Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I788_LEIIN

TriTrypDb:

LINF_310037100

Length:

324

Annotations

LeishMANIAdb annotations

Appears to be unique to Kinetoplastids, with very unclear topology, localization and function.. Despite the topology, no signal peptides are present, although a mitochondrial transit signal cannot be excluded

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4I788

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I788

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	310	312	PF00082	0.443
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.434
DEG_SPOP_SBC_1	30	34	PF00917	0.393
DOC_ANK_TNKS_1	299	306	PF00023	0.636
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.413
DOC_SPAK_OSR1_1	193	197	PF12202	0.409
DOC_USP7_MATH_1	216	220	PF00917	0.420
DOC_USP7_MATH_1	31	35	PF00917	0.413
DOC_USP7_MATH_1	51	55	PF00917	0.350
DOC_WW_Pin1_4	130	135	PF00397	0.672
DOC_WW_Pin1_4	25	30	PF00397	0.445
DOC_WW_Pin1_4	33	38	PF00397	0.455
DOC_WW_Pin1_4	95	100	PF00397	0.630
LIG_AP2alpha_2	4	6	PF02296	0.374
LIG_BRCT_BRCA1_1	9	13	PF00533	0.439
LIG_Clathr_ClatBox_1	275	279	PF01394	0.555
LIG_deltaCOP1_diTrp_1	232	238	PF00928	0.492
LIG_eIF4E_1	270	276	PF01652	0.498
LIG_FHA_1	101	107	PF00498	0.662
LIG_FHA_1	164	170	PF00498	0.509
LIG_FHA_1	177	183	PF00498	0.376
LIG_FHA_1	229	235	PF00498	0.577
LIG_FHA_1	287	293	PF00498	0.554
LIG_FHA_1	297	303	PF00498	0.582
LIG_FHA_1	34	40	PF00498	0.431
LIG_FHA_2	111	117	PF00498	0.471
LIG_FHA_2	227	233	PF00498	0.615
LIG_FHA_2	95	101	PF00498	0.710
LIG_LIR_Gen_1	136	145	PF02991	0.717
LIG_LIR_Gen_1	231	241	PF02991	0.525
LIG_LIR_Nem_3	136	140	PF02991	0.710
LIG_LIR_Nem_3	317	322	PF02991	0.659
LIG_Pex14_2	70	74	PF04695	0.314
LIG_REV1ctd_RIR_1	72	83	PF16727	0.460
LIG_SH2_CRK	137	141	PF00017	0.763
LIG_SH2_CRK	319	323	PF00017	0.560
LIG_SH2_NCK_1	137	141	PF00017	0.768
LIG_SH2_STAP1	76	80	PF00017	0.556
LIG_SH2_STAT5	202	205	PF00017	0.306
LIG_SH2_STAT5	270	273	PF00017	0.358
LIG_SH3_3	125	131	PF00018	0.690
LIG_SH3_3	298	304	PF00018	0.600
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.589
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.413
LIG_SUMO_SIM_par_1	102	109	PF11976	0.589
LIG_SUMO_SIM_par_1	166	172	PF11976	0.346
LIG_UBA3_1	275	280	PF00899	0.560
MOD_CK1_1	33	39	PF00069	0.431
MOD_CK1_1	7	13	PF00069	0.455
MOD_CK2_1	130	136	PF00069	0.689
MOD_CK2_1	226	232	PF00069	0.564
MOD_GlcNHglycan	247	250	PF01048	0.423
MOD_GlcNHglycan	312	315	PF01048	0.446
MOD_GlcNHglycan	319	322	PF01048	0.487
MOD_GSK3_1	106	113	PF00069	0.582
MOD_GSK3_1	159	166	PF00069	0.620
MOD_GSK3_1	216	223	PF00069	0.511
MOD_GSK3_1	25	32	PF00069	0.445
MOD_GSK3_1	306	313	PF00069	0.699
MOD_GSK3_1	317	324	PF00069	0.543
MOD_GSK3_1	33	40	PF00069	0.453
MOD_N-GLC_1	25	30	PF02516	0.632
MOD_NEK2_1	110	115	PF00069	0.568
MOD_NEK2_1	189	194	PF00069	0.360
MOD_NEK2_1	209	214	PF00069	0.368
MOD_NEK2_1	226	231	PF00069	0.526
MOD_NEK2_1	245	250	PF00069	0.420
MOD_NEK2_1	264	269	PF00069	0.437
MOD_NEK2_1	53	58	PF00069	0.383
MOD_NEK2_1	6	11	PF00069	0.403
MOD_PIKK_1	220	226	PF00454	0.647
MOD_PIKK_1	286	292	PF00454	0.557
MOD_PKA_1	310	316	PF00069	0.631
MOD_PKA_2	123	129	PF00069	0.642
MOD_PKA_2	286	292	PF00069	0.598
MOD_PKA_2	310	316	PF00069	0.682
MOD_PKA_2	41	47	PF00069	0.433
MOD_Plk_1	220	226	PF00069	0.623
MOD_Plk_1	296	302	PF00069	0.634
MOD_Plk_4	159	165	PF00069	0.621
MOD_Plk_4	176	182	PF00069	0.327
MOD_Plk_4	184	190	PF00069	0.495
MOD_ProDKin_1	130	136	PF00069	0.675
MOD_ProDKin_1	25	31	PF00069	0.443
MOD_ProDKin_1	33	39	PF00069	0.456
MOD_ProDKin_1	95	101	PF00069	0.625
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.213
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.410
TRG_ENDOCYTIC_2	137	140	PF00928	0.698
TRG_ENDOCYTIC_2	319	322	PF00928	0.582
TRG_ER_diArg_1	122	125	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U5	Leptomonas seymouri	69%	100%
A0A0S4JIB3	Bodo saltans	32%	100%
A0A1X0NIE1	Trypanosomatidae	44%	100%
A0A3R7NC34	Trypanosoma rangeli	43%	100%
A0A3S7X4W5	Leishmania donovani	99%	100%
A4HJS2	Leishmania braziliensis	80%	100%
C9ZMG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZWL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B283	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5X5	Leishmania major	95%	100%
V5BC20	Trypanosoma cruzi	43%	100%