LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

HEAT repeat-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
HEAT repeat-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I710_LEIIN
TriTrypDb:
LINF_310030900
Length:
462

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 6
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 170

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I710
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I710

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0000774 adenyl-nucleotide exchange factor activity 3 1
GO:0005488 binding 1 1
GO:0017076 purine nucleotide binding 4 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0036094 small molecule binding 2 1
GO:0060590 ATPase regulator activity 2 1
GO:0097159 organic cyclic compound binding 2 1
GO:0098772 molecular function regulator activity 1 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 172 176 PF00656 0.519
CLV_C14_Caspase3-7 316 320 PF00656 0.316
CLV_NRD_NRD_1 359 361 PF00675 0.272
CLV_NRD_NRD_1 71 73 PF00675 0.488
CLV_PCSK_KEX2_1 71 73 PF00082 0.488
CLV_PCSK_KEX2_1 91 93 PF00082 0.338
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.372
CLV_PCSK_SKI1_1 360 364 PF00082 0.303
CLV_PCSK_SKI1_1 365 369 PF00082 0.298
CLV_PCSK_SKI1_1 417 421 PF00082 0.426
CLV_PCSK_SKI1_1 80 84 PF00082 0.429
CLV_PCSK_SKI1_1 91 95 PF00082 0.373
DEG_APCC_DBOX_1 79 87 PF00400 0.485
DOC_ANK_TNKS_1 439 446 PF00023 0.432
DOC_CYCLIN_RxL_1 91 101 PF00134 0.362
DOC_CYCLIN_yCln2_LP_2 213 219 PF00134 0.402
DOC_MAPK_gen_1 91 98 PF00069 0.423
DOC_PP1_RVXF_1 363 370 PF00149 0.329
DOC_PP1_RVXF_1 449 455 PF00149 0.378
DOC_PP1_RVXF_1 92 99 PF00149 0.407
DOC_USP7_MATH_1 161 165 PF00917 0.589
DOC_USP7_MATH_1 167 171 PF00917 0.605
DOC_USP7_MATH_1 173 177 PF00917 0.636
DOC_USP7_MATH_1 44 48 PF00917 0.660
DOC_USP7_MATH_1 82 86 PF00917 0.438
DOC_WW_Pin1_4 289 294 PF00397 0.397
DOC_WW_Pin1_4 328 333 PF00397 0.508
DOC_WW_Pin1_4 412 417 PF00397 0.439
DOC_WW_Pin1_4 85 90 PF00397 0.454
LIG_14-3-3_CanoR_1 312 318 PF00244 0.415
LIG_14-3-3_CanoR_1 360 369 PF00244 0.286
LIG_14-3-3_CterR_2 460 462 PF00244 0.404
LIG_APCC_ABBA_1 197 202 PF00400 0.338
LIG_BIR_II_1 1 5 PF00653 0.506
LIG_Clathr_ClatBox_1 97 101 PF01394 0.409
LIG_deltaCOP1_diTrp_1 129 137 PF00928 0.393
LIG_FHA_1 299 305 PF00498 0.380
LIG_FHA_1 312 318 PF00498 0.390
LIG_FHA_1 329 335 PF00498 0.421
LIG_FHA_1 357 363 PF00498 0.443
LIG_FHA_2 314 320 PF00498 0.381
LIG_FHA_2 340 346 PF00498 0.405
LIG_Integrin_RGD_1 179 181 PF01839 0.585
LIG_LIR_Gen_1 136 143 PF02991 0.332
LIG_LIR_Gen_1 201 211 PF02991 0.303
LIG_LIR_Gen_1 75 84 PF02991 0.469
LIG_LIR_Nem_3 201 206 PF02991 0.306
LIG_LIR_Nem_3 349 355 PF02991 0.443
LIG_LIR_Nem_3 75 79 PF02991 0.452
LIG_NRBOX 272 278 PF00104 0.346
LIG_Pex14_1 133 137 PF04695 0.341
LIG_PTAP_UEV_1 30 35 PF05743 0.621
LIG_SH2_CRK 352 356 PF00017 0.434
LIG_SH2_STAT5 372 375 PF00017 0.352
LIG_SH3_3 28 34 PF00018 0.649
LIG_SH3_3 83 89 PF00018 0.442
LIG_SUMO_SIM_anti_2 301 309 PF11976 0.419
LIG_SUMO_SIM_par_1 331 336 PF11976 0.440
LIG_TRAF2_1 120 123 PF00917 0.328
LIG_TRAF2_1 344 347 PF00917 0.519
LIG_TRAF2_1 379 382 PF00917 0.504
MOD_CDC14_SPxK_1 88 91 PF00782 0.437
MOD_CDK_SPK_2 412 417 PF00069 0.392
MOD_CDK_SPxK_1 85 91 PF00069 0.452
MOD_CDK_SPxxK_3 85 92 PF00069 0.444
MOD_CK1_1 2 8 PF00069 0.527
MOD_CK1_1 292 298 PF00069 0.342
MOD_CK1_1 393 399 PF00069 0.468
MOD_CK1_1 40 46 PF00069 0.593
MOD_CK1_1 47 53 PF00069 0.580
MOD_CK1_1 85 91 PF00069 0.452
MOD_CK2_1 317 323 PF00069 0.513
MOD_CK2_1 341 347 PF00069 0.592
MOD_CK2_1 376 382 PF00069 0.478
MOD_GlcNHglycan 166 170 PF01048 0.589
MOD_GlcNHglycan 194 197 PF01048 0.412
MOD_GlcNHglycan 209 212 PF01048 0.262
MOD_GlcNHglycan 24 27 PF01048 0.433
MOD_GlcNHglycan 301 304 PF01048 0.452
MOD_GlcNHglycan 31 34 PF01048 0.629
MOD_GlcNHglycan 392 395 PF01048 0.454
MOD_GlcNHglycan 4 7 PF01048 0.514
MOD_GlcNHglycan 49 52 PF01048 0.571
MOD_GlcNHglycan 80 83 PF01048 0.439
MOD_GSK3_1 161 168 PF00069 0.612
MOD_GSK3_1 288 295 PF00069 0.480
MOD_GSK3_1 313 320 PF00069 0.292
MOD_GSK3_1 333 340 PF00069 0.511
MOD_GSK3_1 356 363 PF00069 0.464
MOD_GSK3_1 372 379 PF00069 0.332
MOD_GSK3_1 40 47 PF00069 0.613
MOD_GSK3_1 78 85 PF00069 0.478
MOD_N-GLC_1 101 106 PF02516 0.490
MOD_N-GLC_1 34 39 PF02516 0.688
MOD_N-GLC_2 13 15 PF02516 0.419
MOD_N-GLC_2 28 30 PF02516 0.594
MOD_NEK2_1 159 164 PF00069 0.555
MOD_NEK2_1 298 303 PF00069 0.508
MOD_NEK2_1 311 316 PF00069 0.357
MOD_NEK2_1 355 360 PF00069 0.381
MOD_NEK2_1 373 378 PF00069 0.251
MOD_PIKK_1 433 439 PF00454 0.419
MOD_PKA_1 360 366 PF00069 0.246
MOD_PKA_2 288 294 PF00069 0.326
MOD_PKA_2 311 317 PF00069 0.493
MOD_PKA_2 40 46 PF00069 0.554
MOD_Plk_2-3 341 347 PF00069 0.423
MOD_Plk_4 269 275 PF00069 0.363
MOD_Plk_4 292 298 PF00069 0.390
MOD_Plk_4 317 323 PF00069 0.390
MOD_ProDKin_1 289 295 PF00069 0.390
MOD_ProDKin_1 328 334 PF00069 0.496
MOD_ProDKin_1 412 418 PF00069 0.437
MOD_ProDKin_1 85 91 PF00069 0.452
MOD_SUMO_rev_2 101 109 PF00179 0.470
TRG_DiLeu_BaEn_3 122 128 PF01217 0.369
TRG_DiLeu_BaEn_4 381 387 PF01217 0.343
TRG_DiLeu_BaLyEn_6 142 147 PF01217 0.386
TRG_DiLeu_BaLyEn_6 155 160 PF01217 0.334
TRG_DiLeu_BaLyEn_6 272 277 PF01217 0.367
TRG_DiLeu_BaLyEn_6 351 356 PF01217 0.439
TRG_ENDOCYTIC_2 352 355 PF00928 0.418
TRG_ENDOCYTIC_2 76 79 PF00928 0.451
TRG_NES_CRM1_1 236 250 PF08389 0.360
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HXH6 Leptomonas seymouri 47% 100%
A0A3S7X4Q0 Leishmania donovani 99% 100%
A4HJL0 Leishmania braziliensis 65% 100%
E9B228 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q634 Leishmania major 87% 100%
V5BA98 Trypanosoma cruzi 27% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS