Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I770_LEIIN

TriTrypDb:

LINF_310034700

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I770

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I770

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.781
CLV_C14_Caspase3-7	435	439	PF00656	0.651
CLV_NRD_NRD_1	427	429	PF00675	0.828
CLV_NRD_NRD_1	432	434	PF00675	0.745
CLV_NRD_NRD_1	444	446	PF00675	0.535
CLV_NRD_NRD_1	482	484	PF00675	0.709
CLV_PCSK_KEX2_1	427	429	PF00082	0.828
CLV_PCSK_KEX2_1	431	433	PF00082	0.764
CLV_PCSK_KEX2_1	444	446	PF00082	0.535
CLV_PCSK_KEX2_1	482	484	PF00082	0.709
CLV_PCSK_PC7_1	427	433	PF00082	0.829
CLV_PCSK_SKI1_1	391	395	PF00082	0.692
CLV_PCSK_SKI1_1	534	538	PF00082	0.719
DEG_SCF_TRCP1_1	553	559	PF00400	0.727
DEG_SPOP_SBC_1	557	561	PF00917	0.671
DEG_SPOP_SBC_1	8	12	PF00917	0.713
DOC_CKS1_1	407	412	PF01111	0.724
DOC_MAPK_gen_1	153	162	PF00069	0.763
DOC_MAPK_gen_1	444	452	PF00069	0.736
DOC_MAPK_gen_1	482	488	PF00069	0.697
DOC_MAPK_gen_1	517	527	PF00069	0.547
DOC_MAPK_JIP1_4	156	162	PF00069	0.728
DOC_MAPK_MEF2A_6	520	529	PF00069	0.552
DOC_PP1_SILK_1	189	194	PF00149	0.746
DOC_PP2B_LxvP_1	530	533	PF13499	0.666
DOC_PP4_FxxP_1	311	314	PF00568	0.728
DOC_USP7_MATH_1	113	117	PF00917	0.712
DOC_USP7_MATH_1	138	142	PF00917	0.771
DOC_USP7_MATH_1	271	275	PF00917	0.702
DOC_USP7_MATH_1	31	35	PF00917	0.686
DOC_USP7_MATH_1	319	323	PF00917	0.824
DOC_USP7_MATH_1	328	332	PF00917	0.683
DOC_USP7_MATH_1	399	403	PF00917	0.825
DOC_USP7_MATH_1	456	460	PF00917	0.690
DOC_USP7_UBL2_3	306	310	PF12436	0.853
DOC_WW_Pin1_4	103	108	PF00397	0.722
DOC_WW_Pin1_4	142	147	PF00397	0.822
DOC_WW_Pin1_4	200	205	PF00397	0.744
DOC_WW_Pin1_4	274	279	PF00397	0.791
DOC_WW_Pin1_4	299	304	PF00397	0.780
DOC_WW_Pin1_4	310	315	PF00397	0.798
DOC_WW_Pin1_4	322	327	PF00397	0.689
DOC_WW_Pin1_4	386	391	PF00397	0.744
DOC_WW_Pin1_4	406	411	PF00397	0.629
DOC_WW_Pin1_4	56	61	PF00397	0.816
LIG_14-3-3_CanoR_1	108	113	PF00244	0.686
LIG_14-3-3_CanoR_1	202	211	PF00244	0.710
LIG_14-3-3_CanoR_1	272	278	PF00244	0.651
LIG_14-3-3_CanoR_1	286	292	PF00244	0.769
LIG_14-3-3_CanoR_1	385	393	PF00244	0.798
LIG_14-3-3_CanoR_1	431	441	PF00244	0.786
LIG_14-3-3_CanoR_1	482	486	PF00244	0.687
LIG_14-3-3_CanoR_1	508	514	PF00244	0.749
LIG_14-3-3_CanoR_1	517	527	PF00244	0.647
LIG_14-3-3_CanoR_1	69	74	PF00244	0.739
LIG_BRCT_BRCA1_1	233	237	PF00533	0.826
LIG_BRCT_BRCA1_1	360	364	PF00533	0.780
LIG_CSL_BTD_1	407	410	PF09270	0.597
LIG_CtBP_PxDLS_1	146	150	PF00389	0.740
LIG_DLG_GKlike_1	444	452	PF00625	0.736
LIG_DLG_GKlike_1	69	77	PF00625	0.737
LIG_FHA_1	107	113	PF00498	0.755
LIG_FHA_1	142	148	PF00498	0.764
LIG_FHA_1	174	180	PF00498	0.638
LIG_FHA_1	224	230	PF00498	0.692
LIG_FHA_1	9	15	PF00498	0.721
LIG_FHA_2	271	277	PF00498	0.614
LIG_FHA_2	536	542	PF00498	0.660
LIG_FHA_2	75	81	PF00498	0.734
LIG_Integrin_isoDGR_2	67	69	PF01839	0.751
LIG_LIR_Apic_2	308	314	PF02991	0.729
LIG_LIR_Nem_3	327	332	PF02991	0.790
LIG_LIR_Nem_3	348	354	PF02991	0.668
LIG_Pex14_2	118	122	PF04695	0.744
LIG_SH2_STAT5	351	354	PF00017	0.724
LIG_SH3_3	329	335	PF00018	0.768
LIG_SH3_3	33	39	PF00018	0.808
LIG_SH3_3	372	378	PF00018	0.754
LIG_SH3_3	407	413	PF00018	0.739
LIG_SH3_3	447	453	PF00018	0.801
LIG_SH3_3	49	55	PF00018	0.566
LIG_SH3_3	499	505	PF00018	0.579
LIG_SH3_3	567	573	PF00018	0.718
LIG_SUMO_SIM_par_1	144	152	PF11976	0.637
LIG_SUMO_SIM_par_1	38	43	PF11976	0.743
MOD_CDC14_SPxK_1	302	305	PF00782	0.777
MOD_CDK_SPK_2	103	108	PF00069	0.768
MOD_CDK_SPK_2	386	391	PF00069	0.744
MOD_CDK_SPxK_1	299	305	PF00069	0.780
MOD_CDK_SPxxK_3	103	110	PF00069	0.633
MOD_CDK_SPxxK_3	299	306	PF00069	0.743
MOD_CK1_1	106	112	PF00069	0.777
MOD_CK1_1	141	147	PF00069	0.827
MOD_CK1_1	196	202	PF00069	0.793
MOD_CK1_1	203	209	PF00069	0.746
MOD_CK1_1	218	224	PF00069	0.736
MOD_CK1_1	231	237	PF00069	0.614
MOD_CK1_1	274	280	PF00069	0.752
MOD_CK1_1	322	328	PF00069	0.809
MOD_CK1_1	337	343	PF00069	0.595
MOD_CK1_1	355	361	PF00069	0.501
MOD_CK1_1	384	390	PF00069	0.826
MOD_CK1_1	398	404	PF00069	0.751
MOD_CK1_1	421	427	PF00069	0.741
MOD_CK1_1	496	502	PF00069	0.801
MOD_CK1_1	542	548	PF00069	0.792
MOD_CK1_1	549	555	PF00069	0.750
MOD_CK1_1	556	562	PF00069	0.641
MOD_CK1_1	71	77	PF00069	0.733
MOD_CK2_1	535	541	PF00069	0.623
MOD_CK2_1	74	80	PF00069	0.734
MOD_GlcNHglycan	136	139	PF01048	0.827
MOD_GlcNHglycan	179	182	PF01048	0.668
MOD_GlcNHglycan	195	198	PF01048	0.630
MOD_GlcNHglycan	221	224	PF01048	0.677
MOD_GlcNHglycan	273	276	PF01048	0.686
MOD_GlcNHglycan	31	34	PF01048	0.684
MOD_GlcNHglycan	359	363	PF01048	0.802
MOD_GlcNHglycan	369	372	PF01048	0.687
MOD_GlcNHglycan	397	400	PF01048	0.830
MOD_GlcNHglycan	401	404	PF01048	0.762
MOD_GlcNHglycan	423	426	PF01048	0.736
MOD_GlcNHglycan	458	461	PF01048	0.682
MOD_GlcNHglycan	463	466	PF01048	0.681
MOD_GlcNHglycan	467	472	PF01048	0.651
MOD_GlcNHglycan	510	513	PF01048	0.700
MOD_GlcNHglycan	548	551	PF01048	0.812
MOD_GlcNHglycan	553	556	PF01048	0.779
MOD_GlcNHglycan	560	563	PF01048	0.675
MOD_GlcNHglycan	98	102	PF01048	0.753
MOD_GSK3_1	102	109	PF00069	0.671
MOD_GSK3_1	113	120	PF00069	0.712
MOD_GSK3_1	123	130	PF00069	0.698
MOD_GSK3_1	134	141	PF00069	0.651
MOD_GSK3_1	145	152	PF00069	0.583
MOD_GSK3_1	156	163	PF00069	0.628
MOD_GSK3_1	173	180	PF00069	0.693
MOD_GSK3_1	192	199	PF00069	0.614
MOD_GSK3_1	210	217	PF00069	0.633
MOD_GSK3_1	219	226	PF00069	0.718
MOD_GSK3_1	249	256	PF00069	0.834
MOD_GSK3_1	270	277	PF00069	0.704
MOD_GSK3_1	310	317	PF00069	0.802
MOD_GSK3_1	324	331	PF00069	0.652
MOD_GSK3_1	380	387	PF00069	0.711
MOD_GSK3_1	395	402	PF00069	0.832
MOD_GSK3_1	477	484	PF00069	0.690
MOD_GSK3_1	496	503	PF00069	0.591
MOD_GSK3_1	535	542	PF00069	0.719
MOD_GSK3_1	544	551	PF00069	0.701
MOD_GSK3_1	553	560	PF00069	0.626
MOD_GSK3_1	69	76	PF00069	0.795
MOD_LATS_1	175	181	PF00433	0.657
MOD_LATS_1	7	13	PF00433	0.713
MOD_N-GLC_1	142	147	PF02516	0.762
MOD_N-GLC_1	173	178	PF02516	0.663
MOD_N-GLC_1	399	404	PF02516	0.827
MOD_NEK2_1	118	123	PF00069	0.763
MOD_NEK2_1	149	154	PF00069	0.854
MOD_NEK2_1	186	191	PF00069	0.720
MOD_NEK2_1	380	385	PF00069	0.826
MOD_NEK2_1	461	466	PF00069	0.734
MOD_NEK2_1	546	551	PF00069	0.829
MOD_NEK2_1	73	78	PF00069	0.805
MOD_NEK2_2	113	118	PF00069	0.756
MOD_PIKK_1	203	209	PF00454	0.732
MOD_PIKK_1	216	222	PF00454	0.649
MOD_PIKK_1	384	390	PF00454	0.666
MOD_PKA_1	427	433	PF00069	0.829
MOD_PKA_1	444	450	PF00069	0.532
MOD_PKA_1	571	577	PF00069	0.630
MOD_PKA_2	102	108	PF00069	0.629
MOD_PKA_2	123	129	PF00069	0.806
MOD_PKA_2	149	155	PF00069	0.737
MOD_PKA_2	192	198	PF00069	0.753
MOD_PKA_2	231	237	PF00069	0.697
MOD_PKA_2	271	277	PF00069	0.652
MOD_PKA_2	384	390	PF00069	0.826
MOD_PKA_2	395	401	PF00069	0.518
MOD_PKA_2	427	433	PF00069	0.829
MOD_PKA_2	444	450	PF00069	0.532
MOD_PKA_2	454	460	PF00069	0.671
MOD_PKA_2	481	487	PF00069	0.599
MOD_PKA_2	507	513	PF00069	0.731
MOD_PKA_2	523	529	PF00069	0.569
MOD_PKA_2	68	74	PF00069	0.813
MOD_Plk_1	118	124	PF00069	0.745
MOD_Plk_4	113	119	PF00069	0.756
MOD_Plk_4	187	193	PF00069	0.643
MOD_Plk_4	224	230	PF00069	0.677
MOD_Plk_4	389	395	PF00069	0.828
MOD_Plk_4	535	541	PF00069	0.584
MOD_Plk_4	74	80	PF00069	0.697
MOD_ProDKin_1	103	109	PF00069	0.724
MOD_ProDKin_1	142	148	PF00069	0.824
MOD_ProDKin_1	200	206	PF00069	0.744
MOD_ProDKin_1	274	280	PF00069	0.789
MOD_ProDKin_1	299	305	PF00069	0.780
MOD_ProDKin_1	310	316	PF00069	0.795
MOD_ProDKin_1	322	328	PF00069	0.689
MOD_ProDKin_1	386	392	PF00069	0.743
MOD_ProDKin_1	406	412	PF00069	0.630
MOD_ProDKin_1	56	62	PF00069	0.817
MOD_SUMO_rev_2	240	245	PF00179	0.833
MOD_SUMO_rev_2	302	311	PF00179	0.737
MOD_SUMO_rev_2	43	50	PF00179	0.644
TRG_DiLeu_BaEn_1	436	441	PF01217	0.746
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.748
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.766
TRG_ENDOCYTIC_2	351	354	PF00928	0.724
TRG_ER_diArg_1	107	110	PF00400	0.620
TRG_ER_diArg_1	284	287	PF00400	0.734
TRG_ER_diArg_1	426	428	PF00400	0.835
TRG_ER_diArg_1	431	433	PF00400	0.748
TRG_ER_diArg_1	444	446	PF00400	0.518
TRG_ER_diArg_1	481	483	PF00400	0.702
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKC7	Leishmania donovani	99%	100%
A4HJQ4	Leishmania braziliensis	53%	100%
E9B265	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q5Z5	Leishmania major	89%	100%