Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KH domain/Domain of unknown function (DUF1771)/Smr domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I785_LEIIN

TriTrypDb:

LINF_310036800

Length:

279

Annotations

Annotations by Jardim et al.

RNA Processing, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I785

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I785

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.233
CLV_NRD_NRD_1	81	83	PF00675	0.339
CLV_PCSK_KEX2_1	201	203	PF00082	0.472
CLV_PCSK_KEX2_1	91	93	PF00082	0.328
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.329
CLV_PCSK_SKI1_1	201	205	PF00082	0.358
DEG_APCC_DBOX_1	201	209	PF00400	0.300
DEG_SPOP_SBC_1	177	181	PF00917	0.327
DOC_CDC14_PxL_1	224	232	PF14671	0.439
DOC_MAPK_gen_1	128	136	PF00069	0.395
DOC_USP7_MATH_1	176	180	PF00917	0.414
DOC_USP7_MATH_1	248	252	PF00917	0.706
DOC_USP7_MATH_1	261	265	PF00917	0.714
DOC_USP7_UBL2_3	171	175	PF12436	0.327
DOC_USP7_UBL2_3	243	247	PF12436	0.786
LIG_14-3-3_CanoR_1	19	25	PF00244	0.500
LIG_14-3-3_CanoR_1	201	206	PF00244	0.479
LIG_14-3-3_CanoR_1	30	36	PF00244	0.409
LIG_Actin_WH2_2	9	27	PF00022	0.408
LIG_APCC_ABBAyCdc20_2	211	217	PF00400	0.179
LIG_APCC_ABBAyCdc20_2	92	98	PF00400	0.378
LIG_BRCT_BRCA1_1	92	96	PF00533	0.378
LIG_FHA_1	195	201	PF00498	0.304
LIG_FHA_1	32	38	PF00498	0.531
LIG_FHA_1	8	14	PF00498	0.273
LIG_FHA_2	179	185	PF00498	0.369
LIG_FHA_2	45	51	PF00498	0.523
LIG_LIR_Apic_2	72	76	PF02991	0.527
LIG_LIR_Gen_1	180	189	PF02991	0.372
LIG_LIR_Gen_1	204	215	PF02991	0.319
LIG_LIR_Nem_3	180	186	PF02991	0.372
LIG_LIR_Nem_3	204	210	PF02991	0.319
LIG_MAD2	63	71	PF02301	0.574
LIG_SH2_NCK_1	215	219	PF00017	0.341
LIG_SH2_PTP2	207	210	PF00017	0.233
LIG_SH2_SRC	215	218	PF00017	0.324
LIG_SH2_STAT5	150	153	PF00017	0.376
LIG_SH2_STAT5	207	210	PF00017	0.326
LIG_SH2_STAT5	213	216	PF00017	0.311
LIG_SH3_3	222	228	PF00018	0.502
LIG_SH3_3	242	248	PF00018	0.641
LIG_TYR_ITIM	205	210	PF00017	0.260
MOD_CK1_1	264	270	PF00069	0.658
MOD_CK2_1	176	182	PF00069	0.333
MOD_CK2_1	233	239	PF00069	0.676
MOD_GlcNHglycan	192	195	PF01048	0.339
MOD_GlcNHglycan	230	233	PF01048	0.541
MOD_GlcNHglycan	250	253	PF01048	0.681
MOD_GlcNHglycan	263	266	PF01048	0.565
MOD_GSK3_1	190	197	PF00069	0.307
MOD_GSK3_1	261	268	PF00069	0.685
MOD_NEK2_2	20	25	PF00069	0.472
MOD_PIKK_1	194	200	PF00454	0.307
MOD_PKA_1	201	207	PF00069	0.300
MOD_PKA_2	201	207	PF00069	0.420
MOD_SUMO_rev_2	123	127	PF00179	0.336
MOD_SUMO_rev_2	170	177	PF00179	0.402
TRG_DiLeu_BaEn_3	159	165	PF01217	0.345
TRG_ENDOCYTIC_2	150	153	PF00928	0.376
TRG_ENDOCYTIC_2	207	210	PF00928	0.428
TRG_ENDOCYTIC_2	215	218	PF00928	0.388
TRG_ER_diArg_1	200	202	PF00400	0.233

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U4	Leptomonas seymouri	65%	100%
A0A0S4JKD1	Bodo saltans	29%	89%
A0A3Q8IKE2	Leishmania donovani	99%	100%
A0A422NF86	Trypanosoma rangeli	55%	100%
A4H981	Leishmania braziliensis	71%	96%
A4HJR9	Leishmania braziliensis	71%	96%
C9ZMG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B280	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5X8	Leishmania major	91%	100%
Q9UTP4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
V5BGM8	Trypanosoma cruzi	56%	98%