Helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

helicase-like protein

Species:

Leishmania infantum

UniProt:

A4I737_LEIIN

TriTrypDb:

LINF_310031400

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I737

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I737

Function

Biological processes
Term	Name	Level	Count
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0044030	regulation of DNA methylation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051052	regulation of DNA metabolic process	5	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004386	helicase activity	2	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0008094	ATP-dependent activity, acting on DNA	2	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140097	catalytic activity, acting on DNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6
GO:0140657	ATP-dependent activity	1	6
GO:0140658	ATP-dependent chromatin remodeler activity	3	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0016491	oxidoreductase activity	2	4
GO:0051213	dioxygenase activity	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.459
CLV_C14_Caspase3-7	549	553	PF00656	0.503
CLV_NRD_NRD_1	179	181	PF00675	0.324
CLV_NRD_NRD_1	294	296	PF00675	0.279
CLV_NRD_NRD_1	309	311	PF00675	0.349
CLV_NRD_NRD_1	314	316	PF00675	0.219
CLV_NRD_NRD_1	372	374	PF00675	0.315
CLV_NRD_NRD_1	419	421	PF00675	0.315
CLV_NRD_NRD_1	440	442	PF00675	0.562
CLV_NRD_NRD_1	475	477	PF00675	0.608
CLV_NRD_NRD_1	534	536	PF00675	0.702
CLV_NRD_NRD_1	628	630	PF00675	0.702
CLV_NRD_NRD_1	690	692	PF00675	0.618
CLV_NRD_NRD_1	813	815	PF00675	0.570
CLV_PCSK_FUR_1	177	181	PF00082	0.384
CLV_PCSK_KEX2_1	179	181	PF00082	0.327
CLV_PCSK_KEX2_1	294	296	PF00082	0.279
CLV_PCSK_KEX2_1	309	311	PF00082	0.349
CLV_PCSK_KEX2_1	314	316	PF00082	0.226
CLV_PCSK_KEX2_1	372	374	PF00082	0.315
CLV_PCSK_KEX2_1	439	441	PF00082	0.562
CLV_PCSK_KEX2_1	474	476	PF00082	0.586
CLV_PCSK_KEX2_1	536	538	PF00082	0.691
CLV_PCSK_KEX2_1	628	630	PF00082	0.699
CLV_PCSK_KEX2_1	692	694	PF00082	0.649
CLV_PCSK_KEX2_1	869	871	PF00082	0.773
CLV_PCSK_KEX2_1	881	883	PF00082	0.565
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.691
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.739
CLV_PCSK_PC1ET2_1	869	871	PF00082	0.773
CLV_PCSK_PC1ET2_1	881	883	PF00082	0.565
CLV_PCSK_PC7_1	175	181	PF00082	0.327
CLV_PCSK_PC7_1	310	316	PF00082	0.349
CLV_PCSK_SKI1_1	14	18	PF00082	0.615
CLV_PCSK_SKI1_1	146	150	PF00082	0.384
CLV_PCSK_SKI1_1	179	183	PF00082	0.315
CLV_PCSK_SKI1_1	259	263	PF00082	0.315
CLV_PCSK_SKI1_1	36	40	PF00082	0.617
CLV_PCSK_SKI1_1	363	367	PF00082	0.315
CLV_PCSK_SKI1_1	372	376	PF00082	0.315
CLV_PCSK_SKI1_1	479	483	PF00082	0.445
CLV_PCSK_SKI1_1	814	818	PF00082	0.551
CLV_PCSK_SKI1_1	882	886	PF00082	0.709
CLV_PCSK_SKI1_1	891	895	PF00082	0.497
CLV_PCSK_SKI1_1	90	94	PF00082	0.423
CLV_Separin_Metazoa	147	151	PF03568	0.584
DEG_APCC_DBOX_1	35	43	PF00400	0.618
DEG_APCC_DBOX_1	449	457	PF00400	0.591
DEG_APCC_DBOX_1	534	542	PF00400	0.662
DEG_APCC_DBOX_1	895	903	PF00400	0.675
DEG_SPOP_SBC_1	570	574	PF00917	0.784
DOC_CKS1_1	390	395	PF01111	0.515
DOC_CKS1_1	612	617	PF01111	0.631
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.584
DOC_MAPK_gen_1	372	382	PF00069	0.515
DOC_MAPK_gen_1	474	483	PF00069	0.468
DOC_MAPK_gen_1	814	823	PF00069	0.587
DOC_MAPK_HePTP_8	370	382	PF00069	0.584
DOC_MAPK_MEF2A_6	253	262	PF00069	0.473
DOC_MAPK_MEF2A_6	373	382	PF00069	0.584
DOC_PP1_RVXF_1	223	230	PF00149	0.515
DOC_PP1_RVXF_1	450	456	PF00149	0.546
DOC_PP1_RVXF_1	477	484	PF00149	0.455
DOC_PP2B_LxvP_1	388	391	PF13499	0.584
DOC_PP4_FxxP_1	567	570	PF00568	0.585
DOC_PP4_FxxP_1	646	649	PF00568	0.710
DOC_USP7_MATH_1	16	20	PF00917	0.602
DOC_USP7_MATH_1	529	533	PF00917	0.678
DOC_USP7_MATH_1	571	575	PF00917	0.794
DOC_USP7_MATH_1	623	627	PF00917	0.602
DOC_USP7_MATH_1	653	657	PF00917	0.762
DOC_USP7_MATH_1	663	667	PF00917	0.483
DOC_USP7_MATH_1	677	681	PF00917	0.456
DOC_USP7_MATH_1	904	908	PF00917	0.755
DOC_USP7_UBL2_3	242	246	PF12436	0.584
DOC_USP7_UBL2_3	381	385	PF12436	0.495
DOC_USP7_UBL2_3	458	462	PF12436	0.528
DOC_WW_Pin1_4	262	267	PF00397	0.515
DOC_WW_Pin1_4	389	394	PF00397	0.515
DOC_WW_Pin1_4	439	444	PF00397	0.740
DOC_WW_Pin1_4	525	530	PF00397	0.720
DOC_WW_Pin1_4	611	616	PF00397	0.632
DOC_WW_Pin1_4	654	659	PF00397	0.715
DOC_WW_Pin1_4	667	672	PF00397	0.668
DOC_WW_Pin1_4	73	78	PF00397	0.706
DOC_WW_Pin1_4	796	801	PF00397	0.479
LIG_14-3-3_CanoR_1	331	339	PF00244	0.549
LIG_14-3-3_CanoR_1	373	379	PF00244	0.515
LIG_14-3-3_CanoR_1	404	411	PF00244	0.534
LIG_14-3-3_CanoR_1	654	658	PF00244	0.762
LIG_14-3-3_CanoR_1	693	702	PF00244	0.763
LIG_14-3-3_CanoR_1	834	842	PF00244	0.634
LIG_14-3-3_CanoR_1	872	878	PF00244	0.729
LIG_14-3-3_CanoR_1	882	892	PF00244	0.480
LIG_Actin_WH2_2	134	152	PF00022	0.584
LIG_Actin_WH2_2	358	374	PF00022	0.517
LIG_Actin_WH2_2	486	502	PF00022	0.544
LIG_APCC_ABBA_1	599	604	PF00400	0.792
LIG_APCC_ABBA_1	771	776	PF00400	0.515
LIG_BRCT_BRCA1_1	584	588	PF00533	0.793
LIG_deltaCOP1_diTrp_1	142	151	PF00928	0.515
LIG_EVH1_2	671	675	PF00568	0.576
LIG_FHA_1	111	117	PF00498	0.515
LIG_FHA_1	124	130	PF00498	0.515
LIG_FHA_1	161	167	PF00498	0.584
LIG_FHA_1	375	381	PF00498	0.584
LIG_FHA_1	485	491	PF00498	0.454
LIG_FHA_1	512	518	PF00498	0.719
LIG_FHA_1	55	61	PF00498	0.681
LIG_FHA_1	634	640	PF00498	0.723
LIG_FHA_1	676	682	PF00498	0.630
LIG_FHA_1	761	767	PF00498	0.515
LIG_FHA_2	230	236	PF00498	0.584
LIG_FHA_2	274	280	PF00498	0.515
LIG_FHA_2	547	553	PF00498	0.492
LIG_FHA_2	612	618	PF00498	0.632
LIG_FHA_2	757	763	PF00498	0.515
LIG_FHA_2	800	806	PF00498	0.497
LIG_FHA_2	836	842	PF00498	0.774
LIG_FHA_2	884	890	PF00498	0.567
LIG_LIR_Apic_2	279	283	PF02991	0.515
LIG_LIR_Apic_2	643	649	PF02991	0.712
LIG_LIR_Gen_1	131	138	PF02991	0.515
LIG_LIR_Gen_1	212	218	PF02991	0.515
LIG_LIR_Gen_1	272	283	PF02991	0.485
LIG_LIR_Gen_1	494	504	PF02991	0.450
LIG_LIR_Nem_3	131	135	PF02991	0.476
LIG_LIR_Nem_3	212	216	PF02991	0.515
LIG_LIR_Nem_3	272	278	PF02991	0.485
LIG_LIR_Nem_3	494	499	PF02991	0.443
LIG_LIR_Nem_3	626	630	PF02991	0.605
LIG_NRBOX	273	279	PF00104	0.515
LIG_NRBOX	889	895	PF00104	0.524
LIG_PCNA_PIPBox_1	268	277	PF02747	0.515
LIG_Pex14_2	646	650	PF04695	0.719
LIG_Rb_LxCxE_1	1	19	PF01857	0.543
LIG_SH2_CRK	386	390	PF00017	0.515
LIG_SH2_CRK	402	406	PF00017	0.515
LIG_SH2_CRK	795	799	PF00017	0.457
LIG_SH2_GRB2like	411	414	PF00017	0.584
LIG_SH2_GRB2like	433	436	PF00017	0.435
LIG_SH2_NCK_1	402	406	PF00017	0.515
LIG_SH2_NCK_1	583	587	PF00017	0.707
LIG_SH2_PTP2	280	283	PF00017	0.515
LIG_SH2_SRC	433	436	PF00017	0.610
LIG_SH2_STAP1	213	217	PF00017	0.515
LIG_SH2_STAP1	386	390	PF00017	0.515
LIG_SH2_STAP1	685	689	PF00017	0.649
LIG_SH2_STAT5	280	283	PF00017	0.515
LIG_SH2_STAT5	496	499	PF00017	0.381
LIG_SH2_STAT5	548	551	PF00017	0.471
LIG_SH3_1	440	446	PF00018	0.681
LIG_SH3_3	334	340	PF00018	0.566
LIG_SH3_3	362	368	PF00018	0.549
LIG_SH3_3	390	396	PF00018	0.584
LIG_SH3_3	440	446	PF00018	0.731
LIG_SH3_3	609	615	PF00018	0.805
LIG_SH3_3	65	71	PF00018	0.728
LIG_SH3_3	844	850	PF00018	0.654
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.549
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.584
LIG_SUMO_SIM_anti_2	762	768	PF11976	0.515
LIG_SUMO_SIM_par_1	762	768	PF11976	0.515
LIG_SUMO_SIM_par_1	91	97	PF11976	0.529
LIG_TRAF2_1	351	354	PF00917	0.495
LIG_TYR_ITIM	400	405	PF00017	0.380
LIG_TYR_ITIM	546	551	PF00017	0.469
LIG_UBA3_1	247	253	PF00899	0.380
LIG_UBA3_1	358	363	PF00899	0.477
LIG_WRC_WIRS_1	129	134	PF05994	0.380
LIG_WW_1	383	386	PF00397	0.380
MOD_CDK_SPK_2	392	397	PF00069	0.352
MOD_CDK_SPK_2	525	530	PF00069	0.720
MOD_CDK_SPxxK_3	611	618	PF00069	0.633
MOD_CK1_1	19	25	PF00069	0.606
MOD_CK1_1	212	218	PF00069	0.380
MOD_CK1_1	414	420	PF00069	0.380
MOD_CK1_1	445	451	PF00069	0.606
MOD_CK1_1	484	490	PF00069	0.450
MOD_CK1_1	696	702	PF00069	0.686
MOD_CK1_1	707	713	PF00069	0.707
MOD_CK1_1	72	78	PF00069	0.661
MOD_CK1_1	720	726	PF00069	0.684
MOD_CK1_1	729	735	PF00069	0.566
MOD_CK1_1	799	805	PF00069	0.481
MOD_CK1_1	873	879	PF00069	0.701
MOD_CK2_1	136	142	PF00069	0.477
MOD_CK2_1	273	279	PF00069	0.380
MOD_CK2_1	41	47	PF00069	0.564
MOD_CK2_1	445	451	PF00069	0.572
MOD_CK2_1	552	558	PF00069	0.559
MOD_CK2_1	663	669	PF00069	0.775
MOD_CK2_1	883	889	PF00069	0.576
MOD_CMANNOS	151	154	PF00535	0.380
MOD_Cter_Amidation	533	536	PF01082	0.655
MOD_DYRK1A_RPxSP_1	654	658	PF00069	0.637
MOD_GlcNHglycan	321	325	PF01048	0.302
MOD_GlcNHglycan	447	450	PF01048	0.605
MOD_GlcNHglycan	459	462	PF01048	0.337
MOD_GlcNHglycan	525	528	PF01048	0.772
MOD_GlcNHglycan	555	558	PF01048	0.649
MOD_GlcNHglycan	584	587	PF01048	0.791
MOD_GlcNHglycan	651	654	PF01048	0.675
MOD_GlcNHglycan	693	696	PF01048	0.648
MOD_GlcNHglycan	732	735	PF01048	0.712
MOD_GlcNHglycan	808	811	PF01048	0.578
MOD_GlcNHglycan	838	841	PF01048	0.724
MOD_GlcNHglycan	872	875	PF01048	0.773
MOD_GSK3_1	136	143	PF00069	0.427
MOD_GSK3_1	169	176	PF00069	0.302
MOD_GSK3_1	269	276	PF00069	0.477
MOD_GSK3_1	326	333	PF00069	0.406
MOD_GSK3_1	525	532	PF00069	0.692
MOD_GSK3_1	54	61	PF00069	0.635
MOD_GSK3_1	582	589	PF00069	0.711
MOD_GSK3_1	649	656	PF00069	0.677
MOD_GSK3_1	663	670	PF00069	0.697
MOD_GSK3_1	687	694	PF00069	0.570
MOD_GSK3_1	69	76	PF00069	0.639
MOD_GSK3_1	696	703	PF00069	0.653
MOD_GSK3_1	704	711	PF00069	0.650
MOD_GSK3_1	719	726	PF00069	0.645
MOD_GSK3_1	756	763	PF00069	0.380
MOD_GSK3_1	872	879	PF00069	0.696
MOD_N-GLC_1	667	672	PF02516	0.657
MOD_N-GLC_1	756	761	PF02516	0.380
MOD_N-GLC_2	435	437	PF02516	0.455
MOD_NEK2_1	110	115	PF00069	0.355
MOD_NEK2_1	123	128	PF00069	0.266
MOD_NEK2_1	201	206	PF00069	0.468
MOD_NEK2_1	247	252	PF00069	0.346
MOD_NEK2_1	260	265	PF00069	0.380
MOD_NEK2_1	481	486	PF00069	0.439
MOD_NEK2_1	546	551	PF00069	0.491
MOD_NEK2_1	675	680	PF00069	0.730
MOD_NEK2_1	725	730	PF00069	0.691
MOD_NEK2_1	745	750	PF00069	0.440
MOD_NEK2_1	756	761	PF00069	0.380
MOD_NEK2_2	677	682	PF00069	0.622
MOD_PIKK_1	16	22	PF00454	0.606
MOD_PIKK_1	481	487	PF00454	0.446
MOD_PIKK_1	540	546	PF00454	0.612
MOD_PIKK_1	829	835	PF00454	0.747
MOD_PKA_1	691	697	PF00069	0.583
MOD_PKA_2	160	166	PF00069	0.380
MOD_PKA_2	330	336	PF00069	0.477
MOD_PKA_2	409	415	PF00069	0.394
MOD_PKA_2	523	529	PF00069	0.749
MOD_PKA_2	653	659	PF00069	0.764
MOD_PKA_2	806	812	PF00069	0.471
MOD_PKB_1	171	179	PF00069	0.333
MOD_PKB_1	535	543	PF00069	0.656
MOD_PKB_1	691	699	PF00069	0.749
MOD_PKB_1	870	878	PF00069	0.789
MOD_Plk_1	229	235	PF00069	0.434
MOD_Plk_1	663	669	PF00069	0.775
MOD_Plk_1	723	729	PF00069	0.745
MOD_Plk_2-3	273	279	PF00069	0.380
MOD_Plk_4	128	134	PF00069	0.355
MOD_Plk_4	212	218	PF00069	0.461
MOD_Plk_4	361	367	PF00069	0.427
MOD_Plk_4	537	543	PF00069	0.496
MOD_Plk_4	760	766	PF00069	0.380
MOD_ProDKin_1	262	268	PF00069	0.380
MOD_ProDKin_1	389	395	PF00069	0.380
MOD_ProDKin_1	439	445	PF00069	0.738
MOD_ProDKin_1	525	531	PF00069	0.714
MOD_ProDKin_1	611	617	PF00069	0.632
MOD_ProDKin_1	654	660	PF00069	0.716
MOD_ProDKin_1	667	673	PF00069	0.670
MOD_ProDKin_1	73	79	PF00069	0.690
MOD_ProDKin_1	796	802	PF00069	0.474
MOD_SUMO_for_1	816	819	PF00179	0.586
MOD_SUMO_rev_2	809	816	PF00179	0.616
TRG_DiLeu_BaEn_1	273	278	PF01217	0.380
TRG_DiLeu_BaEn_1	353	358	PF01217	0.477
TRG_DiLeu_BaEn_1	889	894	PF01217	0.525
TRG_DiLeu_BaEn_2	450	456	PF01217	0.546
TRG_DiLeu_BaEn_4	494	500	PF01217	0.543
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.380
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.477
TRG_DiLeu_BaLyEn_6	888	893	PF01217	0.636
TRG_ENDOCYTIC_2	213	216	PF00928	0.368
TRG_ENDOCYTIC_2	386	389	PF00928	0.380
TRG_ENDOCYTIC_2	402	405	PF00928	0.380
TRG_ENDOCYTIC_2	496	499	PF00928	0.415
TRG_ENDOCYTIC_2	548	551	PF00928	0.443
TRG_ENDOCYTIC_2	685	688	PF00928	0.549
TRG_ENDOCYTIC_2	795	798	PF00928	0.458
TRG_ER_diArg_1	170	173	PF00400	0.392
TRG_ER_diArg_1	174	177	PF00400	0.396
TRG_ER_diArg_1	294	297	PF00400	0.374
TRG_ER_diArg_1	309	311	PF00400	0.428
TRG_ER_diArg_1	371	373	PF00400	0.380
TRG_ER_diArg_1	439	441	PF00400	0.562
TRG_ER_diArg_1	473	476	PF00400	0.483
TRG_ER_diArg_1	535	538	PF00400	0.660
TRG_ER_diArg_1	627	629	PF00400	0.692
TRG_ER_diArg_1	634	637	PF00400	0.704
TRG_NLS_MonoExtC_3	867	872	PF00514	0.770
TRG_NLS_MonoExtN_4	866	873	PF00514	0.766
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.716
TRG_Pf-PMV_PEXEL_1	814	819	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	891	895	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGB2	Leptomonas seymouri	48%	100%
A0A3Q8IIQ9	Leishmania donovani	99%	100%
E9B232	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O74842	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	71%
Q4Q629	Leishmania major	92%	100%
Q9UTN6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	76%