Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I749_LEIIN

TriTrypDb:

LINF_310032600

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I749

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I749

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.414
CLV_NRD_NRD_1	25	27	PF00675	0.394
CLV_NRD_NRD_1	53	55	PF00675	0.478
CLV_PCSK_KEX2_1	140	142	PF00082	0.700
CLV_PCSK_KEX2_1	150	152	PF00082	0.582
CLV_PCSK_KEX2_1	199	201	PF00082	0.417
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.700
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.582
CLV_PCSK_SKI1_1	145	149	PF00082	0.587
CLV_PCSK_SKI1_1	200	204	PF00082	0.504
CLV_PCSK_SKI1_1	226	230	PF00082	0.547
CLV_PCSK_SKI1_1	39	43	PF00082	0.435
CLV_PCSK_SKI1_1	92	96	PF00082	0.433
DEG_APCC_DBOX_1	140	148	PF00400	0.491
DOC_MAPK_gen_1	90	97	PF00069	0.459
DOC_MAPK_MEF2A_6	90	97	PF00069	0.459
DOC_MAPK_NFAT4_5	90	98	PF00069	0.461
DOC_PP2B_PxIxI_1	20	26	PF00149	0.412
DOC_USP7_MATH_1	129	133	PF00917	0.618
DOC_USP7_MATH_1	136	140	PF00917	0.500
DOC_USP7_MATH_1	159	163	PF00917	0.766
DOC_USP7_MATH_1	164	168	PF00917	0.617
DOC_WW_Pin1_4	75	80	PF00397	0.368
LIG_14-3-3_CanoR_1	33	43	PF00244	0.390
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_deltaCOP1_diTrp_1	216	225	PF00928	0.342
LIG_FHA_1	169	175	PF00498	0.420
LIG_FHA_1	36	42	PF00498	0.427
LIG_FHA_2	175	181	PF00498	0.458
LIG_FHA_2	225	231	PF00498	0.491
LIG_FHA_2	96	102	PF00498	0.391
LIG_LIR_Gen_1	83	94	PF02991	0.490
LIG_LIR_Nem_3	60	66	PF02991	0.413
LIG_LIR_Nem_3	72	77	PF02991	0.490
LIG_LIR_Nem_3	83	89	PF02991	0.482
LIG_Pex14_1	172	176	PF04695	0.355
LIG_PTB_Apo_2	149	156	PF02174	0.504
LIG_SH2_CRK	63	67	PF00017	0.449
LIG_SH2_CRK	86	90	PF00017	0.346
LIG_SH2_STAP1	182	186	PF00017	0.426
LIG_SH3_4	6	13	PF00018	0.570
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.446
LIG_SUMO_SIM_par_1	37	44	PF11976	0.435
LIG_SUMO_SIM_par_1	48	53	PF11976	0.443
LIG_TYR_ITIM	61	66	PF00017	0.532
LIG_UBA3_1	187	193	PF00899	0.469
MOD_CK1_1	121	127	PF00069	0.472
MOD_CK1_1	132	138	PF00069	0.692
MOD_CK1_1	162	168	PF00069	0.692
MOD_CK1_1	178	184	PF00069	0.435
MOD_CK1_1	53	59	PF00069	0.633
MOD_CK1_1	85	91	PF00069	0.424
MOD_CK2_1	174	180	PF00069	0.409
MOD_CK2_1	95	101	PF00069	0.398
MOD_GlcNHglycan	123	126	PF01048	0.560
MOD_GlcNHglycan	130	134	PF01048	0.702
MOD_GlcNHglycan	161	164	PF01048	0.641
MOD_GSK3_1	102	109	PF00069	0.543
MOD_GSK3_1	114	121	PF00069	0.419
MOD_GSK3_1	132	139	PF00069	0.576
MOD_GSK3_1	162	169	PF00069	0.562
MOD_GSK3_1	174	181	PF00069	0.401
MOD_GSK3_1	224	231	PF00069	0.505
MOD_GSK3_1	35	42	PF00069	0.410
MOD_N-GLC_1	15	20	PF02516	0.755
MOD_NEK2_1	114	119	PF00069	0.315
MOD_NEK2_1	154	159	PF00069	0.646
MOD_NEK2_1	62	67	PF00069	0.471
MOD_NEK2_1	95	100	PF00069	0.484
MOD_PKA_2	34	40	PF00069	0.494
MOD_PKA_2	53	59	PF00069	0.357
MOD_PKB_1	33	41	PF00069	0.401
MOD_Plk_1	100	106	PF00069	0.400
MOD_Plk_1	129	135	PF00069	0.582
MOD_Plk_1	165	171	PF00069	0.408
MOD_Plk_4	118	124	PF00069	0.441
MOD_ProDKin_1	75	81	PF00069	0.366
MOD_SUMO_for_1	192	195	PF00179	0.376
TRG_ENDOCYTIC_2	63	66	PF00928	0.467
TRG_ENDOCYTIC_2	86	89	PF00928	0.400
TRG_ER_diArg_1	33	36	PF00400	0.538
TRG_NLS_MonoExtC_3	53	58	PF00514	0.414
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I730	Leptomonas seymouri	25%	100%
A0A0N1I8Q6	Leptomonas seymouri	40%	100%
A0A0N1PCW5	Leptomonas seymouri	31%	100%
A0A3Q8IF19	Leishmania donovani	41%	100%
A0A3S5H7Q5	Leishmania donovani	99%	99%
A4HJM7	Leishmania braziliensis	55%	100%
A4HJM8	Leishmania braziliensis	36%	100%
A4I750	Leishmania infantum	41%	100%
E9B243	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B244	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4Q616	Leishmania major	23%	100%
Q4Q617	Leishmania major	40%	100%
Q4Q618	Leishmania major	85%	100%