Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7A7_LEIIN

TriTrypDb:

LINF_310039000

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	225	227	PF00675	0.666
CLV_NRD_NRD_1	443	445	PF00675	0.715
CLV_PCSK_KEX2_1	78	80	PF00082	0.682
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.682
CLV_PCSK_SKI1_1	15	19	PF00082	0.528
CLV_PCSK_SKI1_1	266	270	PF00082	0.462
CLV_PCSK_SKI1_1	428	432	PF00082	0.638
DEG_APCC_DBOX_1	14	22	PF00400	0.594
DEG_APCC_DBOX_1	263	271	PF00400	0.425
DEG_SCF_FBW7_1	194	200	PF00400	0.588
DEG_SCF_FBW7_1	359	365	PF00400	0.600
DOC_CKS1_1	194	199	PF01111	0.607
DOC_CKS1_1	218	223	PF01111	0.639
DOC_CKS1_1	359	364	PF01111	0.601
DOC_CKS1_1	406	411	PF01111	0.687
DOC_MAPK_gen_1	264	272	PF00069	0.424
DOC_MAPK_gen_1	426	435	PF00069	0.684
DOC_MAPK_MEF2A_6	264	272	PF00069	0.424
DOC_PP1_RVXF_1	429	436	PF00149	0.682
DOC_PP4_FxxP_1	411	414	PF00568	0.624
DOC_PP4_FxxP_1	435	438	PF00568	0.639
DOC_USP7_MATH_1	106	110	PF00917	0.639
DOC_USP7_MATH_1	122	126	PF00917	0.603
DOC_USP7_MATH_1	158	162	PF00917	0.686
DOC_USP7_MATH_1	197	201	PF00917	0.683
DOC_USP7_MATH_1	219	223	PF00917	0.621
DOC_USP7_MATH_1	354	358	PF00917	0.799
DOC_USP7_MATH_1	401	405	PF00917	0.614
DOC_USP7_MATH_1	72	76	PF00917	0.636
DOC_WW_Pin1_4	153	158	PF00397	0.660
DOC_WW_Pin1_4	193	198	PF00397	0.649
DOC_WW_Pin1_4	212	217	PF00397	0.654
DOC_WW_Pin1_4	335	340	PF00397	0.776
DOC_WW_Pin1_4	355	360	PF00397	0.750
DOC_WW_Pin1_4	362	367	PF00397	0.656
DOC_WW_Pin1_4	379	384	PF00397	0.502
DOC_WW_Pin1_4	393	398	PF00397	0.603
DOC_WW_Pin1_4	405	410	PF00397	0.692
DOC_WW_Pin1_4	449	454	PF00397	0.777
DOC_WW_Pin1_4	460	465	PF00397	0.578
LIG_14-3-3_CanoR_1	152	157	PF00244	0.640
LIG_14-3-3_CanoR_1	176	184	PF00244	0.544
LIG_14-3-3_CanoR_1	198	202	PF00244	0.603
LIG_14-3-3_CanoR_1	287	297	PF00244	0.556
LIG_14-3-3_CanoR_1	312	317	PF00244	0.675
LIG_14-3-3_CanoR_1	330	335	PF00244	0.505
LIG_14-3-3_CanoR_1	375	380	PF00244	0.604
LIG_14-3-3_CanoR_1	444	448	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BIR_III_2	351	355	PF00653	0.678
LIG_BRCT_BRCA1_1	160	164	PF00533	0.631
LIG_BRCT_BRCA1_1	41	45	PF00533	0.664
LIG_BRCT_BRCA1_1	47	51	PF00533	0.628
LIG_CaM_IQ_9	270	285	PF13499	0.424
LIG_CSL_BTD_1	380	383	PF09270	0.682
LIG_deltaCOP1_diTrp_1	282	289	PF00928	0.535
LIG_FHA_1	169	175	PF00498	0.583
LIG_FHA_1	218	224	PF00498	0.714
LIG_FHA_1	299	305	PF00498	0.726
LIG_FHA_1	408	414	PF00498	0.669
LIG_FHA_1	418	424	PF00498	0.606
LIG_FHA_1	444	450	PF00498	0.652
LIG_Integrin_RGD_1	231	233	PF01839	0.527
LIG_LIR_Apic_2	404	409	PF02991	0.650
LIG_LIR_Apic_2	410	414	PF02991	0.601
LIG_LIR_Apic_2	434	438	PF02991	0.640
LIG_LIR_Gen_1	189	197	PF02991	0.711
LIG_LIR_Gen_1	233	244	PF02991	0.509
LIG_LIR_Gen_1	317	326	PF02991	0.652
LIG_LIR_Gen_1	33	43	PF02991	0.632
LIG_LIR_Gen_1	48	58	PF02991	0.513
LIG_LIR_Nem_3	142	148	PF02991	0.634
LIG_LIR_Nem_3	189	194	PF02991	0.710
LIG_LIR_Nem_3	233	239	PF02991	0.536
LIG_LIR_Nem_3	317	323	PF02991	0.655
LIG_LIR_Nem_3	33	39	PF02991	0.632
LIG_LIR_Nem_3	48	54	PF02991	0.512
LIG_MLH1_MIPbox_1	160	164	PF16413	0.631
LIG_PDZ_Class_2	465	470	PF00595	0.590
LIG_PTAP_UEV_1	169	174	PF05743	0.549
LIG_SH2_CRK	265	269	PF00017	0.499
LIG_SH2_CRK	406	410	PF00017	0.634
LIG_SH2_NCK_1	236	240	PF00017	0.489
LIG_SH2_NCK_1	36	40	PF00017	0.612
LIG_SH2_SRC	236	239	PF00017	0.496
LIG_SH2_STAP1	236	240	PF00017	0.489
LIG_SH2_STAT5	146	149	PF00017	0.731
LIG_SH2_STAT5	163	166	PF00017	0.607
LIG_SH3_1	356	362	PF00018	0.665
LIG_SH3_2	400	405	PF14604	0.674
LIG_SH3_3	167	173	PF00018	0.642
LIG_SH3_3	213	219	PF00018	0.681
LIG_SH3_3	342	348	PF00018	0.670
LIG_SH3_3	356	362	PF00018	0.565
LIG_SH3_3	394	400	PF00018	0.738
LIG_SH3_3	412	418	PF00018	0.551
LIG_SH3_3	452	458	PF00018	0.646
LIG_SH3_3	51	57	PF00018	0.610
LIG_SH3_3	92	98	PF00018	0.653
LIG_SH3_CIN85_PxpxPR_1	362	367	PF14604	0.665
LIG_SUMO_SIM_anti_2	238	243	PF11976	0.548
LIG_SUMO_SIM_par_1	457	463	PF11976	0.505
LIG_TYR_ITIM	234	239	PF00017	0.498
LIG_WRC_WIRS_1	188	193	PF05994	0.607
LIG_WRC_WIRS_1	323	328	PF05994	0.657
LIG_WRC_WIRS_1	389	394	PF05994	0.688
LIG_WW_3	347	351	PF00397	0.646
MOD_CDC14_SPxK_1	463	466	PF00782	0.587
MOD_CDK_SPK_2	193	198	PF00069	0.608
MOD_CDK_SPK_2	362	367	PF00069	0.696
MOD_CDK_SPxK_1	460	466	PF00069	0.642
MOD_CDK_SPxxK_3	360	367	PF00069	0.664
MOD_CK1_1	109	115	PF00069	0.625
MOD_CK1_1	11	17	PF00069	0.626
MOD_CK1_1	121	127	PF00069	0.589
MOD_CK1_1	183	189	PF00069	0.631
MOD_CK1_1	200	206	PF00069	0.592
MOD_CK1_1	217	223	PF00069	0.634
MOD_CK1_1	225	231	PF00069	0.568
MOD_CK1_1	315	321	PF00069	0.640
MOD_CK1_1	335	341	PF00069	0.578
MOD_CK1_1	358	364	PF00069	0.627
MOD_CK1_1	38	44	PF00069	0.671
MOD_CK1_1	396	402	PF00069	0.723
MOD_CK1_1	46	52	PF00069	0.667
MOD_CK2_1	122	128	PF00069	0.728
MOD_CK2_1	183	189	PF00069	0.629
MOD_Cter_Amidation	76	79	PF01082	0.610
MOD_GlcNHglycan	1	4	PF01048	0.632
MOD_GlcNHglycan	120	123	PF01048	0.649
MOD_GlcNHglycan	124	127	PF01048	0.632
MOD_GlcNHglycan	128	131	PF01048	0.618
MOD_GlcNHglycan	135	138	PF01048	0.566
MOD_GlcNHglycan	202	205	PF01048	0.711
MOD_GlcNHglycan	257	260	PF01048	0.620
MOD_GlcNHglycan	290	293	PF01048	0.528
MOD_GlcNHglycan	306	309	PF01048	0.530
MOD_GlcNHglycan	312	315	PF01048	0.657
MOD_GlcNHglycan	334	337	PF01048	0.731
MOD_GlcNHglycan	393	396	PF01048	0.757
MOD_GlcNHglycan	75	78	PF01048	0.658
MOD_GSK3_1	118	125	PF00069	0.731
MOD_GSK3_1	133	140	PF00069	0.592
MOD_GSK3_1	147	154	PF00069	0.623
MOD_GSK3_1	183	190	PF00069	0.623
MOD_GSK3_1	193	200	PF00069	0.571
MOD_GSK3_1	208	215	PF00069	0.527
MOD_GSK3_1	26	33	PF00069	0.601
MOD_GSK3_1	322	329	PF00069	0.645
MOD_GSK3_1	35	42	PF00069	0.599
MOD_GSK3_1	354	361	PF00069	0.761
MOD_GSK3_1	375	382	PF00069	0.646
MOD_GSK3_1	401	408	PF00069	0.743
MOD_GSK3_1	43	50	PF00069	0.558
MOD_GSK3_1	84	91	PF00069	0.725
MOD_N-GLC_1	84	89	PF02516	0.594
MOD_NEK2_1	120	125	PF00069	0.630
MOD_NEK2_1	147	152	PF00069	0.643
MOD_NEK2_1	253	258	PF00069	0.573
MOD_NEK2_1	298	303	PF00069	0.673
MOD_NEK2_1	326	331	PF00069	0.679
MOD_NEK2_1	43	48	PF00069	0.666
MOD_PIKK_1	109	115	PF00454	0.671
MOD_PK_1	312	318	PF00069	0.601
MOD_PK_1	35	41	PF00069	0.611
MOD_PK_1	375	381	PF00069	0.581
MOD_PKA_2	126	132	PF00069	0.637
MOD_PKA_2	151	157	PF00069	0.608
MOD_PKA_2	175	181	PF00069	0.546
MOD_PKA_2	197	203	PF00069	0.668
MOD_PKA_2	225	231	PF00069	0.547
MOD_PKA_2	443	449	PF00069	0.618
MOD_Plk_1	39	45	PF00069	0.632
MOD_Plk_2-3	187	193	PF00069	0.607
MOD_Plk_4	159	165	PF00069	0.678
MOD_Plk_4	180	186	PF00069	0.612
MOD_Plk_4	197	203	PF00069	0.541
MOD_Plk_4	50	56	PF00069	0.632
MOD_Plk_4	96	102	PF00069	0.687
MOD_ProDKin_1	153	159	PF00069	0.660
MOD_ProDKin_1	193	199	PF00069	0.649
MOD_ProDKin_1	212	218	PF00069	0.656
MOD_ProDKin_1	335	341	PF00069	0.777
MOD_ProDKin_1	355	361	PF00069	0.750
MOD_ProDKin_1	362	368	PF00069	0.654
MOD_ProDKin_1	379	385	PF00069	0.499
MOD_ProDKin_1	393	399	PF00069	0.602
MOD_ProDKin_1	405	411	PF00069	0.692
MOD_ProDKin_1	449	455	PF00069	0.776
MOD_ProDKin_1	460	466	PF00069	0.578
TRG_ENDOCYTIC_2	145	148	PF00928	0.700
TRG_ENDOCYTIC_2	236	239	PF00928	0.496
TRG_ENDOCYTIC_2	265	268	PF00928	0.499
TRG_ENDOCYTIC_2	36	39	PF00928	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGM6	Leishmania donovani	99%	100%
A4HJU1	Leishmania braziliensis	51%	99%
E9B2A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q5V6	Leishmania major	87%	100%