LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Component of IIS longevity pathway SMK-1 - putative
Species:
Leishmania infantum
UniProt:
A4I7A3_LEIIN
TriTrypDb:
LINF_310038600
Length:
989

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0008287 protein serine/threonine phosphatase complex 4 1
GO:0030289 protein phosphatase 4 complex 5 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1
GO:1903293 phosphatase complex 3 1

Expansion

Sequence features

A4I7A3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7A3

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016311 dephosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0008047 enzyme activator activity 3 1
GO:0019208 phosphatase regulator activity 3 1
GO:0019211 phosphatase activator activity 4 1
GO:0019888 protein phosphatase regulator activity 4 1
GO:0030234 enzyme regulator activity 2 1
GO:0072542 protein phosphatase activator activity 5 1
GO:0098772 molecular function regulator activity 1 1
GO:0140677 molecular function activator activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.369
CLV_C14_Caspase3-7 39 43 PF00656 0.597
CLV_C14_Caspase3-7 490 494 PF00656 0.412
CLV_C14_Caspase3-7 599 603 PF00656 0.399
CLV_C14_Caspase3-7 649 653 PF00656 0.419
CLV_C14_Caspase3-7 679 683 PF00656 0.515
CLV_C14_Caspase3-7 867 871 PF00656 0.659
CLV_C14_Caspase3-7 890 894 PF00656 0.624
CLV_C14_Caspase3-7 961 965 PF00656 0.763
CLV_MEL_PAP_1 952 958 PF00089 0.611
CLV_NRD_NRD_1 146 148 PF00675 0.466
CLV_NRD_NRD_1 255 257 PF00675 0.286
CLV_NRD_NRD_1 268 270 PF00675 0.231
CLV_NRD_NRD_1 518 520 PF00675 0.407
CLV_NRD_NRD_1 631 633 PF00675 0.564
CLV_NRD_NRD_1 650 652 PF00675 0.440
CLV_NRD_NRD_1 954 956 PF00675 0.743
CLV_PCSK_FUR_1 144 148 PF00082 0.486
CLV_PCSK_KEX2_1 146 148 PF00082 0.489
CLV_PCSK_KEX2_1 179 181 PF00082 0.539
CLV_PCSK_KEX2_1 255 257 PF00082 0.286
CLV_PCSK_KEX2_1 268 270 PF00082 0.231
CLV_PCSK_KEX2_1 518 520 PF00082 0.367
CLV_PCSK_KEX2_1 60 62 PF00082 0.732
CLV_PCSK_KEX2_1 631 633 PF00082 0.564
CLV_PCSK_KEX2_1 650 652 PF00082 0.418
CLV_PCSK_KEX2_1 954 956 PF00082 0.743
CLV_PCSK_KEX2_1 959 961 PF00082 0.739
CLV_PCSK_KEX2_1 980 982 PF00082 0.630
CLV_PCSK_PC1ET2_1 179 181 PF00082 0.514
CLV_PCSK_PC1ET2_1 60 62 PF00082 0.732
CLV_PCSK_PC1ET2_1 959 961 PF00082 0.739
CLV_PCSK_PC1ET2_1 980 982 PF00082 0.612
CLV_PCSK_PC7_1 955 961 PF00082 0.737
CLV_PCSK_SKI1_1 134 138 PF00082 0.469
CLV_PCSK_SKI1_1 216 220 PF00082 0.287
CLV_PCSK_SKI1_1 268 272 PF00082 0.266
CLV_PCSK_SKI1_1 379 383 PF00082 0.383
CLV_PCSK_SKI1_1 469 473 PF00082 0.435
CLV_PCSK_SKI1_1 477 481 PF00082 0.464
CLV_PCSK_SKI1_1 654 658 PF00082 0.541
CLV_Separin_Metazoa 433 437 PF03568 0.298
CLV_Separin_Metazoa 521 525 PF03568 0.469
DEG_APCC_DBOX_1 468 476 PF00400 0.446
DEG_APCC_DBOX_1 533 541 PF00400 0.315
DEG_Nend_UBRbox_2 1 3 PF02207 0.532
DEG_SPOP_SBC_1 684 688 PF00917 0.467
DEG_SPOP_SBC_1 791 795 PF00917 0.493
DEG_SPOP_SBC_1 899 903 PF00917 0.710
DEG_SPOP_SBC_1 919 923 PF00917 0.560
DOC_CKS1_1 824 829 PF01111 0.662
DOC_CKS1_1 874 879 PF01111 0.547
DOC_CYCLIN_RxL_1 469 480 PF00134 0.494
DOC_CYCLIN_yClb5_NLxxxL_5 162 171 PF00134 0.378
DOC_MAPK_gen_1 179 185 PF00069 0.500
DOC_MAPK_gen_1 255 265 PF00069 0.325
DOC_MAPK_gen_1 379 388 PF00069 0.391
DOC_MAPK_gen_1 518 525 PF00069 0.406
DOC_MAPK_gen_1 650 658 PF00069 0.398
DOC_MAPK_MEF2A_6 296 303 PF00069 0.266
DOC_MAPK_MEF2A_6 382 390 PF00069 0.479
DOC_MAPK_MEF2A_6 469 476 PF00069 0.357
DOC_MAPK_NFAT4_5 296 304 PF00069 0.300
DOC_MAPK_NFAT4_5 469 477 PF00069 0.363
DOC_MAPK_RevD_3 504 519 PF00069 0.514
DOC_PP2B_LxvP_1 889 892 PF13499 0.551
DOC_PP2B_LxvP_1 935 938 PF13499 0.602
DOC_PP2B_PxIxI_1 283 289 PF00149 0.331
DOC_PP4_FxxP_1 222 225 PF00568 0.331
DOC_PP4_FxxP_1 272 275 PF00568 0.266
DOC_SPAK_OSR1_1 524 528 PF12202 0.380
DOC_USP7_MATH_1 37 41 PF00917 0.652
DOC_USP7_MATH_1 51 55 PF00917 0.692
DOC_USP7_MATH_1 663 667 PF00917 0.573
DOC_USP7_MATH_1 791 795 PF00917 0.502
DOC_USP7_MATH_1 845 849 PF00917 0.726
DOC_USP7_MATH_1 858 862 PF00917 0.569
DOC_USP7_MATH_1 882 886 PF00917 0.731
DOC_USP7_MATH_1 899 903 PF00917 0.733
DOC_USP7_MATH_1 920 924 PF00917 0.577
DOC_USP7_MATH_1 984 988 PF00917 0.636
DOC_WW_Pin1_4 221 226 PF00397 0.325
DOC_WW_Pin1_4 329 334 PF00397 0.347
DOC_WW_Pin1_4 348 353 PF00397 0.337
DOC_WW_Pin1_4 625 630 PF00397 0.532
DOC_WW_Pin1_4 717 722 PF00397 0.563
DOC_WW_Pin1_4 779 784 PF00397 0.430
DOC_WW_Pin1_4 819 824 PF00397 0.583
DOC_WW_Pin1_4 873 878 PF00397 0.672
DOC_WW_Pin1_4 891 896 PF00397 0.673
LIG_14-3-3_CanoR_1 134 140 PF00244 0.448
LIG_14-3-3_CanoR_1 216 222 PF00244 0.389
LIG_14-3-3_CanoR_1 268 273 PF00244 0.266
LIG_14-3-3_CanoR_1 320 324 PF00244 0.411
LIG_14-3-3_CanoR_1 341 345 PF00244 0.287
LIG_14-3-3_CanoR_1 477 482 PF00244 0.468
LIG_14-3-3_CanoR_1 553 557 PF00244 0.495
LIG_14-3-3_CanoR_1 654 659 PF00244 0.426
LIG_APCC_ABBA_1 506 511 PF00400 0.540
LIG_BRCT_BRCA1_1 290 294 PF00533 0.381
LIG_EH1_1 25 33 PF00400 0.306
LIG_eIF4E_1 539 545 PF01652 0.328
LIG_FHA_1 104 110 PF00498 0.454
LIG_FHA_1 314 320 PF00498 0.411
LIG_FHA_1 325 331 PF00498 0.411
LIG_FHA_1 406 412 PF00498 0.380
LIG_FHA_1 622 628 PF00498 0.426
LIG_FHA_1 639 645 PF00498 0.419
LIG_FHA_1 668 674 PF00498 0.298
LIG_FHA_1 752 758 PF00498 0.384
LIG_FHA_1 791 797 PF00498 0.505
LIG_FHA_1 910 916 PF00498 0.654
LIG_FHA_2 269 275 PF00498 0.411
LIG_FHA_2 340 346 PF00498 0.287
LIG_FHA_2 63 69 PF00498 0.627
LIG_FHA_2 644 650 PF00498 0.474
LIG_FHA_2 845 851 PF00498 0.742
LIG_FHA_2 959 965 PF00498 0.532
LIG_FXI_DFP_1 808 812 PF00024 0.576
LIG_GBD_Chelix_1 540 548 PF00786 0.400
LIG_IRF3_LxIS_1 32 39 PF10401 0.444
LIG_LIR_Apic_2 220 225 PF02991 0.232
LIG_LIR_Apic_2 271 275 PF02991 0.266
LIG_LIR_Gen_1 18 29 PF02991 0.347
LIG_LIR_Gen_1 259 270 PF02991 0.269
LIG_LIR_Gen_1 310 319 PF02991 0.418
LIG_LIR_Gen_1 393 403 PF02991 0.321
LIG_LIR_Gen_1 720 726 PF02991 0.574
LIG_LIR_Gen_1 806 816 PF02991 0.455
LIG_LIR_Gen_1 91 100 PF02991 0.475
LIG_LIR_Nem_3 130 136 PF02991 0.374
LIG_LIR_Nem_3 18 24 PF02991 0.536
LIG_LIR_Nem_3 259 265 PF02991 0.269
LIG_LIR_Nem_3 310 314 PF02991 0.341
LIG_LIR_Nem_3 393 398 PF02991 0.316
LIG_LIR_Nem_3 720 725 PF02991 0.565
LIG_LIR_Nem_3 806 811 PF02991 0.499
LIG_LIR_Nem_3 91 96 PF02991 0.468
LIG_NRBOX 470 476 PF00104 0.285
LIG_PCNA_PIPBox_1 637 646 PF02747 0.379
LIG_PCNA_yPIPBox_3 631 644 PF02747 0.345
LIG_PDZ_Class_1 984 989 PF00595 0.663
LIG_Pex14_2 317 321 PF04695 0.411
LIG_SH2_CRK 133 137 PF00017 0.490
LIG_SH2_CRK 311 315 PF00017 0.411
LIG_SH2_NCK_1 446 450 PF00017 0.425
LIG_SH2_PTP2 93 96 PF00017 0.472
LIG_SH2_SRC 111 114 PF00017 0.531
LIG_SH2_STAP1 111 115 PF00017 0.533
LIG_SH2_STAP1 418 422 PF00017 0.349
LIG_SH2_STAT3 100 103 PF00017 0.335
LIG_SH2_STAT5 100 103 PF00017 0.313
LIG_SH2_STAT5 184 187 PF00017 0.374
LIG_SH2_STAT5 191 194 PF00017 0.282
LIG_SH2_STAT5 539 542 PF00017 0.425
LIG_SH2_STAT5 675 678 PF00017 0.390
LIG_SH2_STAT5 93 96 PF00017 0.370
LIG_SH3_3 327 333 PF00018 0.425
LIG_SH3_3 429 435 PF00018 0.466
LIG_SH3_3 497 503 PF00018 0.466
LIG_SH3_3 529 535 PF00018 0.469
LIG_SH3_3 551 557 PF00018 0.651
LIG_SH3_3 742 748 PF00018 0.519
LIG_SH3_3 871 877 PF00018 0.659
LIG_SH3_3 889 895 PF00018 0.547
LIG_SUMO_SIM_anti_2 243 250 PF11976 0.360
LIG_SUMO_SIM_anti_2 607 614 PF11976 0.532
LIG_SUMO_SIM_par_1 607 614 PF11976 0.487
LIG_SUMO_SIM_par_1 654 660 PF11976 0.505
LIG_SUMO_SIM_par_1 753 758 PF11976 0.385
LIG_TRAF2_1 264 267 PF00917 0.300
LIG_TRAF2_1 65 68 PF00917 0.625
LIG_TRAF2_1 778 781 PF00917 0.405
LIG_TYR_ITIM 770 775 PF00017 0.534
LIG_UBA3_1 609 617 PF00899 0.545
LIG_WRC_WIRS_1 262 267 PF05994 0.325
LIG_WRC_WIRS_1 314 319 PF05994 0.411
LIG_WRC_WIRS_1 640 645 PF05994 0.371
LIG_WW_3 433 437 PF00397 0.397
MOD_CDC14_SPxK_1 628 631 PF00782 0.483
MOD_CDK_SPxK_1 625 631 PF00069 0.455
MOD_CDK_SPxxK_3 625 632 PF00069 0.460
MOD_CK1_1 15 21 PF00069 0.531
MOD_CK1_1 312 318 PF00069 0.293
MOD_CK1_1 447 453 PF00069 0.430
MOD_CK1_1 638 644 PF00069 0.435
MOD_CK1_1 710 716 PF00069 0.623
MOD_CK1_1 795 801 PF00069 0.517
MOD_CK1_1 803 809 PF00069 0.493
MOD_CK1_1 861 867 PF00069 0.732
MOD_CK1_1 885 891 PF00069 0.613
MOD_CK1_1 909 915 PF00069 0.759
MOD_CK1_1 92 98 PF00069 0.543
MOD_CK1_1 923 929 PF00069 0.781
MOD_CK2_1 261 267 PF00069 0.300
MOD_CK2_1 339 345 PF00069 0.287
MOD_CK2_1 481 487 PF00069 0.463
MOD_CK2_1 605 611 PF00069 0.448
MOD_CK2_1 62 68 PF00069 0.633
MOD_CK2_1 730 736 PF00069 0.639
MOD_CK2_1 795 801 PF00069 0.619
MOD_CK2_1 844 850 PF00069 0.680
MOD_CK2_1 866 872 PF00069 0.686
MOD_CK2_1 940 946 PF00069 0.743
MOD_Cter_Amidation 253 256 PF01082 0.300
MOD_Cter_Amidation 58 61 PF01082 0.733
MOD_GlcNHglycan 2 5 PF01048 0.598
MOD_GlcNHglycan 259 262 PF01048 0.325
MOD_GlcNHglycan 352 355 PF01048 0.673
MOD_GlcNHglycan 39 42 PF01048 0.589
MOD_GlcNHglycan 483 486 PF01048 0.445
MOD_GlcNHglycan 53 56 PF01048 0.679
MOD_GlcNHglycan 560 563 PF01048 0.572
MOD_GlcNHglycan 712 715 PF01048 0.628
MOD_GlcNHglycan 801 805 PF01048 0.622
MOD_GlcNHglycan 880 883 PF01048 0.775
MOD_GlcNHglycan 889 892 PF01048 0.592
MOD_GlcNHglycan 902 905 PF01048 0.722
MOD_GlcNHglycan 908 911 PF01048 0.560
MOD_GlcNHglycan 926 929 PF01048 0.754
MOD_GlcNHglycan 938 941 PF01048 0.684
MOD_GlcNHglycan 985 989 PF01048 0.669
MOD_GSK3_1 135 142 PF00069 0.422
MOD_GSK3_1 15 22 PF00069 0.385
MOD_GSK3_1 217 224 PF00069 0.293
MOD_GSK3_1 257 264 PF00069 0.347
MOD_GSK3_1 309 316 PF00069 0.284
MOD_GSK3_1 37 44 PF00069 0.651
MOD_GSK3_1 477 484 PF00069 0.378
MOD_GSK3_1 601 608 PF00069 0.522
MOD_GSK3_1 62 69 PF00069 0.734
MOD_GSK3_1 621 628 PF00069 0.440
MOD_GSK3_1 635 642 PF00069 0.338
MOD_GSK3_1 663 670 PF00069 0.408
MOD_GSK3_1 705 712 PF00069 0.533
MOD_GSK3_1 713 720 PF00069 0.582
MOD_GSK3_1 751 758 PF00069 0.477
MOD_GSK3_1 791 798 PF00069 0.524
MOD_GSK3_1 819 826 PF00069 0.636
MOD_GSK3_1 840 847 PF00069 0.621
MOD_GSK3_1 878 885 PF00069 0.599
MOD_GSK3_1 88 95 PF00069 0.342
MOD_GSK3_1 887 894 PF00069 0.579
MOD_GSK3_1 909 916 PF00069 0.792
MOD_GSK3_1 919 926 PF00069 0.618
MOD_GSK3_1 936 943 PF00069 0.604
MOD_GSK3_1 954 961 PF00069 0.738
MOD_NEK2_1 313 318 PF00069 0.317
MOD_NEK2_1 319 324 PF00069 0.300
MOD_NEK2_1 577 582 PF00069 0.523
MOD_NEK2_1 613 618 PF00069 0.369
MOD_NEK2_1 622 627 PF00069 0.381
MOD_NEK2_1 636 641 PF00069 0.193
MOD_NEK2_1 643 648 PF00069 0.254
MOD_NEK2_1 667 672 PF00069 0.375
MOD_NEK2_1 676 681 PF00069 0.386
MOD_NEK2_1 685 690 PF00069 0.241
MOD_NEK2_1 705 710 PF00069 0.580
MOD_NEK2_1 840 845 PF00069 0.710
MOD_NEK2_1 88 93 PF00069 0.360
MOD_NEK2_1 918 923 PF00069 0.612
MOD_NEK2_1 924 929 PF00069 0.582
MOD_OFUCOSY 442 448 PF10250 0.350
MOD_PIKK_1 755 761 PF00454 0.421
MOD_PK_1 954 960 PF00069 0.721
MOD_PKA_1 268 274 PF00069 0.266
MOD_PKA_1 954 960 PF00069 0.739
MOD_PKA_2 268 274 PF00069 0.274
MOD_PKA_2 319 325 PF00069 0.411
MOD_PKA_2 340 346 PF00069 0.397
MOD_PKA_2 552 558 PF00069 0.535
MOD_PKA_2 762 768 PF00069 0.370
MOD_PKA_2 940 946 PF00069 0.743
MOD_PKA_2 954 960 PF00069 0.739
MOD_PKB_1 960 968 PF00069 0.551
MOD_Plk_1 418 424 PF00069 0.374
MOD_Plk_1 728 734 PF00069 0.609
MOD_Plk_1 791 797 PF00069 0.520
MOD_Plk_1 800 806 PF00069 0.523
MOD_Plk_2-3 207 213 PF00069 0.331
MOD_Plk_2-3 355 361 PF00069 0.549
MOD_Plk_2-3 487 493 PF00069 0.443
MOD_Plk_2-3 866 872 PF00069 0.661
MOD_Plk_4 103 109 PF00069 0.291
MOD_Plk_4 217 223 PF00069 0.295
MOD_Plk_4 27 33 PF00069 0.372
MOD_Plk_4 278 284 PF00069 0.283
MOD_Plk_4 309 315 PF00069 0.266
MOD_Plk_4 331 337 PF00069 0.442
MOD_Plk_4 394 400 PF00069 0.333
MOD_Plk_4 441 447 PF00069 0.391
MOD_Plk_4 487 493 PF00069 0.443
MOD_Plk_4 577 583 PF00069 0.512
MOD_Plk_4 605 611 PF00069 0.385
MOD_Plk_4 622 628 PF00069 0.336
MOD_Plk_4 639 645 PF00069 0.336
MOD_Plk_4 654 660 PF00069 0.297
MOD_Plk_4 663 669 PF00069 0.480
MOD_Plk_4 721 727 PF00069 0.630
MOD_Plk_4 751 757 PF00069 0.491
MOD_Plk_4 89 95 PF00069 0.407
MOD_Plk_4 940 946 PF00069 0.743
MOD_ProDKin_1 221 227 PF00069 0.325
MOD_ProDKin_1 329 335 PF00069 0.347
MOD_ProDKin_1 348 354 PF00069 0.333
MOD_ProDKin_1 625 631 PF00069 0.546
MOD_ProDKin_1 717 723 PF00069 0.563
MOD_ProDKin_1 779 785 PF00069 0.434
MOD_ProDKin_1 819 825 PF00069 0.592
MOD_ProDKin_1 873 879 PF00069 0.670
MOD_ProDKin_1 891 897 PF00069 0.673
MOD_SUMO_rev_2 224 233 PF00179 0.307
MOD_SUMO_rev_2 972 982 PF00179 0.616
TRG_AP2beta_CARGO_1 259 269 PF09066 0.309
TRG_DiLeu_BaEn_2 368 374 PF01217 0.326
TRG_DiLeu_BaLyEn_6 470 475 PF01217 0.283
TRG_ENDOCYTIC_2 133 136 PF00928 0.377
TRG_ENDOCYTIC_2 311 314 PF00928 0.411
TRG_ENDOCYTIC_2 772 775 PF00928 0.533
TRG_ENDOCYTIC_2 93 96 PF00928 0.472
TRG_ER_diArg_1 144 147 PF00400 0.482
TRG_ER_diArg_1 631 633 PF00400 0.567
TRG_ER_diArg_1 953 955 PF00400 0.741
TRG_NLS_MonoExtC_3 958 964 PF00514 0.734
TRG_NLS_MonoExtC_3 979 985 PF00514 0.615
TRG_Pf-PMV_PEXEL_1 777 781 PF00026 0.515

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3P1 Leptomonas seymouri 66% 100%
A0A1X0NIG3 Trypanosomatidae 36% 100%
A0A3Q8IFV0 Leishmania donovani 99% 100%
A0A3S5IR35 Trypanosoma rangeli 36% 100%
A4HJT7 Leishmania braziliensis 82% 100%
C9ZMI0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZWJ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9B298 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q5W0 Leishmania major 96% 100%
V5B7M8 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS