WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I743_LEIIN

TriTrypDb:

LINF_310032000

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I743

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I743

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	346	352	PF00089	0.451
CLV_NRD_NRD_1	137	139	PF00675	0.412
CLV_NRD_NRD_1	189	191	PF00675	0.585
CLV_NRD_NRD_1	309	311	PF00675	0.567
CLV_NRD_NRD_1	45	47	PF00675	0.535
CLV_NRD_NRD_1	75	77	PF00675	0.587
CLV_PCSK_KEX2_1	149	151	PF00082	0.503
CLV_PCSK_KEX2_1	309	311	PF00082	0.649
CLV_PCSK_KEX2_1	45	47	PF00082	0.661
CLV_PCSK_KEX2_1	59	61	PF00082	0.678
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.503
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.711
CLV_PCSK_SKI1_1	119	123	PF00082	0.382
CLV_PCSK_SKI1_1	173	177	PF00082	0.318
CLV_PCSK_SKI1_1	290	294	PF00082	0.455
CLV_PCSK_SKI1_1	379	383	PF00082	0.346
DEG_APCC_DBOX_1	17	25	PF00400	0.447
DEG_APCC_DBOX_1	487	495	PF00400	0.374
DEG_Nend_UBRbox_3	1	3	PF02207	0.483
DEG_SCF_SKP2-CKS1_1	401	408	PF00560	0.428
DOC_AGCK_PIF_1	347	352	PF00069	0.454
DOC_CKS1_1	435	440	PF01111	0.463
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	447	453	PF00134	0.512
DOC_MAPK_gen_1	138	146	PF00069	0.368
DOC_MAPK_MEF2A_6	256	263	PF00069	0.476
DOC_MAPK_MEF2A_6	329	337	PF00069	0.466
DOC_MIT_MIM_1	198	207	PF04212	0.439
DOC_PP1_RVXF_1	341	348	PF00149	0.407
DOC_PP1_RVXF_1	377	383	PF00149	0.298
DOC_USP7_MATH_1	103	107	PF00917	0.573
DOC_USP7_MATH_1	117	121	PF00917	0.419
DOC_USP7_MATH_1	222	226	PF00917	0.500
DOC_USP7_MATH_1	29	33	PF00917	0.534
DOC_USP7_MATH_1	303	307	PF00917	0.599
DOC_USP7_MATH_1	362	366	PF00917	0.404
DOC_USP7_MATH_1	80	84	PF00917	0.617
DOC_USP7_MATH_1	89	93	PF00917	0.589
DOC_USP7_MATH_1	96	100	PF00917	0.560
DOC_USP7_UBL2_3	141	145	PF12436	0.460
DOC_USP7_UBL2_3	290	294	PF12436	0.455
DOC_USP7_UBL2_3	55	59	PF12436	0.653
DOC_WW_Pin1_4	30	35	PF00397	0.540
DOC_WW_Pin1_4	335	340	PF00397	0.350
DOC_WW_Pin1_4	402	407	PF00397	0.583
DOC_WW_Pin1_4	434	439	PF00397	0.457
DOC_WW_Pin1_4	85	90	PF00397	0.647
LIG_14-3-3_CanoR_1	154	159	PF00244	0.469
LIG_14-3-3_CanoR_1	349	353	PF00244	0.438
LIG_14-3-3_CanoR_1	482	489	PF00244	0.547
LIG_14-3-3_CanoR_1	62	67	PF00244	0.788
LIG_Actin_WH2_2	436	454	PF00022	0.527
LIG_BRCT_BRCA1_1	464	468	PF00533	0.380
LIG_BRCT_BRCA1_1	495	499	PF00533	0.272
LIG_CtBP_PxDLS_1	409	413	PF00389	0.441
LIG_FHA_1	106	112	PF00498	0.708
LIG_FHA_1	215	221	PF00498	0.525
LIG_FHA_1	248	254	PF00498	0.409
LIG_FHA_1	340	346	PF00498	0.515
LIG_FHA_1	384	390	PF00498	0.373
LIG_FHA_1	411	417	PF00498	0.494
LIG_FHA_1	5	11	PF00498	0.504
LIG_FHA_2	250	256	PF00498	0.373
LIG_FHA_2	272	278	PF00498	0.390
LIG_FHA_2	420	426	PF00498	0.496
LIG_FHA_2	481	487	PF00498	0.401
LIG_FHA_2	502	508	PF00498	0.341
LIG_LIR_Apic_2	507	512	PF02991	0.352
LIG_LIR_Gen_1	140	148	PF02991	0.503
LIG_LIR_Gen_1	348	357	PF02991	0.370
LIG_LIR_Nem_3	140	146	PF02991	0.511
LIG_LIR_Nem_3	348	353	PF02991	0.359
LIG_PDZ_Class_2	508	513	PF00595	0.378
LIG_Pex14_2	142	146	PF04695	0.357
LIG_RPA_C_Fungi	477	489	PF08784	0.380
LIG_SH2_CRK	11	15	PF00017	0.487
LIG_SH2_STAP1	355	359	PF00017	0.442
LIG_SH2_STAT5	11	14	PF00017	0.467
LIG_SH2_STAT5	143	146	PF00017	0.505
LIG_SH2_STAT5	164	167	PF00017	0.351
LIG_SH2_STAT5	493	496	PF00017	0.374
LIG_SH3_3	356	362	PF00018	0.495
LIG_SH3_3	368	374	PF00018	0.494
LIG_SH3_3	403	409	PF00018	0.521
LIG_SH3_3	418	424	PF00018	0.307
LIG_SUMO_SIM_anti_2	120	127	PF11976	0.382
LIG_SUMO_SIM_par_1	120	127	PF11976	0.312
LIG_SUMO_SIM_par_1	248	255	PF11976	0.480
LIG_SUMO_SIM_par_1	277	285	PF11976	0.370
LIG_SUMO_SIM_par_1	417	422	PF11976	0.475
MOD_CDK_SPxK_1	402	408	PF00069	0.430
MOD_CDK_SPxK_1	434	440	PF00069	0.458
MOD_CK1_1	214	220	PF00069	0.410
MOD_CK1_1	246	252	PF00069	0.417
MOD_CK1_1	267	273	PF00069	0.492
MOD_CK1_1	30	36	PF00069	0.696
MOD_CK1_1	308	314	PF00069	0.683
MOD_CK1_1	348	354	PF00069	0.451
MOD_CK1_1	469	475	PF00069	0.396
MOD_CK1_1	79	85	PF00069	0.637
MOD_CK1_1	88	94	PF00069	0.554
MOD_CK2_1	249	255	PF00069	0.421
MOD_CK2_1	271	277	PF00069	0.470
MOD_CK2_1	324	330	PF00069	0.657
MOD_CK2_1	381	387	PF00069	0.401
MOD_CK2_1	419	425	PF00069	0.467
MOD_CK2_1	480	486	PF00069	0.309
MOD_CK2_1	501	507	PF00069	0.483
MOD_CK2_1	62	68	PF00069	0.639
MOD_CK2_1	72	78	PF00069	0.558
MOD_GlcNHglycan	105	108	PF01048	0.709
MOD_GlcNHglycan	119	122	PF01048	0.326
MOD_GlcNHglycan	167	170	PF01048	0.332
MOD_GlcNHglycan	27	30	PF01048	0.647
MOD_GlcNHglycan	326	329	PF01048	0.633
MOD_GlcNHglycan	471	475	PF01048	0.389
MOD_GlcNHglycan	495	498	PF01048	0.344
MOD_GlcNHglycan	50	53	PF01048	0.700
MOD_GlcNHglycan	78	81	PF01048	0.748
MOD_GlcNHglycan	84	87	PF01048	0.777
MOD_GSK3_1	101	108	PF00069	0.543
MOD_GSK3_1	154	161	PF00069	0.472
MOD_GSK3_1	243	250	PF00069	0.366
MOD_GSK3_1	25	32	PF00069	0.745
MOD_GSK3_1	267	274	PF00069	0.479
MOD_GSK3_1	320	327	PF00069	0.683
MOD_GSK3_1	335	342	PF00069	0.312
MOD_GSK3_1	37	44	PF00069	0.538
MOD_GSK3_1	419	426	PF00069	0.432
MOD_GSK3_1	462	469	PF00069	0.378
MOD_GSK3_1	68	75	PF00069	0.702
MOD_GSK3_1	76	83	PF00069	0.640
MOD_GSK3_1	85	92	PF00069	0.510
MOD_N-GLC_1	410	415	PF02516	0.637
MOD_NEK2_1	1	6	PF00069	0.528
MOD_NEK2_1	123	128	PF00069	0.459
MOD_NEK2_1	175	180	PF00069	0.328
MOD_NEK2_1	271	276	PF00069	0.307
MOD_NEK2_1	410	415	PF00069	0.605
MOD_NEK2_2	362	367	PF00069	0.417
MOD_PIKK_1	222	228	PF00454	0.364
MOD_PK_1	154	160	PF00069	0.404
MOD_PK_1	243	249	PF00069	0.376
MOD_PK_1	62	68	PF00069	0.627
MOD_PKA_1	76	82	PF00069	0.622
MOD_PKA_2	183	189	PF00069	0.588
MOD_PKA_2	308	314	PF00069	0.707
MOD_PKA_2	320	326	PF00069	0.739
MOD_PKA_2	348	354	PF00069	0.451
MOD_PKA_2	481	487	PF00069	0.405
MOD_PKA_2	501	507	PF00069	0.331
MOD_PKA_2	72	78	PF00069	0.655
MOD_PKB_1	241	249	PF00069	0.355
MOD_PKB_1	60	68	PF00069	0.723
MOD_Plk_1	214	220	PF00069	0.467
MOD_Plk_1	243	249	PF00069	0.359
MOD_Plk_1	355	361	PF00069	0.334
MOD_Plk_4	206	212	PF00069	0.313
MOD_Plk_4	320	326	PF00069	0.570
MOD_Plk_4	355	361	PF00069	0.505
MOD_Plk_4	463	469	PF00069	0.367
MOD_ProDKin_1	30	36	PF00069	0.543
MOD_ProDKin_1	335	341	PF00069	0.345
MOD_ProDKin_1	402	408	PF00069	0.587
MOD_ProDKin_1	434	440	PF00069	0.458
MOD_ProDKin_1	85	91	PF00069	0.646
TRG_DiLeu_BaEn_1	215	220	PF01217	0.390
TRG_ENDOCYTIC_2	143	146	PF00928	0.505
TRG_ER_diArg_1	240	243	PF00400	0.332
TRG_NLS_Bipartite_1	45	63	PF00514	0.790
TRG_NLS_MonoExtC_3	189	194	PF00514	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P1	Leptomonas seymouri	63%	100%
A0A0S4JK75	Bodo saltans	33%	100%
A0A1X0NFD4	Trypanosomatidae	37%	99%
A0A3Q8ICP9	Leishmania donovani	99%	100%
A0A3R7KS12	Trypanosoma rangeli	46%	100%
A4HJM1	Leishmania braziliensis	79%	100%
C9ZME4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
C9ZWN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
E9B237	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q624	Leishmania major	90%	100%
V5B2M4	Trypanosoma cruzi	44%	100%