Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I703_LEIIN

TriTrypDb:

LINF_310030200

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I703

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I703

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.637
CLV_C14_Caspase3-7	261	265	PF00656	0.720
CLV_NRD_NRD_1	202	204	PF00675	0.677
CLV_NRD_NRD_1	222	224	PF00675	0.633
CLV_NRD_NRD_1	24	26	PF00675	0.773
CLV_NRD_NRD_1	300	302	PF00675	0.789
CLV_NRD_NRD_1	339	341	PF00675	0.702
CLV_PCSK_KEX2_1	222	224	PF00082	0.633
CLV_PCSK_KEX2_1	24	26	PF00082	0.777
CLV_PCSK_KEX2_1	300	302	PF00082	0.789
CLV_PCSK_KEX2_1	339	341	PF00082	0.702
CLV_PCSK_KEX2_1	473	475	PF00082	0.605
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.578
CLV_PCSK_PC7_1	335	341	PF00082	0.600
CLV_PCSK_SKI1_1	203	207	PF00082	0.714
CLV_PCSK_SKI1_1	36	40	PF00082	0.649
CLV_PCSK_SKI1_1	47	51	PF00082	0.596
DEG_APCC_DBOX_1	214	222	PF00400	0.635
DEG_COP1_1	433	443	PF00400	0.685
DEG_SCF_FBW7_1	115	122	PF00400	0.618
DEG_SPOP_SBC_1	11	15	PF00917	0.682
DOC_MAPK_gen_1	344	351	PF00069	0.712
DOC_MAPK_gen_1	51	58	PF00069	0.677
DOC_USP7_MATH_1	109	113	PF00917	0.779
DOC_USP7_MATH_1	142	146	PF00917	0.743
DOC_USP7_MATH_1	284	288	PF00917	0.805
DOC_USP7_MATH_1	338	342	PF00917	0.675
DOC_USP7_MATH_1	392	396	PF00917	0.737
DOC_WW_Pin1_4	107	112	PF00397	0.717
DOC_WW_Pin1_4	115	120	PF00397	0.697
DOC_WW_Pin1_4	194	199	PF00397	0.756
DOC_WW_Pin1_4	328	333	PF00397	0.710
DOC_WW_Pin1_4	439	444	PF00397	0.689
LIG_14-3-3_CanoR_1	123	127	PF00244	0.723
LIG_14-3-3_CanoR_1	151	157	PF00244	0.688
LIG_14-3-3_CanoR_1	215	219	PF00244	0.703
LIG_14-3-3_CanoR_1	222	228	PF00244	0.785
LIG_14-3-3_CanoR_1	300	305	PF00244	0.791
LIG_14-3-3_CanoR_1	339	343	PF00244	0.769
LIG_14-3-3_CanoR_1	34	39	PF00244	0.719
LIG_14-3-3_CanoR_1	393	402	PF00244	0.670
LIG_BRCT_BRCA1_1	209	213	PF00533	0.608
LIG_BRCT_BRCA1_1	271	275	PF00533	0.705
LIG_BRCT_BRCA1_1	420	424	PF00533	0.758
LIG_BRCT_BRCA1_1	435	439	PF00533	0.686
LIG_FHA_1	150	156	PF00498	0.714
LIG_FHA_1	301	307	PF00498	0.791
LIG_FHA_1	353	359	PF00498	0.648
LIG_FHA_1	70	76	PF00498	0.676
LIG_FHA_2	151	157	PF00498	0.688
LIG_FHA_2	280	286	PF00498	0.787
LIG_LIR_Apic_2	125	130	PF02991	0.718
LIG_LIR_Apic_2	145	150	PF02991	0.604
LIG_LIR_Gen_1	135	146	PF02991	0.648
LIG_LIR_Gen_1	442	450	PF02991	0.671
LIG_LIR_Nem_3	122	127	PF02991	0.653
LIG_LIR_Nem_3	135	141	PF02991	0.610
LIG_LIR_Nem_3	226	230	PF02991	0.634
LIG_LIR_Nem_3	250	256	PF02991	0.616
LIG_LIR_Nem_3	442	448	PF02991	0.723
LIG_PAM2_1	173	185	PF00658	0.634
LIG_PDZ_Class_2	480	485	PF00595	0.598
LIG_SH2_CRK	127	131	PF00017	0.666
LIG_SH2_CRK	138	142	PF00017	0.666
LIG_SH2_CRK	147	151	PF00017	0.575
LIG_SH2_CRK	253	257	PF00017	0.621
LIG_SH2_NCK_1	138	142	PF00017	0.720
LIG_SH2_STAT5	138	141	PF00017	0.798
LIG_SH2_STAT5	147	150	PF00017	0.566
LIG_SH3_3	303	309	PF00018	0.736
LIG_SH3_3	437	443	PF00018	0.676
LIG_SH3_3	70	76	PF00018	0.791
LIG_SH3_3	81	87	PF00018	0.637
LIG_TRFH_1	138	142	PF08558	0.681
LIG_TYR_ITIM	251	256	PF00017	0.618
LIG_WW_3	390	394	PF00397	0.620
MOD_CDK_SPK_2	194	199	PF00069	0.639
MOD_CDK_SPxxK_3	328	335	PF00069	0.626
MOD_CK1_1	197	203	PF00069	0.799
MOD_CK1_1	214	220	PF00069	0.673
MOD_CK1_1	246	252	PF00069	0.691
MOD_CK1_1	287	293	PF00069	0.747
MOD_CK1_1	294	300	PF00069	0.661
MOD_CK1_1	347	353	PF00069	0.708
MOD_CK1_1	416	422	PF00069	0.814
MOD_CK1_1	433	439	PF00069	0.692
MOD_CK2_1	100	106	PF00069	0.588
MOD_CK2_1	150	156	PF00069	0.696
MOD_CK2_1	24	30	PF00069	0.703
MOD_CK2_1	246	252	PF00069	0.779
MOD_CK2_1	264	270	PF00069	0.520
MOD_CK2_1	85	91	PF00069	0.769
MOD_GlcNHglycan	14	17	PF01048	0.682
MOD_GlcNHglycan	264	267	PF01048	0.720
MOD_GlcNHglycan	435	438	PF01048	0.643
MOD_GlcNHglycan	47	50	PF01048	0.641
MOD_GSK3_1	100	107	PF00069	0.720
MOD_GSK3_1	115	122	PF00069	0.584
MOD_GSK3_1	173	180	PF00069	0.698
MOD_GSK3_1	20	27	PF00069	0.740
MOD_GSK3_1	205	212	PF00069	0.677
MOD_GSK3_1	243	250	PF00069	0.696
MOD_GSK3_1	258	265	PF00069	0.621
MOD_GSK3_1	286	293	PF00069	0.773
MOD_GSK3_1	296	303	PF00069	0.647
MOD_GSK3_1	345	352	PF00069	0.699
MOD_GSK3_1	36	43	PF00069	0.609
MOD_GSK3_1	393	400	PF00069	0.722
MOD_GSK3_1	426	433	PF00069	0.653
MOD_N-GLC_1	352	357	PF02516	0.676
MOD_N-GLC_1	416	421	PF02516	0.820
MOD_N-GLC_1	61	66	PF02516	0.633
MOD_N-GLC_2	98	100	PF02516	0.768
MOD_NEK2_1	1	6	PF00069	0.799
MOD_NEK2_1	20	25	PF00069	0.508
MOD_NEK2_1	349	354	PF00069	0.684
MOD_NEK2_1	418	423	PF00069	0.778
MOD_NEK2_1	430	435	PF00069	0.461
MOD_NEK2_2	142	147	PF00069	0.638
MOD_NMyristoyl	1	7	PF02799	0.813
MOD_PIKK_1	291	297	PF00454	0.797
MOD_PKA_1	24	30	PF00069	0.780
MOD_PKA_1	300	306	PF00069	0.789
MOD_PKA_2	122	128	PF00069	0.757
MOD_PKA_2	150	156	PF00069	0.685
MOD_PKA_2	214	220	PF00069	0.673
MOD_PKA_2	24	30	PF00069	0.769
MOD_PKA_2	276	282	PF00069	0.712
MOD_PKA_2	300	306	PF00069	0.789
MOD_PKA_2	338	344	PF00069	0.780
MOD_PKA_2	39	45	PF00069	0.569
MOD_PKA_2	392	398	PF00069	0.700
MOD_PKA_2	91	97	PF00069	0.737
MOD_PKB_1	45	53	PF00069	0.700
MOD_Plk_1	134	140	PF00069	0.588
MOD_Plk_1	177	183	PF00069	0.661
MOD_Plk_1	243	249	PF00069	0.694
MOD_Plk_1	269	275	PF00069	0.698
MOD_Plk_1	426	432	PF00069	0.693
MOD_Plk_4	109	115	PF00069	0.747
MOD_Plk_4	122	128	PF00069	0.643
MOD_Plk_4	136	142	PF00069	0.617
MOD_Plk_4	270	276	PF00069	0.773
MOD_Plk_4	287	293	PF00069	0.553
MOD_ProDKin_1	107	113	PF00069	0.719
MOD_ProDKin_1	115	121	PF00069	0.694
MOD_ProDKin_1	194	200	PF00069	0.757
MOD_ProDKin_1	328	334	PF00069	0.708
MOD_ProDKin_1	439	445	PF00069	0.695
MOD_SUMO_rev_2	187	195	PF00179	0.735
MOD_SUMO_rev_2	452	456	PF00179	0.568
TRG_DiLeu_BaEn_4	453	459	PF01217	0.684
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.615
TRG_ENDOCYTIC_2	138	141	PF00928	0.720
TRG_ENDOCYTIC_2	253	256	PF00928	0.619
TRG_ER_diArg_1	221	223	PF00400	0.638
TRG_ER_diArg_1	420	423	PF00400	0.696
TRG_NES_CRM1_1	65	79	PF08389	0.709
TRG_NLS_MonoExtC_3	469	474	PF00514	0.582
TRG_NLS_MonoExtN_4	468	474	PF00514	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q7	Leishmania donovani	99%	100%
A4HJK2	Leishmania braziliensis	56%	98%
E9B221	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q641	Leishmania major	83%	100%