Putative p-nitrophenylphosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p-nitrophenylphosphatase - putative

Species:

Leishmania infantum

UniProt:

A4I740_LEIIN

TriTrypDb:

LINF_310031700

Length:

338

Annotations

Annotations by Jardim et al.

Phosphatase, p-nitrophenylphosphatase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I740

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I740

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.230
CLV_C14_Caspase3-7	261	265	PF00656	0.268
CLV_PCSK_SKI1_1	12	16	PF00082	0.348
CLV_PCSK_SKI1_1	221	225	PF00082	0.303
CLV_PCSK_SKI1_1	279	283	PF00082	0.220
CLV_PCSK_SKI1_1	293	297	PF00082	0.152
CLV_PCSK_SKI1_1	77	81	PF00082	0.274
DOC_CYCLIN_RxL_1	218	227	PF00134	0.298
DOC_CYCLIN_RxL_1	45	59	PF00134	0.365
DOC_MAPK_DCC_7	315	324	PF00069	0.177
DOC_MAPK_gen_1	69	76	PF00069	0.485
DOC_MAPK_MEF2A_6	315	324	PF00069	0.177
DOC_PP1_RVXF_1	49	56	PF00149	0.456
DOC_PP2B_LxvP_1	157	160	PF13499	0.378
DOC_PP2B_LxvP_1	331	334	PF13499	0.243
DOC_PP4_FxxP_1	222	225	PF00568	0.296
DOC_PP4_FxxP_1	99	102	PF00568	0.365
DOC_USP7_MATH_1	88	92	PF00917	0.400
DOC_USP7_MATH_2	81	87	PF00917	0.365
DOC_WW_Pin1_4	141	146	PF00397	0.260
DOC_WW_Pin1_4	98	103	PF00397	0.365
LIG_14-3-3_CanoR_1	279	286	PF00244	0.296
LIG_Actin_WH2_2	39	56	PF00022	0.365
LIG_APCC_ABBA_1	117	122	PF00400	0.365
LIG_BIR_II_1	1	5	PF00653	0.322
LIG_BRCT_BRCA1_1	51	55	PF00533	0.365
LIG_Clathr_ClatBox_1	22	26	PF01394	0.464
LIG_FHA_1	151	157	PF00498	0.414
LIG_FHA_1	200	206	PF00498	0.349
LIG_FHA_1	292	298	PF00498	0.253
LIG_FHA_1	314	320	PF00498	0.398
LIG_FHA_1	57	63	PF00498	0.365
LIG_FHA_2	207	213	PF00498	0.370
LIG_FHA_2	303	309	PF00498	0.239
LIG_LIR_Apic_2	150	155	PF02991	0.541
LIG_LIR_Apic_2	97	102	PF02991	0.365
LIG_LIR_Gen_1	17	28	PF02991	0.173
LIG_LIR_Gen_1	329	338	PF02991	0.444
LIG_LIR_Nem_3	130	134	PF02991	0.327
LIG_LIR_Nem_3	17	23	PF02991	0.194
LIG_LIR_Nem_3	329	333	PF02991	0.400
LIG_NRBOX	10	16	PF00104	0.229
LIG_PDZ_Class_1	333	338	PF00595	0.309
LIG_SH2_NCK_1	85	89	PF00017	0.540
LIG_SH2_PTP2	20	23	PF00017	0.297
LIG_SH2_STAP1	185	189	PF00017	0.250
LIG_SH2_STAP1	85	89	PF00017	0.484
LIG_SH2_STAT5	20	23	PF00017	0.278
LIG_SH2_STAT5	94	97	PF00017	0.494
LIG_SH3_3	110	116	PF00018	0.461
LIG_SH3_3	123	129	PF00018	0.515
LIG_SH3_3	139	145	PF00018	0.345
LIG_SH3_3	152	158	PF00018	0.484
LIG_SH3_3	210	216	PF00018	0.411
LIG_SUMO_SIM_par_1	21	26	PF11976	0.464
LIG_TYR_ITIM	18	23	PF00017	0.321
LIG_UBA3_1	280	288	PF00899	0.250
LIG_WRC_WIRS_1	46	51	PF05994	0.365
MOD_CDK_SPxxK_3	98	105	PF00069	0.365
MOD_CK2_1	296	302	PF00069	0.302
MOD_CK2_1	97	103	PF00069	0.447
MOD_GlcNHglycan	226	229	PF01048	0.335
MOD_GlcNHglycan	298	301	PF01048	0.341
MOD_GlcNHglycan	30	33	PF01048	0.176
MOD_GlcNHglycan	85	88	PF01048	0.259
MOD_GlcNHglycan	90	93	PF01048	0.252
MOD_GSK3_1	129	136	PF00069	0.234
MOD_GSK3_1	137	144	PF00069	0.227
MOD_GSK3_1	45	52	PF00069	0.456
MOD_N-GLC_1	187	192	PF02516	0.217
MOD_NEK2_1	1	6	PF00069	0.408
MOD_NEK2_1	206	211	PF00069	0.235
MOD_NEK2_1	296	301	PF00069	0.296
MOD_NEK2_1	49	54	PF00069	0.514
MOD_PIKK_1	313	319	PF00454	0.268
MOD_Plk_1	129	135	PF00069	0.238
MOD_Plk_4	122	128	PF00069	0.365
MOD_Plk_4	137	143	PF00069	0.212
MOD_Plk_4	56	62	PF00069	0.472
MOD_ProDKin_1	141	147	PF00069	0.256
MOD_ProDKin_1	98	104	PF00069	0.365
MOD_SUMO_rev_2	259	268	PF00179	0.177
MOD_SUMO_rev_2	4	14	PF00179	0.247
TRG_DiLeu_BaEn_1	10	15	PF01217	0.314
TRG_DiLeu_BaEn_1	318	323	PF01217	0.177
TRG_ENDOCYTIC_2	20	23	PF00928	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P266	Leptomonas seymouri	54%	99%
A0A0S4IZ46	Bodo saltans	40%	100%
A0A3Q8IFQ8	Leishmania donovani	42%	82%
A0A422N412	Trypanosoma rangeli	43%	91%
A4HJL7	Leishmania braziliensis	42%	100%
A4HJL8	Leishmania braziliensis	40%	100%
A4I739	Leishmania infantum	42%	100%
A4QFW4	Corynebacterium glutamicum (strain R)	25%	100%
A6NDG6	Homo sapiens	30%	100%
C9ZWP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	87%
D3ZDK7	Rattus norvegicus	31%	100%
E9B234	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
O32125	Bacillus subtilis (strain 168)	25%	100%
O33194	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	96%
P0DKC3	Arabidopsis thaliana	31%	93%
P0DKC4	Arabidopsis thaliana	31%	93%
P19881	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P46351	Paenibacillus thiaminolyticus	26%	82%
P60487	Mus musculus	31%	100%
Q00472	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q2FIE5	Staphylococcus aureus (strain USA300)	28%	100%
Q2FZX0	Staphylococcus aureus (strain NCTC 8325 / PS 47)	28%	100%
Q2T9S4	Bos taurus	30%	100%
Q2YWR1	Staphylococcus aureus (strain bovine RF122 / ET3-1)	27%	100%
Q3ZBF9	Bos taurus	31%	100%
Q4L4U2	Staphylococcus haemolyticus (strain JCSC1435)	27%	100%
Q4Q627	Leishmania major	41%	100%
Q5F4B1	Gallus gallus	28%	100%
Q5HHF6	Staphylococcus aureus (strain COL)	28%	100%
Q5HQN3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	26%	100%
Q6GAZ7	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GIF9	Staphylococcus aureus (strain MRSA252)	28%	100%
Q7A1D4	Staphylococcus aureus (strain MW2)	28%	100%
Q7A6K4	Staphylococcus aureus (strain N315)	28%	100%
Q8CHP8	Mus musculus	31%	100%
Q8CPW3	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	26%	100%
Q8GWU0	Arabidopsis thaliana	31%	100%
Q8VD52	Rattus norvegicus	30%	100%
Q96GD0	Homo sapiens	31%	100%
Q99VE8	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
V5D2X9	Trypanosoma cruzi	40%	78%