LeishMANIAdb
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Putative 3,2-trans-enoyl-CoA isomerase, mitochondrial

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 3,2-trans-enoyl-CoA isomerase, mitochondrial
Gene product:
3 -2-trans-enoyl-CoA isomerase - mitochondrial precursor - putative
Species:
Leishmania infantum
UniProt:
A4I738_LEIIN
TriTrypDb:
LINF_310031500
Length:
349

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, 3,2-trans-enoyl-CoA isomerase, mitochondrial

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 4
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I738
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I738

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 2
GO:0006629 lipid metabolic process 3 2
GO:0006631 fatty acid metabolic process 4 2
GO:0006635 fatty acid beta-oxidation 6 2
GO:0008152 metabolic process 1 2
GO:0009056 catabolic process 2 2
GO:0009062 fatty acid catabolic process 5 2
GO:0009987 cellular process 1 2
GO:0016042 lipid catabolic process 4 2
GO:0016054 organic acid catabolic process 4 2
GO:0019395 fatty acid oxidation 5 2
GO:0019752 carboxylic acid metabolic process 5 2
GO:0030258 lipid modification 4 2
GO:0032787 monocarboxylic acid metabolic process 6 2
GO:0034440 lipid oxidation 5 2
GO:0043436 oxoacid metabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044242 cellular lipid catabolic process 4 2
GO:0044248 cellular catabolic process 3 2
GO:0044255 cellular lipid metabolic process 3 2
GO:0044281 small molecule metabolic process 2 2
GO:0044282 small molecule catabolic process 3 2
GO:0046395 carboxylic acid catabolic process 5 2
GO:0071704 organic substance metabolic process 2 2
GO:0072329 monocarboxylic acid catabolic process 6 2
GO:1901575 organic substance catabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 19
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity 5 5
GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity 5 12
GO:0016491 oxidoreductase activity 2 5
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 5
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 5
GO:0016853 isomerase activity 2 19
GO:0016860 intramolecular oxidoreductase activity 3 12
GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4 12
GO:0004300 enoyl-CoA hydratase activity 5 2
GO:0016829 lyase activity 2 2
GO:0016835 carbon-oxygen lyase activity 3 2
GO:0016836 hydro-lyase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.638
CLV_NRD_NRD_1 295 297 PF00675 0.381
CLV_NRD_NRD_1 347 349 PF00675 0.645
CLV_PCSK_KEX2_1 2 4 PF00082 0.639
CLV_PCSK_KEX2_1 295 297 PF00082 0.367
CLV_PCSK_KEX2_1 61 63 PF00082 0.590
CLV_PCSK_PC1ET2_1 61 63 PF00082 0.590
CLV_PCSK_SKI1_1 43 47 PF00082 0.523
CLV_PCSK_SKI1_1 90 94 PF00082 0.378
DEG_Nend_UBRbox_1 1 4 PF02207 0.659
DEG_SPOP_SBC_1 4 8 PF00917 0.761
DOC_CYCLIN_RxL_1 243 254 PF00134 0.328
DOC_CYCLIN_yClb5_NLxxxL_5 334 340 PF00134 0.459
DOC_PP2B_LxvP_1 226 229 PF13499 0.406
DOC_PP2B_LxvP_1 288 291 PF13499 0.403
DOC_PP4_FxxP_1 173 176 PF00568 0.330
DOC_PP4_FxxP_1 70 73 PF00568 0.502
DOC_USP7_MATH_1 101 105 PF00917 0.322
DOC_USP7_MATH_1 4 8 PF00917 0.622
DOC_USP7_MATH_1 57 61 PF00917 0.605
DOC_WW_Pin1_4 182 187 PF00397 0.305
DOC_WW_Pin1_4 251 256 PF00397 0.353
LIG_14-3-3_CanoR_1 11 17 PF00244 0.610
LIG_14-3-3_CanoR_1 286 291 PF00244 0.447
LIG_14-3-3_CanoR_1 308 318 PF00244 0.265
LIG_APCC_ABBA_1 107 112 PF00400 0.337
LIG_BIR_III_2 65 69 PF00653 0.628
LIG_BRCT_BRCA1_1 19 23 PF00533 0.556
LIG_deltaCOP1_diTrp_1 165 173 PF00928 0.330
LIG_FHA_1 124 130 PF00498 0.376
LIG_FHA_1 13 19 PF00498 0.742
LIG_FHA_2 310 316 PF00498 0.341
LIG_LIR_Apic_2 172 176 PF02991 0.351
LIG_LIR_Apic_2 69 73 PF02991 0.530
LIG_LIR_Gen_1 108 118 PF02991 0.342
LIG_LIR_Gen_1 162 170 PF02991 0.352
LIG_LIR_Gen_1 285 294 PF02991 0.330
LIG_LIR_Gen_1 305 311 PF02991 0.394
LIG_LIR_Nem_3 108 113 PF02991 0.342
LIG_LIR_Nem_3 165 170 PF02991 0.345
LIG_LIR_Nem_3 285 290 PF02991 0.330
LIG_LIR_Nem_3 305 309 PF02991 0.348
LIG_LIR_Nem_3 320 326 PF02991 0.429
LIG_LYPXL_SIV_4 280 288 PF13949 0.476
LIG_PCNA_PIPBox_1 333 342 PF02747 0.403
LIG_PCNA_yPIPBox_3 329 340 PF02747 0.366
LIG_Pex14_2 159 163 PF04695 0.330
LIG_SH2_CRK 236 240 PF00017 0.325
LIG_SH2_STAP1 236 240 PF00017 0.325
LIG_SH2_STAP1 318 322 PF00017 0.318
LIG_SH2_STAT3 28 31 PF00017 0.681
LIG_SH2_STAT5 238 241 PF00017 0.342
LIG_SH2_STAT5 306 309 PF00017 0.430
LIG_SH2_STAT5 339 342 PF00017 0.379
LIG_SH3_3 145 151 PF00018 0.476
LIG_SH3_3 224 230 PF00018 0.438
LIG_SH3_3 33 39 PF00018 0.612
LIG_SH3_3 70 76 PF00018 0.497
LIG_SxIP_EBH_1 127 141 PF03271 0.343
LIG_TRAF2_1 162 165 PF00917 0.320
LIG_TRAF2_1 271 274 PF00917 0.517
LIG_TRFH_1 326 330 PF08558 0.250
LIG_UBA3_1 82 90 PF00899 0.385
MOD_CK1_1 60 66 PF00069 0.649
MOD_CK1_1 7 13 PF00069 0.776
MOD_CK2_1 159 165 PF00069 0.410
MOD_CK2_1 272 278 PF00069 0.479
MOD_CK2_1 335 341 PF00069 0.340
MOD_CMANNOS 116 119 PF00535 0.353
MOD_GlcNHglycan 132 135 PF01048 0.379
MOD_GlcNHglycan 139 142 PF01048 0.330
MOD_GlcNHglycan 19 22 PF01048 0.649
MOD_GSK3_1 130 137 PF00069 0.323
MOD_GSK3_1 3 10 PF00069 0.744
MOD_GSK3_1 317 324 PF00069 0.466
MOD_N-GLC_1 219 224 PF02516 0.335
MOD_NEK2_1 159 164 PF00069 0.342
MOD_NEK2_1 219 224 PF00069 0.348
MOD_NEK2_1 23 28 PF00069 0.543
MOD_NEK2_1 239 244 PF00069 0.185
MOD_PIKK_1 23 29 PF00454 0.601
MOD_PIKK_1 321 327 PF00454 0.330
MOD_PK_1 286 292 PF00069 0.434
MOD_PKA_1 74 80 PF00069 0.636
MOD_Plk_1 272 278 PF00069 0.488
MOD_Plk_2-3 273 279 PF00069 0.338
MOD_Plk_4 134 140 PF00069 0.349
MOD_Plk_4 335 341 PF00069 0.340
MOD_ProDKin_1 182 188 PF00069 0.305
MOD_ProDKin_1 251 257 PF00069 0.353
MOD_SUMO_rev_2 124 129 PF00179 0.436
TRG_DiLeu_BaEn_1 305 310 PF01217 0.265
TRG_DiLeu_LyEn_5 305 310 PF01217 0.265
TRG_ENDOCYTIC_2 198 201 PF00928 0.476
TRG_ENDOCYTIC_2 236 239 PF00928 0.340
TRG_ENDOCYTIC_2 306 309 PF00928 0.430
TRG_ER_diArg_1 1 3 PF00400 0.642
TRG_ER_diArg_1 295 297 PF00400 0.363
TRG_Pf-PMV_PEXEL_1 308 313 PF00026 0.429

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4C8 Leptomonas seymouri 72% 99%
A0A0S4IKH3 Bodo saltans 57% 100%
A0A0S4JA19 Bodo saltans 35% 100%
A0A1X0NRI1 Trypanosomatidae 52% 95%
A0A1X0P9A2 Trypanosomatidae 25% 100%
A0A3Q8IE71 Leishmania donovani 35% 100%
A0A3Q8IIZ5 Leishmania donovani 26% 100%
A0A3Q8IV04 Leishmania donovani 28% 100%
A0A3R7N7B2 Trypanosoma rangeli 25% 100%
A0A3S7X4R5 Leishmania donovani 91% 100%
A0A3S7X4T7 Leishmania donovani 88% 100%
A0A422N418 Trypanosoma rangeli 59% 100%
A0A422NUW6 Trypanosoma rangeli 32% 100%
A1KN36 Mycobacterium bovis (strain BCG / Pasteur 1173P2) 27% 100%
A4HH09 Leishmania braziliensis 34% 100%
A4HJK3 Leishmania braziliensis 72% 98%
A4HJK8 Leishmania braziliensis 76% 98%
A4HJL5 Leishmania braziliensis 72% 98%
A4I438 Leishmania infantum 34% 100%
A4I4U5 Leishmania infantum 26% 100%
A4I708 Leishmania infantum 91% 98%
A5U753 Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) 27% 100%
A9JS71 Xenopus laevis 26% 100%
C9ZKS4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZME0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 74%
C9ZWP5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 97%
E9ADK3 Leishmania major 33% 100%
E9AE93 Leishmania major 27% 100%
E9AEL3 Leishmania major 27% 100%
E9AHU0 Leishmania infantum 28% 100%
E9ALJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AM78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B226 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 98%
E9B233 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 97%
E9B5S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
O07137 Mycobacterium leprae (strain TN) 22% 100%
O35459 Mus musculus 22% 100%
P14604 Rattus norvegicus 24% 100%
P23965 Rattus norvegicus 39% 100%
P30084 Homo sapiens 23% 100%
P34559 Caenorhabditis elegans 21% 100%
P42125 Mus musculus 38% 100%
P42126 Homo sapiens 38% 100%
P52046 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) 22% 100%
P64017 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 22% 100%
P9WNN2 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 27% 100%
P9WNN3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 27% 100%
P9WNN8 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 22% 100%
P9WNN9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 22% 100%
Q0AVM1 Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) 25% 100%
Q1ZXF1 Dictyostelium discoideum 24% 100%
Q4Q628 Leishmania major 90% 100%
Q4Q636 Leishmania major 87% 100%
Q52995 Rhizobium meliloti (strain 1021) 24% 100%
Q58DM8 Bos taurus 24% 100%
Q5R646 Pongo abelii 23% 100%
Q62651 Rattus norvegicus 22% 100%
Q6AYG5 Rattus norvegicus 27% 100%
Q7TXE1 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 27% 100%
Q8BH95 Mus musculus 24% 100%
V5B2L9 Trypanosoma cruzi 56% 89%
V5BK92 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS