LeishMANIAdb
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Putative 3'-nucleotidase/nuclease

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 3'-nucleotidase/nuclease
Gene product:
3'-nucleotidase/nuclease precursor - putative
Species:
Leishmania infantum
UniProt:
A4I736_LEIIN
TriTrypDb:
LINF_310031300
Length:
378

Annotations

Annotations by Jardim et al.

Nucleases, 3'-nucleotidase/nuclease

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 22, no: 6
NetGPI no yes: 0, no: 28
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0009986 cell surface 2 1

Expansion

Sequence features

A4I736
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I736

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 29
GO:0006259 DNA metabolic process 4 29
GO:0006308 DNA catabolic process 5 29
GO:0006725 cellular aromatic compound metabolic process 3 29
GO:0006807 nitrogen compound metabolic process 2 29
GO:0008152 metabolic process 1 29
GO:0009056 catabolic process 2 29
GO:0009057 macromolecule catabolic process 4 29
GO:0009987 cellular process 1 29
GO:0019439 aromatic compound catabolic process 4 29
GO:0034641 cellular nitrogen compound metabolic process 3 29
GO:0034655 nucleobase-containing compound catabolic process 4 29
GO:0043170 macromolecule metabolic process 3 29
GO:0044237 cellular metabolic process 2 29
GO:0044238 primary metabolic process 2 29
GO:0044248 cellular catabolic process 3 29
GO:0044260 obsolete cellular macromolecule metabolic process 3 29
GO:0044265 obsolete cellular macromolecule catabolic process 4 29
GO:0044270 cellular nitrogen compound catabolic process 4 29
GO:0046483 heterocycle metabolic process 3 29
GO:0046700 heterocycle catabolic process 4 29
GO:0071704 organic substance metabolic process 2 29
GO:0090304 nucleic acid metabolic process 4 29
GO:1901360 organic cyclic compound metabolic process 3 29
GO:1901361 organic cyclic compound catabolic process 4 29
GO:1901575 organic substance catabolic process 3 29
GO:0006163 purine nucleotide metabolic process 5 1
GO:0006195 purine nucleotide catabolic process 6 1
GO:0006196 AMP catabolic process 7 1
GO:0006753 nucleoside phosphate metabolic process 4 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0009117 nucleotide metabolic process 5 1
GO:0009123 nucleoside monophosphate metabolic process 5 1
GO:0009125 nucleoside monophosphate catabolic process 6 1
GO:0009126 purine nucleoside monophosphate metabolic process 6 1
GO:0009128 purine nucleoside monophosphate catabolic process 7 1
GO:0009150 purine ribonucleotide metabolic process 6 1
GO:0009154 purine ribonucleotide catabolic process 6 1
GO:0009158 ribonucleoside monophosphate catabolic process 7 1
GO:0009161 ribonucleoside monophosphate metabolic process 6 1
GO:0009166 nucleotide catabolic process 6 1
GO:0009167 purine ribonucleoside monophosphate metabolic process 7 1
GO:0009169 purine ribonucleoside monophosphate catabolic process 8 1
GO:0009259 ribonucleotide metabolic process 5 1
GO:0009261 ribonucleotide catabolic process 5 1
GO:0019637 organophosphate metabolic process 3 1
GO:0019693 ribose phosphate metabolic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0046033 AMP metabolic process 7 1
GO:0046434 organophosphate catabolic process 4 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0072521 purine-containing compound metabolic process 4 1
GO:0072523 purine-containing compound catabolic process 5 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901136 carbohydrate derivative catabolic process 4 1
GO:1901292 nucleoside phosphate catabolic process 5 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 29
GO:0003824 catalytic activity 1 29
GO:0004518 nuclease activity 4 29
GO:0004519 endonuclease activity 5 29
GO:0005488 binding 1 29
GO:0016787 hydrolase activity 2 29
GO:0016788 hydrolase activity, acting on ester bonds 3 29
GO:0043167 ion binding 2 29
GO:0043169 cation binding 3 29
GO:0046872 metal ion binding 4 29
GO:0097159 organic cyclic compound binding 2 29
GO:1901363 heterocyclic compound binding 2 29
GO:0008252 nucleotidase activity 6 1
GO:0008254 3'-nucleotidase activity 7 1
GO:0016791 phosphatase activity 5 1
GO:0042578 phosphoric ester hydrolase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 366 368 PF00082 0.360
CLV_PCSK_KEX2_1 40 42 PF00082 0.435
CLV_PCSK_PC1ET2_1 366 368 PF00082 0.324
CLV_PCSK_PC1ET2_1 40 42 PF00082 0.443
CLV_PCSK_SKI1_1 185 189 PF00082 0.530
CLV_PCSK_SKI1_1 280 284 PF00082 0.414
CLV_PCSK_SKI1_1 288 292 PF00082 0.429
DEG_SCF_FBW7_1 94 100 PF00400 0.164
DOC_CKS1_1 94 99 PF01111 0.247
DOC_CYCLIN_RxL_1 2 13 PF00134 0.338
DOC_CYCLIN_RxL_1 50 61 PF00134 0.197
DOC_MAPK_gen_1 3 12 PF00069 0.361
DOC_MAPK_MEF2A_6 3 11 PF00069 0.412
DOC_MAPK_MEF2A_6 30 37 PF00069 0.345
DOC_PP1_RVXF_1 54 61 PF00149 0.179
DOC_PP4_FxxP_1 60 63 PF00568 0.275
DOC_USP7_UBL2_3 271 275 PF12436 0.272
DOC_WW_Pin1_4 106 111 PF00397 0.264
DOC_WW_Pin1_4 64 69 PF00397 0.310
DOC_WW_Pin1_4 93 98 PF00397 0.249
LIG_14-3-3_CanoR_1 206 213 PF00244 0.251
LIG_Actin_WH2_2 285 300 PF00022 0.222
LIG_BIR_II_1 1 5 PF00653 0.468
LIG_BIR_III_3 1 5 PF00653 0.382
LIG_Clathr_ClatBox_1 176 180 PF01394 0.207
LIG_FHA_1 103 109 PF00498 0.338
LIG_FHA_1 11 17 PF00498 0.407
LIG_FHA_1 111 117 PF00498 0.298
LIG_FHA_1 182 188 PF00498 0.279
LIG_FHA_1 239 245 PF00498 0.326
LIG_FHA_1 246 252 PF00498 0.270
LIG_FHA_1 336 342 PF00498 0.339
LIG_FHA_1 352 358 PF00498 0.337
LIG_FHA_1 80 86 PF00498 0.318
LIG_FHA_2 123 129 PF00498 0.240
LIG_FHA_2 228 234 PF00498 0.347
LIG_FHA_2 263 269 PF00498 0.336
LIG_FHA_2 98 104 PF00498 0.241
LIG_GBD_Chelix_1 137 145 PF00786 0.385
LIG_GBD_Chelix_1 289 297 PF00786 0.471
LIG_GBD_Chelix_1 347 355 PF00786 0.182
LIG_GBD_Chelix_1 356 364 PF00786 0.315
LIG_LIR_Apic_2 59 63 PF02991 0.275
LIG_LIR_Gen_1 210 220 PF02991 0.282
LIG_LIR_Gen_1 372 378 PF02991 0.523
LIG_LIR_Gen_1 89 99 PF02991 0.301
LIG_LIR_LC3C_4 354 357 PF02991 0.201
LIG_LIR_Nem_3 210 216 PF02991 0.282
LIG_LIR_Nem_3 368 373 PF02991 0.537
LIG_LIR_Nem_3 89 94 PF02991 0.308
LIG_NRBOX 140 146 PF00104 0.185
LIG_NRBOX 6 12 PF00104 0.498
LIG_PDZ_Class_2 373 378 PF00595 0.568
LIG_SH2_CRK 255 259 PF00017 0.240
LIG_SH2_NCK_1 373 377 PF00017 0.543
LIG_SH2_SRC 222 225 PF00017 0.349
LIG_SH2_SRC 255 258 PF00017 0.219
LIG_SH2_SRC 373 376 PF00017 0.545
LIG_SH2_STAP1 227 231 PF00017 0.305
LIG_SH2_STAP1 373 377 PF00017 0.552
LIG_SH2_STAT5 222 225 PF00017 0.256
LIG_SH2_STAT5 363 366 PF00017 0.522
LIG_SH2_STAT5 93 96 PF00017 0.223
LIG_SH2_STAT5 99 102 PF00017 0.220
LIG_SH3_3 201 207 PF00018 0.241
LIG_SH3_3 62 68 PF00018 0.241
LIG_SUMO_SIM_anti_2 13 19 PF11976 0.404
LIG_SUMO_SIM_anti_2 140 145 PF11976 0.197
LIG_SUMO_SIM_anti_2 34 39 PF11976 0.336
LIG_SUMO_SIM_anti_2 354 359 PF11976 0.201
LIG_SUMO_SIM_par_1 100 109 PF11976 0.359
LIG_SUMO_SIM_par_1 175 181 PF11976 0.238
LIG_SUMO_SIM_par_1 8 13 PF11976 0.469
LIG_UBA3_1 305 310 PF00899 0.231
LIG_Vh1_VBS_1 340 358 PF01044 0.179
LIG_WRC_WIRS_1 57 62 PF05994 0.179
MOD_CK1_1 181 187 PF00069 0.245
MOD_CK1_1 229 235 PF00069 0.303
MOD_CK1_1 245 251 PF00069 0.385
MOD_CK1_1 301 307 PF00069 0.347
MOD_CK1_1 311 317 PF00069 0.384
MOD_CK2_1 122 128 PF00069 0.234
MOD_CK2_1 191 197 PF00069 0.336
MOD_CK2_1 229 235 PF00069 0.301
MOD_CK2_1 43 49 PF00069 0.308
MOD_GlcNHglycan 199 202 PF01048 0.548
MOD_GlcNHglycan 24 27 PF01048 0.612
MOD_GlcNHglycan 333 336 PF01048 0.518
MOD_GlcNHglycan 60 63 PF01048 0.432
MOD_GSK3_1 102 109 PF00069 0.248
MOD_GSK3_1 12 19 PF00069 0.453
MOD_GSK3_1 22 29 PF00069 0.473
MOD_GSK3_1 223 230 PF00069 0.245
MOD_GSK3_1 238 245 PF00069 0.272
MOD_GSK3_1 292 299 PF00069 0.267
MOD_GSK3_1 311 318 PF00069 0.453
MOD_GSK3_1 331 338 PF00069 0.429
MOD_GSK3_1 93 100 PF00069 0.356
MOD_N-GLC_1 293 298 PF02516 0.545
MOD_NEK2_1 10 15 PF00069 0.411
MOD_NEK2_1 122 127 PF00069 0.320
MOD_NEK2_1 16 21 PF00069 0.478
MOD_NEK2_1 223 228 PF00069 0.271
MOD_NEK2_1 292 297 PF00069 0.296
MOD_NEK2_1 43 48 PF00069 0.255
MOD_NEK2_1 58 63 PF00069 0.207
MOD_NEK2_1 70 75 PF00069 0.250
MOD_PKA_1 275 281 PF00069 0.273
MOD_PKB_1 367 375 PF00069 0.514
MOD_Plk_1 102 108 PF00069 0.241
MOD_Plk_1 223 229 PF00069 0.250
MOD_Plk_1 293 299 PF00069 0.306
MOD_Plk_2-3 102 108 PF00069 0.289
MOD_Plk_4 115 121 PF00069 0.238
MOD_Plk_4 12 18 PF00069 0.412
MOD_Plk_4 301 307 PF00069 0.326
MOD_Plk_4 351 357 PF00069 0.231
MOD_Plk_4 43 49 PF00069 0.286
MOD_ProDKin_1 106 112 PF00069 0.264
MOD_ProDKin_1 64 70 PF00069 0.310
MOD_ProDKin_1 93 99 PF00069 0.249
MOD_SUMO_rev_2 193 200 PF00179 0.280
MOD_SUMO_rev_2 267 272 PF00179 0.204
MOD_SUMO_rev_2 314 322 PF00179 0.346
MOD_SUMO_rev_2 323 333 PF00179 0.337
MOD_SUMO_rev_2 78 83 PF00179 0.270
TRG_DiLeu_BaEn_1 279 284 PF01217 0.222
TRG_ENDOCYTIC_2 213 216 PF00928 0.258
TRG_ENDOCYTIC_2 373 376 PF00928 0.560
TRG_ER_diArg_1 3 6 PF00400 0.360
TRG_NES_CRM1_1 150 164 PF08389 0.288
TRG_Pf-PMV_PEXEL_1 206 210 PF00026 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8Q7 Leptomonas seymouri 36% 100%
A0A0S4JAL3 Bodo saltans 41% 100%
A0A0S4JML7 Bodo saltans 24% 100%
A0A1X0P2K7 Trypanosomatidae 44% 100%
A0A3Q8IBF6 Leishmania donovani 45% 99%
A0A3Q8IEW3 Leishmania donovani 37% 100%
A0A3Q8IFH4 Leishmania donovani 100% 100%
A0A3Q8IK90 Leishmania donovani 63% 100%
A0A3S7X3A6 Leishmania donovani 37% 100%
A0A422N7B0 Trypanosoma rangeli 43% 100%
A4H6V5 Leishmania braziliensis 46% 100%
A4HI96 Leishmania braziliensis 34% 100%
A4HJL3 Leishmania braziliensis 76% 100%
A4I5I0 Leishmania infantum 37% 100%
C9ZQH5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZQH6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZQW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AGC7 Leishmania infantum 45% 99%
E9ANW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9B0S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B0S5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B231 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
F4JJL0 Arabidopsis thaliana 30% 100%
F4JJL3 Arabidopsis thaliana 28% 100%
P24021 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 26% 100%
Q4Q630 Leishmania major 92% 100%
Q4Q7F3 Leishmania major 38% 100%
Q4Q7F4 Leishmania major 39% 100%
Q4QGQ3 Leishmania major 46% 100%
Q66VY6 Leishmania major 65% 100%
Q8LDW6 Arabidopsis thaliana 27% 100%
Q9C9G4 Arabidopsis thaliana 29% 100%
Q9SXA6 Arabidopsis thaliana 27% 100%
V5B8Z9 Trypanosoma cruzi 39% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS