LeishMANIAdb
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3'-5' exonuclease domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
3'-5' exonuclease domain-containing protein
Gene product:
3'-5' exonuclease - putative
Species:
Leishmania infantum
UniProt:
A4I774_LEIIN
TriTrypDb:
LINF_310035300
Length:
891

Annotations

Annotations by Jardim et al.

Nucleic acid binding, nucelase activity Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4I774
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I774

Function

Biological processes
Term Name Level Count
GO:0000459 exonucleolytic trimming involved in rRNA processing 8 5
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 9 5
GO:0000469 cleavage involved in rRNA processing 7 5
GO:0006139 nucleobase-containing compound metabolic process 3 5
GO:0006364 rRNA processing 8 5
GO:0006396 RNA processing 6 5
GO:0006725 cellular aromatic compound metabolic process 3 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016070 RNA metabolic process 5 5
GO:0016072 rRNA metabolic process 7 5
GO:0031123 RNA 3'-end processing 7 5
GO:0031125 rRNA 3'-end processing 9 5
GO:0034470 ncRNA processing 7 5
GO:0034641 cellular nitrogen compound metabolic process 3 5
GO:0034660 ncRNA metabolic process 6 5
GO:0043170 macromolecule metabolic process 3 5
GO:0043628 regulatory ncRNA 3'-end processing 8 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0046483 heterocycle metabolic process 3 5
GO:0071704 organic substance metabolic process 2 5
GO:0090304 nucleic acid metabolic process 4 5
GO:0090305 nucleic acid phosphodiester bond hydrolysis 5 5
GO:0090501 RNA phosphodiester bond hydrolysis 6 5
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 7 5
GO:1901360 organic cyclic compound metabolic process 3 5
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0005488 binding 1 10
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10
GO:0003824 catalytic activity 1 7
GO:0004518 nuclease activity 4 7
GO:0004527 exonuclease activity 5 7
GO:0008408 3'-5' exonuclease activity 6 6
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0000175 3'-5'-RNA exonuclease activity 7 5
GO:0004532 RNA exonuclease activity 5 5
GO:0004540 RNA nuclease activity 4 5
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 5
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6 5
GO:0140098 catalytic activity, acting on RNA 3 5
GO:0140640 catalytic activity, acting on a nucleic acid 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 182 186 PF00656 0.499
CLV_C14_Caspase3-7 282 286 PF00656 0.594
CLV_C14_Caspase3-7 423 427 PF00656 0.634
CLV_NRD_NRD_1 149 151 PF00675 0.585
CLV_NRD_NRD_1 4 6 PF00675 0.405
CLV_NRD_NRD_1 453 455 PF00675 0.493
CLV_NRD_NRD_1 487 489 PF00675 0.396
CLV_NRD_NRD_1 514 516 PF00675 0.431
CLV_NRD_NRD_1 657 659 PF00675 0.760
CLV_NRD_NRD_1 661 663 PF00675 0.754
CLV_NRD_NRD_1 682 684 PF00675 0.534
CLV_NRD_NRD_1 72 74 PF00675 0.529
CLV_PCSK_KEX2_1 149 151 PF00082 0.500
CLV_PCSK_KEX2_1 3 5 PF00082 0.405
CLV_PCSK_KEX2_1 453 455 PF00082 0.493
CLV_PCSK_KEX2_1 487 489 PF00082 0.499
CLV_PCSK_KEX2_1 514 516 PF00082 0.431
CLV_PCSK_KEX2_1 656 658 PF00082 0.768
CLV_PCSK_KEX2_1 661 663 PF00082 0.721
CLV_PCSK_KEX2_1 682 684 PF00082 0.500
CLV_PCSK_KEX2_1 72 74 PF00082 0.552
CLV_PCSK_PC7_1 657 663 PF00082 0.591
CLV_PCSK_SKI1_1 149 153 PF00082 0.452
CLV_PCSK_SKI1_1 213 217 PF00082 0.414
CLV_PCSK_SKI1_1 302 306 PF00082 0.494
CLV_PCSK_SKI1_1 487 491 PF00082 0.424
CLV_PCSK_SKI1_1 603 607 PF00082 0.348
CLV_PCSK_SKI1_1 72 76 PF00082 0.572
CLV_PCSK_SKI1_1 734 738 PF00082 0.444
CLV_PCSK_SKI1_1 764 768 PF00082 0.390
CLV_PCSK_SKI1_1 839 843 PF00082 0.470
DEG_APCC_DBOX_1 586 594 PF00400 0.491
DEG_APCC_DBOX_1 602 610 PF00400 0.359
DEG_APCC_DBOX_1 71 79 PF00400 0.543
DEG_APCC_DBOX_1 733 741 PF00400 0.506
DEG_APCC_KENBOX_2 462 466 PF00400 0.360
DEG_APCC_KENBOX_2 635 639 PF00400 0.551
DEG_COP1_1 42 52 PF00400 0.523
DEG_MDM2_SWIB_1 39 47 PF02201 0.561
DEG_SCF_FBW7_2 568 575 PF00400 0.591
DOC_CDC14_PxL_1 779 787 PF14671 0.558
DOC_CKS1_1 408 413 PF01111 0.537
DOC_CKS1_1 569 574 PF01111 0.660
DOC_CKS1_1 640 645 PF01111 0.676
DOC_CYCLIN_RxL_1 833 846 PF00134 0.476
DOC_CYCLIN_yCln2_LP_2 109 115 PF00134 0.534
DOC_MAPK_gen_1 149 158 PF00069 0.421
DOC_MAPK_gen_1 460 468 PF00069 0.464
DOC_MAPK_MEF2A_6 487 495 PF00069 0.373
DOC_PP1_RVXF_1 402 409 PF00149 0.436
DOC_PP2B_LxvP_1 47 50 PF13499 0.636
DOC_PP4_FxxP_1 459 462 PF00568 0.436
DOC_PP4_FxxP_1 528 531 PF00568 0.380
DOC_SPAK_OSR1_1 478 482 PF12202 0.347
DOC_USP7_MATH_1 193 197 PF00917 0.558
DOC_USP7_MATH_1 257 261 PF00917 0.327
DOC_USP7_MATH_1 281 285 PF00917 0.678
DOC_USP7_MATH_1 344 348 PF00917 0.697
DOC_USP7_MATH_1 629 633 PF00917 0.707
DOC_USP7_MATH_1 795 799 PF00917 0.676
DOC_USP7_MATH_1 809 813 PF00917 0.739
DOC_WW_Pin1_4 243 248 PF00397 0.399
DOC_WW_Pin1_4 407 412 PF00397 0.512
DOC_WW_Pin1_4 568 573 PF00397 0.724
DOC_WW_Pin1_4 639 644 PF00397 0.729
DOC_WW_Pin1_4 649 654 PF00397 0.756
DOC_WW_Pin1_4 810 815 PF00397 0.748
DOC_WW_Pin1_4 881 886 PF00397 0.561
LIG_14-3-3_CanoR_1 128 133 PF00244 0.482
LIG_14-3-3_CanoR_1 682 686 PF00244 0.525
LIG_14-3-3_CanoR_1 865 871 PF00244 0.366
LIG_Actin_WH2_2 131 146 PF00022 0.410
LIG_Actin_WH2_2 185 200 PF00022 0.372
LIG_AP2alpha_2 111 113 PF02296 0.531
LIG_APCC_ABBA_1 156 161 PF00400 0.446
LIG_APCC_ABBA_1 163 168 PF00400 0.462
LIG_APCC_ABBA_1 599 604 PF00400 0.423
LIG_BIR_III_4 336 340 PF00653 0.555
LIG_BIR_III_4 745 749 PF00653 0.577
LIG_BRCT_BRCA1_1 269 273 PF00533 0.432
LIG_BRCT_BRCA1_1 32 36 PF00533 0.412
LIG_BRCT_BRCA1_1 831 835 PF00533 0.380
LIG_DLG_GKlike_1 208 215 PF00625 0.462
LIG_EH1_1 834 842 PF00400 0.453
LIG_FHA_1 138 144 PF00498 0.491
LIG_FHA_1 207 213 PF00498 0.535
LIG_FHA_1 328 334 PF00498 0.562
LIG_FHA_1 42 48 PF00498 0.483
LIG_FHA_1 682 688 PF00498 0.510
LIG_FHA_1 78 84 PF00498 0.429
LIG_FHA_1 87 93 PF00498 0.363
LIG_FHA_2 198 204 PF00498 0.634
LIG_FHA_2 221 227 PF00498 0.453
LIG_FHA_2 280 286 PF00498 0.660
LIG_FHA_2 293 299 PF00498 0.404
LIG_FHA_2 389 395 PF00498 0.444
LIG_FHA_2 421 427 PF00498 0.573
LIG_FHA_2 784 790 PF00498 0.611
LIG_FHA_2 882 888 PF00498 0.534
LIG_LIR_Apic_2 457 462 PF02991 0.436
LIG_LIR_Apic_2 526 531 PF02991 0.372
LIG_LIR_Gen_1 22 32 PF02991 0.380
LIG_LIR_Gen_1 445 452 PF02991 0.556
LIG_LIR_Gen_1 499 507 PF02991 0.349
LIG_LIR_Gen_1 541 548 PF02991 0.561
LIG_LIR_Gen_1 595 601 PF02991 0.418
LIG_LIR_Gen_1 832 842 PF02991 0.370
LIG_LIR_LC3C_4 429 433 PF02991 0.348
LIG_LIR_Nem_3 117 123 PF02991 0.554
LIG_LIR_Nem_3 22 27 PF02991 0.353
LIG_LIR_Nem_3 33 39 PF02991 0.312
LIG_LIR_Nem_3 443 447 PF02991 0.509
LIG_LIR_Nem_3 499 503 PF02991 0.355
LIG_LIR_Nem_3 541 546 PF02991 0.566
LIG_LIR_Nem_3 595 599 PF02991 0.417
LIG_LIR_Nem_3 695 700 PF02991 0.514
LIG_LIR_Nem_3 832 838 PF02991 0.369
LIG_LIR_Nem_3 9 15 PF02991 0.352
LIG_LYPXL_S_1 696 700 PF13949 0.456
LIG_PAM2_1 25 37 PF00658 0.375
LIG_Pex14_1 866 870 PF04695 0.379
LIG_Pex14_2 39 43 PF04695 0.417
LIG_Pex14_2 440 444 PF04695 0.401
LIG_Pex14_2 862 866 PF04695 0.362
LIG_Rb_LxCxE_1 295 314 PF01857 0.561
LIG_REV1ctd_RIR_1 697 706 PF16727 0.567
LIG_RPA_C_Fungi 666 678 PF08784 0.618
LIG_SH2_CRK 34 38 PF00017 0.421
LIG_SH2_CRK 372 376 PF00017 0.374
LIG_SH2_CRK 500 504 PF00017 0.336
LIG_SH2_CRK 517 521 PF00017 0.388
LIG_SH2_GRB2like 372 375 PF00017 0.374
LIG_SH2_GRB2like 396 399 PF00017 0.484
LIG_SH2_NCK_1 372 376 PF00017 0.399
LIG_SH2_NCK_1 845 849 PF00017 0.499
LIG_SH2_SRC 372 375 PF00017 0.399
LIG_SH2_SRC 543 546 PF00017 0.512
LIG_SH2_SRC 561 564 PF00017 0.546
LIG_SH2_SRC 829 832 PF00017 0.498
LIG_SH2_STAP1 139 143 PF00017 0.453
LIG_SH2_STAP1 261 265 PF00017 0.441
LIG_SH2_STAP1 500 504 PF00017 0.336
LIG_SH2_STAP1 543 547 PF00017 0.497
LIG_SH2_STAP1 86 90 PF00017 0.368
LIG_SH2_STAT3 252 255 PF00017 0.405
LIG_SH2_STAT3 458 461 PF00017 0.384
LIG_SH2_STAT5 139 142 PF00017 0.452
LIG_SH2_STAT5 396 399 PF00017 0.391
LIG_SH2_STAT5 458 461 PF00017 0.384
LIG_SH2_STAT5 689 692 PF00017 0.442
LIG_SH2_STAT5 829 832 PF00017 0.503
LIG_SH3_3 109 115 PF00018 0.534
LIG_SH3_3 272 278 PF00018 0.436
LIG_SH3_3 374 380 PF00018 0.472
LIG_SH3_3 4 10 PF00018 0.399
LIG_SH3_3 637 643 PF00018 0.730
LIG_SUMO_SIM_anti_2 131 136 PF11976 0.508
LIG_SUMO_SIM_anti_2 176 182 PF11976 0.391
LIG_SUMO_SIM_anti_2 203 211 PF11976 0.490
LIG_SUMO_SIM_anti_2 501 506 PF11976 0.338
LIG_SUMO_SIM_anti_2 595 601 PF11976 0.460
LIG_SUMO_SIM_anti_2 776 784 PF11976 0.495
LIG_SUMO_SIM_par_1 179 185 PF11976 0.442
LIG_TRAF2_1 200 203 PF00917 0.673
LIG_TRAF2_1 560 563 PF00917 0.538
LIG_TYR_ITIM 32 37 PF00017 0.406
LIG_UBA3_1 532 538 PF00899 0.468
LIG_WRC_WIRS_1 609 614 PF05994 0.484
MOD_CDK_SPxxK_3 649 656 PF00069 0.669
MOD_CK1_1 211 217 PF00069 0.559
MOD_CK1_1 220 226 PF00069 0.500
MOD_CK1_1 284 290 PF00069 0.675
MOD_CK1_1 496 502 PF00069 0.385
MOD_CK1_1 66 72 PF00069 0.723
MOD_CK1_1 762 768 PF00069 0.473
MOD_CK1_1 798 804 PF00069 0.724
MOD_CK1_1 822 828 PF00069 0.590
MOD_CK1_1 84 90 PF00069 0.326
MOD_CK1_1 846 852 PF00069 0.595
MOD_CK2_1 19 25 PF00069 0.415
MOD_CK2_1 197 203 PF00069 0.599
MOD_CK2_1 220 226 PF00069 0.489
MOD_CK2_1 292 298 PF00069 0.495
MOD_CK2_1 783 789 PF00069 0.601
MOD_CK2_1 794 800 PF00069 0.730
MOD_CK2_1 866 872 PF00069 0.483
MOD_Cter_Amidation 654 657 PF01082 0.596
MOD_GlcNHglycan 116 119 PF01048 0.589
MOD_GlcNHglycan 175 178 PF01048 0.466
MOD_GlcNHglycan 219 222 PF01048 0.464
MOD_GlcNHglycan 269 272 PF01048 0.571
MOD_GlcNHglycan 27 30 PF01048 0.528
MOD_GlcNHglycan 313 316 PF01048 0.631
MOD_GlcNHglycan 319 322 PF01048 0.604
MOD_GlcNHglycan 344 347 PF01048 0.594
MOD_GlcNHglycan 471 474 PF01048 0.515
MOD_GlcNHglycan 557 560 PF01048 0.437
MOD_GlcNHglycan 631 634 PF01048 0.716
MOD_GlcNHglycan 649 652 PF01048 0.689
MOD_GlcNHglycan 65 68 PF01048 0.716
MOD_GlcNHglycan 728 731 PF01048 0.571
MOD_GlcNHglycan 740 743 PF01048 0.609
MOD_GlcNHglycan 753 756 PF01048 0.709
MOD_GlcNHglycan 849 852 PF01048 0.552
MOD_GSK3_1 193 200 PF00069 0.574
MOD_GSK3_1 202 209 PF00069 0.453
MOD_GSK3_1 384 391 PF00069 0.454
MOD_GSK3_1 489 496 PF00069 0.370
MOD_GSK3_1 62 69 PF00069 0.719
MOD_GSK3_1 647 654 PF00069 0.779
MOD_GSK3_1 77 84 PF00069 0.402
MOD_GSK3_1 794 801 PF00069 0.738
MOD_GSK3_1 843 850 PF00069 0.512
MOD_N-GLC_1 327 332 PF02516 0.546
MOD_N-GLC_1 342 347 PF02516 0.567
MOD_N-GLC_1 373 378 PF02516 0.418
MOD_N-GLC_1 760 765 PF02516 0.517
MOD_N-GLC_2 217 219 PF02516 0.485
MOD_N-GLC_2 465 467 PF02516 0.351
MOD_NEK2_1 197 202 PF00069 0.603
MOD_NEK2_1 316 321 PF00069 0.736
MOD_NEK2_1 41 46 PF00069 0.378
MOD_NEK2_1 431 436 PF00069 0.464
MOD_NEK2_1 510 515 PF00069 0.398
MOD_NEK2_1 735 740 PF00069 0.496
MOD_NEK2_2 193 198 PF00069 0.511
MOD_NEK2_2 292 297 PF00069 0.503
MOD_PK_1 128 134 PF00069 0.449
MOD_PKA_1 656 662 PF00069 0.674
MOD_PKA_2 647 653 PF00069 0.683
MOD_PKA_2 656 662 PF00069 0.590
MOD_PKA_2 681 687 PF00069 0.529
MOD_PKA_2 751 757 PF00069 0.679
MOD_PKA_2 801 807 PF00069 0.810
MOD_PKA_2 866 872 PF00069 0.435
MOD_PKB_1 664 672 PF00069 0.769
MOD_Plk_1 193 199 PF00069 0.449
MOD_Plk_1 202 208 PF00069 0.479
MOD_Plk_1 257 263 PF00069 0.343
MOD_Plk_1 373 379 PF00069 0.416
MOD_Plk_1 442 448 PF00069 0.450
MOD_Plk_2-3 373 379 PF00069 0.416
MOD_Plk_2-3 420 426 PF00069 0.434
MOD_Plk_4 19 25 PF00069 0.415
MOD_Plk_4 202 208 PF00069 0.634
MOD_Plk_4 436 442 PF00069 0.311
MOD_Plk_4 489 495 PF00069 0.347
MOD_Plk_4 595 601 PF00069 0.429
MOD_Plk_4 673 679 PF00069 0.590
MOD_Plk_4 692 698 PF00069 0.417
MOD_Plk_4 86 92 PF00069 0.331
MOD_Plk_4 866 872 PF00069 0.412
MOD_ProDKin_1 243 249 PF00069 0.393
MOD_ProDKin_1 407 413 PF00069 0.516
MOD_ProDKin_1 568 574 PF00069 0.728
MOD_ProDKin_1 639 645 PF00069 0.732
MOD_ProDKin_1 649 655 PF00069 0.755
MOD_ProDKin_1 810 816 PF00069 0.748
MOD_ProDKin_1 881 887 PF00069 0.557
MOD_SUMO_for_1 548 551 PF00179 0.413
MOD_SUMO_rev_2 161 165 PF00179 0.497
MOD_SUMO_rev_2 418 423 PF00179 0.564
TRG_DiLeu_BaEn_1 774 779 PF01217 0.464
TRG_DiLeu_BaEn_3 680 686 PF01217 0.478
TRG_DiLeu_BaEn_4 419 425 PF01217 0.477
TRG_DiLeu_BaLyEn_6 141 146 PF01217 0.394
TRG_DiLeu_BaLyEn_6 70 75 PF01217 0.606
TRG_DiLeu_BaLyEn_6 836 841 PF01217 0.456
TRG_ENDOCYTIC_2 139 142 PF00928 0.446
TRG_ENDOCYTIC_2 20 23 PF00928 0.518
TRG_ENDOCYTIC_2 34 37 PF00928 0.346
TRG_ENDOCYTIC_2 372 375 PF00928 0.377
TRG_ENDOCYTIC_2 447 450 PF00928 0.591
TRG_ENDOCYTIC_2 486 489 PF00928 0.401
TRG_ENDOCYTIC_2 500 503 PF00928 0.279
TRG_ENDOCYTIC_2 517 520 PF00928 0.388
TRG_ENDOCYTIC_2 543 546 PF00928 0.512
TRG_ENDOCYTIC_2 620 623 PF00928 0.562
TRG_ENDOCYTIC_2 697 700 PF00928 0.473
TRG_ER_diArg_1 149 151 PF00400 0.454
TRG_ER_diArg_1 2 5 PF00400 0.447
TRG_ER_diArg_1 452 454 PF00400 0.491
TRG_ER_diArg_1 486 488 PF00400 0.491
TRG_ER_diArg_1 514 516 PF00400 0.389
TRG_ER_diArg_1 586 589 PF00400 0.516
TRG_ER_diArg_1 656 658 PF00400 0.720
TRG_ER_diArg_1 661 664 PF00400 0.675
TRG_ER_diArg_1 72 74 PF00400 0.584
TRG_NES_CRM1_1 173 185 PF08389 0.478
TRG_Pf-PMV_PEXEL_1 225 230 PF00026 0.543
TRG_Pf-PMV_PEXEL_1 4 9 PF00026 0.462
TRG_Pf-PMV_PEXEL_1 514 518 PF00026 0.453
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.416
TRG_Pf-PMV_PEXEL_1 839 843 PF00026 0.470

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJE4 Leptomonas seymouri 54% 97%
A0A1X0NK05 Trypanosomatidae 35% 100%
A0A3Q8ISV5 Leishmania donovani 100% 100%
A0A422NPF9 Trypanosoma rangeli 36% 100%
A4HJQ7 Leishmania braziliensis 78% 100%
E9B268 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q5Z1 Leishmania major 93% 100%
V5D1X6 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS