Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I744_LEIIN

TriTrypDb:

LINF_310032100

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I744

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I744

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.580
CLV_C14_Caspase3-7	158	162	PF00656	0.792
CLV_C14_Caspase3-7	769	773	PF00656	0.745
CLV_NRD_NRD_1	158	160	PF00675	0.722
CLV_NRD_NRD_1	188	190	PF00675	0.741
CLV_NRD_NRD_1	222	224	PF00675	0.564
CLV_NRD_NRD_1	274	276	PF00675	0.725
CLV_NRD_NRD_1	311	313	PF00675	0.726
CLV_NRD_NRD_1	393	395	PF00675	0.820
CLV_NRD_NRD_1	399	401	PF00675	0.768
CLV_NRD_NRD_1	465	467	PF00675	0.859
CLV_NRD_NRD_1	469	471	PF00675	0.780
CLV_NRD_NRD_1	473	475	PF00675	0.702
CLV_NRD_NRD_1	514	516	PF00675	0.645
CLV_NRD_NRD_1	585	587	PF00675	0.817
CLV_NRD_NRD_1	610	612	PF00675	0.751
CLV_NRD_NRD_1	780	782	PF00675	0.841
CLV_PCSK_FUR_1	781	785	PF00082	0.836
CLV_PCSK_KEX2_1	188	190	PF00082	0.741
CLV_PCSK_KEX2_1	222	224	PF00082	0.564
CLV_PCSK_KEX2_1	274	276	PF00082	0.725
CLV_PCSK_KEX2_1	313	315	PF00082	0.731
CLV_PCSK_KEX2_1	370	372	PF00082	0.662
CLV_PCSK_KEX2_1	392	394	PF00082	0.814
CLV_PCSK_KEX2_1	399	401	PF00082	0.762
CLV_PCSK_KEX2_1	469	471	PF00082	0.846
CLV_PCSK_KEX2_1	514	516	PF00082	0.645
CLV_PCSK_KEX2_1	584	586	PF00082	0.816
CLV_PCSK_KEX2_1	610	612	PF00082	0.751
CLV_PCSK_KEX2_1	783	785	PF00082	0.831
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.731
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.662
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.831
CLV_PCSK_PC7_1	580	586	PF00082	0.706
CLV_PCSK_SKI1_1	399	403	PF00082	0.709
CLV_PCSK_SKI1_1	580	584	PF00082	0.712
CLV_PCSK_SKI1_1	670	674	PF00082	0.813
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DEG_SPOP_SBC_1	11	15	PF00917	0.632
DEG_SPOP_SBC_1	375	379	PF00917	0.748
DEG_SPOP_SBC_1	414	418	PF00917	0.680
DEG_SPOP_SBC_1	494	498	PF00917	0.761
DEG_SPOP_SBC_1	658	662	PF00917	0.693
DEG_SPOP_SBC_1	767	771	PF00917	0.726
DOC_PP2B_LxvP_1	195	198	PF13499	0.736
DOC_PP2B_LxvP_1	289	292	PF13499	0.677
DOC_PP2B_LxvP_1	725	728	PF13499	0.721
DOC_PP4_FxxP_1	131	134	PF00568	0.735
DOC_USP7_MATH_1	198	202	PF00917	0.742
DOC_USP7_MATH_1	27	31	PF00917	0.619
DOC_USP7_MATH_1	332	336	PF00917	0.743
DOC_USP7_MATH_1	355	359	PF00917	0.767
DOC_USP7_MATH_1	361	365	PF00917	0.729
DOC_USP7_MATH_1	409	413	PF00917	0.855
DOC_USP7_MATH_1	503	507	PF00917	0.848
DOC_USP7_MATH_1	518	522	PF00917	0.592
DOC_USP7_MATH_1	61	65	PF00917	0.744
DOC_USP7_MATH_1	658	662	PF00917	0.724
DOC_USP7_MATH_1	728	732	PF00917	0.748
DOC_USP7_MATH_1	805	809	PF00917	0.746
DOC_USP7_UBL2_3	467	471	PF12436	0.848
DOC_WW_Pin1_4	163	168	PF00397	0.718
DOC_WW_Pin1_4	23	28	PF00397	0.619
DOC_WW_Pin1_4	307	312	PF00397	0.765
DOC_WW_Pin1_4	327	332	PF00397	0.502
DOC_WW_Pin1_4	343	348	PF00397	0.560
DOC_WW_Pin1_4	451	456	PF00397	0.632
DOC_WW_Pin1_4	567	572	PF00397	0.833
DOC_WW_Pin1_4	605	610	PF00397	0.815
DOC_WW_Pin1_4	650	655	PF00397	0.774
DOC_WW_Pin1_4	664	669	PF00397	0.583
LIG_14-3-3_CanoR_1	116	120	PF00244	0.711
LIG_14-3-3_CanoR_1	141	146	PF00244	0.722
LIG_14-3-3_CanoR_1	188	192	PF00244	0.796
LIG_14-3-3_CanoR_1	247	254	PF00244	0.674
LIG_14-3-3_CanoR_1	281	289	PF00244	0.637
LIG_14-3-3_CanoR_1	386	392	PF00244	0.830
LIG_14-3-3_CanoR_1	393	403	PF00244	0.791
LIG_14-3-3_CanoR_1	480	487	PF00244	0.741
LIG_14-3-3_CanoR_1	558	567	PF00244	0.771
LIG_14-3-3_CanoR_1	758	763	PF00244	0.803
LIG_14-3-3_CanoR_1	768	777	PF00244	0.665
LIG_14-3-3_CanoR_1	78	83	PF00244	0.753
LIG_14-3-3_CanoR_1	87	96	PF00244	0.766
LIG_BRCT_BRCA1_1	332	336	PF00533	0.704
LIG_BRCT_BRCA1_1	62	66	PF00533	0.665
LIG_BRCT_BRCA1_1	660	664	PF00533	0.824
LIG_CSL_BTD_1	651	654	PF09270	0.835
LIG_CtBP_PxDLS_1	614	618	PF00389	0.555
LIG_EH_1	751	755	PF12763	0.704
LIG_FHA_1	12	18	PF00498	0.776
LIG_FHA_1	271	277	PF00498	0.776
LIG_FHA_1	284	290	PF00498	0.621
LIG_FHA_1	351	357	PF00498	0.744
LIG_FHA_1	377	383	PF00498	0.661
LIG_FHA_2	282	288	PF00498	0.757
LIG_FHA_2	314	320	PF00498	0.758
LIG_FHA_2	34	40	PF00498	0.750
LIG_FHA_2	376	382	PF00498	0.756
LIG_FHA_2	529	535	PF00498	0.769
LIG_LIR_Apic_2	118	123	PF02991	0.702
LIG_LIR_Gen_1	346	356	PF02991	0.601
LIG_LIR_Gen_1	669	675	PF02991	0.772
LIG_LIR_Nem_3	212	217	PF02991	0.584
LIG_LIR_Nem_3	346	351	PF02991	0.733
LIG_LIR_Nem_3	669	674	PF02991	0.774
LIG_MYND_1	426	430	PF01753	0.671
LIG_Pex14_2	62	66	PF04695	0.768
LIG_RPA_C_Fungi	381	393	PF08784	0.628
LIG_SH2_CRK	114	118	PF00017	0.758
LIG_SH2_CRK	120	124	PF00017	0.716
LIG_SH2_CRK	640	644	PF00017	0.609
LIG_SH2_NCK_1	114	118	PF00017	0.676
LIG_SH2_NCK_1	323	327	PF00017	0.622
LIG_SH2_NCK_1	640	644	PF00017	0.609
LIG_SH2_SRC	103	106	PF00017	0.736
LIG_SH2_SRC	587	590	PF00017	0.727
LIG_SH2_STAT5	216	219	PF00017	0.792
LIG_SH2_STAT5	35	38	PF00017	0.808
LIG_SH2_STAT5	587	590	PF00017	0.644
LIG_SH3_2	606	611	PF14604	0.742
LIG_SH3_3	420	426	PF00018	0.775
LIG_SH3_3	543	549	PF00018	0.780
LIG_SH3_3	566	572	PF00018	0.737
LIG_SH3_3	603	609	PF00018	0.808
LIG_SH3_3	625	631	PF00018	0.787
LIG_SH3_3	640	646	PF00018	0.629
LIG_SH3_4	467	474	PF00018	0.839
LIG_TYR_ITIM	638	643	PF00017	0.608
LIG_WW_1	571	574	PF00397	0.737
MOD_CDC14_SPxK_1	310	313	PF00782	0.726
MOD_CDC14_SPxK_1	608	611	PF00782	0.746
MOD_CDK_SPK_2	307	312	PF00069	0.762
MOD_CDK_SPK_2	605	610	PF00069	0.737
MOD_CDK_SPxK_1	307	313	PF00069	0.725
MOD_CDK_SPxK_1	605	611	PF00069	0.740
MOD_CDK_SPxK_1	664	670	PF00069	0.815
MOD_CDK_SPxxK_3	307	314	PF00069	0.764
MOD_CK1_1	115	121	PF00069	0.709
MOD_CK1_1	144	150	PF00069	0.804
MOD_CK1_1	169	175	PF00069	0.659
MOD_CK1_1	176	182	PF00069	0.667
MOD_CK1_1	184	190	PF00069	0.807
MOD_CK1_1	200	206	PF00069	0.553
MOD_CK1_1	209	215	PF00069	0.656
MOD_CK1_1	249	255	PF00069	0.681
MOD_CK1_1	262	268	PF00069	0.779
MOD_CK1_1	298	304	PF00069	0.679
MOD_CK1_1	325	331	PF00069	0.812
MOD_CK1_1	385	391	PF00069	0.628
MOD_CK1_1	410	416	PF00069	0.854
MOD_CK1_1	446	452	PF00069	0.827
MOD_CK1_1	479	485	PF00069	0.840
MOD_CK1_1	496	502	PF00069	0.572
MOD_CK1_1	506	512	PF00069	0.698
MOD_CK1_1	541	547	PF00069	0.755
MOD_CK1_1	562	568	PF00069	0.832
MOD_CK1_1	570	576	PF00069	0.676
MOD_CK1_1	60	66	PF00069	0.719
MOD_CK1_1	616	622	PF00069	0.855
MOD_CK1_1	659	665	PF00069	0.816
MOD_CK1_1	713	719	PF00069	0.845
MOD_CK1_1	739	745	PF00069	0.803
MOD_CK1_1	763	769	PF00069	0.802
MOD_CK1_1	88	94	PF00069	0.790
MOD_CK1_1	9	15	PF00069	0.802
MOD_CK2_1	281	287	PF00069	0.665
MOD_CK2_1	375	381	PF00069	0.753
MOD_CK2_1	570	576	PF00069	0.816
MOD_CK2_1	593	599	PF00069	0.661
MOD_CK2_1	705	711	PF00069	0.781
MOD_CK2_1	718	724	PF00069	0.677
MOD_CK2_1	743	749	PF00069	0.792
MOD_CK2_1	78	84	PF00069	0.837
MOD_GlcNHglycan	137	140	PF01048	0.782
MOD_GlcNHglycan	147	150	PF01048	0.678
MOD_GlcNHglycan	168	171	PF01048	0.644
MOD_GlcNHglycan	2	5	PF01048	0.685
MOD_GlcNHglycan	211	214	PF01048	0.746
MOD_GlcNHglycan	241	244	PF01048	0.773
MOD_GlcNHglycan	297	300	PF01048	0.642
MOD_GlcNHglycan	324	327	PF01048	0.811
MOD_GlcNHglycan	332	335	PF01048	0.732
MOD_GlcNHglycan	365	368	PF01048	0.768
MOD_GlcNHglycan	406	410	PF01048	0.755
MOD_GlcNHglycan	412	415	PF01048	0.721
MOD_GlcNHglycan	419	422	PF01048	0.679
MOD_GlcNHglycan	462	465	PF01048	0.820
MOD_GlcNHglycan	50	53	PF01048	0.737
MOD_GlcNHglycan	532	538	PF01048	0.766
MOD_GlcNHglycan	561	564	PF01048	0.634
MOD_GlcNHglycan	59	62	PF01048	0.660
MOD_GlcNHglycan	595	598	PF01048	0.653
MOD_GlcNHglycan	620	623	PF01048	0.769
MOD_GlcNHglycan	63	66	PF01048	0.601
MOD_GlcNHglycan	654	657	PF01048	0.836
MOD_GlcNHglycan	675	678	PF01048	0.633
MOD_GlcNHglycan	720	723	PF01048	0.839
MOD_GlcNHglycan	758	761	PF01048	0.748
MOD_GlcNHglycan	765	768	PF01048	0.731
MOD_GlcNHglycan	772	775	PF01048	0.626
MOD_GlcNHglycan	97	100	PF01048	0.695
MOD_GSK3_1	135	142	PF00069	0.790
MOD_GSK3_1	169	176	PF00069	0.697
MOD_GSK3_1	187	194	PF00069	0.811
MOD_GSK3_1	198	205	PF00069	0.636
MOD_GSK3_1	23	30	PF00069	0.503
MOD_GSK3_1	248	255	PF00069	0.678
MOD_GSK3_1	258	265	PF00069	0.649
MOD_GSK3_1	281	288	PF00069	0.805
MOD_GSK3_1	295	302	PF00069	0.571
MOD_GSK3_1	318	325	PF00069	0.757
MOD_GSK3_1	382	389	PF00069	0.716
MOD_GSK3_1	405	412	PF00069	0.832
MOD_GSK3_1	413	420	PF00069	0.754
MOD_GSK3_1	446	453	PF00069	0.792
MOD_GSK3_1	476	483	PF00069	0.710
MOD_GSK3_1	493	500	PF00069	0.570
MOD_GSK3_1	5	12	PF00069	0.718
MOD_GSK3_1	503	510	PF00069	0.690
MOD_GSK3_1	533	540	PF00069	0.734
MOD_GSK3_1	561	568	PF00069	0.821
MOD_GSK3_1	57	64	PF00069	0.774
MOD_GSK3_1	613	620	PF00069	0.767
MOD_GSK3_1	641	648	PF00069	0.798
MOD_GSK3_1	650	657	PF00069	0.669
MOD_GSK3_1	658	665	PF00069	0.537
MOD_GSK3_1	702	709	PF00069	0.745
MOD_GSK3_1	739	746	PF00069	0.801
MOD_GSK3_1	756	763	PF00069	0.519
MOD_GSK3_1	766	773	PF00069	0.657
MOD_GSK3_1	85	92	PF00069	0.774
MOD_N-GLC_1	229	234	PF02516	0.621
MOD_N-GLC_1	382	387	PF02516	0.620
MOD_N-GLC_1	476	481	PF02516	0.821
MOD_NEK2_1	145	150	PF00069	0.670
MOD_NEK2_1	191	196	PF00069	0.790
MOD_NEK2_1	202	207	PF00069	0.657
MOD_NEK2_1	21	26	PF00069	0.566
MOD_NEK2_1	248	253	PF00069	0.829
MOD_NEK2_1	270	275	PF00069	0.729
MOD_NEK2_1	295	300	PF00069	0.802
MOD_NEK2_1	48	53	PF00069	0.766
MOD_NEK2_1	5	10	PF00069	0.750
MOD_NEK2_1	57	62	PF00069	0.639
MOD_NEK2_1	617	622	PF00069	0.580
MOD_NEK2_1	693	698	PF00069	0.794
MOD_NEK2_1	736	741	PF00069	0.778
MOD_NEK2_2	760	765	PF00069	0.727
MOD_PIKK_1	318	324	PF00454	0.642
MOD_PIKK_1	541	547	PF00454	0.763
MOD_PIKK_1	6	12	PF00454	0.722
MOD_PIKK_1	622	628	PF00454	0.789
MOD_PIKK_1	680	686	PF00454	0.735
MOD_PK_1	480	486	PF00069	0.839
MOD_PKA_1	313	319	PF00069	0.721
MOD_PKA_1	399	405	PF00069	0.718
MOD_PKA_2	115	121	PF00069	0.709
MOD_PKA_2	187	193	PF00069	0.740
MOD_PKA_2	206	212	PF00069	0.557
MOD_PKA_2	246	252	PF00069	0.757
MOD_PKA_2	262	268	PF00069	0.743
MOD_PKA_2	280	286	PF00069	0.736
MOD_PKA_2	313	319	PF00069	0.759
MOD_PKA_2	385	391	PF00069	0.647
MOD_PKA_2	399	405	PF00069	0.657
MOD_PKA_2	479	485	PF00069	0.840
MOD_PKA_2	506	512	PF00069	0.746
MOD_PKA_2	767	773	PF00069	0.687
MOD_PKA_2	88	94	PF00069	0.739
MOD_PKB_1	392	400	PF00069	0.697
MOD_PKB_1	87	95	PF00069	0.666
MOD_Plk_1	176	182	PF00069	0.718
MOD_Plk_1	217	223	PF00069	0.812
MOD_Plk_1	249	255	PF00069	0.654
MOD_Plk_1	318	324	PF00069	0.620
MOD_Plk_1	710	716	PF00069	0.736
MOD_Plk_1	743	749	PF00069	0.714
MOD_Plk_4	115	121	PF00069	0.709
MOD_Plk_4	169	175	PF00069	0.586
MOD_Plk_4	27	33	PF00069	0.715
MOD_Plk_4	424	430	PF00069	0.666
MOD_ProDKin_1	163	169	PF00069	0.717
MOD_ProDKin_1	23	29	PF00069	0.619
MOD_ProDKin_1	307	313	PF00069	0.768
MOD_ProDKin_1	327	333	PF00069	0.504
MOD_ProDKin_1	343	349	PF00069	0.561
MOD_ProDKin_1	451	457	PF00069	0.633
MOD_ProDKin_1	567	573	PF00069	0.828
MOD_ProDKin_1	605	611	PF00069	0.817
MOD_ProDKin_1	650	656	PF00069	0.775
MOD_ProDKin_1	664	670	PF00069	0.583
MOD_SUMO_rev_2	437	443	PF00179	0.704
TRG_DiLeu_BaEn_3	797	803	PF01217	0.607
TRG_ENDOCYTIC_2	114	117	PF00928	0.718
TRG_ENDOCYTIC_2	214	217	PF00928	0.591
TRG_ENDOCYTIC_2	640	643	PF00928	0.609
TRG_ER_diArg_1	221	223	PF00400	0.566
TRG_ER_diArg_1	274	276	PF00400	0.631
TRG_ER_diArg_1	311	314	PF00400	0.727
TRG_ER_diArg_1	391	394	PF00400	0.839
TRG_ER_diArg_1	468	470	PF00400	0.847
TRG_ER_diArg_1	583	586	PF00400	0.817
TRG_ER_diArg_1	609	611	PF00400	0.750
TRG_ER_diArg_1	86	89	PF00400	0.671
TRG_NLS_MonoCore_2	465	470	PF00514	0.853
TRG_NLS_MonoCore_2	780	785	PF00514	0.836
TRG_NLS_MonoExtC_3	465	470	PF00514	0.853
TRG_NLS_MonoExtC_3	781	787	PF00514	0.834
TRG_NLS_MonoExtN_4	311	316	PF00514	0.725
TRG_NLS_MonoExtN_4	781	786	PF00514	0.833
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.698
TRG_Pf-PMV_PEXEL_1	586	591	PF00026	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGI6	Leishmania donovani	98%	99%
A4HJM2	Leishmania braziliensis	61%	100%
E9B238	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q623	Leishmania major	84%	100%