Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I798_LEIIN

TriTrypDb:

LINF_310038100

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I798

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I798

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.539
CLV_PCSK_SKI1_1	65	69	PF00082	0.530
DEG_Nend_UBRbox_3	1	3	PF02207	0.507
DOC_CDC14_PxL_1	195	203	PF14671	0.624
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.489
DOC_MAPK_gen_1	7	15	PF00069	0.467
DOC_MAPK_MEF2A_6	7	15	PF00069	0.467
DOC_PP1_RVXF_1	233	240	PF00149	0.472
DOC_USP7_MATH_1	118	122	PF00917	0.574
DOC_USP7_MATH_1	154	158	PF00917	0.651
DOC_USP7_MATH_1	168	172	PF00917	0.480
DOC_WW_Pin1_4	166	171	PF00397	0.570
DOC_WW_Pin1_4	19	24	PF00397	0.623
DOC_WW_Pin1_4	88	93	PF00397	0.536
DOC_WW_Pin1_4	96	101	PF00397	0.472
LIG_14-3-3_CanoR_1	107	112	PF00244	0.543
LIG_14-3-3_CanoR_1	7	12	PF00244	0.474
LIG_FHA_1	19	25	PF00498	0.488
LIG_FHA_1	214	220	PF00498	0.617
LIG_FHA_1	88	94	PF00498	0.441
LIG_FHA_1	97	103	PF00498	0.462
LIG_FHA_2	66	72	PF00498	0.513
LIG_FHA_2	92	98	PF00498	0.454
LIG_LIR_Apic_2	162	168	PF02991	0.490
LIG_LIR_Apic_2	17	23	PF02991	0.536
LIG_LIR_Gen_1	131	142	PF02991	0.522
LIG_LIR_Gen_1	171	180	PF02991	0.508
LIG_LIR_Nem_3	131	137	PF02991	0.551
LIG_LIR_Nem_3	171	176	PF02991	0.502
LIG_LIR_Nem_3	196	201	PF02991	0.543
LIG_LIR_Nem_3	63	67	PF02991	0.493
LIG_LYPXL_yS_3	198	201	PF13949	0.539
LIG_NRBOX	229	235	PF00104	0.493
LIG_PDZ_Class_2	244	249	PF00595	0.571
LIG_SH2_CRK	134	138	PF00017	0.500
LIG_SH2_CRK	20	24	PF00017	0.545
LIG_SH2_CRK	64	68	PF00017	0.566
LIG_SH2_NCK_1	119	123	PF00017	0.712
LIG_SH2_NCK_1	134	138	PF00017	0.473
LIG_SH2_STAP1	119	123	PF00017	0.711
LIG_SH2_STAP1	134	138	PF00017	0.459
LIG_SH2_STAP1	173	177	PF00017	0.548
LIG_SH2_STAT5	134	137	PF00017	0.504
LIG_SH2_STAT5	20	23	PF00017	0.543
LIG_SH3_1	144	150	PF00018	0.548
LIG_SH3_3	143	149	PF00018	0.535
LIG_SH3_3	185	191	PF00018	0.542
LIG_SUMO_SIM_anti_2	10	18	PF11976	0.473
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.434
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.482
LIG_SUMO_SIM_par_1	10	18	PF11976	0.473
LIG_SUMO_SIM_par_1	135	141	PF11976	0.438
LIG_SUMO_SIM_par_1	65	71	PF11976	0.583
LIG_SUMO_SIM_par_1	90	97	PF11976	0.488
LIG_TRAF2_1	84	87	PF00917	0.503
LIG_TYR_ITIM	62	67	PF00017	0.565
LIG_UBA3_1	233	240	PF00899	0.472
MOD_CK1_1	121	127	PF00069	0.717
MOD_CK1_1	171	177	PF00069	0.550
MOD_CK1_1	179	185	PF00069	0.551
MOD_CK1_1	18	24	PF00069	0.574
MOD_CK1_1	91	97	PF00069	0.451
MOD_CK2_1	125	131	PF00069	0.719
MOD_CK2_1	65	71	PF00069	0.506
MOD_GlcNHglycan	120	123	PF01048	0.618
MOD_GlcNHglycan	126	130	PF01048	0.547
MOD_GlcNHglycan	156	159	PF01048	0.626
MOD_GlcNHglycan	182	185	PF01048	0.607
MOD_GlcNHglycan	230	233	PF01048	0.523
MOD_GlcNHglycan	81	84	PF01048	0.559
MOD_GSK3_1	117	124	PF00069	0.543
MOD_GSK3_1	14	21	PF00069	0.484
MOD_GSK3_1	150	157	PF00069	0.583
MOD_GSK3_1	176	183	PF00069	0.536
MOD_GSK3_1	67	74	PF00069	0.509
MOD_GSK3_1	87	94	PF00069	0.486
MOD_N-GLC_1	15	20	PF02516	0.368
MOD_N-GLC_1	60	65	PF02516	0.496
MOD_N-GLC_2	226	228	PF02516	0.584
MOD_N-GLC_2	6	8	PF02516	0.475
MOD_NEK2_1	14	19	PF00069	0.500
MOD_NEK2_1	176	181	PF00069	0.555
MOD_NEK2_1	79	84	PF00069	0.516
MOD_PK_1	7	13	PF00069	0.471
MOD_PKA_2	208	214	PF00069	0.641
MOD_Plk_1	15	21	PF00069	0.378
MOD_Plk_1	60	66	PF00069	0.497
MOD_Plk_4	107	113	PF00069	0.444
MOD_Plk_4	132	138	PF00069	0.476
MOD_Plk_4	15	21	PF00069	0.424
MOD_Plk_4	168	174	PF00069	0.516
MOD_Plk_4	91	97	PF00069	0.448
MOD_ProDKin_1	166	172	PF00069	0.567
MOD_ProDKin_1	19	25	PF00069	0.617
MOD_ProDKin_1	88	94	PF00069	0.532
MOD_ProDKin_1	96	102	PF00069	0.485
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.525
TRG_ENDOCYTIC_2	134	137	PF00928	0.504
TRG_ENDOCYTIC_2	173	176	PF00928	0.585
TRG_ENDOCYTIC_2	198	201	PF00928	0.486
TRG_ENDOCYTIC_2	64	67	PF00928	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJH1	Leptomonas seymouri	47%	97%
A0A3Q8IF52	Leishmania donovani	100%	100%
A0A3R7LVK8	Trypanosoma rangeli	27%	100%
A4HJT2	Leishmania braziliensis	72%	100%
E9B293	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5W5	Leishmania major	94%	100%