Autophagy_act_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 10 (ATG10)

Species:

Leishmania infantum

UniProt:

A4I7B7_LEIIN

TriTrypDb:

LINF_310040000

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7B7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.448
CLV_NRD_NRD_1	181	183	PF00675	0.465
CLV_PCSK_FUR_1	64	68	PF00082	0.465
CLV_PCSK_KEX2_1	150	152	PF00082	0.327
CLV_PCSK_KEX2_1	181	183	PF00082	0.465
CLV_PCSK_KEX2_1	66	68	PF00082	0.543
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.543
DEG_APCC_DBOX_1	6	14	PF00400	0.490
DOC_CDC14_PxL_1	202	210	PF14671	0.435
DOC_MAPK_DCC_7	125	133	PF00069	0.421
DOC_MAPK_gen_1	150	156	PF00069	0.300
DOC_MAPK_MEF2A_6	125	133	PF00069	0.421
DOC_MAPK_RevD_3	166	182	PF00069	0.393
DOC_PP2B_LxvP_1	207	210	PF13499	0.407
DOC_PP2B_LxvP_1	70	73	PF13499	0.349
DOC_PP4_FxxP_1	106	109	PF00568	0.384
DOC_PP4_FxxP_1	87	90	PF00568	0.361
DOC_USP7_MATH_1	152	156	PF00917	0.359
DOC_USP7_MATH_2	60	66	PF00917	0.454
DOC_WW_Pin1_4	25	30	PF00397	0.486
DOC_WW_Pin1_4	56	61	PF00397	0.450
LIG_14-3-3_CanoR_1	151	157	PF00244	0.438
LIG_14-3-3_CanoR_1	196	204	PF00244	0.332
LIG_14-3-3_CanoR_1	45	49	PF00244	0.399
LIG_14-3-3_CanoR_1	7	15	PF00244	0.490
LIG_Actin_WH2_2	6	23	PF00022	0.463
LIG_BH_BH3_1	187	203	PF00452	0.383
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BRCT_BRCA1_1	198	202	PF00533	0.336
LIG_FHA_1	172	178	PF00498	0.323
LIG_FHA_1	36	42	PF00498	0.542
LIG_FHA_1	78	84	PF00498	0.390
LIG_FHA_1	95	101	PF00498	0.296
LIG_FHA_2	117	123	PF00498	0.391
LIG_LIR_Apic_2	105	109	PF02991	0.334
LIG_LIR_Apic_2	85	90	PF02991	0.422
LIG_LIR_Gen_1	47	52	PF02991	0.407
LIG_LIR_Nem_3	199	204	PF02991	0.395
LIG_LIR_Nem_3	47	51	PF02991	0.541
LIG_MLH1_MIPbox_1	198	202	PF16413	0.336
LIG_MYND_1	206	210	PF01753	0.449
LIG_PCNA_yPIPBox_3	181	194	PF02747	0.358
LIG_Pex14_2	102	106	PF04695	0.397
LIG_PTB_Apo_2	100	107	PF02174	0.392
LIG_PTB_Apo_2	127	134	PF02174	0.380
LIG_SH2_STAT5	201	204	PF00017	0.415
LIG_SH3_3	131	137	PF00018	0.603
LIG_SH3_3	200	206	PF00018	0.437
LIG_SH3_3	23	29	PF00018	0.479
LIG_Sin3_3	205	212	PF02671	0.436
LIG_WRC_WIRS_1	153	158	PF05994	0.406
MOD_CK1_1	116	122	PF00069	0.499
MOD_CK1_1	3	9	PF00069	0.498
MOD_CK2_1	116	122	PF00069	0.451
MOD_CK2_1	135	141	PF00069	0.419
MOD_CK2_1	56	62	PF00069	0.546
MOD_CK2_1	82	88	PF00069	0.432
MOD_GlcNHglycan	91	94	PF01048	0.387
MOD_GSK3_1	113	120	PF00069	0.475
MOD_GSK3_1	33	40	PF00069	0.651
MOD_N-GLC_1	114	119	PF02516	0.456
MOD_N-GLC_1	129	134	PF02516	0.293
MOD_N-GLC_2	82	84	PF02516	0.403
MOD_NEK2_1	113	118	PF00069	0.472
MOD_NEK2_1	77	82	PF00069	0.363
MOD_NEK2_2	30	35	PF00069	0.502
MOD_PKA_2	3	9	PF00069	0.493
MOD_PKA_2	44	50	PF00069	0.457
MOD_Plk_1	114	120	PF00069	0.457
MOD_Plk_1	129	135	PF00069	0.304
MOD_Plk_1	77	83	PF00069	0.390
MOD_Plk_4	129	135	PF00069	0.422
MOD_Plk_4	189	195	PF00069	0.454
MOD_ProDKin_1	25	31	PF00069	0.488
MOD_ProDKin_1	56	62	PF00069	0.452
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.417
TRG_ENDOCYTIC_2	165	168	PF00928	0.418
TRG_ENDOCYTIC_2	201	204	PF00928	0.415
TRG_ER_diArg_1	149	151	PF00400	0.494
TRG_ER_diArg_1	17	20	PF00400	0.413
TRG_ER_diArg_1	181	183	PF00400	0.461
TRG_ER_diArg_1	7	10	PF00400	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N4	Leptomonas seymouri	50%	100%
A0A1X0NI81	Trypanosomatidae	28%	100%
A0A3S5H7Q9	Leishmania donovani	100%	87%
A4HJV5	Leishmania braziliensis	77%	100%
C9ZWJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B2B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5U6	Leishmania major	92%	100%