Calreticulin

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Calreticulin

Gene product:

calreticulin - putative

Species:

Leishmania infantum

UniProt:

A4I765_LEIIN

TriTrypDb:

LINF_310034100

Length:

400

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, calreticulin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	12
GO:0031974	membrane-enclosed lumen	2	12
GO:0043233	organelle lumen	3	12
GO:0070013	intracellular organelle lumen	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I765

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I765

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0005515	protein binding	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051082	unfolded protein binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.336
CLV_C14_Caspase3-7	390	394	PF00656	0.661
CLV_NRD_NRD_1	278	280	PF00675	0.495
CLV_PCSK_KEX2_1	278	280	PF00082	0.495
CLV_PCSK_SKI1_1	365	369	PF00082	0.426
CLV_PCSK_SKI1_1	4	8	PF00082	0.615
CLV_PCSK_SKI1_1	48	52	PF00082	0.512
DEG_APCC_DBOX_1	3	11	PF00400	0.612
DEG_MDM2_SWIB_1	195	202	PF02201	0.193
DOC_PP1_RVXF_1	140	146	PF00149	0.345
DOC_PP1_RVXF_1	247	254	PF00149	0.263
DOC_PP4_MxPP_1	201	204	PF00568	0.346
DOC_USP7_MATH_2	389	395	PF00917	0.692
DOC_USP7_UBL2_3	365	369	PF12436	0.463
DOC_USP7_UBL2_3	79	83	PF12436	0.318
DOC_USP7_UBL2_3	99	103	PF12436	0.110
DOC_WW_Pin1_4	273	278	PF00397	0.210
DOC_WW_Pin1_4	385	390	PF00397	0.685
LIG_14-3-3_CanoR_1	161	170	PF00244	0.296
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_CSL_BTD_1	274	277	PF09270	0.249
LIG_FHA_1	150	156	PF00498	0.323
LIG_FHA_1	170	176	PF00498	0.231
LIG_FHA_1	178	184	PF00498	0.224
LIG_FHA_1	336	342	PF00498	0.504
LIG_FHA_2	204	210	PF00498	0.305
LIG_FHA_2	228	234	PF00498	0.270
LIG_FHA_2	239	245	PF00498	0.276
LIG_FHA_2	386	392	PF00498	0.704
LIG_LIR_Apic_2	258	264	PF02991	0.293
LIG_LIR_Gen_1	109	117	PF02991	0.290
LIG_LIR_Gen_1	126	134	PF02991	0.241
LIG_LIR_Gen_1	196	207	PF02991	0.276
LIG_LIR_Gen_1	29	38	PF02991	0.328
LIG_LIR_Gen_1	326	333	PF02991	0.302
LIG_LIR_Nem_3	109	113	PF02991	0.290
LIG_LIR_Nem_3	126	132	PF02991	0.241
LIG_LIR_Nem_3	180	184	PF02991	0.247
LIG_LIR_Nem_3	196	202	PF02991	0.282
LIG_LIR_Nem_3	326	331	PF02991	0.241
LIG_LIR_Nem_3	43	49	PF02991	0.264
LIG_LIR_Nem_3	71	77	PF02991	0.247
LIG_PDZ_Class_3	395	400	PF00595	0.686
LIG_Pex14_2	195	199	PF04695	0.193
LIG_Pex14_2	27	31	PF04695	0.328
LIG_PTB_Apo_2	265	272	PF02174	0.291
LIG_PTB_Apo_2	279	286	PF02174	0.178
LIG_PTB_Apo_2	293	300	PF02174	0.241
LIG_PTB_Phospho_1	265	271	PF10480	0.291
LIG_PTB_Phospho_1	279	285	PF10480	0.178
LIG_PTB_Phospho_1	293	299	PF10480	0.241
LIG_SH2_CRK	306	310	PF00017	0.327
LIG_SH2_CRK	46	50	PF00017	0.312
LIG_SH2_PTP2	314	317	PF00017	0.327
LIG_SH2_SRC	184	187	PF00017	0.327
LIG_SH2_STAP1	171	175	PF00017	0.241
LIG_SH2_STAT3	19	22	PF00017	0.520
LIG_SH2_STAT5	110	113	PF00017	0.249
LIG_SH2_STAT5	171	174	PF00017	0.241
LIG_SH2_STAT5	184	187	PF00017	0.241
LIG_SH2_STAT5	19	22	PF00017	0.499
LIG_SH2_STAT5	314	317	PF00017	0.311
LIG_SH3_3	261	267	PF00018	0.252
LIG_TRAF2_1	194	197	PF00917	0.312
LIG_TYR_ITIM	312	317	PF00017	0.327
LIG_WRC_WIRS_1	93	98	PF05994	0.252
MOD_CDK_SPK_2	273	278	PF00069	0.193
MOD_CDK_SPxK_1	273	279	PF00069	0.193
MOD_CK1_1	40	46	PF00069	0.263
MOD_CK2_1	191	197	PF00069	0.318
MOD_CK2_1	227	233	PF00069	0.333
MOD_CK2_1	240	246	PF00069	0.261
MOD_CK2_1	385	391	PF00069	0.756
MOD_GlcNHglycan	125	128	PF01048	0.490
MOD_GSK3_1	102	109	PF00069	0.340
MOD_GSK3_1	133	140	PF00069	0.221
MOD_GSK3_1	145	152	PF00069	0.213
MOD_GSK3_1	161	168	PF00069	0.204
MOD_GSK3_1	238	245	PF00069	0.289
MOD_GSK3_1	37	44	PF00069	0.318
MOD_GSK3_1	88	95	PF00069	0.276
MOD_N-GLC_1	149	154	PF02516	0.490
MOD_N-GLC_1	177	182	PF02516	0.546
MOD_NEK2_1	145	150	PF00069	0.290
MOD_Plk_1	177	183	PF00069	0.279
MOD_Plk_2-3	238	244	PF00069	0.309
MOD_Plk_2-3	30	36	PF00069	0.309
MOD_Plk_2-3	323	329	PF00069	0.327
MOD_Plk_2-3	391	397	PF00069	0.768
MOD_Plk_4	106	112	PF00069	0.290
MOD_Plk_4	323	329	PF00069	0.241
MOD_Plk_4	88	94	PF00069	0.285
MOD_ProDKin_1	273	279	PF00069	0.210
MOD_ProDKin_1	385	391	PF00069	0.687
MOD_SUMO_for_1	98	101	PF00179	0.252
MOD_SUMO_rev_2	115	122	PF00179	0.312
MOD_SUMO_rev_2	209	216	PF00179	0.251
MOD_SUMO_rev_2	225	232	PF00179	0.317
MOD_SUMO_rev_2	357	367	PF00179	0.448
MOD_SUMO_rev_2	70	74	PF00179	0.323
MOD_SUMO_rev_2	86	92	PF00179	0.176
MOD_SUMO_rev_2	95	105	PF00179	0.275
TRG_DiLeu_BaEn_3	196	202	PF01217	0.263
TRG_DiLeu_BaEn_4	197	203	PF01217	0.290
TRG_ENDOCYTIC_2	110	113	PF00928	0.252
TRG_ENDOCYTIC_2	128	131	PF00928	0.241
TRG_ENDOCYTIC_2	314	317	PF00928	0.327
TRG_ENDOCYTIC_2	348	351	PF00928	0.421
TRG_ENDOCYTIC_2	46	49	PF00928	0.277
TRG_ER_diArg_1	277	279	PF00400	0.321
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1C6P2	Ustilago maydis (strain 521 / FGSC 9021)	32%	76%
A0A0N1IJA0	Leptomonas seymouri	65%	100%
A0A0S4KMN1	Bodo saltans	55%	100%
A0A1X0NIG9	Trypanosomatidae	55%	100%
A0A3R7KPX3	Trypanosoma rangeli	54%	95%
A0A3S7X4V0	Leishmania donovani	100%	100%
A4HJP8	Leishmania braziliensis	68%	100%
C9ZMF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D4AVD4	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	36%	71%
E9B259	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
J9VLH0	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	34%	73%
O04151	Arabidopsis thaliana	45%	94%
O04153	Arabidopsis thaliana	41%	94%
O81919	Beta vulgaris	46%	96%
O82709	Pisum sativum	30%	73%
P11012	Onchocerca volvulus	45%	100%
P14211	Mus musculus	47%	96%
P15253	Oryctolagus cuniculus	46%	96%
P18418	Rattus norvegicus	46%	96%
P24643	Canis lupus familiaris	33%	67%
P27797	Homo sapiens	45%	96%
P27798	Caenorhabditis elegans	45%	100%
P27824	Homo sapiens	34%	68%
P27825	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	80%
P28491	Sus scrofa	45%	96%
P29402	Arabidopsis thaliana	32%	75%
P29413	Drosophila melanogaster	43%	99%
P35564	Mus musculus	33%	68%
P35565	Rattus norvegicus	34%	68%
P36581	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	71%
P52193	Bos taurus	45%	96%
P93508	Ricinus communis	46%	96%
Q06814	Schistosoma mansoni	46%	100%
Q23858	Dictyostelium discoideum	44%	94%
Q2HWU3	Macaca fuscata fuscata	45%	96%
Q2TBR8	Bos taurus	35%	100%
Q38798	Arabidopsis thaliana	31%	75%
Q38858	Arabidopsis thaliana	44%	94%
Q39817	Glycine max	30%	73%
Q39994	Helianthus tuberosus	32%	74%
Q3SYT6	Bos taurus	33%	66%
Q40401	Nicotiana plumbaginifolia	49%	96%
Q4Q601	Leishmania major	92%	100%
Q4R6K8	Macaca fascicularis	45%	96%
Q4VIT5	Chlorocebus aethiops	45%	96%
Q5R440	Pongo abelii	34%	68%
Q61KR9	Caenorhabditis briggsae	44%	100%
Q6Q487	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	33%	71%
Q7Z1E6	Bombyx mori	48%	100%
Q8K3H7	Cricetulus griseus	46%	96%
Q96L12	Homo sapiens	35%	100%
Q9D9Q6	Mus musculus	34%	100%
Q9SLY8	Oryza sativa subsp. japonica	45%	94%
Q9SP22	Zea mays	44%	95%
Q9STD3	Chlamydomonas reinhardtii	46%	95%
Q9XF98	Prunus armeniaca	46%	95%
Q9ZNY3	Euglena gracilis	45%	100%
Q9ZPP1	Berberis stolonifera	44%	96%
V5AMP1	Trypanosoma cruzi	53%	99%