Uridine kinase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

uridine kinase-like protein

Species:

Leishmania infantum

UniProt:

A4I754_LEIIN

TriTrypDb:

LINF_310033000

Length:

129

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, Uridine kinase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I754

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I754

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004849	uridine kinase activity	7	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0017076	purine nucleotide binding	4	2
GO:0019205	nucleobase-containing compound kinase activity	5	2
GO:0019206	nucleoside kinase activity	6	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	57	59	PF00675	0.199
CLV_PCSK_KEX2_1	57	59	PF00082	0.199
CLV_PCSK_SKI1_1	68	72	PF00082	0.199
DOC_MAPK_gen_1	102	110	PF00069	0.400
DOC_USP7_MATH_1	89	93	PF00917	0.400
DOC_WW_Pin1_4	16	21	PF00397	0.400
LIG_14-3-3_CanoR_1	114	123	PF00244	0.400
LIG_14-3-3_CanoR_1	66	71	PF00244	0.400
LIG_FHA_1	19	25	PF00498	0.400
LIG_FHA_2	31	37	PF00498	0.400
LIG_LIR_Nem_3	69	73	PF02991	0.400
LIG_SH2_CRK	4	8	PF00017	0.400
LIG_SH2_NCK_1	88	92	PF00017	0.400
LIG_SH2_SRC	4	7	PF00017	0.400
LIG_SH2_SRC	88	91	PF00017	0.400
LIG_SH2_STAP1	77	81	PF00017	0.400
LIG_SH2_STAT5	6	9	PF00017	0.400
LIG_SH3_5	2	6	PF00018	0.400
LIG_SUMO_SIM_par_1	21	27	PF11976	0.400
MOD_CDK_SPxK_1	16	22	PF00069	0.400
MOD_CK1_1	12	18	PF00069	0.400
MOD_CK1_1	92	98	PF00069	0.400
MOD_CK2_1	30	36	PF00069	0.400
MOD_CK2_1	69	75	PF00069	0.400
MOD_GlcNHglycan	11	14	PF01048	0.199
MOD_GlcNHglycan	97	101	PF01048	0.199
MOD_GSK3_1	11	18	PF00069	0.400
MOD_GSK3_1	92	99	PF00069	0.400
MOD_LATS_1	9	15	PF00433	0.400
MOD_NEK2_1	113	118	PF00069	0.370
MOD_NEK2_1	30	35	PF00069	0.400
MOD_NEK2_1	46	51	PF00069	0.400
MOD_NEK2_2	77	82	PF00069	0.400
MOD_PIKK_1	113	119	PF00454	0.375
MOD_PKA_2	113	119	PF00069	0.375
MOD_Plk_4	69	75	PF00069	0.400
MOD_ProDKin_1	16	22	PF00069	0.400
TRG_DiLeu_BaEn_1	40	45	PF01217	0.400
TRG_ENDOCYTIC_2	4	7	PF00928	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0AIU6	LISW6	38%	62%
A0KKF8	AERHH	41%	60%
A0KW26	SHESA	42%	61%
A0Q140	CLONN	38%	62%
A0RIZ3	BACAH	45%	61%
A1JTX4	YERE8	42%	61%
A1QYG8	BORT9	38%	63%
A1RIY2	SHESW	43%	61%
A1S796	SHEAM	43%	61%
A1SUY9	PSYIN	40%	61%
A2RDZ9	STRPG	41%	62%
A2RJB4	LACLM	39%	63%
A3D5E3	SHEB5	43%	61%
A4IR72	GEOTN	42%	61%
A4SML3	AERS4	41%	60%
A4TKM7	YERPP	42%	61%
A4WCB6	ENT38	44%	61%
A4Y7K6	SHEPC	43%	61%
A5ITD6	STAA9	42%	62%
A5UB17	HAEIE	42%	61%
A5UFT8	HAEIG	42%	61%
A5VKU8	LIMRD	40%	59%
A6QHF2	STAAE	42%	62%
A6TBG6	KLEP7	44%	61%
A6TR08	ALKMQ	38%	62%
A6U280	STAA2	42%	62%
A6WP54	SHEB8	43%	61%
A7FJJ4	YERP3	42%	61%
A7GGE1	CLOBL	41%	63%
A7GT59	BACCN	46%	61%
A7MHG8	CROS8	43%	61%
A7MVE7	VIBC1	43%	61%
A7X320	STAA1	42%	62%
A7Z727	BACVZ	42%	61%
A8AWT2	STRGC	39%	61%
A8FFL8	BACP2	39%	61%
A8GC40	SERP5	42%	61%
A8H3V4	SHEPA	43%	61%
A8YU29	LACH4	42%	61%
A8Z4E9	STAAT	42%	62%
A9L4F4	SHEB9	43%	61%
A9N7M0	SALPB	44%	61%
A9R2M5	YERPG	42%	61%
A9VI01	BACMK	44%	61%
A9WCC8	CHLAA	40%	62%
B0TJ03	SHEHH	43%	61%
B0UT65	HISS2	41%	61%
B1AIX1	UREP2	35%	62%
B1H116	XENTR	35%	49%
B1IC10	STRPI	39%	61%
B1IJ68	CLOBK	42%	63%
B1JPY6	YERPY	42%	61%
B1KXA7	CLOBM	42%	63%
B1MXP1	LEUCK	39%	61%
B2G882	LIMRJ	40%	59%
B2IPS2	STRPS	39%	61%
B2JZK5	YERPB	42%	61%
B2S1K4	BORHD	38%	63%
B2VFR1	ERWT9	46%	61%
B4ESY8	PROMH	49%	61%
B4SXV3	SALNS	44%	61%
B4T9T4	SALHS	44%	61%
B4TNH9	SALSV	44%	61%
B4U220	STREM	41%	62%
B5BF73	SALPK	43%	61%
B5E4U6	STRP4	35%	61%
B5EXV0	SALA4	44%	61%
B5FG51	ALIFM	43%	60%
B5FMU1	SALDC	44%	61%
B5R0B5	SALEP	44%	61%
B5RBW3	SALG2	44%	61%
B5RLM3	BORDL	41%	63%
B5RQJ8	BORRA	41%	63%
B5XM21	STRPZ	41%	62%
B5XPC8	KLEP3	44%	61%
B5ZBE2	UREU1	34%	62%
B6EIY7	ALISL	42%	60%
B7GIU0	ANOFW	44%	61%
B7HE15	BACC4	45%	61%
B7HQD8	BACC7	45%	61%
B7IYN4	BACC2	46%	61%
B7J0V4	BORBZ	37%	63%
B7JP70	BACC0	45%	61%
B7LV30	ESCF3	43%	61%
B7VLX0	VIBA3	44%	61%
B8CPI6	SHEPW	40%	61%
B8DE13	LISMH	39%	62%
B8E960	SHEB2	43%	61%
B8G8N0	CHLAD	40%	62%
B8ZQ77	STRPJ	39%	61%
B9DNJ4	STACT	44%	62%
B9DSN2	STRU0	42%	61%
B9E6Y9	MACCJ	45%	63%
B9IYE5	BACCQ	45%	61%
B9LED5	CHLSY	40%	62%
C0M9M0	STRE4	41%	62%
C0MCM8	STRS7	41%	62%
C0Q1G0	SALPC	44%	61%
C0ZAS6	BREBN	36%	60%
C1C7H7	STRP7	39%	61%
C1CEH1	STRZJ	39%	61%
C1CKV4	STRZP	39%	61%
C1CR90	STRZT	39%	61%
C1CXN1	DEIDV	36%	62%
C1ESS5	BACC3	45%	61%
C1FSX6	CLOBJ	42%	63%
C1KVE4	LISMC	39%	62%
C3L140	CLOB6	42%	63%
C3L5Y6	BACAC	45%	61%
C3P969	BACAA	45%	61%
C4LEX3	TOLAT	45%	60%
C5D4Y5	GEOSW	43%	61%
C6DCI6	PECCP	45%	61%
O32033	BACSU	41%	61%
P0A8F4	ECOLI	44%	61%
P0A8F5	ECOL6	44%	61%
P0A8F6	ECO57	44%	61%
P0A8F7	SHIFL	44%	61%
P0DH36	STRP3	41%	62%
P0DH37	STRPQ	41%	62%
P44533	HAEIN	42%	61%
P47622	MYCGE	29%	61%
P52623	MOUSE	32%	47%
P67408	SALTY	44%	61%
P67409	SALTI	44%	61%
P67410	STAAM	42%	62%
P67411	STAAN	42%	62%
P67412	STAAW	42%	62%
P67413	STRPN	39%	61%
P67414	STRR6	39%	61%
P67415	STRP1	41%	62%
P75217	MYCPN	31%	61%
Q02XK6	LACLS	39%	63%
Q03K46	STRTD	37%	61%
Q04KA9	STRP2	39%	61%
Q081H5	SHEFN	43%	61%
Q0HJN4	SHESM	42%	61%
Q0HVY0	SHESR	42%	61%
Q0I2Y9	HAES1	41%	61%
Q0P5A4	BOVIN	33%	47%
Q0SPE9	BORAP	38%	62%
Q0SS52	CLOPS	38%	62%
Q0TPI4	CLOP1	38%	62%
Q12MJ0	SHEDO	42%	61%
Q17413	CAEEL	30%	52%
Q1C9T6	YERPA	42%	61%
Q1CGU6	YERPN	42%	61%
Q1WTY6	LIGS1	42%	61%
Q2FGB5	STAA3	42%	62%
Q2FXW6	STAA8	42%	62%
Q2NUC7	SODGM	43%	61%
Q2YT67	STAAB	42%	62%
Q38VV6	LATSS	38%	61%
Q3K1N1	STRA1	40%	62%
Q49Y49	STAS1	42%	62%
Q4L6V8	STAHJ	42%	62%
Q4QP55	HAEI8	42%	61%
Q57MN1	SALCH	44%	61%
Q59190	BORBU	37%	63%
Q5E3Z9	ALIF1	43%	60%
Q5HFF1	STAAC	42%	62%
Q5HNT9	STAEQ	43%	62%
Q5KWV3	GEOKA	45%	61%
Q5LZ98	STRT1	37%	61%
Q5M3V0	STRT2	37%	61%
Q5PDX6	SALPA	43%	61%
Q5SKR5	THET8	35%	61%
Q5XBI8	STRP6	41%	62%
Q634G4	BACCZ	45%	61%
Q65GT3	BACLD	41%	61%
Q65S71	MANSM	40%	60%
Q662Z7	BORGP	38%	63%
Q66C70	YERPS	42%	61%
Q66I71	DANRE	33%	47%
Q6D7B4	PECAS	45%	61%
Q6G8V8	STAAS	42%	62%
Q6GG92	STAAR	42%	62%
Q6GPD9	XENLA	35%	48%
Q6HDE5	BACHK	45%	61%
Q6PA79	XENLA	35%	48%
Q71ZH3	LISMF	39%	62%
Q72L53	THET2	35%	61%
Q730F4	BACC1	45%	61%
Q74KI9	LACJO	43%	61%
Q7MM12	VIBVY	44%	61%
Q7N6J4	PHOLL	49%	61%
Q7SYM0	DANRE	36%	49%
Q7VL27	HAEDU	40%	59%
Q7ZV79	DANRE	35%	49%
Q817Z5	BACCR	45%	61%
Q81LK8	BACAN	45%	61%
Q87N09	VIBPA	44%	61%
Q88WR0	LACPL	43%	62%
Q896E3	CLOTE	43%	62%
Q8CSB2	STAES	43%	62%
Q8D8F4	VIBVU	44%	61%
Q8DTG1	STRMU	38%	62%
Q8E0A8	STRA5	40%	62%
Q8E5Y5	STRA3	40%	62%
Q8EDX4	SHEON	42%	61%
Q8EPT5	OCEIH	43%	61%
Q8P0F8	STRP8	41%	62%
Q8T154	DICDI	36%	53%
Q8XJI6	CLOPE	38%	62%
Q8Y727	LISMO	39%	62%
Q8ZFZ9	YERPE	42%	61%
Q92BL6	LISIN	38%	62%
Q99PM9	MOUSE	35%	49%
Q9BZX2	HUMAN	35%	49%
Q9CF21	LACLA	39%	63%
Q9CM85	PASMU	42%	60%
Q9HA47	HUMAN	33%	47%
Q9HQC9	HALSA	37%	57%
Q9KDD8	HALH5	43%	61%
Q9KT67	VIBCH	44%	61%
Q9PQF9	UREPA	35%	62%
Q9QYG8	RAT	35%	49%
Q9RXZ5	DEIRA	37%	61%
Q9VC99	DROME	32%	50%
Q9Z7H0	CHLPN	38%	58%