Metallo-peptidase, Clan MA(E), Family M1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aminopeptidase - putative

Species:

Leishmania infantum

UniProt:

A4I709_LEIIN

TriTrypDb:

LINF_310030800

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I709

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I709

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043171	peptide catabolic process	4	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0008270	zinc ion binding	6	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0004177	aminopeptidase activity	5	9
GO:0008235	metalloexopeptidase activity	5	1
GO:0008238	exopeptidase activity	4	9
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0070006	metalloaminopeptidase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.546
CLV_NRD_NRD_1	152	154	PF00675	0.622
CLV_NRD_NRD_1	159	161	PF00675	0.570
CLV_NRD_NRD_1	287	289	PF00675	0.419
CLV_NRD_NRD_1	371	373	PF00675	0.474
CLV_NRD_NRD_1	43	45	PF00675	0.456
CLV_NRD_NRD_1	79	81	PF00675	0.467
CLV_PCSK_FUR_1	41	45	PF00082	0.462
CLV_PCSK_FUR_1	77	81	PF00082	0.516
CLV_PCSK_KEX2_1	152	154	PF00082	0.658
CLV_PCSK_KEX2_1	371	373	PF00082	0.474
CLV_PCSK_KEX2_1	43	45	PF00082	0.456
CLV_PCSK_KEX2_1	556	558	PF00082	0.341
CLV_PCSK_KEX2_1	79	81	PF00082	0.511
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.707
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.357
CLV_PCSK_PC7_1	367	373	PF00082	0.473
CLV_PCSK_SKI1_1	101	105	PF00082	0.510
CLV_PCSK_SKI1_1	189	193	PF00082	0.391
CLV_PCSK_SKI1_1	250	254	PF00082	0.314
CLV_PCSK_SKI1_1	277	281	PF00082	0.456
CLV_PCSK_SKI1_1	375	379	PF00082	0.514
CLV_PCSK_SKI1_1	541	545	PF00082	0.269
CLV_PCSK_SKI1_1	553	557	PF00082	0.294
CLV_PCSK_SKI1_1	85	89	PF00082	0.479
DEG_Nend_UBRbox_2	1	3	PF02207	0.452
DEG_SPOP_SBC_1	323	327	PF00917	0.462
DEG_SPOP_SBC_1	517	521	PF00917	0.400
DEG_SPOP_SBC_1	522	526	PF00917	0.323
DOC_CYCLIN_RxL_1	380	390	PF00134	0.467
DOC_MAPK_MEF2A_6	572	581	PF00069	0.324
DOC_PP1_RVXF_1	187	194	PF00149	0.355
DOC_PP1_RVXF_1	260	266	PF00149	0.386
DOC_PP2B_PxIxI_1	581	587	PF00149	0.418
DOC_PP4_FxxP_1	19	22	PF00568	0.419
DOC_PP4_FxxP_1	253	256	PF00568	0.290
DOC_PP4_FxxP_1	399	402	PF00568	0.290
DOC_USP7_MATH_1	142	146	PF00917	0.707
DOC_USP7_MATH_1	172	176	PF00917	0.562
DOC_USP7_MATH_1	509	513	PF00917	0.338
DOC_USP7_MATH_1	517	521	PF00917	0.314
DOC_USP7_MATH_1	522	526	PF00917	0.298
DOC_USP7_MATH_1	57	61	PF00917	0.639
DOC_USP7_UBL2_3	154	158	PF12436	0.584
DOC_WW_Pin1_4	299	304	PF00397	0.386
DOC_WW_Pin1_4	518	523	PF00397	0.397
DOC_WW_Pin1_4	601	606	PF00397	0.540
LIG_14-3-3_CanoR_1	214	219	PF00244	0.324
LIG_14-3-3_CanoR_1	375	384	PF00244	0.440
LIG_14-3-3_CanoR_1	535	543	PF00244	0.324
LIG_APCC_ABBA_1	199	204	PF00400	0.491
LIG_Clathr_ClatBox_1	190	194	PF01394	0.470
LIG_deltaCOP1_diTrp_1	185	193	PF00928	0.464
LIG_FHA_1	12	18	PF00498	0.372
LIG_FHA_1	207	213	PF00498	0.256
LIG_FHA_1	233	239	PF00498	0.452
LIG_FHA_1	35	41	PF00498	0.433
LIG_FHA_1	354	360	PF00498	0.569
LIG_FHA_1	376	382	PF00498	0.488
LIG_FHA_1	453	459	PF00498	0.414
LIG_FHA_1	524	530	PF00498	0.347
LIG_FHA_2	172	178	PF00498	0.677
LIG_FHA_2	240	246	PF00498	0.290
LIG_FHA_2	279	285	PF00498	0.419
LIG_FHA_2	513	519	PF00498	0.295
LIG_LIR_Gen_1	313	321	PF02991	0.526
LIG_LIR_Gen_1	360	369	PF02991	0.366
LIG_LIR_Gen_1	70	76	PF02991	0.531
LIG_LIR_Nem_3	274	279	PF02991	0.335
LIG_LIR_Nem_3	313	317	PF02991	0.369
LIG_LIR_Nem_3	360	364	PF02991	0.394
LIG_LIR_Nem_3	5	11	PF02991	0.307
LIG_LIR_Nem_3	70	75	PF02991	0.491
LIG_NRBOX	410	416	PF00104	0.383
LIG_PDZ_Class_1	616	621	PF00595	0.501
LIG_Pex14_2	244	248	PF04695	0.393
LIG_SH2_CRK	361	365	PF00017	0.386
LIG_SH2_NCK_1	361	365	PF00017	0.493
LIG_SH2_SRC	438	441	PF00017	0.324
LIG_SH2_SRC	548	551	PF00017	0.419
LIG_SH2_STAP1	72	76	PF00017	0.521
LIG_SH2_STAT5	310	313	PF00017	0.350
LIG_SH2_STAT5	361	364	PF00017	0.388
LIG_SH2_STAT5	421	424	PF00017	0.324
LIG_SH2_STAT5	607	610	PF00017	0.361
LIG_SH3_3	253	259	PF00018	0.358
LIG_SH3_3	300	306	PF00018	0.337
LIG_SH3_3	337	343	PF00018	0.482
LIG_SH3_3	414	420	PF00018	0.328
LIG_SH3_3	474	480	PF00018	0.222
LIG_SH3_3	576	582	PF00018	0.496
LIG_SH3_3	599	605	PF00018	0.537
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.533
LIG_SUMO_SIM_anti_2	409	415	PF11976	0.312
LIG_SUMO_SIM_par_1	104	110	PF11976	0.377
LIG_SUMO_SIM_par_1	128	133	PF11976	0.523
LIG_TRAF2_1	585	588	PF00917	0.508
LIG_TRFH_1	361	365	PF08558	0.386
LIG_TYR_ITIM	359	364	PF00017	0.399
LIG_WRC_WIRS_1	215	220	PF05994	0.419
LIG_WRC_WIRS_1	311	316	PF05994	0.431
MOD_CK1_1	117	123	PF00069	0.601
MOD_CK1_1	141	147	PF00069	0.640
MOD_CK1_1	175	181	PF00069	0.610
MOD_CK1_1	20	26	PF00069	0.529
MOD_CK1_1	275	281	PF00069	0.294
MOD_CK1_1	351	357	PF00069	0.598
MOD_CK1_1	511	517	PF00069	0.401
MOD_CK1_1	521	527	PF00069	0.285
MOD_CK1_1	60	66	PF00069	0.663
MOD_CK2_1	239	245	PF00069	0.290
MOD_CK2_1	278	284	PF00069	0.419
MOD_CK2_1	420	426	PF00069	0.290
MOD_CK2_1	512	518	PF00069	0.462
MOD_Cter_Amidation	286	289	PF01082	0.419
MOD_Cter_Amidation	440	443	PF01082	0.399
MOD_GlcNHglycan	116	119	PF01048	0.542
MOD_GlcNHglycan	140	143	PF01048	0.579
MOD_GlcNHglycan	146	149	PF01048	0.656
MOD_GlcNHglycan	23	26	PF01048	0.468
MOD_GlcNHglycan	31	34	PF01048	0.375
MOD_GlcNHglycan	326	329	PF01048	0.664
MOD_GlcNHglycan	350	353	PF01048	0.608
MOD_GlcNHglycan	422	425	PF01048	0.290
MOD_GlcNHglycan	450	453	PF01048	0.349
MOD_GlcNHglycan	510	514	PF01048	0.312
MOD_GlcNHglycan	52	55	PF01048	0.715
MOD_GlcNHglycan	531	534	PF01048	0.491
MOD_GlcNHglycan	587	591	PF01048	0.369
MOD_GlcNHglycan	618	621	PF01048	0.569
MOD_GSK3_1	138	145	PF00069	0.634
MOD_GSK3_1	17	24	PF00069	0.510
MOD_GSK3_1	171	178	PF00069	0.681
MOD_GSK3_1	228	235	PF00069	0.405
MOD_GSK3_1	271	278	PF00069	0.309
MOD_GSK3_1	322	329	PF00069	0.680
MOD_GSK3_1	353	360	PF00069	0.589
MOD_GSK3_1	448	455	PF00069	0.334
MOD_GSK3_1	508	515	PF00069	0.298
MOD_GSK3_1	517	524	PF00069	0.308
MOD_GSK3_1	525	532	PF00069	0.167
MOD_GSK3_1	56	63	PF00069	0.683
MOD_N-GLC_1	357	362	PF02516	0.475
MOD_NEK2_1	17	22	PF00069	0.411
MOD_NEK2_1	359	364	PF00069	0.526
MOD_NEK2_1	495	500	PF00069	0.483
MOD_NEK2_1	543	548	PF00069	0.480
MOD_PIKK_1	206	212	PF00454	0.324
MOD_PK_1	128	134	PF00069	0.516
MOD_PKA_1	153	159	PF00069	0.610
MOD_PKA_2	20	26	PF00069	0.473
MOD_PKA_2	385	391	PF00069	0.458
MOD_PKA_2	47	53	PF00069	0.593
MOD_PKA_2	534	540	PF00069	0.414
MOD_Plk_1	142	148	PF00069	0.495
MOD_Plk_1	357	363	PF00069	0.440
MOD_Plk_2-3	67	73	PF00069	0.567
MOD_Plk_4	35	41	PF00069	0.500
MOD_Plk_4	359	365	PF00069	0.487
MOD_Plk_4	427	433	PF00069	0.396
MOD_Plk_4	495	501	PF00069	0.492
MOD_ProDKin_1	299	305	PF00069	0.386
MOD_ProDKin_1	518	524	PF00069	0.397
MOD_ProDKin_1	601	607	PF00069	0.546
MOD_SUMO_for_1	321	324	PF00179	0.512
TRG_DiLeu_BaEn_1	459	464	PF01217	0.344
TRG_DiLeu_BaEn_2	70	76	PF01217	0.528
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.393
TRG_DiLeu_LyEn_5	236	241	PF01217	0.383
TRG_ENDOCYTIC_2	361	364	PF00928	0.495
TRG_ENDOCYTIC_2	72	75	PF00928	0.526
TRG_ER_diArg_1	42	44	PF00400	0.445
TRG_ER_diArg_1	76	79	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC92	Leptomonas seymouri	57%	100%
A0A1X0NRQ5	Trypanosomatidae	38%	100%
A0A3S7X4Q1	Leishmania donovani	100%	100%
A0A422N3Z8	Trypanosoma rangeli	35%	100%
A4HJK9	Leishmania braziliensis	75%	99%
C9ZWP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9B227	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q635	Leishmania major	92%	100%
V5AMB1	Trypanosoma cruzi	35%	100%