Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I760_LEIIN

TriTrypDb:

LINF_310033600

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 649

Expansion

Sequence features

A4I760

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I760

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.461
CLV_C14_Caspase3-7	469	473	PF00656	0.416
CLV_C14_Caspase3-7	50	54	PF00656	0.759
CLV_C14_Caspase3-7	672	676	PF00656	0.596
CLV_NRD_NRD_1	101	103	PF00675	0.613
CLV_NRD_NRD_1	261	263	PF00675	0.419
CLV_NRD_NRD_1	28	30	PF00675	0.425
CLV_NRD_NRD_1	445	447	PF00675	0.475
CLV_NRD_NRD_1	462	464	PF00675	0.455
CLV_NRD_NRD_1	488	490	PF00675	0.601
CLV_NRD_NRD_1	564	566	PF00675	0.650
CLV_PCSK_FUR_1	562	566	PF00082	0.667
CLV_PCSK_KEX2_1	101	103	PF00082	0.610
CLV_PCSK_KEX2_1	261	263	PF00082	0.419
CLV_PCSK_KEX2_1	28	30	PF00082	0.425
CLV_PCSK_KEX2_1	356	358	PF00082	0.512
CLV_PCSK_KEX2_1	445	447	PF00082	0.444
CLV_PCSK_KEX2_1	462	464	PF00082	0.455
CLV_PCSK_KEX2_1	488	490	PF00082	0.601
CLV_PCSK_KEX2_1	564	566	PF00082	0.628
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.512
CLV_PCSK_SKI1_1	102	106	PF00082	0.415
CLV_PCSK_SKI1_1	182	186	PF00082	0.481
CLV_PCSK_SKI1_1	249	253	PF00082	0.465
CLV_PCSK_SKI1_1	311	315	PF00082	0.430
CLV_PCSK_SKI1_1	356	360	PF00082	0.507
CLV_PCSK_SKI1_1	489	493	PF00082	0.569
DEG_APCC_DBOX_1	37	45	PF00400	0.399
DEG_APCC_DBOX_1	779	787	PF00400	0.558
DEG_MDM2_SWIB_1	260	267	PF02201	0.319
DEG_Nend_Nbox_1	1	3	PF02207	0.389
DEG_SPOP_SBC_1	54	58	PF00917	0.611
DOC_ANK_TNKS_1	657	664	PF00023	0.535
DOC_CKS1_1	647	652	PF01111	0.735
DOC_CYCLIN_RxL_1	176	187	PF00134	0.477
DOC_CYCLIN_RxL_1	379	388	PF00134	0.508
DOC_CYCLIN_yClb1_LxF_4	247	252	PF00134	0.411
DOC_MAPK_gen_1	101	112	PF00069	0.444
DOC_MAPK_gen_1	356	366	PF00069	0.385
DOC_PP1_RVXF_1	18	25	PF00149	0.466
DOC_PP1_RVXF_1	247	253	PF00149	0.483
DOC_PP4_FxxP_1	422	425	PF00568	0.484
DOC_USP7_MATH_1	206	210	PF00917	0.562
DOC_USP7_MATH_1	628	632	PF00917	0.688
DOC_USP7_MATH_1	668	672	PF00917	0.703
DOC_USP7_MATH_1	731	735	PF00917	0.692
DOC_USP7_MATH_1	740	744	PF00917	0.716
DOC_USP7_UBL2_3	356	360	PF12436	0.414
DOC_WW_Pin1_4	143	148	PF00397	0.616
DOC_WW_Pin1_4	228	233	PF00397	0.507
DOC_WW_Pin1_4	349	354	PF00397	0.445
DOC_WW_Pin1_4	436	441	PF00397	0.532
DOC_WW_Pin1_4	45	50	PF00397	0.628
DOC_WW_Pin1_4	626	631	PF00397	0.744
DOC_WW_Pin1_4	646	651	PF00397	0.774
DOC_WW_Pin1_4	75	80	PF00397	0.721
DOC_WW_Pin1_4	753	758	PF00397	0.590
LIG_14-3-3_CanoR_1	703	710	PF00244	0.619
LIG_14-3-3_CanoR_1	732	738	PF00244	0.542
LIG_AP2alpha_2	177	179	PF02296	0.419
LIG_FHA_1	105	111	PF00498	0.384
LIG_FHA_1	17	23	PF00498	0.366
LIG_FHA_1	350	356	PF00498	0.644
LIG_FHA_1	375	381	PF00498	0.534
LIG_FHA_1	401	407	PF00498	0.496
LIG_FHA_1	430	436	PF00498	0.567
LIG_FHA_1	437	443	PF00498	0.492
LIG_FHA_1	459	465	PF00498	0.535
LIG_FHA_1	641	647	PF00498	0.705
LIG_FHA_1	72	78	PF00498	0.685
LIG_FHA_2	112	118	PF00498	0.507
LIG_FHA_2	2	8	PF00498	0.450
LIG_FHA_2	322	328	PF00498	0.441
LIG_FHA_2	480	486	PF00498	0.537
LIG_FHA_2	54	60	PF00498	0.762
LIG_FHA_2	762	768	PF00498	0.630
LIG_LIR_Apic_2	420	425	PF02991	0.482
LIG_LIR_Apic_2	695	700	PF02991	0.683
LIG_LIR_Gen_1	183	192	PF02991	0.431
LIG_LIR_Gen_1	301	309	PF02991	0.468
LIG_LIR_Gen_1	391	402	PF02991	0.421
LIG_LIR_Gen_1	453	464	PF02991	0.546
LIG_LIR_Gen_1	513	523	PF02991	0.647
LIG_LIR_Gen_1	717	727	PF02991	0.512
LIG_LIR_Nem_3	126	132	PF02991	0.412
LIG_LIR_Nem_3	183	188	PF02991	0.410
LIG_LIR_Nem_3	190	195	PF02991	0.424
LIG_LIR_Nem_3	257	263	PF02991	0.383
LIG_LIR_Nem_3	301	306	PF02991	0.470
LIG_LIR_Nem_3	391	397	PF02991	0.394
LIG_LIR_Nem_3	420	426	PF02991	0.436
LIG_LIR_Nem_3	453	459	PF02991	0.529
LIG_LIR_Nem_3	513	518	PF02991	0.640
LIG_LIR_Nem_3	692	697	PF02991	0.662
LIG_LIR_Nem_3	717	722	PF02991	0.502
LIG_LYPXL_SIV_4	714	722	PF13949	0.490
LIG_MYND_1	151	155	PF01753	0.526
LIG_Pex14_2	13	17	PF04695	0.593
LIG_Pex14_2	260	264	PF04695	0.319
LIG_Rb_pABgroove_1	179	187	PF01858	0.475
LIG_REV1ctd_RIR_1	177	186	PF16727	0.474
LIG_SH2_CRK	273	277	PF00017	0.463
LIG_SH2_CRK	281	285	PF00017	0.455
LIG_SH2_CRK	438	442	PF00017	0.416
LIG_SH2_CRK	719	723	PF00017	0.635
LIG_SH2_NCK_1	715	719	PF00017	0.569
LIG_SH2_SRC	194	197	PF00017	0.349
LIG_SH2_STAP1	273	277	PF00017	0.532
LIG_SH2_STAP1	33	37	PF00017	0.534
LIG_SH2_STAP1	537	541	PF00017	0.527
LIG_SH2_STAP1	694	698	PF00017	0.566
LIG_SH2_STAP1	715	719	PF00017	0.477
LIG_SH2_STAT3	265	268	PF00017	0.403
LIG_SH2_STAT3	704	707	PF00017	0.530
LIG_SH2_STAT5	174	177	PF00017	0.477
LIG_SH2_STAT5	194	197	PF00017	0.349
LIG_SH2_STAT5	265	268	PF00017	0.403
LIG_SH2_STAT5	3	6	PF00017	0.428
LIG_SH2_STAT5	30	33	PF00017	0.435
LIG_SH2_STAT5	315	318	PF00017	0.358
LIG_SH2_STAT5	323	326	PF00017	0.402
LIG_SH2_STAT5	363	366	PF00017	0.381
LIG_SH2_STAT5	438	441	PF00017	0.394
LIG_SH2_STAT5	478	481	PF00017	0.431
LIG_SH2_STAT5	697	700	PF00017	0.648
LIG_SH2_STAT5	704	707	PF00017	0.641
LIG_SH3_3	145	151	PF00018	0.491
LIG_SH3_3	229	235	PF00018	0.602
LIG_SH3_3	241	247	PF00018	0.651
LIG_SH3_3	283	289	PF00018	0.454
LIG_SH3_3	422	428	PF00018	0.393
LIG_SH3_3	566	572	PF00018	0.592
LIG_SH3_3	88	94	PF00018	0.602
LIG_Sin3_3	586	593	PF02671	0.446
LIG_TRAF2_1	482	485	PF00917	0.451
LIG_TRAF2_1	706	709	PF00917	0.614
LIG_TRAF2_1	775	778	PF00917	0.575
LIG_TYR_ITIM	271	276	PF00017	0.472
LIG_WRC_WIRS_1	314	319	PF05994	0.431
MOD_CDK_SPK_2	228	233	PF00069	0.507
MOD_CDK_SPK_2	349	354	PF00069	0.445
MOD_CDK_SPxxK_3	349	356	PF00069	0.424
MOD_CK1_1	330	336	PF00069	0.712
MOD_CK1_1	348	354	PF00069	0.626
MOD_CK1_1	458	464	PF00069	0.629
MOD_CK1_1	474	480	PF00069	0.545
MOD_CK1_1	500	506	PF00069	0.660
MOD_CK1_1	626	632	PF00069	0.784
MOD_CK1_1	678	684	PF00069	0.742
MOD_CK1_1	685	691	PF00069	0.705
MOD_CK1_1	692	698	PF00069	0.658
MOD_CK1_1	720	726	PF00069	0.701
MOD_CK1_1	743	749	PF00069	0.748
MOD_CK1_1	80	86	PF00069	0.648
MOD_CK1_1	89	95	PF00069	0.493
MOD_CK2_1	1	7	PF00069	0.413
MOD_CK2_1	111	117	PF00069	0.470
MOD_CK2_1	157	163	PF00069	0.543
MOD_CK2_1	251	257	PF00069	0.499
MOD_CK2_1	321	327	PF00069	0.594
MOD_CK2_1	479	485	PF00069	0.580
MOD_CK2_1	549	555	PF00069	0.581
MOD_CK2_1	680	686	PF00069	0.764
MOD_CK2_1	703	709	PF00069	0.618
MOD_CK2_1	761	767	PF00069	0.680
MOD_GlcNHglycan	117	121	PF01048	0.524
MOD_GlcNHglycan	208	211	PF01048	0.593
MOD_GlcNHglycan	551	554	PF01048	0.489
MOD_GlcNHglycan	618	621	PF01048	0.748
MOD_GlcNHglycan	625	628	PF01048	0.748
MOD_GlcNHglycan	63	66	PF01048	0.810
MOD_GlcNHglycan	677	680	PF01048	0.739
MOD_GlcNHglycan	711	714	PF01048	0.718
MOD_GlcNHglycan	719	722	PF01048	0.704
MOD_GlcNHglycan	733	736	PF01048	0.567
MOD_GlcNHglycan	741	745	PF01048	0.674
MOD_GlcNHglycan	80	83	PF01048	0.614
MOD_GSK3_1	298	305	PF00069	0.520
MOD_GSK3_1	326	333	PF00069	0.584
MOD_GSK3_1	341	348	PF00069	0.695
MOD_GSK3_1	451	458	PF00069	0.470
MOD_GSK3_1	622	629	PF00069	0.692
MOD_GSK3_1	674	681	PF00069	0.746
MOD_GSK3_1	685	692	PF00069	0.714
MOD_GSK3_1	71	78	PF00069	0.702
MOD_GSK3_1	740	747	PF00069	0.750
MOD_N-GLC_1	167	172	PF02516	0.466
MOD_N-GLC_1	498	503	PF02516	0.672
MOD_N-GLC_1	60	65	PF02516	0.654
MOD_N-GLC_1	747	752	PF02516	0.596
MOD_NEK2_1	1	6	PF00069	0.462
MOD_NEK2_1	104	109	PF00069	0.307
MOD_NEK2_1	184	189	PF00069	0.494
MOD_NEK2_1	340	345	PF00069	0.677
MOD_NEK2_1	374	379	PF00069	0.489
MOD_NEK2_1	776	781	PF00069	0.706
MOD_NEK2_2	23	28	PF00069	0.511
MOD_OFUCOSY	449	455	PF10250	0.476
MOD_PIKK_1	157	163	PF00454	0.564
MOD_PIKK_1	666	672	PF00454	0.743
MOD_PIKK_1	703	709	PF00454	0.544
MOD_PKA_2	374	380	PF00069	0.519
MOD_PKA_2	61	67	PF00069	0.802
MOD_PKA_2	616	622	PF00069	0.639
MOD_PKA_2	657	663	PF00069	0.534
MOD_PKA_2	731	737	PF00069	0.535
MOD_PKB_1	599	607	PF00069	0.702
MOD_Plk_1	341	347	PF00069	0.734
MOD_Plk_1	471	477	PF00069	0.495
MOD_Plk_1	498	504	PF00069	0.555
MOD_Plk_1	601	607	PF00069	0.700
MOD_Plk_1	685	691	PF00069	0.684
MOD_Plk_1	692	698	PF00069	0.559
MOD_Plk_1	747	753	PF00069	0.771
MOD_Plk_1	761	767	PF00069	0.658
MOD_Plk_1	89	95	PF00069	0.680
MOD_Plk_2-3	761	767	PF00069	0.680
MOD_Plk_4	1	7	PF00069	0.414
MOD_Plk_4	217	223	PF00069	0.657
MOD_Plk_4	225	231	PF00069	0.547
MOD_Plk_4	266	272	PF00069	0.430
MOD_Plk_4	298	304	PF00069	0.439
MOD_Plk_4	313	319	PF00069	0.343
MOD_Plk_4	367	373	PF00069	0.478
MOD_Plk_4	474	480	PF00069	0.529
MOD_Plk_4	510	516	PF00069	0.694
MOD_Plk_4	685	691	PF00069	0.595
MOD_Plk_4	693	699	PF00069	0.510
MOD_ProDKin_1	143	149	PF00069	0.619
MOD_ProDKin_1	228	234	PF00069	0.507
MOD_ProDKin_1	349	355	PF00069	0.430
MOD_ProDKin_1	436	442	PF00069	0.525
MOD_ProDKin_1	45	51	PF00069	0.634
MOD_ProDKin_1	626	632	PF00069	0.745
MOD_ProDKin_1	646	652	PF00069	0.734
MOD_ProDKin_1	75	81	PF00069	0.721
MOD_ProDKin_1	753	759	PF00069	0.589
MOD_SUMO_for_1	235	238	PF00179	0.560
TRG_AP2beta_CARGO_1	190	199	PF09066	0.526
TRG_AP2beta_CARGO_1	453	463	PF09066	0.548
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.527
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.427
TRG_ENDOCYTIC_2	273	276	PF00928	0.460
TRG_ENDOCYTIC_2	281	284	PF00928	0.493
TRG_ENDOCYTIC_2	3	6	PF00928	0.304
TRG_ENDOCYTIC_2	315	318	PF00928	0.383
TRG_ENDOCYTIC_2	363	366	PF00928	0.372
TRG_ENDOCYTIC_2	438	441	PF00928	0.421
TRG_ENDOCYTIC_2	719	722	PF00928	0.721
TRG_ER_diArg_1	100	102	PF00400	0.605
TRG_ER_diArg_1	252	255	PF00400	0.413
TRG_ER_diArg_1	260	262	PF00400	0.386
TRG_ER_diArg_1	27	29	PF00400	0.488
TRG_ER_diArg_1	444	446	PF00400	0.455
TRG_ER_diArg_1	462	464	PF00400	0.369
TRG_ER_diArg_1	465	468	PF00400	0.443
TRG_ER_diArg_1	488	490	PF00400	0.592
TRG_ER_diArg_1	596	599	PF00400	0.677
TRG_NLS_MonoExtN_4	101	106	PF00514	0.432
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	577	582	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	703	707	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	763	767	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW18	Leptomonas seymouri	41%	88%
A0A0N1PBA0	Leptomonas seymouri	57%	96%
A0A1X0NIQ9	Trypanosomatidae	35%	100%
A0A3Q8ICR1	Leishmania donovani	42%	89%
A0A3Q8ISU5	Leishmania donovani	100%	100%
A0A3R7KGN9	Trypanosoma rangeli	34%	100%
A4HJP3	Leishmania braziliensis	73%	99%
A4HJP4	Leishmania braziliensis	44%	100%
A4I761	Leishmania infantum	41%	89%
E9B254	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B255	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4Q605	Leishmania major	42%	78%
Q4Q606	Leishmania major	91%	100%
V5BC23	Trypanosoma cruzi	35%	100%