Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I753_LEIIN

TriTrypDb:

LINF_310032950

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I753

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I753

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	422	426	PF00656	0.357
CLV_NRD_NRD_1	432	434	PF00675	0.518
CLV_NRD_NRD_1	491	493	PF00675	0.614
CLV_PCSK_KEX2_1	432	434	PF00082	0.378
CLV_PCSK_KEX2_1	491	493	PF00082	0.552
CLV_PCSK_SKI1_1	245	249	PF00082	0.535
CLV_PCSK_SKI1_1	344	348	PF00082	0.381
CLV_PCSK_SKI1_1	432	436	PF00082	0.376
CLV_PCSK_SKI1_1	444	448	PF00082	0.511
DEG_APCC_DBOX_1	343	351	PF00400	0.296
DEG_Nend_Nbox_1	1	3	PF02207	0.353
DEG_SPOP_SBC_1	283	287	PF00917	0.560
DOC_ANK_TNKS_1	420	427	PF00023	0.355
DOC_CDC14_PxL_1	98	106	PF14671	0.449
DOC_CKS1_1	2	7	PF01111	0.335
DOC_CKS1_1	445	450	PF01111	0.498
DOC_CYCLIN_RxL_1	255	266	PF00134	0.324
DOC_MAPK_gen_1	228	235	PF00069	0.343
DOC_MAPK_JIP1_4	405	411	PF00069	0.424
DOC_MAPK_MEF2A_6	228	235	PF00069	0.343
DOC_PP1_RVXF_1	243	250	PF00149	0.309
DOC_PP2B_LxvP_1	312	315	PF13499	0.278
DOC_PP2B_LxvP_1	462	465	PF13499	0.442
DOC_PP2B_PxIxI_1	334	340	PF00149	0.416
DOC_PP4_FxxP_1	393	396	PF00568	0.516
DOC_USP7_MATH_1	14	18	PF00917	0.554
DOC_USP7_MATH_1	284	288	PF00917	0.624
DOC_USP7_MATH_1	361	365	PF00917	0.527
DOC_USP7_MATH_1	449	453	PF00917	0.460
DOC_WW_Pin1_4	1	6	PF00397	0.338
DOC_WW_Pin1_4	285	290	PF00397	0.742
DOC_WW_Pin1_4	444	449	PF00397	0.567
LIG_14-3-3_CanoR_1	108	114	PF00244	0.679
LIG_14-3-3_CanoR_1	194	199	PF00244	0.505
LIG_14-3-3_CanoR_1	351	358	PF00244	0.463
LIG_14-3-3_CanoR_1	45	49	PF00244	0.400
LIG_14-3-3_CanoR_1	467	477	PF00244	0.410
LIG_Actin_WH2_2	168	186	PF00022	0.424
LIG_BRCT_BRCA1_1	16	20	PF00533	0.394
LIG_FHA_1	113	119	PF00498	0.503
LIG_FHA_1	162	168	PF00498	0.350
LIG_FHA_1	445	451	PF00498	0.552
LIG_FHA_1	472	478	PF00498	0.557
LIG_FHA_2	183	189	PF00498	0.424
LIG_FHA_2	2	8	PF00498	0.334
LIG_FHA_2	241	247	PF00498	0.274
LIG_FHA_2	302	308	PF00498	0.322
LIG_LIR_Apic_2	269	273	PF02991	0.398
LIG_LIR_Apic_2	390	396	PF02991	0.578
LIG_LIR_Gen_1	17	26	PF02991	0.417
LIG_LIR_Gen_1	236	247	PF02991	0.314
LIG_LIR_Gen_1	296	303	PF02991	0.445
LIG_LIR_Gen_1	47	56	PF02991	0.371
LIG_LIR_Nem_3	17	23	PF02991	0.381
LIG_LIR_Nem_3	197	201	PF02991	0.409
LIG_LIR_Nem_3	236	242	PF02991	0.305
LIG_LIR_Nem_3	296	302	PF02991	0.392
LIG_LIR_Nem_3	474	479	PF02991	0.504
LIG_MYND_1	402	406	PF01753	0.467
LIG_PCNA_yPIPBox_3	65	75	PF02747	0.502
LIG_PDZ_Class_3	492	497	PF00595	0.479
LIG_REV1ctd_RIR_1	139	148	PF16727	0.417
LIG_SH2_CRK	215	219	PF00017	0.277
LIG_SH2_CRK	239	243	PF00017	0.280
LIG_SH2_CRK	270	274	PF00017	0.362
LIG_SH2_NCK_1	215	219	PF00017	0.297
LIG_SH2_NCK_1	239	243	PF00017	0.280
LIG_SH2_SRC	12	15	PF00017	0.543
LIG_SH2_SRC	384	387	PF00017	0.508
LIG_SH2_SRC	423	426	PF00017	0.413
LIG_SH2_STAP1	215	219	PF00017	0.297
LIG_SH2_STAP1	299	303	PF00017	0.299
LIG_SH2_STAT5	119	122	PF00017	0.518
LIG_SH2_STAT5	201	204	PF00017	0.332
LIG_SH2_STAT5	215	218	PF00017	0.276
LIG_SH2_STAT5	234	237	PF00017	0.328
LIG_SH2_STAT5	31	34	PF00017	0.273
LIG_SH2_STAT5	384	387	PF00017	0.508
LIG_SH2_STAT5	423	426	PF00017	0.351
LIG_SH3_3	286	292	PF00018	0.739
LIG_SH3_3	3	9	PF00018	0.339
LIG_SH3_3	393	399	PF00018	0.628
LIG_SH3_3	400	406	PF00018	0.660
LIG_SH3_3	409	415	PF00018	0.377
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.357
LIG_SUMO_SIM_par_1	163	169	PF11976	0.356
LIG_SUMO_SIM_par_1	259	266	PF11976	0.464
LIG_TYR_ITIM	213	218	PF00017	0.285
LIG_TYR_ITIM	82	87	PF00017	0.484
MOD_CDK_SPxxK_3	1	8	PF00069	0.336
MOD_CK1_1	112	118	PF00069	0.506
MOD_CK1_1	126	132	PF00069	0.541
MOD_CK1_1	240	246	PF00069	0.465
MOD_CK1_1	305	311	PF00069	0.415
MOD_CK1_1	329	335	PF00069	0.532
MOD_CK1_1	338	344	PF00069	0.378
MOD_CK1_1	354	360	PF00069	0.437
MOD_CK1_1	391	397	PF00069	0.521
MOD_CK1_1	416	422	PF00069	0.372
MOD_CK2_1	1	7	PF00069	0.400
MOD_CK2_1	124	130	PF00069	0.727
MOD_CK2_1	260	266	PF00069	0.386
MOD_CK2_1	301	307	PF00069	0.300
MOD_CK2_1	87	93	PF00069	0.412
MOD_GlcNHglycan	156	159	PF01048	0.410
MOD_GlcNHglycan	304	307	PF01048	0.457
MOD_GlcNHglycan	316	319	PF01048	0.442
MOD_GlcNHglycan	32	35	PF01048	0.318
MOD_GlcNHglycan	325	329	PF01048	0.634
MOD_GlcNHglycan	331	334	PF01048	0.439
MOD_GlcNHglycan	370	374	PF01048	0.643
MOD_GlcNHglycan	451	454	PF01048	0.460
MOD_GlcNHglycan	79	82	PF01048	0.390
MOD_GSK3_1	108	115	PF00069	0.474
MOD_GSK3_1	125	132	PF00069	0.526
MOD_GSK3_1	233	240	PF00069	0.443
MOD_GSK3_1	256	263	PF00069	0.320
MOD_GSK3_1	278	285	PF00069	0.618
MOD_GSK3_1	30	37	PF00069	0.342
MOD_GSK3_1	301	308	PF00069	0.381
MOD_GSK3_1	87	94	PF00069	0.564
MOD_N-GLC_1	361	366	PF02516	0.530
MOD_N-GLC_2	324	326	PF02516	0.438
MOD_N-GLC_2	369	371	PF02516	0.546
MOD_NEK2_1	427	432	PF00069	0.566
MOD_NEK2_1	75	80	PF00069	0.474
MOD_NEK2_2	14	19	PF00069	0.364
MOD_PIKK_1	413	419	PF00454	0.479
MOD_PKA_2	275	281	PF00069	0.731
MOD_PKA_2	44	50	PF00069	0.364
MOD_Plk_1	129	135	PF00069	0.691
MOD_Plk_2-3	91	97	PF00069	0.381
MOD_Plk_4	166	172	PF00069	0.376
MOD_Plk_4	260	266	PF00069	0.451
MOD_Plk_4	388	394	PF00069	0.505
MOD_Plk_4	44	50	PF00069	0.368
MOD_ProDKin_1	1	7	PF00069	0.337
MOD_ProDKin_1	285	291	PF00069	0.737
MOD_ProDKin_1	444	450	PF00069	0.564
MOD_SUMO_rev_2	147	151	PF00179	0.321
TRG_ENDOCYTIC_2	156	159	PF00928	0.479
TRG_ENDOCYTIC_2	215	218	PF00928	0.293
TRG_ENDOCYTIC_2	219	222	PF00928	0.298
TRG_ENDOCYTIC_2	239	242	PF00928	0.257
TRG_ENDOCYTIC_2	299	302	PF00928	0.365
TRG_ENDOCYTIC_2	49	52	PF00928	0.404
TRG_ENDOCYTIC_2	84	87	PF00928	0.534
TRG_ER_diArg_1	227	230	PF00400	0.389
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD80	Leptomonas seymouri	48%	87%
A0A3R7M4U1	Trypanosoma rangeli	24%	100%
A0A3S7X4S0	Leishmania donovani	97%	100%
V5D2Y5	Trypanosoma cruzi	24%	100%