Putative nucleoporin (NUP54/57)

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoporin (NUP54/57) - putative

Species:

Leishmania infantum

UniProt:

A4I794_LEIIN

TriTrypDb:

LINF_310037700

Length:

451

Annotations

Annotations by Jardim et al.

Nuclear proteins, nucleoporin (NUP54/57)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:0044613	nuclear pore central transport channel	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I794

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I794

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	1
GO:0006607	NLS-bearing protein import into nucleus	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0006996	organelle organization	4	1
GO:0006997	nucleus organization	5	1
GO:0006999	nuclear pore organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0036228	protein localization to nuclear inner membrane	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090435	protein localization to nuclear envelope	7	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1
GO:0017056	structural constituent of nuclear pore	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.329
CLV_NRD_NRD_1	291	293	PF00675	0.353
CLV_NRD_NRD_1	318	320	PF00675	0.340
CLV_NRD_NRD_1	337	339	PF00675	0.417
CLV_NRD_NRD_1	385	387	PF00675	0.492
CLV_PCSK_KEX2_1	256	258	PF00082	0.324
CLV_PCSK_KEX2_1	291	293	PF00082	0.353
CLV_PCSK_KEX2_1	318	320	PF00082	0.340
CLV_PCSK_KEX2_1	385	387	PF00082	0.492
CLV_PCSK_SKI1_1	270	274	PF00082	0.278
CLV_PCSK_SKI1_1	338	342	PF00082	0.264
CLV_PCSK_SKI1_1	355	359	PF00082	0.271
CLV_Separin_Metazoa	253	257	PF03568	0.278
CLV_Separin_Metazoa	315	319	PF03568	0.326
DEG_Nend_Nbox_1	1	3	PF02207	0.627
DOC_MAPK_DCC_7	242	250	PF00069	0.240
DOC_MAPK_gen_1	256	267	PF00069	0.324
DOC_PP2B_LxvP_1	341	344	PF13499	0.250
DOC_PP4_FxxP_1	119	122	PF00568	0.590
DOC_PP4_FxxP_1	59	62	PF00568	0.588
DOC_USP7_MATH_1	169	173	PF00917	0.584
DOC_USP7_MATH_1	37	41	PF00917	0.485
DOC_USP7_MATH_1	443	447	PF00917	0.532
DOC_USP7_MATH_1	47	51	PF00917	0.470
DOC_USP7_MATH_1	62	66	PF00917	0.578
DOC_USP7_UBL2_3	266	270	PF12436	0.278
DOC_USP7_UBL2_3	435	439	PF12436	0.438
DOC_WW_Pin1_4	243	248	PF00397	0.241
DOC_WW_Pin1_4	49	54	PF00397	0.584
LIG_14-3-3_CanoR_1	170	178	PF00244	0.464
LIG_14-3-3_CanoR_1	306	311	PF00244	0.255
LIG_14-3-3_CanoR_1	319	329	PF00244	0.263
LIG_14-3-3_CanoR_1	346	354	PF00244	0.315
LIG_14-3-3_CanoR_1	355	365	PF00244	0.365
LIG_BRCT_BRCA1_1	39	43	PF00533	0.462
LIG_Clathr_ClatBox_1	178	182	PF01394	0.365
LIG_FHA_1	160	166	PF00498	0.559
LIG_FHA_1	215	221	PF00498	0.494
LIG_FHA_1	25	31	PF00498	0.592
LIG_FHA_1	271	277	PF00498	0.278
LIG_FHA_2	162	168	PF00498	0.572
LIG_FHA_2	427	433	PF00498	0.400
LIG_LIR_Apic_2	116	122	PF02991	0.592
LIG_LIR_Apic_2	57	62	PF02991	0.529
LIG_LIR_Gen_1	182	190	PF02991	0.359
LIG_LIR_Nem_3	182	188	PF02991	0.357
LIG_LIR_Nem_3	214	219	PF02991	0.411
LIG_NRBOX	336	342	PF00104	0.326
LIG_NRBOX	429	435	PF00104	0.371
LIG_PCNA_PIPBox_1	171	180	PF02747	0.376
LIG_PCNA_yPIPBox_3	170	178	PF02747	0.464
LIG_PCNA_yPIPBox_3	262	276	PF02747	0.278
LIG_Pex14_2	55	59	PF04695	0.592
LIG_SH2_CRK	185	189	PF00017	0.365
LIG_SH2_CRK	308	312	PF00017	0.250
LIG_SH2_GRB2like	219	222	PF00017	0.490
LIG_SH2_SRC	219	222	PF00017	0.436
LIG_SH2_STAP1	216	220	PF00017	0.509
LIG_SH2_STAT5	177	180	PF00017	0.368
LIG_SH2_STAT5	216	219	PF00017	0.491
LIG_SH3_3	150	156	PF00018	0.631
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.334
LIG_SUMO_SIM_par_1	161	167	PF11976	0.579
MOD_CK1_1	114	120	PF00069	0.537
MOD_CK1_1	28	34	PF00069	0.525
MOD_CK1_1	78	84	PF00069	0.581
MOD_CK2_1	320	326	PF00069	0.326
MOD_CK2_1	329	335	PF00069	0.234
MOD_CK2_1	426	432	PF00069	0.404
MOD_CK2_1	443	449	PF00069	0.330
MOD_GlcNHglycan	113	116	PF01048	0.624
MOD_GlcNHglycan	171	174	PF01048	0.532
MOD_GlcNHglycan	27	30	PF01048	0.514
MOD_GlcNHglycan	371	374	PF01048	0.538
MOD_GlcNHglycan	389	392	PF01048	0.557
MOD_GlcNHglycan	39	42	PF01048	0.558
MOD_GlcNHglycan	49	52	PF01048	0.553
MOD_GlcNHglycan	64	67	PF01048	0.540
MOD_GlcNHglycan	7	10	PF01048	0.505
MOD_GlcNHglycan	72	75	PF01048	0.497
MOD_GlcNHglycan	77	80	PF01048	0.450
MOD_GSK3_1	169	176	PF00069	0.507
MOD_GSK3_1	21	28	PF00069	0.498
MOD_GSK3_1	32	39	PF00069	0.555
MOD_GSK3_1	345	352	PF00069	0.356
MOD_GSK3_1	356	363	PF00069	0.372
MOD_GSK3_1	369	376	PF00069	0.382
MOD_GSK3_1	70	77	PF00069	0.553
MOD_N-GLC_1	33	38	PF02516	0.595
MOD_N-GLC_1	373	378	PF02516	0.531
MOD_N-GLC_2	200	202	PF02516	0.335
MOD_NEK2_1	111	116	PF00069	0.576
MOD_NEK2_1	181	186	PF00069	0.423
MOD_NEK2_1	2	7	PF00069	0.499
MOD_NEK2_1	25	30	PF00069	0.591
MOD_NEK2_1	329	334	PF00069	0.326
MOD_NEK2_1	387	392	PF00069	0.537
MOD_NEK2_1	75	80	PF00069	0.549
MOD_PIKK_1	248	254	PF00454	0.356
MOD_PIKK_1	345	351	PF00454	0.316
MOD_PIKK_1	366	372	PF00454	0.470
MOD_PKA_1	270	276	PF00069	0.290
MOD_PKA_2	169	175	PF00069	0.482
MOD_PKA_2	214	220	PF00069	0.475
MOD_PKA_2	255	261	PF00069	0.326
MOD_PKA_2	345	351	PF00069	0.302
MOD_Plk_1	181	187	PF00069	0.424
MOD_Plk_1	360	366	PF00069	0.504
MOD_Plk_4	173	179	PF00069	0.442
MOD_Plk_4	306	312	PF00069	0.250
MOD_ProDKin_1	243	249	PF00069	0.241
MOD_ProDKin_1	49	55	PF00069	0.585
MOD_SUMO_rev_2	432	441	PF00179	0.441
TRG_DiLeu_BaEn_2	352	358	PF01217	0.250
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.512
TRG_ENDOCYTIC_2	185	188	PF00928	0.371
TRG_ENDOCYTIC_2	308	311	PF00928	0.250
TRG_ER_diArg_1	255	257	PF00400	0.408
TRG_ER_diArg_1	290	292	PF00400	0.367
TRG_ER_diArg_1	317	319	PF00400	0.329
TRG_ER_diArg_1	385	387	PF00400	0.492
TRG_ER_diArg_1	444	447	PF00400	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICT1	Leishmania donovani	99%	100%
A0A3R7KYW1	Trypanosoma rangeli	41%	100%
A4HJS8	Leishmania braziliensis	79%	100%
E9B289	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q5W9	Leishmania major	94%	100%