Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat - putative

Species:

Leishmania infantum

UniProt:

A4I777_LEIIN

TriTrypDb:

LINF_310035800

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I777

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I777

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.761
CLV_C14_Caspase3-7	244	248	PF00656	0.421
CLV_C14_Caspase3-7	75	79	PF00656	0.453
CLV_C14_Caspase3-7	97	101	PF00656	0.425
CLV_NRD_NRD_1	186	188	PF00675	0.346
CLV_NRD_NRD_1	3	5	PF00675	0.492
CLV_NRD_NRD_1	43	45	PF00675	0.555
CLV_PCSK_KEX2_1	186	188	PF00082	0.346
CLV_PCSK_KEX2_1	3	5	PF00082	0.492
CLV_PCSK_KEX2_1	43	45	PF00082	0.555
CLV_PCSK_SKI1_1	274	278	PF00082	0.390
CLV_PCSK_SKI1_1	284	288	PF00082	0.291
DEG_COP1_1	496	507	PF00400	0.425
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DEG_ODPH_VHL_1	460	472	PF01847	0.490
DOC_MAPK_DCC_7	465	474	PF00069	0.292
DOC_MAPK_gen_1	183	191	PF00069	0.438
DOC_MAPK_gen_1	281	290	PF00069	0.317
DOC_MAPK_MEF2A_6	281	290	PF00069	0.312
DOC_PP1_RVXF_1	185	192	PF00149	0.362
DOC_PP1_RVXF_1	272	278	PF00149	0.360
DOC_PP2B_LxvP_1	67	70	PF13499	0.553
DOC_USP7_MATH_1	108	112	PF00917	0.587
DOC_USP7_MATH_1	122	126	PF00917	0.636
DOC_USP7_MATH_1	172	176	PF00917	0.387
DOC_USP7_MATH_1	218	222	PF00917	0.481
DOC_USP7_MATH_1	407	411	PF00917	0.526
DOC_WW_Pin1_4	120	125	PF00397	0.679
DOC_WW_Pin1_4	18	23	PF00397	0.464
DOC_WW_Pin1_4	268	273	PF00397	0.299
DOC_WW_Pin1_4	30	35	PF00397	0.466
DOC_WW_Pin1_4	383	388	PF00397	0.399
DOC_WW_Pin1_4	62	67	PF00397	0.693
LIG_14-3-3_CanoR_1	142	147	PF00244	0.655
LIG_14-3-3_CanoR_1	227	231	PF00244	0.545
LIG_14-3-3_CanoR_1	529	535	PF00244	0.487
LIG_14-3-3_CanoR_1	56	66	PF00244	0.741
LIG_BRCT_BRCA1_1	385	389	PF00533	0.391
LIG_deltaCOP1_diTrp_1	215	223	PF00928	0.398
LIG_EVH1_2	316	320	PF00568	0.452
LIG_FHA_1	104	110	PF00498	0.531
LIG_FHA_1	293	299	PF00498	0.308
LIG_FHA_1	423	429	PF00498	0.348
LIG_FHA_1	448	454	PF00498	0.505
LIG_FHA_1	5	11	PF00498	0.456
LIG_FHA_2	242	248	PF00498	0.471
LIG_FHA_2	410	416	PF00498	0.567
LIG_FHA_2	95	101	PF00498	0.403
LIG_Integrin_isoDGR_2	184	186	PF01839	0.380
LIG_KLC1_Yacidic_2	151	156	PF13176	0.502
LIG_LIR_Apic_2	499	504	PF02991	0.598
LIG_LIR_Gen_1	151	162	PF02991	0.503
LIG_LIR_Gen_1	175	181	PF02991	0.314
LIG_LIR_Gen_1	293	298	PF02991	0.323
LIG_LIR_Gen_1	386	397	PF02991	0.373
LIG_LIR_Gen_1	411	419	PF02991	0.450
LIG_LIR_Gen_1	71	81	PF02991	0.461
LIG_LIR_Nem_3	151	157	PF02991	0.449
LIG_LIR_Nem_3	175	180	PF02991	0.314
LIG_LIR_Nem_3	232	238	PF02991	0.355
LIG_LIR_Nem_3	293	297	PF02991	0.323
LIG_LIR_Nem_3	386	392	PF02991	0.356
LIG_LIR_Nem_3	411	417	PF02991	0.461
LIG_LIR_Nem_3	467	473	PF02991	0.455
LIG_LIR_Nem_3	71	77	PF02991	0.428
LIG_Pex14_2	491	495	PF04695	0.354
LIG_REV1ctd_RIR_1	275	285	PF16727	0.344
LIG_SH2_CRK	414	418	PF00017	0.397
LIG_SH2_NCK_1	414	418	PF00017	0.445
LIG_SH2_NCK_1	74	78	PF00017	0.467
LIG_SH2_PTP2	154	157	PF00017	0.398
LIG_SH2_SRC	414	417	PF00017	0.448
LIG_SH2_STAT5	154	157	PF00017	0.398
LIG_SH2_STAT5	235	238	PF00017	0.357
LIG_SH2_STAT5	400	403	PF00017	0.405
LIG_SH3_2	269	274	PF14604	0.344
LIG_SH3_3	17	23	PF00018	0.516
LIG_SH3_3	266	272	PF00018	0.284
LIG_SH3_3	320	326	PF00018	0.435
LIG_SH3_3	379	385	PF00018	0.411
LIG_SH3_3	469	475	PF00018	0.379
LIG_SH3_3	60	66	PF00018	0.552
LIG_SUMO_SIM_par_1	94	100	PF11976	0.465
LIG_TYR_ITSM	410	417	PF00017	0.425
LIG_WRC_WIRS_1	328	333	PF05994	0.333
MOD_CDC14_SPxK_1	271	274	PF00782	0.392
MOD_CDK_SPK_2	383	388	PF00069	0.399
MOD_CDK_SPxK_1	268	274	PF00069	0.332
MOD_CK1_1	127	133	PF00069	0.673
MOD_CK1_1	135	141	PF00069	0.604
MOD_CK1_1	175	181	PF00069	0.321
MOD_CK1_1	65	71	PF00069	0.645
MOD_CK2_1	108	114	PF00069	0.684
MOD_CK2_1	226	232	PF00069	0.423
MOD_CK2_1	373	379	PF00069	0.401
MOD_CK2_1	65	71	PF00069	0.623
MOD_Cter_Amidation	184	187	PF01082	0.356
MOD_GlcNHglycan	114	118	PF01048	0.653
MOD_GlcNHglycan	134	137	PF01048	0.674
MOD_GlcNHglycan	166	169	PF01048	0.347
MOD_GlcNHglycan	365	368	PF01048	0.367
MOD_GlcNHglycan	486	489	PF01048	0.364
MOD_GlcNHglycan	515	518	PF01048	0.616
MOD_GlcNHglycan	67	70	PF01048	0.661
MOD_GSK3_1	120	127	PF00069	0.738
MOD_GSK3_1	128	135	PF00069	0.670
MOD_GSK3_1	292	299	PF00069	0.284
MOD_GSK3_1	417	424	PF00069	0.373
MOD_GSK3_1	58	65	PF00069	0.697
MOD_N-GLC_1	175	180	PF02516	0.341
MOD_N-GLC_1	447	452	PF02516	0.491
MOD_N-GLC_2	432	434	PF02516	0.355
MOD_NEK2_1	126	131	PF00069	0.676
MOD_NEK2_1	27	32	PF00069	0.465
MOD_NEK2_1	290	295	PF00069	0.400
MOD_NEK2_1	327	332	PF00069	0.399
MOD_NEK2_1	530	535	PF00069	0.526
MOD_PK_1	142	148	PF00069	0.646
MOD_PKA_2	127	133	PF00069	0.762
MOD_PKA_2	141	147	PF00069	0.632
MOD_PKA_2	226	232	PF00069	0.375
MOD_Plk_1	175	181	PF00069	0.322
MOD_Plk_4	136	142	PF00069	0.724
MOD_Plk_4	218	224	PF00069	0.480
MOD_Plk_4	226	232	PF00069	0.502
MOD_Plk_4	422	428	PF00069	0.331
MOD_ProDKin_1	120	126	PF00069	0.680
MOD_ProDKin_1	18	24	PF00069	0.458
MOD_ProDKin_1	268	274	PF00069	0.299
MOD_ProDKin_1	30	36	PF00069	0.468
MOD_ProDKin_1	383	389	PF00069	0.391
MOD_ProDKin_1	62	68	PF00069	0.690
MOD_SUMO_for_1	367	370	PF00179	0.476
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.301
TRG_ENDOCYTIC_2	154	157	PF00928	0.398
TRG_ENDOCYTIC_2	235	238	PF00928	0.357
TRG_ENDOCYTIC_2	380	383	PF00928	0.576
TRG_ENDOCYTIC_2	414	417	PF00928	0.536
TRG_ENDOCYTIC_2	42	45	PF00928	0.476
TRG_ENDOCYTIC_2	74	77	PF00928	0.513
TRG_ER_diArg_1	186	188	PF00400	0.374
TRG_ER_diArg_1	2	4	PF00400	0.495
TRG_ER_diArg_1	42	44	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIU3	Leptomonas seymouri	71%	99%
A0A0S4JSP7	Bodo saltans	37%	86%
A0A3Q8ICS2	Leishmania donovani	99%	100%
A4HJR0	Leishmania braziliensis	84%	100%
C9ZWM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B271	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5Y8	Leishmania major	96%	100%
V5BGM3	Trypanosoma cruzi	56%	100%