Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I787_LEIIN

TriTrypDb:

LINF_310037000

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I787

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I787

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.628
CLV_C14_Caspase3-7	55	59	PF00656	0.609
CLV_C14_Caspase3-7	64	68	PF00656	0.543
CLV_NRD_NRD_1	11	13	PF00675	0.562
CLV_NRD_NRD_1	132	134	PF00675	0.654
CLV_NRD_NRD_1	139	141	PF00675	0.585
CLV_NRD_NRD_1	242	244	PF00675	0.548
CLV_NRD_NRD_1	250	252	PF00675	0.500
CLV_NRD_NRD_1	331	333	PF00675	0.513
CLV_NRD_NRD_1	423	425	PF00675	0.798
CLV_NRD_NRD_1	482	484	PF00675	0.657
CLV_NRD_NRD_1	486	488	PF00675	0.596
CLV_NRD_NRD_1	520	522	PF00675	0.687
CLV_NRD_NRD_1	555	557	PF00675	0.612
CLV_NRD_NRD_1	612	614	PF00675	0.673
CLV_NRD_NRD_1	83	85	PF00675	0.702
CLV_PCSK_KEX2_1	132	134	PF00082	0.654
CLV_PCSK_KEX2_1	139	141	PF00082	0.585
CLV_PCSK_KEX2_1	242	244	PF00082	0.548
CLV_PCSK_KEX2_1	250	252	PF00082	0.500
CLV_PCSK_KEX2_1	333	335	PF00082	0.501
CLV_PCSK_KEX2_1	484	486	PF00082	0.642
CLV_PCSK_KEX2_1	498	500	PF00082	0.508
CLV_PCSK_KEX2_1	519	521	PF00082	0.646
CLV_PCSK_KEX2_1	587	589	PF00082	0.626
CLV_PCSK_KEX2_1	607	609	PF00082	0.520
CLV_PCSK_KEX2_1	83	85	PF00082	0.702
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.501
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.623
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.481
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.646
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.626
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.520
CLV_PCSK_PC7_1	516	522	PF00082	0.648
CLV_PCSK_SKI1_1	133	137	PF00082	0.664
CLV_PCSK_SKI1_1	227	231	PF00082	0.516
CLV_PCSK_SKI1_1	263	267	PF00082	0.549
CLV_PCSK_SKI1_1	351	355	PF00082	0.516
CLV_PCSK_SKI1_1	584	588	PF00082	0.614
CLV_PCSK_SKI1_1	602	606	PF00082	0.534
DEG_APCC_DBOX_1	226	234	PF00400	0.511
DEG_APCC_DBOX_1	346	354	PF00400	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.527
DEG_SPOP_SBC_1	163	167	PF00917	0.681
DOC_CYCLIN_RxL_1	221	234	PF00134	0.522
DOC_CYCLIN_RxL_1	257	270	PF00134	0.552
DOC_MAPK_RevD_3	235	251	PF00069	0.531
DOC_USP7_MATH_1	146	150	PF00917	0.646
DOC_USP7_MATH_1	163	167	PF00917	0.600
DOC_USP7_MATH_1	220	224	PF00917	0.664
DOC_USP7_MATH_1	30	34	PF00917	0.642
DOC_USP7_MATH_1	40	44	PF00917	0.581
DOC_USP7_MATH_1	536	540	PF00917	0.617
DOC_USP7_MATH_1	567	571	PF00917	0.625
DOC_USP7_MATH_1	59	63	PF00917	0.568
DOC_USP7_MATH_1	593	597	PF00917	0.674
DOC_USP7_MATH_1	609	613	PF00917	0.568
DOC_USP7_MATH_1	95	99	PF00917	0.621
DOC_USP7_MATH_2	145	151	PF00917	0.600
DOC_USP7_UBL2_3	484	488	PF12436	0.608
DOC_USP7_UBL2_3	553	557	PF12436	0.596
DOC_USP7_UBL2_3	601	605	PF12436	0.696
DOC_WW_Pin1_4	126	131	PF00397	0.684
DOC_WW_Pin1_4	140	145	PF00397	0.548
DOC_WW_Pin1_4	164	169	PF00397	0.681
DOC_WW_Pin1_4	405	410	PF00397	0.668
DOC_WW_Pin1_4	589	594	PF00397	0.656
DOC_WW_Pin1_4	607	612	PF00397	0.533
LIG_14-3-3_CanoR_1	132	138	PF00244	0.642
LIG_14-3-3_CanoR_1	21	30	PF00244	0.648
LIG_14-3-3_CanoR_1	242	248	PF00244	0.544
LIG_14-3-3_CanoR_1	250	255	PF00244	0.490
LIG_14-3-3_CanoR_1	257	265	PF00244	0.416
LIG_14-3-3_CanoR_1	422	432	PF00244	0.695
LIG_14-3-3_CanoR_1	556	561	PF00244	0.670
LIG_14-3-3_CanoR_1	588	593	PF00244	0.604
LIG_14-3-3_CanoR_1	94	100	PF00244	0.682
LIG_BIR_III_2	533	537	PF00653	0.637
LIG_FHA_1	257	263	PF00498	0.569
LIG_FHA_1	304	310	PF00498	0.552
LIG_FHA_1	49	55	PF00498	0.605
LIG_FHA_2	203	209	PF00498	0.681
LIG_FHA_2	285	291	PF00498	0.488
LIG_FHA_2	365	371	PF00498	0.666
LIG_FHA_2	452	458	PF00498	0.678
LIG_FHA_2	462	468	PF00498	0.605
LIG_LIR_Gen_1	264	272	PF02991	0.544
LIG_LIR_Gen_1	359	368	PF02991	0.528
LIG_LIR_Nem_3	223	229	PF02991	0.525
LIG_LIR_Nem_3	270	276	PF02991	0.557
LIG_LIR_Nem_3	359	364	PF02991	0.529
LIG_NRBOX	349	355	PF00104	0.505
LIG_NRP_CendR_1	621	624	PF00754	0.645
LIG_RPA_C_Fungi	246	258	PF08784	0.513
LIG_SH2_CRK	226	230	PF00017	0.520
LIG_SH2_NCK_1	336	340	PF00017	0.610
LIG_SH2_SRC	336	339	PF00017	0.481
LIG_SH2_STAP1	336	340	PF00017	0.544
LIG_SH2_STAT5	292	295	PF00017	0.473
LIG_SH2_STAT5	317	320	PF00017	0.643
LIG_SH2_STAT5	352	355	PF00017	0.548
LIG_SH3_3	189	195	PF00018	0.599
LIG_SH3_3	279	285	PF00018	0.695
LIG_SH3_3	379	385	PF00018	0.585
LIG_SH3_3	67	73	PF00018	0.551
LIG_SH3_3	85	91	PF00018	0.608
LIG_TRAF2_1	437	440	PF00917	0.673
MOD_CDC14_SPxK_1	129	132	PF00782	0.637
MOD_CDC14_SPxK_1	610	613	PF00782	0.632
MOD_CDK_SPK_2	164	169	PF00069	0.702
MOD_CDK_SPK_2	405	410	PF00069	0.634
MOD_CDK_SPxK_1	126	132	PF00069	0.691
MOD_CDK_SPxK_1	607	613	PF00069	0.634
MOD_CDK_SPxxK_3	126	133	PF00069	0.691
MOD_CDK_SPxxK_3	607	614	PF00069	0.671
MOD_CK1_1	100	106	PF00069	0.652
MOD_CK1_1	149	155	PF00069	0.602
MOD_CK1_1	212	218	PF00069	0.615
MOD_CK1_1	246	252	PF00069	0.557
MOD_CK1_1	253	259	PF00069	0.490
MOD_CK1_1	423	429	PF00069	0.669
MOD_CK1_1	43	49	PF00069	0.641
MOD_CK1_1	524	530	PF00069	0.653
MOD_CK1_1	592	598	PF00069	0.572
MOD_CK2_1	119	125	PF00069	0.600
MOD_CK2_1	164	170	PF00069	0.703
MOD_CK2_1	202	208	PF00069	0.685
MOD_CK2_1	356	362	PF00069	0.637
MOD_CK2_1	364	370	PF00069	0.484
MOD_CK2_1	451	457	PF00069	0.657
MOD_Cter_Amidation	330	333	PF01082	0.518
MOD_Cter_Amidation	481	484	PF01082	0.636
MOD_Cter_Amidation	485	488	PF01082	0.588
MOD_DYRK1A_RPxSP_1	126	130	PF00069	0.649
MOD_GlcNHglycan	102	105	PF01048	0.669
MOD_GlcNHglycan	106	109	PF01048	0.642
MOD_GlcNHglycan	111	114	PF01048	0.612
MOD_GlcNHglycan	124	129	PF01048	0.526
MOD_GlcNHglycan	202	205	PF01048	0.669
MOD_GlcNHglycan	211	214	PF01048	0.573
MOD_GlcNHglycan	34	37	PF01048	0.653
MOD_GlcNHglycan	440	444	PF01048	0.673
MOD_GlcNHglycan	494	497	PF01048	0.566
MOD_GlcNHglycan	503	506	PF01048	0.540
MOD_GlcNHglycan	513	516	PF01048	0.561
MOD_GlcNHglycan	526	529	PF01048	0.593
MOD_GlcNHglycan	538	541	PF01048	0.595
MOD_GlcNHglycan	543	546	PF01048	0.545
MOD_GlcNHglycan	595	598	PF01048	0.688
MOD_GlcNHglycan	78	81	PF01048	0.751
MOD_GSK3_1	202	209	PF00069	0.609
MOD_GSK3_1	215	222	PF00069	0.471
MOD_GSK3_1	246	253	PF00069	0.651
MOD_GSK3_1	271	278	PF00069	0.704
MOD_GSK3_1	28	35	PF00069	0.671
MOD_GSK3_1	352	359	PF00069	0.577
MOD_GSK3_1	40	47	PF00069	0.547
MOD_GSK3_1	461	468	PF00069	0.772
MOD_GSK3_1	588	595	PF00069	0.636
MOD_GSK3_1	95	102	PF00069	0.681
MOD_N-GLC_1	303	308	PF02516	0.610
MOD_NEK2_1	22	27	PF00069	0.533
MOD_NEK2_1	364	369	PF00069	0.523
MOD_NEK2_2	23	28	PF00069	0.610
MOD_PIKK_1	119	125	PF00454	0.576
MOD_PIKK_1	256	262	PF00454	0.554
MOD_PIKK_1	487	493	PF00454	0.591
MOD_PIKK_1	521	527	PF00454	0.644
MOD_PK_1	243	249	PF00069	0.545
MOD_PK_1	250	256	PF00069	0.498
MOD_PK_1	28	34	PF00069	0.627
MOD_PK_1	477	483	PF00069	0.648
MOD_PKA_1	250	256	PF00069	0.544
MOD_PKA_1	487	493	PF00069	0.570
MOD_PKA_1	556	562	PF00069	0.597
MOD_PKA_2	119	125	PF00069	0.576
MOD_PKA_2	2	8	PF00069	0.564
MOD_PKA_2	23	29	PF00069	0.599
MOD_PKA_2	250	256	PF00069	0.648
MOD_PKA_2	423	429	PF00069	0.693
MOD_PKB_1	485	493	PF00069	0.576
MOD_Plk_1	146	152	PF00069	0.579
MOD_Plk_1	369	375	PF00069	0.510
MOD_Plk_4	44	50	PF00069	0.654
MOD_ProDKin_1	126	132	PF00069	0.684
MOD_ProDKin_1	140	146	PF00069	0.550
MOD_ProDKin_1	164	170	PF00069	0.682
MOD_ProDKin_1	405	411	PF00069	0.668
MOD_ProDKin_1	589	595	PF00069	0.661
MOD_ProDKin_1	607	613	PF00069	0.533
MOD_SUMO_rev_2	348	353	PF00179	0.499
MOD_SUMO_rev_2	552	559	PF00179	0.634
TRG_DiLeu_BaEn_1	349	354	PF01217	0.498
TRG_ENDOCYTIC_2	226	229	PF00928	0.522
TRG_ENDOCYTIC_2	325	328	PF00928	0.484
TRG_ER_diArg_1	132	134	PF00400	0.621
TRG_ER_diArg_1	332	335	PF00400	0.509
TRG_ER_diArg_1	82	84	PF00400	0.702
TRG_ER_diArg_1	91	94	PF00400	0.608
TRG_ER_diLys_1	621	624	PF00400	0.686
TRG_NLS_MonoExtC_3	331	337	PF00514	0.505
TRG_NLS_MonoExtC_3	482	487	PF00514	0.609
TRG_NLS_MonoExtC_3	583	588	PF00514	0.612
TRG_NLS_MonoExtN_4	329	336	PF00514	0.509
TRG_NLS_MonoExtN_4	483	488	PF00514	0.600
TRG_NLS_MonoExtN_4	516	523	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIU7	Leishmania donovani	100%	100%
A4HJS1	Leishmania braziliensis	69%	100%
E9B282	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5X6	Leishmania major	91%	100%