LeishMANIAdb
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TPH domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPH domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I7B8_LEIIN
TriTrypDb:
LINF_310040100
Length:
846

Annotations

Annotations by Jardim et al.

Flagella, Flagellum attachment zone 14

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 444
Promastigote/Amastigote: 579

Expansion

Sequence features

A4I7B8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7B8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 29 33 PF00656 0.592
CLV_C14_Caspase3-7 417 421 PF00656 0.548
CLV_C14_Caspase3-7 667 671 PF00656 0.720
CLV_NRD_NRD_1 141 143 PF00675 0.525
CLV_NRD_NRD_1 191 193 PF00675 0.528
CLV_NRD_NRD_1 243 245 PF00675 0.521
CLV_NRD_NRD_1 277 279 PF00675 0.577
CLV_NRD_NRD_1 30 32 PF00675 0.624
CLV_NRD_NRD_1 302 304 PF00675 0.619
CLV_NRD_NRD_1 384 386 PF00675 0.649
CLV_NRD_NRD_1 394 396 PF00675 0.587
CLV_NRD_NRD_1 45 47 PF00675 0.643
CLV_NRD_NRD_1 456 458 PF00675 0.533
CLV_NRD_NRD_1 471 473 PF00675 0.483
CLV_NRD_NRD_1 521 523 PF00675 0.619
CLV_NRD_NRD_1 527 529 PF00675 0.565
CLV_NRD_NRD_1 542 544 PF00675 0.576
CLV_NRD_NRD_1 60 62 PF00675 0.351
CLV_NRD_NRD_1 600 602 PF00675 0.701
CLV_NRD_NRD_1 646 648 PF00675 0.555
CLV_NRD_NRD_1 656 658 PF00675 0.662
CLV_NRD_NRD_1 709 711 PF00675 0.515
CLV_NRD_NRD_1 800 802 PF00675 0.584
CLV_PCSK_FUR_1 189 193 PF00082 0.519
CLV_PCSK_FUR_1 28 32 PF00082 0.600
CLV_PCSK_KEX2_1 140 142 PF00082 0.502
CLV_PCSK_KEX2_1 191 193 PF00082 0.593
CLV_PCSK_KEX2_1 230 232 PF00082 0.630
CLV_PCSK_KEX2_1 30 32 PF00082 0.624
CLV_PCSK_KEX2_1 304 306 PF00082 0.604
CLV_PCSK_KEX2_1 45 47 PF00082 0.675
CLV_PCSK_KEX2_1 471 473 PF00082 0.566
CLV_PCSK_KEX2_1 485 487 PF00082 0.602
CLV_PCSK_KEX2_1 492 494 PF00082 0.496
CLV_PCSK_KEX2_1 521 523 PF00082 0.703
CLV_PCSK_KEX2_1 542 544 PF00082 0.549
CLV_PCSK_KEX2_1 602 604 PF00082 0.695
CLV_PCSK_KEX2_1 800 802 PF00082 0.561
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.624
CLV_PCSK_PC1ET2_1 304 306 PF00082 0.546
CLV_PCSK_PC1ET2_1 485 487 PF00082 0.666
CLV_PCSK_PC1ET2_1 492 494 PF00082 0.592
CLV_PCSK_PC1ET2_1 602 604 PF00082 0.605
CLV_PCSK_PC7_1 598 604 PF00082 0.658
CLV_PCSK_SKI1_1 102 106 PF00082 0.455
CLV_PCSK_SKI1_1 142 146 PF00082 0.536
CLV_PCSK_SKI1_1 259 263 PF00082 0.517
CLV_PCSK_SKI1_1 338 342 PF00082 0.456
CLV_PCSK_SKI1_1 385 389 PF00082 0.684
CLV_PCSK_SKI1_1 419 423 PF00082 0.602
CLV_PCSK_SKI1_1 481 485 PF00082 0.614
CLV_PCSK_SKI1_1 528 532 PF00082 0.498
CLV_PCSK_SKI1_1 586 590 PF00082 0.734
CLV_PCSK_SKI1_1 657 661 PF00082 0.702
CLV_PCSK_SKI1_1 692 696 PF00082 0.445
CLV_PCSK_SKI1_1 786 790 PF00082 0.433
DEG_APCC_DBOX_1 691 699 PF00400 0.444
DOC_MAPK_gen_1 159 166 PF00069 0.602
DOC_MAPK_gen_1 710 717 PF00069 0.593
DOC_MAPK_MEF2A_6 5 12 PF00069 0.529
DOC_USP7_MATH_1 17 21 PF00917 0.609
DOC_USP7_MATH_1 218 222 PF00917 0.548
DOC_USP7_MATH_1 346 350 PF00917 0.684
DOC_USP7_MATH_1 370 374 PF00917 0.687
DOC_USP7_MATH_1 407 411 PF00917 0.600
DOC_USP7_MATH_1 441 445 PF00917 0.618
DOC_USP7_MATH_1 669 673 PF00917 0.671
DOC_USP7_MATH_1 676 680 PF00917 0.776
DOC_USP7_MATH_1 76 80 PF00917 0.543
DOC_USP7_MATH_1 770 774 PF00917 0.640
DOC_USP7_MATH_1 825 829 PF00917 0.593
DOC_USP7_UBL2_3 481 485 PF12436 0.512
DOC_USP7_UBL2_3 817 821 PF12436 0.542
DOC_WW_Pin1_4 13 18 PF00397 0.678
DOC_WW_Pin1_4 581 586 PF00397 0.658
DOC_WW_Pin1_4 588 593 PF00397 0.667
DOC_WW_Pin1_4 672 677 PF00397 0.769
LIG_14-3-3_CanoR_1 45 50 PF00244 0.583
LIG_14-3-3_CanoR_1 595 601 PF00244 0.757
LIG_14-3-3_CanoR_1 786 794 PF00244 0.409
LIG_BIR_II_1 1 5 PF00653 0.622
LIG_BRCT_BRCA1_1 35 39 PF00533 0.606
LIG_deltaCOP1_diTrp_1 87 92 PF00928 0.428
LIG_FHA_1 143 149 PF00498 0.535
LIG_FHA_1 210 216 PF00498 0.471
LIG_FHA_1 750 756 PF00498 0.624
LIG_FHA_1 772 778 PF00498 0.587
LIG_FHA_2 103 109 PF00498 0.449
LIG_FHA_2 183 189 PF00498 0.481
LIG_FHA_2 211 217 PF00498 0.650
LIG_FHA_2 241 247 PF00498 0.630
LIG_FHA_2 270 276 PF00498 0.545
LIG_FHA_2 767 773 PF00498 0.694
LIG_IRF3_LxIS_1 527 534 PF10401 0.582
LIG_LIR_Gen_1 87 96 PF02991 0.424
LIG_LIR_LC3C_4 713 717 PF02991 0.576
LIG_LIR_Nem_3 87 92 PF02991 0.427
LIG_Pex14_2 88 92 PF04695 0.536
LIG_RPA_C_Fungi 214 226 PF08784 0.526
LIG_RPA_C_Plants 692 703 PF08784 0.516
LIG_SH2_STAP1 712 716 PF00017 0.562
LIG_SH2_STAP1 751 755 PF00017 0.630
LIG_SH2_STAT5 751 754 PF00017 0.690
LIG_SUMO_SIM_anti_2 108 114 PF11976 0.519
LIG_SUMO_SIM_anti_2 555 560 PF11976 0.462
LIG_TRAF2_1 105 108 PF00917 0.479
LIG_TRAF2_1 329 332 PF00917 0.576
LIG_TRAF2_1 579 582 PF00917 0.626
LIG_TRAF2_1 776 779 PF00917 0.609
LIG_TRAF2_2 377 382 PF00917 0.686
MOD_CDK_SPK_2 581 586 PF00069 0.644
MOD_CDK_SPK_2 593 598 PF00069 0.665
MOD_CDK_SPxxK_3 588 595 PF00069 0.716
MOD_CK1_1 33 39 PF00069 0.617
MOD_CK1_1 41 47 PF00069 0.575
MOD_CK1_1 663 669 PF00069 0.659
MOD_CK1_1 672 678 PF00069 0.784
MOD_CK1_1 750 756 PF00069 0.623
MOD_CK2_1 102 108 PF00069 0.479
MOD_CK2_1 182 188 PF00069 0.547
MOD_CK2_1 210 216 PF00069 0.648
MOD_CK2_1 240 246 PF00069 0.636
MOD_CK2_1 269 275 PF00069 0.573
MOD_CK2_1 346 352 PF00069 0.590
MOD_CK2_1 52 58 PF00069 0.524
MOD_CK2_1 576 582 PF00069 0.624
MOD_CK2_1 758 764 PF00069 0.770
MOD_CK2_1 766 772 PF00069 0.714
MOD_GlcNHglycan 152 157 PF01048 0.521
MOD_GlcNHglycan 220 223 PF01048 0.558
MOD_GlcNHglycan 307 312 PF01048 0.435
MOD_GlcNHglycan 372 375 PF01048 0.734
MOD_GlcNHglycan 409 412 PF01048 0.548
MOD_GlcNHglycan 496 502 PF01048 0.527
MOD_GlcNHglycan 513 516 PF01048 0.631
MOD_GlcNHglycan 752 755 PF01048 0.626
MOD_GlcNHglycan 774 777 PF01048 0.512
MOD_GlcNHglycan 817 820 PF01048 0.585
MOD_GlcNHglycan 829 832 PF01048 0.642
MOD_GlcNHglycan 842 845 PF01048 0.477
MOD_GSK3_1 13 20 PF00069 0.668
MOD_GSK3_1 26 33 PF00069 0.612
MOD_GSK3_1 307 314 PF00069 0.439
MOD_GSK3_1 34 41 PF00069 0.544
MOD_GSK3_1 346 353 PF00069 0.682
MOD_GSK3_1 507 514 PF00069 0.606
MOD_GSK3_1 584 591 PF00069 0.736
MOD_GSK3_1 660 667 PF00069 0.676
MOD_GSK3_1 668 675 PF00069 0.798
MOD_GSK3_1 766 773 PF00069 0.643
MOD_N-GLC_1 26 31 PF02516 0.675
MOD_N-GLC_1 825 830 PF02516 0.588
MOD_NEK2_1 26 31 PF00069 0.626
MOD_NEK2_1 34 39 PF00069 0.591
MOD_NEK2_1 440 445 PF00069 0.614
MOD_NEK2_1 660 665 PF00069 0.604
MOD_PIKK_1 312 318 PF00454 0.590
MOD_PIKK_1 507 513 PF00454 0.516
MOD_PIKK_1 531 537 PF00454 0.534
MOD_PK_1 175 181 PF00069 0.524
MOD_PK_1 45 51 PF00069 0.736
MOD_PKA_1 30 36 PF00069 0.639
MOD_PKA_1 45 51 PF00069 0.708
MOD_PKA_1 542 548 PF00069 0.521
MOD_PKA_2 121 127 PF00069 0.568
MOD_PKA_2 174 180 PF00069 0.619
MOD_PKA_2 218 224 PF00069 0.666
MOD_PKA_2 30 36 PF00069 0.575
MOD_PKA_2 37 43 PF00069 0.611
MOD_PKA_2 407 413 PF00069 0.546
MOD_PKA_2 44 50 PF00069 0.600
MOD_PKA_2 542 548 PF00069 0.514
MOD_PKA_2 719 725 PF00069 0.580
MOD_PKB_1 140 148 PF00069 0.601
MOD_PKB_1 238 246 PF00069 0.494
MOD_PKB_1 28 36 PF00069 0.646
MOD_PKB_1 348 356 PF00069 0.550
MOD_Plk_1 152 158 PF00069 0.553
MOD_Plk_1 175 181 PF00069 0.582
MOD_Plk_1 297 303 PF00069 0.591
MOD_Plk_1 6 12 PF00069 0.530
MOD_Plk_2-3 182 188 PF00069 0.443
MOD_Plk_2-3 52 58 PF00069 0.524
MOD_Plk_4 175 181 PF00069 0.542
MOD_ProDKin_1 13 19 PF00069 0.679
MOD_ProDKin_1 581 587 PF00069 0.661
MOD_ProDKin_1 588 594 PF00069 0.668
MOD_ProDKin_1 672 678 PF00069 0.768
MOD_SUMO_for_1 160 163 PF00179 0.591
MOD_SUMO_for_1 484 487 PF00179 0.484
MOD_SUMO_rev_2 274 281 PF00179 0.589
MOD_SUMO_rev_2 332 336 PF00179 0.583
MOD_SUMO_rev_2 373 380 PF00179 0.596
MOD_SUMO_rev_2 454 460 PF00179 0.544
MOD_SUMO_rev_2 462 467 PF00179 0.489
MOD_SUMO_rev_2 640 650 PF00179 0.548
TRG_DiLeu_BaEn_1 108 113 PF01217 0.466
TRG_DiLeu_BaEn_1 77 82 PF01217 0.556
TRG_DiLeu_BaEn_4 152 158 PF01217 0.595
TRG_DiLeu_BaEn_4 297 303 PF01217 0.423
TRG_DiLeu_BaEn_4 803 809 PF01217 0.505
TRG_ENDOCYTIC_2 712 715 PF00928 0.584
TRG_ER_diArg_1 139 142 PF00400 0.496
TRG_ER_diArg_1 189 192 PF00400 0.582
TRG_ER_diArg_1 28 31 PF00400 0.603
TRG_ER_diArg_1 302 305 PF00400 0.604
TRG_ER_diArg_1 470 472 PF00400 0.523
TRG_ER_diArg_1 520 522 PF00400 0.712
TRG_ER_diArg_1 600 603 PF00400 0.715
TRG_NLS_Bipartite_1 45 65 PF00514 0.607
TRG_NLS_MonoExtC_3 600 605 PF00514 0.655
TRG_NLS_MonoExtN_4 598 605 PF00514 0.623
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.499
TRG_Pf-PMV_PEXEL_1 458 462 PF00026 0.575
TRG_Pf-PMV_PEXEL_1 465 469 PF00026 0.565
TRG_Pf-PMV_PEXEL_1 493 497 PF00026 0.564
TRG_Pf-PMV_PEXEL_1 786 790 PF00026 0.549
TRG_Pf-PMV_PEXEL_1 80 84 PF00026 0.528

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I335 Leptomonas seymouri 53% 97%
A0A1X0NIP5 Trypanosomatidae 28% 100%
A0A3R7NBX7 Trypanosoma rangeli 30% 100%
A0A3S7X4Z8 Leishmania donovani 100% 100%
A4HJV6 Leishmania braziliensis 67% 98%
E9B2B1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q5U5 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS