Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7A6_LEIIN

TriTrypDb:

LINF_310038900

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7A6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.501
CLV_NRD_NRD_1	143	145	PF00675	0.572
CLV_NRD_NRD_1	17	19	PF00675	0.719
CLV_NRD_NRD_1	198	200	PF00675	0.628
CLV_NRD_NRD_1	425	427	PF00675	0.694
CLV_NRD_NRD_1	436	438	PF00675	0.672
CLV_NRD_NRD_1	45	47	PF00675	0.549
CLV_NRD_NRD_1	455	457	PF00675	0.733
CLV_NRD_NRD_1	61	63	PF00675	0.416
CLV_PCSK_KEX2_1	143	145	PF00082	0.632
CLV_PCSK_KEX2_1	164	166	PF00082	0.526
CLV_PCSK_KEX2_1	17	19	PF00082	0.743
CLV_PCSK_KEX2_1	200	202	PF00082	0.585
CLV_PCSK_KEX2_1	212	214	PF00082	0.559
CLV_PCSK_KEX2_1	325	327	PF00082	0.675
CLV_PCSK_KEX2_1	425	427	PF00082	0.661
CLV_PCSK_KEX2_1	436	438	PF00082	0.613
CLV_PCSK_KEX2_1	45	47	PF00082	0.542
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.526
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.585
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.446
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.625
CLV_PCSK_PC7_1	160	166	PF00082	0.505
CLV_PCSK_SKI1_1	175	179	PF00082	0.407
CLV_PCSK_SKI1_1	23	27	PF00082	0.599
CLV_Separin_Metazoa	157	161	PF03568	0.521
DOC_CKS1_1	411	416	PF01111	0.569
DOC_CKS1_1	452	457	PF01111	0.660
DOC_MAPK_gen_1	425	433	PF00069	0.601
DOC_MAPK_gen_1	45	53	PF00069	0.402
DOC_MAPK_MEF2A_6	342	351	PF00069	0.570
DOC_MAPK_MEF2A_6	45	53	PF00069	0.402
DOC_PP1_RVXF_1	178	184	PF00149	0.462
DOC_USP7_MATH_1	188	192	PF00917	0.531
DOC_USP7_MATH_1	221	225	PF00917	0.593
DOC_USP7_MATH_1	312	316	PF00917	0.574
DOC_USP7_MATH_1	335	339	PF00917	0.590
DOC_USP7_MATH_1	361	365	PF00917	0.689
DOC_USP7_MATH_1	393	397	PF00917	0.605
DOC_USP7_MATH_1	421	425	PF00917	0.673
DOC_USP7_MATH_1	73	77	PF00917	0.540
DOC_WW_Pin1_4	27	32	PF00397	0.513
DOC_WW_Pin1_4	365	370	PF00397	0.653
DOC_WW_Pin1_4	377	382	PF00397	0.554
DOC_WW_Pin1_4	410	415	PF00397	0.633
DOC_WW_Pin1_4	451	456	PF00397	0.650
DOC_WW_Pin1_4	7	12	PF00397	0.727
LIG_14-3-3_CanoR_1	296	304	PF00244	0.473
LIG_14-3-3_CanoR_1	425	434	PF00244	0.677
LIG_BRCT_BRCA1_1	429	433	PF00533	0.636
LIG_deltaCOP1_diTrp_1	322	329	PF00928	0.490
LIG_EVH1_1	410	414	PF00568	0.564
LIG_FHA_1	176	182	PF00498	0.568
LIG_FHA_1	27	33	PF00498	0.601
LIG_FHA_1	339	345	PF00498	0.595
LIG_FHA_1	350	356	PF00498	0.460
LIG_FHA_2	117	123	PF00498	0.512
LIG_FHA_2	193	199	PF00498	0.473
LIG_FHA_2	36	42	PF00498	0.558
LIG_FHA_2	430	436	PF00498	0.571
LIG_LIR_Gen_1	224	233	PF02991	0.565
LIG_LIR_Gen_1	446	455	PF02991	0.639
LIG_LIR_Nem_3	224	229	PF02991	0.606
LIG_LIR_Nem_3	37	42	PF02991	0.552
LIG_LIR_Nem_3	446	452	PF02991	0.632
LIG_Pex14_2	449	453	PF04695	0.639
LIG_SH2_NCK_1	167	171	PF00017	0.523
LIG_SH2_STAT5	173	176	PF00017	0.577
LIG_SH2_STAT5	92	95	PF00017	0.521
LIG_SH3_1	408	414	PF00018	0.595
LIG_SH3_3	25	31	PF00018	0.602
LIG_SH3_3	408	414	PF00018	0.592
LIG_SH3_3	415	421	PF00018	0.584
LIG_SH3_3	428	434	PF00018	0.544
LIG_SH3_4	244	251	PF00018	0.656
LIG_SUMO_SIM_par_1	345	350	PF11976	0.539
LIG_SUMO_SIM_par_1	48	55	PF11976	0.401
LIG_TRAF2_1	106	109	PF00917	0.378
LIG_TRAF2_1	138	141	PF00917	0.512
LIG_TRAF2_1	149	152	PF00917	0.466
LIG_TRAF2_1	195	198	PF00917	0.546
LIG_WRC_WIRS_1	36	41	PF05994	0.511
MOD_CDK_SPK_2	451	456	PF00069	0.650
MOD_CDK_SPxK_1	451	457	PF00069	0.657
MOD_CDK_SPxxK_3	365	372	PF00069	0.616
MOD_CK1_1	224	230	PF00069	0.558
MOD_CK1_1	338	344	PF00069	0.594
MOD_CK1_1	35	41	PF00069	0.537
MOD_CK1_1	364	370	PF00069	0.668
MOD_CK1_1	396	402	PF00069	0.790
MOD_CK1_1	443	449	PF00069	0.584
MOD_CK1_1	76	82	PF00069	0.391
MOD_CK2_1	116	122	PF00069	0.509
MOD_CK2_1	192	198	PF00069	0.519
MOD_CK2_1	281	287	PF00069	0.542
MOD_CK2_1	35	41	PF00069	0.563
MOD_CK2_1	429	435	PF00069	0.594
MOD_GlcNHglycan	225	229	PF01048	0.560
MOD_GlcNHglycan	283	286	PF01048	0.541
MOD_GlcNHglycan	363	366	PF01048	0.598
MOD_GlcNHglycan	369	372	PF01048	0.663
MOD_GlcNHglycan	395	398	PF01048	0.754
MOD_GlcNHglycan	399	402	PF01048	0.730
MOD_GlcNHglycan	404	407	PF01048	0.671
MOD_GlcNHglycan	5	8	PF01048	0.636
MOD_GlcNHglycan	75	78	PF01048	0.572
MOD_GSK3_1	117	124	PF00069	0.437
MOD_GSK3_1	188	195	PF00069	0.547
MOD_GSK3_1	3	10	PF00069	0.716
MOD_GSK3_1	304	311	PF00069	0.506
MOD_GSK3_1	343	350	PF00069	0.583
MOD_GSK3_1	361	368	PF00069	0.574
MOD_GSK3_1	393	400	PF00069	0.749
MOD_GSK3_1	416	423	PF00069	0.698
MOD_GSK3_1	425	432	PF00069	0.586
MOD_N-GLC_1	26	31	PF02516	0.579
MOD_N-GLC_1	393	398	PF02516	0.648
MOD_NEK2_1	192	197	PF00069	0.517
MOD_NEK2_1	26	31	PF00069	0.608
MOD_NEK2_1	268	273	PF00069	0.616
MOD_NEK2_1	3	8	PF00069	0.573
MOD_NEK2_1	304	309	PF00069	0.542
MOD_NEK2_1	347	352	PF00069	0.555
MOD_NEK2_2	448	453	PF00069	0.635
MOD_PKA_1	425	431	PF00069	0.627
MOD_PKA_2	231	237	PF00069	0.625
MOD_PKA_2	295	301	PF00069	0.567
MOD_PKA_2	425	431	PF00069	0.687
MOD_Plk_1	224	230	PF00069	0.586
MOD_Plk_1	347	353	PF00069	0.552
MOD_Plk_2-3	429	435	PF00069	0.576
MOD_Plk_4	448	454	PF00069	0.637
MOD_ProDKin_1	27	33	PF00069	0.510
MOD_ProDKin_1	365	371	PF00069	0.656
MOD_ProDKin_1	377	383	PF00069	0.552
MOD_ProDKin_1	410	416	PF00069	0.637
MOD_ProDKin_1	451	457	PF00069	0.657
MOD_ProDKin_1	7	13	PF00069	0.724
MOD_SUMO_for_1	106	109	PF00179	0.490
MOD_SUMO_for_1	179	182	PF00179	0.509
MOD_SUMO_rev_2	109	117	PF00179	0.560
TRG_DiLeu_BaEn_1	300	305	PF01217	0.453
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.663
TRG_ENDOCYTIC_2	156	159	PF00928	0.553
TRG_ENDOCYTIC_2	167	170	PF00928	0.528
TRG_ER_diArg_1	16	18	PF00400	0.619
TRG_ER_diArg_1	199	202	PF00400	0.623
TRG_ER_diArg_1	436	438	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X505	Leishmania donovani	98%	88%
A4HJU0	Leishmania braziliensis	60%	100%
E9B2A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q5V7	Leishmania major	86%	100%