LeishMANIAdb
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EGF-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EGF-like domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I712_LEIIN
TriTrypDb:
LINF_310033550
Length:
467

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 1
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I712
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I712

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 287 291 PF00656 0.340
CLV_NRD_NRD_1 398 400 PF00675 0.550
CLV_NRD_NRD_1 433 435 PF00675 0.514
CLV_NRD_NRD_1 453 455 PF00675 0.485
CLV_NRD_NRD_1 458 460 PF00675 0.584
CLV_PCSK_KEX2_1 398 400 PF00082 0.553
CLV_PCSK_KEX2_1 435 437 PF00082 0.496
CLV_PCSK_KEX2_1 453 455 PF00082 0.504
CLV_PCSK_KEX2_1 457 459 PF00082 0.589
CLV_PCSK_PC1ET2_1 435 437 PF00082 0.452
CLV_PCSK_PC1ET2_1 457 459 PF00082 0.601
CLV_PCSK_PC7_1 453 459 PF00082 0.588
CLV_PCSK_SKI1_1 116 120 PF00082 0.533
CLV_PCSK_SKI1_1 453 457 PF00082 0.586
DEG_SCF_FBW7_1 28 35 PF00400 0.395
DOC_CKS1_1 29 34 PF01111 0.587
DOC_CKS1_1 346 351 PF01111 0.526
DOC_CYCLIN_yCln2_LP_2 382 388 PF00134 0.287
DOC_MAPK_gen_1 434 445 PF00069 0.718
DOC_MAPK_MEF2A_6 185 192 PF00069 0.492
DOC_MAPK_MEF2A_6 438 447 PF00069 0.730
DOC_MAPK_RevD_3 385 399 PF00069 0.453
DOC_MAPK_RevD_3 445 459 PF00069 0.803
DOC_PP1_RVXF_1 114 120 PF00149 0.326
DOC_PP2B_LxvP_1 382 385 PF13499 0.287
DOC_PP4_FxxP_1 29 32 PF00568 0.583
DOC_USP7_MATH_1 194 198 PF00917 0.532
DOC_USP7_MATH_1 295 299 PF00917 0.326
DOC_USP7_MATH_1 32 36 PF00917 0.508
DOC_USP7_MATH_1 41 45 PF00917 0.496
DOC_USP7_MATH_1 72 76 PF00917 0.497
DOC_WW_Pin1_4 28 33 PF00397 0.582
DOC_WW_Pin1_4 345 350 PF00397 0.430
LIG_14-3-3_CanoR_1 120 129 PF00244 0.364
LIG_14-3-3_CanoR_1 306 311 PF00244 0.521
LIG_14-3-3_CanoR_1 58 66 PF00244 0.351
LIG_Actin_WH2_2 170 187 PF00022 0.320
LIG_APCC_ABBA_1 131 136 PF00400 0.476
LIG_BIR_II_1 1 5 PF00653 0.467
LIG_BIR_III_4 275 279 PF00653 0.510
LIG_BRCT_BRCA1_1 327 331 PF00533 0.493
LIG_eIF4E_1 123 129 PF01652 0.543
LIG_FHA_1 65 71 PF00498 0.490
LIG_FHA_1 84 90 PF00498 0.269
LIG_FHA_2 45 51 PF00498 0.355
LIG_LIR_Apic_2 343 349 PF02991 0.527
LIG_LIR_Gen_1 122 131 PF02991 0.518
LIG_LIR_Gen_1 373 382 PF02991 0.387
LIG_LIR_Gen_1 408 418 PF02991 0.645
LIG_LIR_Nem_3 11 17 PF02991 0.552
LIG_LIR_Nem_3 373 377 PF02991 0.387
LIG_LIR_Nem_3 408 413 PF02991 0.645
LIG_LIR_Nem_3 417 421 PF02991 0.618
LIG_PCNA_PIPBox_1 449 458 PF02747 0.796
LIG_PCNA_yPIPBox_3 448 456 PF02747 0.796
LIG_SH2_CRK 346 350 PF00017 0.522
LIG_SH2_NCK_1 134 138 PF00017 0.493
LIG_SH2_NCK_1 346 350 PF00017 0.522
LIG_SH2_SRC 134 137 PF00017 0.483
LIG_SH2_STAP1 342 346 PF00017 0.534
LIG_SH2_STAP1 6 10 PF00017 0.377
LIG_SH2_STAP1 66 70 PF00017 0.488
LIG_SH2_STAT3 21 24 PF00017 0.419
LIG_SH2_STAT5 14 17 PF00017 0.528
LIG_SH2_STAT5 342 345 PF00017 0.531
LIG_SH2_STAT5 66 69 PF00017 0.492
LIG_SH2_STAT5 8 11 PF00017 0.505
LIG_SH3_3 174 180 PF00018 0.513
LIG_SH3_3 223 229 PF00018 0.325
LIG_SUMO_SIM_anti_2 373 379 PF11976 0.387
LIG_SUMO_SIM_anti_2 67 72 PF11976 0.294
LIG_SUMO_SIM_par_1 139 144 PF11976 0.466
LIG_SUMO_SIM_par_1 69 75 PF11976 0.483
LIG_UBA3_1 442 448 PF00899 0.531
LIG_WRC_WIRS_1 76 81 PF05994 0.393
LIG_WW_1 366 369 PF00397 0.481
LIG_WW_3 266 270 PF00397 0.447
MOD_CK1_1 122 128 PF00069 0.441
MOD_CK1_1 210 216 PF00069 0.631
MOD_CK1_1 262 268 PF00069 0.730
MOD_CK1_1 345 351 PF00069 0.658
MOD_CK1_1 361 367 PF00069 0.469
MOD_CK1_1 44 50 PF00069 0.403
MOD_CK1_1 75 81 PF00069 0.389
MOD_GlcNHglycan 185 188 PF01048 0.607
MOD_GlcNHglycan 210 213 PF01048 0.625
MOD_GlcNHglycan 243 246 PF01048 0.616
MOD_GlcNHglycan 262 265 PF01048 0.414
MOD_GlcNHglycan 292 295 PF01048 0.381
MOD_GlcNHglycan 335 338 PF01048 0.657
MOD_GlcNHglycan 382 385 PF01048 0.331
MOD_GSK3_1 28 35 PF00069 0.473
MOD_GSK3_1 340 347 PF00069 0.664
MOD_GSK3_1 44 51 PF00069 0.341
MOD_N-GLC_1 241 246 PF02516 0.362
MOD_N-GLC_1 259 264 PF02516 0.393
MOD_N-GLC_1 4 9 PF02516 0.446
MOD_N-GLC_1 64 69 PF02516 0.623
MOD_NEK2_1 119 124 PF00069 0.452
MOD_NEK2_1 183 188 PF00069 0.611
MOD_NEK2_1 380 385 PF00069 0.375
MOD_NEK2_1 56 61 PF00069 0.669
MOD_NEK2_2 194 199 PF00069 0.407
MOD_NEK2_2 72 77 PF00069 0.354
MOD_OFUCOSY 207 214 PF10250 0.640
MOD_OFUCOSY 325 330 PF10250 0.610
MOD_OFUCOSY 39 45 PF10250 0.654
MOD_OFUCOSY 54 61 PF10250 0.424
MOD_PIKK_1 30 36 PF00454 0.482
MOD_PIKK_1 350 356 PF00454 0.661
MOD_PIKK_1 44 50 PF00454 0.342
MOD_PKA_2 119 125 PF00069 0.623
MOD_PKA_2 361 367 PF00069 0.487
MOD_PKA_2 57 63 PF00069 0.432
MOD_Plk_1 141 147 PF00069 0.587
MOD_Plk_1 172 178 PF00069 0.646
MOD_Plk_1 326 332 PF00069 0.611
MOD_Plk_1 4 10 PF00069 0.474
MOD_Plk_1 64 70 PF00069 0.618
MOD_Plk_4 173 179 PF00069 0.639
MOD_Plk_4 32 38 PF00069 0.469
MOD_Plk_4 66 72 PF00069 0.335
MOD_ProDKin_1 28 34 PF00069 0.735
MOD_ProDKin_1 345 351 PF00069 0.527
TRG_ENDOCYTIC_2 123 126 PF00928 0.722
TRG_ENDOCYTIC_2 134 137 PF00928 0.404
TRG_ENDOCYTIC_2 14 17 PF00928 0.685
TRG_ENDOCYTIC_2 369 372 PF00928 0.462
TRG_ER_diArg_1 359 362 PF00400 0.743
TRG_ER_diArg_1 397 399 PF00400 0.611
TRG_ER_diArg_1 434 437 PF00400 0.621
TRG_ER_diArg_1 452 454 PF00400 0.483
TRG_NLS_MonoExtC_3 433 438 PF00514 0.554
TRG_Pf-PMV_PEXEL_1 419 424 PF00026 0.745
TRG_Pf-PMV_PEXEL_1 88 92 PF00026 0.653

Homologs

Protein Taxonomy Sequence identity Coverage
A4HJP1 Leishmania braziliensis 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS