.636
MOD_CK1_1 49 55 PF00069 0.542
MOD_CK2_1 12 18 PF00069 0.723
MOD_CK2_1 295 301 PF00069 0.632
MOD_CK2_1 428 434 PF00069 0.394
MOD_CK2_1 453 459 PF00069 0.392
MOD_CK2_1 558 564 PF00069 0.569
MOD_GlcNHglycan 4 7 PF01048 0.490
MOD_GlcNHglycan 431 434 PF01048 0.639
MOD_GlcNHglycan 482 485 PF01048 0.289
MOD_GlcNHglycan 498 501 PF01048 0.218
MOD_GlcNHglycan 507 510 PF01048 0.305
MOD_GlcNHglycan 8 11 PF01048 0.494
MOD_GSK3_1 10 17 PF00069 0.694
MOD_GSK3_1 102 109 PF00069 0.537
MOD_GSK3_1 2 9 PF00069 0.717
MOD_GSK3_1 404 411 PF00069 0.342
MOD_GSK3_1 492 499 PF00069 0.468
MOD_LATS_1 104 110 PF00433 0.604
MOD_N-GLC_1 229 234 PF02516 0.569
MOD_N-GLC_1 310 315 PF02516 0.312
MOD_N-GLC_1 404 409 PF02516 0.338
MOD_N-GLC_1 411 416 PF02516 0.313
MOD_N-GLC_1 480 485 PF02516 0.296
MOD_NEK2_1 12 17 PF00069 0.722
MOD_NEK2_1 128 133 PF00069 0.510
MOD_NEK2_1 258 263 PF00069 0.328
MOD_NEK2_1 265 270 PF00069 0.328
MOD_NEK2_1 338 343 PF00069 0.409
MOD_NEK2_1 345 350 PF00069 0.381
MOD_NEK2_1 480 485 PF00069 0.481
MOD_NEK2_1 496 501 PF00069 0.255
MOD_NEK2_1 558 563 PF00069 0.644
MOD_NEK2_1 71 76 PF00069 0.366
MOD_PKA_1 378 384 PF00069 0.582
MOD_PKA_2 331 337 PF00069 0.496
MOD_PKA_2 378 384 PF00069 0.608
MOD_Plk_1 128 134 PF00069 0.508
MOD_Plk_1 229 235 PF00069 0.335
MOD_Plk_1 287 293 PF00069 0.472
MOD_Plk_1 404 410 PF00069 0.338
MOD_Plk_1 411 417 PF00069 0.313
MOD_Plk_1 492 498 PF00069 0.472
MOD_Plk_2-3 36 42 PF00069 0.633
MOD_Plk_4 106 112 PF00069 0.532
MOD_Plk_4 128 134 PF00069 0.543
MOD_Plk_4 171 177 PF00069 0.503
MOD_Plk_4 260 266 PF00069 0.328
MOD_Plk_4 338 344 PF00069 0.385
MOD_Plk_4 345 351 PF00069 0.332
MOD_Plk_4 36 42 PF00069 0.560
MOD_Plk_4 441 447 PF00069 0.460
MOD_Plk_4 52 58 PF00069 0.454
MOD_ProDKin_1 182 188 PF00069 0.496
MOD_ProDKin_1 293 299 PF00069 0.656
MOD_ProDKin_1 389 395 PF00069 0.587
MOD_ProDKin_1 43 49 PF00069 0.564
MOD_ProDKin_1 507 513 PF00069 0.361
MOD_SUMO_for_1 377 380 PF00179 0.555
MOD_SUMO_for_1 574 577 PF00179 0.580
MOD_SUMO_rev_2 136 143 PF00179 0.626
MOD_SUMO_rev_2 561 569 PF00179 0.611
TRG_DiLeu_BaEn_1 21 26 PF01217 0.572
TRG_DiLeu_BaEn_1 318 323 PF01217 0.576
TRG_DiLeu_BaEn_2 433 439 PF01217 0.296
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.573
TRG_ENDOCYTIC_2 107 110 PF00928 0.539
TRG_ENDOCYTIC_2 114 117 PF00928 0.543
TRG_ENDOCYTIC_2 170 173 PF00928 0.489
TRG_ENDOCYTIC_2 23 26 PF00928 0.581
TRG_ENDOCYTIC_2 249 252 PF00928 0.272
TRG_ENDOCYTIC_2 262 265 PF00928 0.328
TRG_ENDOCYTIC_2 266 269 PF00928 0.328
TRG_ENDOCYTIC_2 291 294 PF00928 0.592
TRG_ENDOCYTIC_2 458 461 PF00928 0.486
TRG_ENDOCYTIC_2 464 467 PF00928 0.492
TRG_ENDOCYTIC_2 468 471 PF00928 0.502
TRG_ENDOCYTIC_2 482 485 PF00928 0.386
TRG_ENDOCYTIC_2 486 489 PF00928 0.401
TRG_ENDOCYTIC_2 501 504 PF00928 0.328
TRG_ER_diArg_1 114 116 PF00400 0.537
TRG_ER_diArg_1 125 127 PF00400 0.559
TRG_ER_diArg_1 536 539 PF00400 0.466
TRG_ER_diArg_1 555 557 PF00400 0.591
TRG_NLS_MonoExtC_3 536 542 PF00514 0.444
TRG_NLS_MonoExtN_4 534 541 PF00514 0.513
TRG_Pf-PMV_PEXEL_1 125 129 PF00026 0.367
TRG_Pf-PMV_PEXEL_1 211 215 PF00026 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1S1 Leptomonas seymouri 80% 100%
A0A0S4ITN2 Bodo saltans 53% 100%
A0A1X0NK27 Trypanosomatidae 58% 97%
A0A3Q8IF60 Leishmania donovani 100% 100%
A3LQW6 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 30% 68%
A4HJV7 Leishmania braziliensis 87% 100%
A5DL79 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 31% 67%
A6ZUG8 Saccharomyces cerevisiae (strain YJM789) 30% 67%
A7TLA7 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 32% 69%
A7TNI7 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 32% 69%
B3LI73 Saccharomyces cerevisiae (strain RM11-1a) 30% 67%
B5VJA0 Saccharomyces cerevisiae (strain AWRI1631) 30% 67%
C4Y206 Clavispora lusitaniae (strain ATCC 42720) 29% 68%
C5DGB6 Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) 34% 69%
C5DZU3 Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) 32% 70%
C5M4D4 Candida tropicalis (strain ATCC MYA-3404 / T1) 29% 67%
C7GQ65 Saccharomyces cerevisiae (strain JAY291) 30% 67%
C8Z951 Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) 30% 67%
E9B2B2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P05374 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 67%
Q4Q5U4 Leishmania major 97% 100%
Q6BY28 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 31% 67%
Q6CJI9 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 29% 69%
Q6FVB6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 33% 68%
Q754G0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 32% 69%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS