Kinetoplastid_kinetochore_protein_2_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 8 - putative

Species:

Leishmania infantum

UniProt:

A4I780_LEIIN

TriTrypDb:

LINF_310036100

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I780

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I780

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.617
CLV_NRD_NRD_1	186	188	PF00675	0.559
CLV_NRD_NRD_1	19	21	PF00675	0.595
CLV_NRD_NRD_1	269	271	PF00675	0.494
CLV_NRD_NRD_1	282	284	PF00675	0.338
CLV_NRD_NRD_1	307	309	PF00675	0.544
CLV_NRD_NRD_1	337	339	PF00675	0.733
CLV_NRD_NRD_1	426	428	PF00675	0.690
CLV_PCSK_FUR_1	280	284	PF00082	0.523
CLV_PCSK_KEX2_1	19	21	PF00082	0.566
CLV_PCSK_KEX2_1	268	270	PF00082	0.490
CLV_PCSK_KEX2_1	280	282	PF00082	0.338
CLV_PCSK_KEX2_1	298	300	PF00082	0.528
CLV_PCSK_KEX2_1	337	339	PF00082	0.750
CLV_PCSK_KEX2_1	425	427	PF00082	0.555
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.411
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.555
CLV_PCSK_SKI1_1	315	319	PF00082	0.508
CLV_PCSK_SKI1_1	342	346	PF00082	0.557
DEG_APCC_DBOX_1	176	184	PF00400	0.490
DEG_APCC_DBOX_1	319	327	PF00400	0.613
DEG_APCC_DBOX_1	76	84	PF00400	0.522
DEG_SPOP_SBC_1	42	46	PF00917	0.651
DEG_SPOP_SBC_1	83	87	PF00917	0.531
DOC_MAPK_gen_1	177	185	PF00069	0.456
DOC_MAPK_gen_1	288	297	PF00069	0.570
DOC_MAPK_gen_1	425	431	PF00069	0.560
DOC_MAPK_MEF2A_6	210	219	PF00069	0.492
DOC_PP1_RVXF_1	340	347	PF00149	0.542
DOC_PP2B_LxvP_1	39	42	PF13499	0.574
DOC_USP7_MATH_1	161	165	PF00917	0.407
DOC_USP7_MATH_1	348	352	PF00917	0.576
DOC_USP7_MATH_1	42	46	PF00917	0.668
DOC_USP7_MATH_1	65	69	PF00917	0.648
DOC_USP7_MATH_1	8	12	PF00917	0.672
DOC_USP7_UBL2_3	305	309	PF12436	0.506
DOC_WW_Pin1_4	10	15	PF00397	0.539
DOC_WW_Pin1_4	92	97	PF00397	0.677
LIG_14-3-3_CanoR_1	10	14	PF00244	0.539
LIG_14-3-3_CanoR_1	141	145	PF00244	0.607
LIG_14-3-3_CanoR_1	210	215	PF00244	0.523
LIG_14-3-3_CanoR_1	337	344	PF00244	0.587
LIG_14-3-3_CanoR_1	40	48	PF00244	0.637
LIG_14-3-3_CanoR_1	66	72	PF00244	0.668
LIG_14-3-3_CanoR_1	77	81	PF00244	0.615
LIG_14-3-3_CanoR_1	82	92	PF00244	0.582
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BRCT_BRCA1_1	410	414	PF00533	0.671
LIG_CaM_IQ_9	180	196	PF13499	0.543
LIG_FHA_1	11	17	PF00498	0.537
LIG_FHA_1	211	217	PF00498	0.484
LIG_FHA_1	252	258	PF00498	0.560
LIG_FHA_2	367	373	PF00498	0.741
LIG_GSK3_LRP6_1	92	97	PF00069	0.572
LIG_IBAR_NPY_1	108	110	PF08397	0.652
LIG_LIR_Apic_2	143	147	PF02991	0.611
LIG_LIR_Apic_2	209	215	PF02991	0.454
LIG_LIR_Apic_2	27	32	PF02991	0.622
LIG_LIR_Apic_2	63	67	PF02991	0.736
LIG_LIR_Apic_2	99	104	PF02991	0.666
LIG_LIR_Gen_1	198	205	PF02991	0.410
LIG_LIR_Gen_1	273	279	PF02991	0.414
LIG_LIR_Nem_3	27	31	PF02991	0.623
LIG_LIR_Nem_3	273	278	PF02991	0.401
LIG_LIR_Nem_3	290	295	PF02991	0.400
LIG_LIR_Nem_3	396	402	PF02991	0.739
LIG_LYPXL_yS_3	149	152	PF13949	0.651
LIG_MYND_1	150	154	PF01753	0.567
LIG_SH2_CRK	144	148	PF00017	0.569
LIG_SH2_CRK	29	33	PF00017	0.690
LIG_SH2_CRK	6	10	PF00017	0.620
LIG_SH2_NCK_1	29	33	PF00017	0.690
LIG_SH2_PTP2	101	104	PF00017	0.558
LIG_SH2_STAT3	132	135	PF00017	0.630
LIG_SH2_STAT5	101	104	PF00017	0.696
LIG_SH2_STAT5	132	135	PF00017	0.570
LIG_SH2_STAT5	196	199	PF00017	0.522
LIG_SH2_STAT5	212	215	PF00017	0.432
LIG_SH2_STAT5	256	259	PF00017	0.552
LIG_SH2_STAT5	29	32	PF00017	0.576
LIG_SH2_STAT5	292	295	PF00017	0.528
LIG_SH2_STAT5	381	384	PF00017	0.645
LIG_SH3_1	144	150	PF00018	0.482
LIG_SH3_3	103	109	PF00018	0.536
LIG_SH3_3	120	126	PF00018	0.642
LIG_SH3_3	144	150	PF00018	0.678
LIG_SH3_3	90	96	PF00018	0.612
LIG_SH3_CIN85_PxpxPR_1	92	97	PF14604	0.572
LIG_SUMO_SIM_par_1	366	374	PF11976	0.636
LIG_TRAF2_1	170	173	PF00917	0.524
LIG_TRAF2_1	274	277	PF00917	0.523
LIG_WW_1	14	17	PF00397	0.538
MOD_CDK_SPK_2	92	97	PF00069	0.660
MOD_CK1_1	27	33	PF00069	0.685
MOD_CK1_1	361	367	PF00069	0.691
MOD_CK1_1	380	386	PF00069	0.689
MOD_CK1_1	43	49	PF00069	0.439
MOD_CK2_1	360	366	PF00069	0.624
MOD_Cter_Amidation	335	338	PF01082	0.659
MOD_DYRK1A_RPxSP_1	10	14	PF00069	0.539
MOD_GlcNHglycan	1	4	PF01048	0.705
MOD_GlcNHglycan	338	341	PF01048	0.715
MOD_GlcNHglycan	359	363	PF01048	0.622
MOD_GlcNHglycan	371	376	PF01048	0.701
MOD_GlcNHglycan	382	385	PF01048	0.740
MOD_GlcNHglycan	6	9	PF01048	0.660
MOD_GlcNHglycan	67	70	PF01048	0.675
MOD_GlcNHglycan	98	101	PF01048	0.660
MOD_GSK3_1	108	115	PF00069	0.468
MOD_GSK3_1	332	339	PF00069	0.669
MOD_GSK3_1	371	378	PF00069	0.721
MOD_GSK3_1	380	387	PF00069	0.685
MOD_GSK3_1	4	11	PF00069	0.680
MOD_GSK3_1	408	415	PF00069	0.549
MOD_GSK3_1	67	74	PF00069	0.555
MOD_GSK3_1	92	99	PF00069	0.639
MOD_N-GLC_1	416	421	PF02516	0.630
MOD_NEK2_1	183	188	PF00069	0.379
MOD_NEK2_1	195	200	PF00069	0.424
MOD_NEK2_1	377	382	PF00069	0.615
MOD_NEK2_1	9	14	PF00069	0.540
MOD_NEK2_2	67	72	PF00069	0.587
MOD_PIKK_1	108	114	PF00454	0.605
MOD_PIKK_1	246	252	PF00454	0.507
MOD_PIKK_1	309	315	PF00454	0.505
MOD_PKA_2	140	146	PF00069	0.546
MOD_PKA_2	336	342	PF00069	0.674
MOD_PKA_2	419	425	PF00069	0.725
MOD_PKA_2	65	71	PF00069	0.648
MOD_PKA_2	76	82	PF00069	0.626
MOD_PKA_2	9	15	PF00069	0.539
MOD_PKA_2	96	102	PF00069	0.716
MOD_Plk_1	172	178	PF00069	0.441
MOD_Plk_1	348	354	PF00069	0.643
MOD_Plk_1	75	81	PF00069	0.642
MOD_Plk_2-3	260	266	PF00069	0.457
MOD_Plk_2-3	366	372	PF00069	0.676
MOD_Plk_4	102	108	PF00069	0.577
MOD_Plk_4	128	134	PF00069	0.669
MOD_Plk_4	24	30	PF00069	0.606
MOD_Plk_4	348	354	PF00069	0.531
MOD_Plk_4	419	425	PF00069	0.661
MOD_ProDKin_1	10	16	PF00069	0.539
MOD_ProDKin_1	92	98	PF00069	0.680
MOD_SUMO_rev_2	290	300	PF00179	0.414
TRG_DiLeu_BaEn_4	192	198	PF01217	0.540
TRG_ENDOCYTIC_2	149	152	PF00928	0.651
TRG_ENDOCYTIC_2	28	31	PF00928	0.727
TRG_ENDOCYTIC_2	292	295	PF00928	0.532
TRG_ENDOCYTIC_2	6	9	PF00928	0.730
TRG_ER_diArg_1	18	20	PF00400	0.613
TRG_ER_diArg_1	268	270	PF00400	0.458
TRG_ER_diArg_1	280	283	PF00400	0.368
TRG_ER_FFAT_2	376	387	PF00635	0.618
TRG_NLS_MonoCore_2	424	429	PF00514	0.761
TRG_NLS_MonoExtC_3	424	430	PF00514	0.741
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH8	Leptomonas seymouri	64%	100%
A0A1X0NJ59	Trypanosomatidae	38%	100%
A0A3S7X4V3	Leishmania donovani	100%	100%
A0A422NPB6	Trypanosoma rangeli	39%	100%
A4HJR3	Leishmania braziliensis	85%	99%
C9ZMG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B274	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5Y5	Leishmania major	95%	100%
V5D822	Trypanosoma cruzi	42%	100%