Putative 3,2-trans-enoyl-CoA isomerase, mitochondrial

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3 -2-trans-enoyl-CoA isomerase - mitochondrial precursor - putative

Species:

Leishmania infantum

UniProt:

A4I708_LEIIN

TriTrypDb:

LINF_310030700

Length:

342

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, 3,2-trans-enoyl-CoA isomerase, mitochondrial

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I708

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I708

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	12
GO:0016853	isomerase activity	2	19
GO:0016860	intramolecular oxidoreductase activity	3	12
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	12
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	4
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4
GO:0004300	enoyl-CoA hydratase activity	5	2
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.566
CLV_NRD_NRD_1	296	298	PF00675	0.249
CLV_NRD_NRD_1	340	342	PF00675	0.536
CLV_PCSK_KEX2_1	2	4	PF00082	0.567
CLV_PCSK_KEX2_1	296	298	PF00082	0.249
CLV_PCSK_KEX2_1	54	56	PF00082	0.518
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.518
CLV_PCSK_PC7_1	292	298	PF00082	0.227
CLV_PCSK_SKI1_1	83	87	PF00082	0.296
DEG_APCC_DBOX_1	296	304	PF00400	0.234
DEG_Nend_UBRbox_1	1	4	PF02207	0.579
DEG_SPOP_SBC_1	4	8	PF00917	0.684
DOC_CYCLIN_RxL_1	236	247	PF00134	0.245
DOC_CYCLIN_yClb5_NLxxxL_5	327	333	PF00134	0.373
DOC_PP2B_LxvP_1	219	222	PF13499	0.322
DOC_PP2B_LxvP_1	281	284	PF13499	0.320
DOC_PP4_FxxP_1	166	169	PF00568	0.248
DOC_PP4_FxxP_1	63	66	PF00568	0.426
DOC_USP7_MATH_1	284	288	PF00917	0.208
DOC_USP7_MATH_1	50	54	PF00917	0.761
DOC_USP7_MATH_1	94	98	PF00917	0.239
DOC_WW_Pin1_4	175	180	PF00397	0.222
DOC_WW_Pin1_4	244	249	PF00397	0.248
DOC_WW_Pin1_4	319	324	PF00397	0.208
LIG_14-3-3_CanoR_1	11	17	PF00244	0.526
LIG_14-3-3_CanoR_1	279	284	PF00244	0.350
LIG_14-3-3_CanoR_1	29	34	PF00244	0.496
LIG_APCC_ABBA_1	100	105	PF00400	0.254
LIG_BIR_III_2	58	62	PF00653	0.563
LIG_deltaCOP1_diTrp_1	158	166	PF00928	0.248
LIG_FHA_1	117	123	PF00498	0.273
LIG_FHA_1	13	19	PF00498	0.626
LIG_FHA_1	315	321	PF00498	0.237
LIG_LIR_Apic_2	165	169	PF02991	0.247
LIG_LIR_Apic_2	62	66	PF02991	0.455
LIG_LIR_Gen_1	101	111	PF02991	0.250
LIG_LIR_Gen_1	155	163	PF02991	0.223
LIG_LIR_Gen_1	278	284	PF02991	0.248
LIG_LIR_Gen_1	298	304	PF02991	0.091
LIG_LIR_Gen_1	313	323	PF02991	0.242
LIG_LIR_Nem_3	101	106	PF02991	0.250
LIG_LIR_Nem_3	158	163	PF02991	0.239
LIG_LIR_Nem_3	278	283	PF02991	0.248
LIG_LIR_Nem_3	313	319	PF02991	0.337
LIG_LYPXL_SIV_4	273	281	PF13949	0.389
LIG_PCNA_PIPBox_1	326	335	PF02747	0.320
LIG_PCNA_yPIPBox_3	326	339	PF02747	0.271
LIG_Pex14_2	152	156	PF04695	0.248
LIG_Pex14_2	315	319	PF04695	0.350
LIG_SH2_CRK	229	233	PF00017	0.231
LIG_SH2_STAP1	229	233	PF00017	0.231
LIG_SH2_STAP1	311	315	PF00017	0.235
LIG_SH2_STAT3	28	31	PF00017	0.558
LIG_SH2_STAT5	231	234	PF00017	0.259
LIG_SH2_STAT5	299	302	PF00017	0.346
LIG_SH2_STAT5	332	335	PF00017	0.296
LIG_SH3_3	138	144	PF00018	0.389
LIG_SH3_3	217	223	PF00018	0.340
LIG_SH3_3	317	323	PF00018	0.283
LIG_SH3_3	33	39	PF00018	0.567
LIG_SH3_3	63	69	PF00018	0.419
LIG_SxIP_EBH_1	120	134	PF03271	0.261
LIG_TRAF2_1	115	118	PF00917	0.373
LIG_TRAF2_1	155	158	PF00917	0.237
LIG_TRAF2_1	264	267	PF00917	0.426
LIG_TRAF2_1	305	308	PF00917	0.296
MOD_CK1_1	53	59	PF00069	0.595
MOD_CK1_1	7	13	PF00069	0.699
MOD_CK2_1	112	118	PF00069	0.328
MOD_CK2_1	152	158	PF00069	0.310
MOD_CK2_1	265	271	PF00069	0.392
MOD_CK2_1	302	308	PF00069	0.296
MOD_CK2_1	328	334	PF00069	0.266
MOD_CMANNOS	109	112	PF00535	0.248
MOD_GlcNHglycan	125	128	PF01048	0.262
MOD_GlcNHglycan	132	135	PF01048	0.230
MOD_GSK3_1	112	119	PF00069	0.269
MOD_GSK3_1	123	130	PF00069	0.225
MOD_GSK3_1	3	10	PF00069	0.657
MOD_GSK3_1	310	317	PF00069	0.379
MOD_N-GLC_1	212	217	PF02516	0.253
MOD_NEK2_1	152	157	PF00069	0.259
MOD_NEK2_1	212	217	PF00069	0.256
MOD_NEK2_1	23	28	PF00069	0.456
MOD_NEK2_1	232	237	PF00069	0.091
MOD_PIKK_1	23	29	PF00454	0.503
MOD_PIKK_1	314	320	PF00454	0.247
MOD_PK_1	279	285	PF00069	0.350
MOD_PKA_1	67	73	PF00069	0.551
MOD_Plk_1	265	271	PF00069	0.400
MOD_Plk_2-3	266	272	PF00069	0.264
MOD_Plk_4	127	133	PF00069	0.266
MOD_Plk_4	328	334	PF00069	0.266
MOD_ProDKin_1	175	181	PF00069	0.222
MOD_ProDKin_1	244	250	PF00069	0.248
MOD_ProDKin_1	319	325	PF00069	0.208
MOD_SUMO_rev_2	115	122	PF00179	0.348
TRG_DiLeu_BaEn_2	70	76	PF01217	0.504
TRG_ENDOCYTIC_2	191	194	PF00928	0.389
TRG_ENDOCYTIC_2	229	232	PF00928	0.248
TRG_ENDOCYTIC_2	299	302	PF00928	0.346
TRG_ER_diArg_1	1	3	PF00400	0.572
TRG_ER_diArg_1	295	297	PF00400	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C8	Leptomonas seymouri	77%	97%
A0A0S4IKH3	Bodo saltans	59%	99%
A0A0S4JA19	Bodo saltans	35%	100%
A0A1X0NJ83	Trypanosomatidae	28%	100%
A0A1X0NRI1	Trypanosomatidae	54%	93%
A0A1X0P9A2	Trypanosomatidae	25%	100%
A0A3Q8IE71	Leishmania donovani	36%	100%
A0A3Q8IIZ5	Leishmania donovani	25%	100%
A0A3R7N7B2	Trypanosoma rangeli	25%	100%
A0A3S7X4R5	Leishmania donovani	100%	100%
A0A3S7X4T7	Leishmania donovani	97%	100%
A0A422N418	Trypanosoma rangeli	61%	99%
A4HH09	Leishmania braziliensis	35%	100%
A4HJK3	Leishmania braziliensis	76%	100%
A4HJK8	Leishmania braziliensis	83%	100%
A4HJL5	Leishmania braziliensis	76%	100%
A4HM74	Leishmania braziliensis	26%	100%
A4I438	Leishmania infantum	35%	100%
A4I4U5	Leishmania infantum	25%	100%
A4I738	Leishmania infantum	91%	98%
A9JS71	Xenopus laevis	26%	100%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZME0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	73%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	96%
E9ADK3	Leishmania major	34%	100%
E9AE93	Leishmania major	26%	100%
E9AEL3	Leishmania major	26%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O07137	Mycobacterium leprae (strain TN)	25%	100%
O35459	Mus musculus	23%	100%
P14604	Rattus norvegicus	24%	100%
P23965	Rattus norvegicus	39%	100%
P30084	Homo sapiens	23%	100%
P34559	Caenorhabditis elegans	21%	100%
P42125	Mus musculus	39%	100%
P42126	Homo sapiens	34%	100%
P52046	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	21%	100%
P64017	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	22%	100%
P76082	Escherichia coli (strain K12)	24%	100%
P94549	Bacillus subtilis (strain 168)	27%	100%
P9WNN8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	22%	100%
P9WNN9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	100%
Q0AVM1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	23%	100%
Q13011	Homo sapiens	25%	100%
Q1ZXF1	Dictyostelium discoideum	27%	100%
Q4Q628	Leishmania major	85%	100%
Q4Q636	Leishmania major	95%	100%
Q52995	Rhizobium meliloti (strain 1021)	22%	100%
Q58DM8	Bos taurus	24%	100%
Q5R646	Pongo abelii	23%	100%
Q5RFG0	Pongo abelii	26%	100%
Q62651	Rattus norvegicus	22%	100%
Q8BH95	Mus musculus	24%	100%
V5B2L9	Trypanosoma cruzi	58%	88%
V5BK92	Trypanosoma cruzi	31%	100%
V5DTT7	Trypanosoma cruzi	24%	100%