AP2 domain transcription factor AP2X-11

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I732_LEIIN

TriTrypDb:

LINF_310028100

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4I732

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I732

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.550
CLV_C14_Caspase3-7	362	366	PF00656	0.497
CLV_C14_Caspase3-7	521	525	PF00656	0.568
CLV_NRD_NRD_1	386	388	PF00675	0.796
CLV_NRD_NRD_1	43	45	PF00675	0.641
CLV_NRD_NRD_1	585	587	PF00675	0.848
CLV_NRD_NRD_1	60	62	PF00675	0.640
CLV_PCSK_KEX2_1	43	45	PF00082	0.641
CLV_PCSK_KEX2_1	585	587	PF00082	0.847
CLV_PCSK_KEX2_1	60	62	PF00082	0.640
CLV_PCSK_PC7_1	39	45	PF00082	0.636
CLV_PCSK_SKI1_1	121	125	PF00082	0.807
CLV_PCSK_SKI1_1	5	9	PF00082	0.550
CLV_PCSK_SKI1_1	590	594	PF00082	0.783
DEG_SCF_FBW7_1	428	433	PF00400	0.560
DEG_SPOP_SBC_1	190	194	PF00917	0.565
DEG_SPOP_SBC_1	417	421	PF00917	0.614
DEG_SPOP_SBC_1	564	568	PF00917	0.494
DOC_CKS1_1	253	258	PF01111	0.646
DOC_CKS1_1	649	654	PF01111	0.634
DOC_PP4_FxxP_1	684	687	PF00568	0.587
DOC_USP7_MATH_1	189	193	PF00917	0.628
DOC_USP7_MATH_1	217	221	PF00917	0.552
DOC_USP7_MATH_1	26	30	PF00917	0.385
DOC_USP7_MATH_1	287	291	PF00917	0.594
DOC_USP7_MATH_1	355	359	PF00917	0.473
DOC_USP7_MATH_1	416	420	PF00917	0.620
DOC_USP7_MATH_1	430	434	PF00917	0.624
DOC_USP7_MATH_1	476	480	PF00917	0.591
DOC_USP7_MATH_1	698	702	PF00917	0.497
DOC_USP7_MATH_1	71	75	PF00917	0.449
DOC_USP7_MATH_1	92	96	PF00917	0.394
DOC_WW_Pin1_4	138	143	PF00397	0.633
DOC_WW_Pin1_4	228	233	PF00397	0.531
DOC_WW_Pin1_4	243	248	PF00397	0.518
DOC_WW_Pin1_4	252	257	PF00397	0.647
DOC_WW_Pin1_4	325	330	PF00397	0.558
DOC_WW_Pin1_4	412	417	PF00397	0.604
DOC_WW_Pin1_4	419	424	PF00397	0.519
DOC_WW_Pin1_4	426	431	PF00397	0.591
DOC_WW_Pin1_4	480	485	PF00397	0.632
DOC_WW_Pin1_4	569	574	PF00397	0.592
DOC_WW_Pin1_4	596	601	PF00397	0.577
DOC_WW_Pin1_4	603	608	PF00397	0.579
DOC_WW_Pin1_4	648	653	PF00397	0.635
LIG_14-3-3_CanoR_1	16	25	PF00244	0.365
LIG_14-3-3_CanoR_1	252	256	PF00244	0.609
LIG_14-3-3_CanoR_1	343	353	PF00244	0.567
LIG_14-3-3_CanoR_1	39	43	PF00244	0.434
LIG_Actin_WH2_2	516	531	PF00022	0.495
LIG_deltaCOP1_diTrp_1	341	349	PF00928	0.553
LIG_DLG_GKlike_1	643	651	PF00625	0.564
LIG_FHA_1	32	38	PF00498	0.419
LIG_FHA_1	423	429	PF00498	0.637
LIG_FHA_1	438	444	PF00498	0.482
LIG_FHA_1	460	466	PF00498	0.582
LIG_FHA_1	515	521	PF00498	0.580
LIG_FHA_1	578	584	PF00498	0.486
LIG_FHA_1	597	603	PF00498	0.495
LIG_FHA_2	25	31	PF00498	0.388
LIG_FHA_2	333	339	PF00498	0.502
LIG_FHA_2	427	433	PF00498	0.636
LIG_FHA_2	519	525	PF00498	0.633
LIG_FHA_2	555	561	PF00498	0.572
LIG_LIR_Apic_2	571	577	PF02991	0.511
LIG_LIR_Apic_2	618	623	PF02991	0.561
LIG_LIR_Gen_1	202	212	PF02991	0.548
LIG_LIR_Gen_1	701	711	PF02991	0.339
LIG_LIR_Nem_3	137	143	PF02991	0.508
LIG_LIR_Nem_3	202	207	PF02991	0.595
LIG_LIR_Nem_3	678	684	PF02991	0.591
LIG_LIR_Nem_3	701	706	PF02991	0.339
LIG_MYND_1	258	262	PF01753	0.509
LIG_NRBOX	335	341	PF00104	0.555
LIG_Pex14_2	3	7	PF04695	0.361
LIG_Pex14_2	699	703	PF04695	0.339
LIG_Pex14_2	8	12	PF04695	0.329
LIG_REV1ctd_RIR_1	466	475	PF16727	0.633
LIG_SH2_CRK	204	208	PF00017	0.597
LIG_SH2_NCK_1	574	578	PF00017	0.490
LIG_SH2_STAP1	204	208	PF00017	0.484
LIG_SH3_3	127	133	PF00018	0.576
LIG_SH3_3	136	142	PF00018	0.500
LIG_SH3_3	478	484	PF00018	0.636
LIG_SH3_3	52	58	PF00018	0.455
LIG_SH3_3	649	655	PF00018	0.631
LIG_SH3_CIN85_PxpxPR_1	247	252	PF14604	0.509
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.408
LIG_SUMO_SIM_par_1	599	606	PF11976	0.528
LIG_SUMO_SIM_par_1	82	88	PF11976	0.408
LIG_TRAF2_1	335	338	PF00917	0.423
LIG_TRAF2_1	642	645	PF00917	0.501
LIG_TRAF2_1	676	679	PF00917	0.535
LIG_WRC_WIRS_1	465	470	PF05994	0.514
LIG_WW_3	57	61	PF00397	0.460
MOD_CDK_SPK_2	648	653	PF00069	0.635
MOD_CDK_SPxxK_3	252	259	PF00069	0.598
MOD_CK1_1	119	125	PF00069	0.608
MOD_CK1_1	164	170	PF00069	0.631
MOD_CK1_1	19	25	PF00069	0.367
MOD_CK1_1	194	200	PF00069	0.593
MOD_CK1_1	202	208	PF00069	0.433
MOD_CK1_1	220	226	PF00069	0.483
MOD_CK1_1	231	237	PF00069	0.474
MOD_CK1_1	264	270	PF00069	0.596
MOD_CK1_1	31	37	PF00069	0.393
MOD_CK1_1	315	321	PF00069	0.562
MOD_CK1_1	344	350	PF00069	0.460
MOD_CK1_1	358	364	PF00069	0.502
MOD_CK1_1	393	399	PF00069	0.589
MOD_CK1_1	419	425	PF00069	0.582
MOD_CK1_1	449	455	PF00069	0.601
MOD_CK1_1	474	480	PF00069	0.591
MOD_CK1_1	572	578	PF00069	0.585
MOD_CK1_1	596	602	PF00069	0.541
MOD_CK1_1	627	633	PF00069	0.614
MOD_CK1_1	648	654	PF00069	0.584
MOD_CK2_1	153	159	PF00069	0.572
MOD_CK2_1	207	213	PF00069	0.571
MOD_CK2_1	24	30	PF00069	0.384
MOD_CK2_1	332	338	PF00069	0.483
MOD_CK2_1	397	403	PF00069	0.551
MOD_CK2_1	426	432	PF00069	0.637
MOD_CK2_1	457	463	PF00069	0.640
MOD_CK2_1	502	508	PF00069	0.525
MOD_CK2_1	554	560	PF00069	0.575
MOD_CK2_1	639	645	PF00069	0.497
MOD_CK2_1	71	77	PF00069	0.438
MOD_CK2_1	85	91	PF00069	0.377
MOD_GlcNHglycan	118	121	PF01048	0.768
MOD_GlcNHglycan	166	169	PF01048	0.796
MOD_GlcNHglycan	247	250	PF01048	0.737
MOD_GlcNHglycan	263	266	PF01048	0.796
MOD_GlcNHglycan	289	292	PF01048	0.830
MOD_GlcNHglycan	298	301	PF01048	0.749
MOD_GlcNHglycan	30	33	PF01048	0.603
MOD_GlcNHglycan	315	318	PF01048	0.756
MOD_GlcNHglycan	346	349	PF01048	0.758
MOD_GlcNHglycan	455	458	PF01048	0.798
MOD_GlcNHglycan	474	477	PF01048	0.636
MOD_GlcNHglycan	536	539	PF01048	0.847
MOD_GlcNHglycan	590	593	PF01048	0.705
MOD_GlcNHglycan	595	598	PF01048	0.660
MOD_GlcNHglycan	624	627	PF01048	0.754
MOD_GlcNHglycan	63	66	PF01048	0.670
MOD_GlcNHglycan	633	636	PF01048	0.701
MOD_GlcNHglycan	700	703	PF01048	0.497
MOD_GlcNHglycan	79	84	PF01048	0.581
MOD_GSK3_1	134	141	PF00069	0.516
MOD_GSK3_1	147	154	PF00069	0.486
MOD_GSK3_1	16	23	PF00069	0.361
MOD_GSK3_1	190	197	PF00069	0.605
MOD_GSK3_1	199	206	PF00069	0.405
MOD_GSK3_1	24	31	PF00069	0.371
MOD_GSK3_1	301	308	PF00069	0.578
MOD_GSK3_1	393	400	PF00069	0.575
MOD_GSK3_1	412	419	PF00069	0.489
MOD_GSK3_1	422	429	PF00069	0.643
MOD_GSK3_1	449	456	PF00069	0.587
MOD_GSK3_1	467	474	PF00069	0.442
MOD_GSK3_1	476	483	PF00069	0.547
MOD_GSK3_1	514	521	PF00069	0.580
MOD_GSK3_1	544	551	PF00069	0.620
MOD_GSK3_1	564	571	PF00069	0.524
MOD_GSK3_1	61	68	PF00069	0.469
MOD_GSK3_1	624	631	PF00069	0.586
MOD_GSK3_1	639	646	PF00069	0.516
MOD_LATS_1	641	647	PF00433	0.560
MOD_N-GLC_1	116	121	PF02516	0.720
MOD_N-GLC_1	174	179	PF02516	0.785
MOD_N-GLC_1	627	632	PF02516	0.772
MOD_NEK2_1	10	15	PF00069	0.336
MOD_NEK2_1	153	158	PF00069	0.571
MOD_NEK2_1	203	208	PF00069	0.596
MOD_NEK2_1	21	26	PF00069	0.350
MOD_NEK2_1	548	553	PF00069	0.596
MOD_NEK2_1	554	559	PF00069	0.553
MOD_NEK2_1	602	607	PF00069	0.588
MOD_NEK2_2	38	43	PF00069	0.432
MOD_PIKK_1	161	167	PF00454	0.576
MOD_PIKK_1	315	321	PF00454	0.579
MOD_PIKK_1	393	399	PF00454	0.638
MOD_PIKK_1	446	452	PF00454	0.605
MOD_PIKK_1	457	463	PF00454	0.598
MOD_PIKK_1	491	497	PF00454	0.572
MOD_PIKK_1	509	515	PF00454	0.442
MOD_PIKK_1	645	651	PF00454	0.588
MOD_PK_1	191	197	PF00069	0.493
MOD_PKA_1	61	67	PF00069	0.470
MOD_PKA_2	190	196	PF00069	0.498
MOD_PKA_2	251	257	PF00069	0.609
MOD_PKA_2	38	44	PF00069	0.433
MOD_PKB_1	44	52	PF00069	0.451
MOD_Plk_1	199	205	PF00069	0.591
MOD_Plk_1	364	370	PF00069	0.583
MOD_Plk_1	46	52	PF00069	0.454
MOD_Plk_1	627	633	PF00069	0.594
MOD_Plk_1	643	649	PF00069	0.510
MOD_Plk_1	79	85	PF00069	0.412
MOD_Plk_4	191	197	PF00069	0.603
MOD_Plk_4	199	205	PF00069	0.415
MOD_Plk_4	464	470	PF00069	0.515
MOD_Plk_4	518	524	PF00069	0.606
MOD_ProDKin_1	138	144	PF00069	0.633
MOD_ProDKin_1	228	234	PF00069	0.533
MOD_ProDKin_1	243	249	PF00069	0.517
MOD_ProDKin_1	252	258	PF00069	0.647
MOD_ProDKin_1	325	331	PF00069	0.555
MOD_ProDKin_1	412	418	PF00069	0.605
MOD_ProDKin_1	419	425	PF00069	0.520
MOD_ProDKin_1	426	432	PF00069	0.582
MOD_ProDKin_1	480	486	PF00069	0.632
MOD_ProDKin_1	569	575	PF00069	0.592
MOD_ProDKin_1	596	602	PF00069	0.576
MOD_ProDKin_1	603	609	PF00069	0.579
MOD_ProDKin_1	648	654	PF00069	0.634
MOD_SUMO_rev_2	74	83	PF00179	0.420
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.581
TRG_ENDOCYTIC_2	204	207	PF00928	0.595
TRG_ENDOCYTIC_2	681	684	PF00928	0.592
TRG_ER_diArg_1	42	44	PF00400	0.439
TRG_ER_diArg_1	50	53	PF00400	0.446
TRG_ER_diArg_1	585	587	PF00400	0.485
TRG_ER_diArg_1	59	61	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.777
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	526	530	PF00026	0.761
TRG_Pf-PMV_PEXEL_1	670	674	PF00026	0.749

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q2	Leishmania donovani	100%	100%
A4HJI3	Leishmania braziliensis	56%	99%
E9B200	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q661	Leishmania major	89%	100%