Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain) - putative

Species:

Leishmania infantum

UniProt:

A4I782_LEIIN

TriTrypDb:

LINF_310036300

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Phosphorylation

Promastigote: 182, 183

Expansion

Sequence features

A4I782

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I782

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.510
CLV_NRD_NRD_1	128	130	PF00675	0.569
CLV_NRD_NRD_1	61	63	PF00675	0.310
CLV_PCSK_KEX2_1	128	130	PF00082	0.569
CLV_PCSK_KEX2_1	61	63	PF00082	0.310
CLV_Separin_Metazoa	125	129	PF03568	0.544
DEG_APCC_DBOX_1	225	233	PF00400	0.669
DEG_SCF_FBW7_2	55	60	PF00400	0.512
DOC_PP4_FxxP_1	89	92	PF00568	0.505
DOC_USP7_MATH_1	176	180	PF00917	0.710
DOC_USP7_MATH_1	235	239	PF00917	0.624
DOC_USP7_MATH_1	250	254	PF00917	0.658
DOC_USP7_MATH_1	5	9	PF00917	0.534
DOC_USP7_MATH_2	250	256	PF00917	0.736
DOC_WW_Pin1_4	107	112	PF00397	0.488
DOC_WW_Pin1_4	156	161	PF00397	0.592
DOC_WW_Pin1_4	53	58	PF00397	0.513
DOC_WW_Pin1_4	88	93	PF00397	0.490
LIG_14-3-3_CanoR_1	118	127	PF00244	0.527
LIG_14-3-3_CanoR_1	178	186	PF00244	0.618
LIG_14-3-3_CanoR_1	197	203	PF00244	0.669
LIG_14-3-3_CanoR_1	261	270	PF00244	0.701
LIG_14-3-3_CanoR_1	284	294	PF00244	0.659
LIG_14-3-3_CanoR_1	50	56	PF00244	0.510
LIG_14-3-3_CanoR_1	9	19	PF00244	0.471
LIG_APCC_ABBA_1	202	207	PF00400	0.629
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_FHA_1	304	310	PF00498	0.591
LIG_FHA_1	63	69	PF00498	0.514
LIG_FHA_2	120	126	PF00498	0.508
LIG_FHA_2	27	33	PF00498	0.469
LIG_FHA_2	276	282	PF00498	0.575
LIG_FHA_2	290	296	PF00498	0.630
LIG_FHA_2	54	60	PF00498	0.511
LIG_FHA_2	70	76	PF00498	0.510
LIG_LIR_Apic_2	155	160	PF02991	0.604
LIG_LIR_Apic_2	288	294	PF02991	0.642
LIG_LIR_Apic_2	88	92	PF02991	0.506
LIG_LIR_Gen_1	216	223	PF02991	0.655
LIG_LIR_Nem_3	216	220	PF02991	0.699
LIG_LIR_Nem_3	32	37	PF02991	0.477
LIG_LIR_Nem_3	38	43	PF02991	0.456
LIG_LIR_Nem_3	65	70	PF02991	0.467
LIG_LYPXL_S_1	33	37	PF13949	0.310
LIG_SH2_CRK	157	161	PF00017	0.606
LIG_SH2_CRK	217	221	PF00017	0.639
LIG_SH2_CRK	40	44	PF00017	0.510
LIG_SH2_GRB2like	217	220	PF00017	0.637
LIG_SH2_NCK_1	146	150	PF00017	0.744
LIG_SH2_NCK_1	157	161	PF00017	0.538
LIG_SH2_NCK_1	291	295	PF00017	0.625
LIG_SH2_PTP2	101	104	PF00017	0.462
LIG_SH2_STAP1	217	221	PF00017	0.639
LIG_SH2_STAT5	101	104	PF00017	0.462
LIG_SH2_STAT5	191	194	PF00017	0.577
LIG_SH2_STAT5	242	245	PF00017	0.635
LIG_SH2_STAT5	27	30	PF00017	0.510
LIG_SH2_STAT5	291	294	PF00017	0.626
LIG_TRAF2_1	57	60	PF00917	0.510
LIG_TRAF2_1	92	95	PF00917	0.630
LIG_TYR_ITIM	99	104	PF00017	0.476
LIG_WRC_WIRS_1	86	91	PF05994	0.479
MOD_CDK_SPxxK_3	111	118	PF00069	0.483
MOD_CK1_1	147	153	PF00069	0.708
MOD_CK1_1	155	161	PF00069	0.584
MOD_CK1_1	179	185	PF00069	0.597
MOD_CK1_1	253	259	PF00069	0.748
MOD_CK1_1	263	269	PF00069	0.651
MOD_CK2_1	119	125	PF00069	0.489
MOD_CK2_1	289	295	PF00069	0.662
MOD_CK2_1	53	59	PF00069	0.511
MOD_CK2_1	69	75	PF00069	0.510
MOD_CK2_1	88	94	PF00069	0.513
MOD_CMANNOS	116	119	PF00535	0.481
MOD_GlcNHglycan	132	135	PF01048	0.640
MOD_GlcNHglycan	170	173	PF01048	0.672
MOD_GlcNHglycan	182	185	PF01048	0.636
MOD_GlcNHglycan	252	255	PF01048	0.642
MOD_GlcNHglycan	310	313	PF01048	0.594
MOD_GSK3_1	107	114	PF00069	0.476
MOD_GSK3_1	130	137	PF00069	0.573
MOD_GSK3_1	152	159	PF00069	0.633
MOD_GSK3_1	166	173	PF00069	0.572
MOD_GSK3_1	176	183	PF00069	0.593
MOD_GSK3_1	185	192	PF00069	0.548
MOD_GSK3_1	285	292	PF00069	0.659
MOD_GSK3_1	303	310	PF00069	0.722
MOD_GSK3_1	49	56	PF00069	0.510
MOD_N-GLC_1	268	273	PF02516	0.758
MOD_NEK2_1	127	132	PF00069	0.533
MOD_NEK2_1	168	173	PF00069	0.573
MOD_NEK2_1	189	194	PF00069	0.618
MOD_NEK2_1	285	290	PF00069	0.688
MOD_NEK2_1	307	312	PF00069	0.606
MOD_NEK2_1	87	92	PF00069	0.496
MOD_NEK2_2	35	40	PF00069	0.510
MOD_PIKK_1	10	16	PF00454	0.485
MOD_PIKK_1	119	125	PF00454	0.485
MOD_PIKK_1	177	183	PF00454	0.645
MOD_PKA_1	275	281	PF00069	0.623
MOD_PKA_2	127	133	PF00069	0.592
MOD_PKA_2	177	183	PF00069	0.646
MOD_PKA_2	189	195	PF00069	0.659
MOD_PKA_2	260	266	PF00069	0.694
MOD_PKA_2	285	291	PF00069	0.660
MOD_PKA_2	49	55	PF00069	0.521
MOD_PKA_2	5	11	PF00069	0.549
MOD_Plk_1	184	190	PF00069	0.634
MOD_Plk_2-3	71	77	PF00069	0.510
MOD_Plk_4	263	269	PF00069	0.662
MOD_ProDKin_1	107	113	PF00069	0.486
MOD_ProDKin_1	156	162	PF00069	0.594
MOD_ProDKin_1	53	59	PF00069	0.513
MOD_ProDKin_1	88	94	PF00069	0.493
MOD_SUMO_rev_2	271	277	PF00179	0.527
MOD_SUMO_rev_2	90	99	PF00179	0.546
TRG_ENDOCYTIC_2	101	104	PF00928	0.462
TRG_ENDOCYTIC_2	146	149	PF00928	0.685
TRG_ENDOCYTIC_2	217	220	PF00928	0.642
TRG_ENDOCYTIC_2	34	37	PF00928	0.477
TRG_ENDOCYTIC_2	40	43	PF00928	0.456
TRG_ER_diArg_1	127	129	PF00400	0.558
TRG_ER_diArg_1	61	63	PF00400	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M2	Leptomonas seymouri	67%	100%
A0A3S5H7Q7	Leishmania donovani	99%	100%
A0A422NJ32	Trypanosoma rangeli	28%	78%
A4HJR5	Leishmania braziliensis	85%	100%
E9B276	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q5Y3	Leishmania major	96%	100%