Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6Z8_LEIIN

TriTrypDb:

LINF_310030100

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Z8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.647
CLV_NRD_NRD_1	275	277	PF00675	0.695
CLV_NRD_NRD_1	300	302	PF00675	0.663
CLV_NRD_NRD_1	34	36	PF00675	0.665
CLV_NRD_NRD_1	341	343	PF00675	0.744
CLV_NRD_NRD_1	431	433	PF00675	0.736
CLV_NRD_NRD_1	584	586	PF00675	0.590
CLV_PCSK_KEX2_1	275	277	PF00082	0.741
CLV_PCSK_KEX2_1	300	302	PF00082	0.663
CLV_PCSK_KEX2_1	34	36	PF00082	0.665
CLV_PCSK_KEX2_1	340	342	PF00082	0.762
CLV_PCSK_KEX2_1	583	585	PF00082	0.703
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.703
CLV_PCSK_PC7_1	579	585	PF00082	0.658
CLV_PCSK_SKI1_1	304	308	PF00082	0.673
CLV_PCSK_SKI1_1	341	345	PF00082	0.677
CLV_PCSK_SKI1_1	37	41	PF00082	0.548
CLV_PCSK_SKI1_1	392	396	PF00082	0.619
CLV_PCSK_SKI1_1	426	430	PF00082	0.643
CLV_PCSK_SKI1_1	585	589	PF00082	0.641
DEG_SPOP_SBC_1	320	324	PF00917	0.614
DEG_SPOP_SBC_1	50	54	PF00917	0.572
DEG_SPOP_SBC_1	536	540	PF00917	0.614
DEG_SPOP_SBC_1	561	565	PF00917	0.690
DOC_ANK_TNKS_1	671	678	PF00023	0.607
DOC_CKS1_1	305	310	PF01111	0.643
DOC_CYCLIN_RxL_1	579	591	PF00134	0.595
DOC_MAPK_gen_1	583	589	PF00069	0.705
DOC_PP1_SILK_1	700	705	PF00149	0.684
DOC_PP2B_LxvP_1	126	129	PF13499	0.651
DOC_PP2B_LxvP_1	174	177	PF13499	0.554
DOC_PP2B_LxvP_1	194	197	PF13499	0.614
DOC_PP2B_LxvP_1	352	355	PF13499	0.701
DOC_PP2B_LxvP_1	450	453	PF13499	0.654
DOC_USP7_MATH_1	119	123	PF00917	0.672
DOC_USP7_MATH_1	293	297	PF00917	0.680
DOC_USP7_MATH_1	320	324	PF00917	0.667
DOC_USP7_MATH_1	419	423	PF00917	0.642
DOC_USP7_MATH_1	478	482	PF00917	0.616
DOC_USP7_MATH_1	536	540	PF00917	0.640
DOC_USP7_MATH_1	556	560	PF00917	0.589
DOC_USP7_MATH_1	561	565	PF00917	0.701
DOC_USP7_MATH_1	631	635	PF00917	0.652
DOC_USP7_MATH_1	723	727	PF00917	0.682
DOC_USP7_MATH_1	739	743	PF00917	0.498
DOC_USP7_MATH_2	85	91	PF00917	0.622
DOC_USP7_UBL2_3	366	370	PF12436	0.638
DOC_USP7_UBL2_3	755	759	PF12436	0.677
DOC_WW_Pin1_4	104	109	PF00397	0.652
DOC_WW_Pin1_4	188	193	PF00397	0.674
DOC_WW_Pin1_4	198	203	PF00397	0.599
DOC_WW_Pin1_4	210	215	PF00397	0.592
DOC_WW_Pin1_4	233	238	PF00397	0.653
DOC_WW_Pin1_4	241	246	PF00397	0.609
DOC_WW_Pin1_4	270	275	PF00397	0.786
DOC_WW_Pin1_4	286	291	PF00397	0.643
DOC_WW_Pin1_4	304	309	PF00397	0.564
DOC_WW_Pin1_4	421	426	PF00397	0.803
DOC_WW_Pin1_4	439	444	PF00397	0.534
DOC_WW_Pin1_4	51	56	PF00397	0.735
DOC_WW_Pin1_4	62	67	PF00397	0.775
DOC_WW_Pin1_4	640	645	PF00397	0.678
DOC_WW_Pin1_4	662	667	PF00397	0.747
DOC_WW_Pin1_4	712	717	PF00397	0.662
DOC_WW_Pin1_4	81	86	PF00397	0.480
LIG_14-3-3_CanoR_1	163	167	PF00244	0.666
LIG_14-3-3_CanoR_1	251	260	PF00244	0.724
LIG_14-3-3_CanoR_1	34	40	PF00244	0.582
LIG_14-3-3_CanoR_1	584	590	PF00244	0.814
LIG_14-3-3_CanoR_1	682	687	PF00244	0.583
LIG_BIR_III_2	142	146	PF00653	0.638
LIG_BRCT_BRCA1_1	163	167	PF00533	0.681
LIG_BRCT_BRCA1_1	478	482	PF00533	0.554
LIG_BRCT_BRCA1_1	725	729	PF00533	0.674
LIG_CtBP_PxDLS_1	177	181	PF00389	0.619
LIG_CtBP_PxDLS_1	690	694	PF00389	0.607
LIG_CtBP_PxDLS_1	85	89	PF00389	0.573
LIG_EH1_1	696	704	PF00400	0.632
LIG_eIF4E_1	469	475	PF01652	0.517
LIG_FHA_1	105	111	PF00498	0.666
LIG_FHA_1	236	242	PF00498	0.672
LIG_FHA_1	316	322	PF00498	0.665
LIG_FHA_1	561	567	PF00498	0.796
LIG_FHA_1	599	605	PF00498	0.681
LIG_FHA_2	401	407	PF00498	0.643
LIG_FHA_2	586	592	PF00498	0.684
LIG_LIR_Apic_2	511	515	PF02991	0.566
LIG_LIR_Gen_1	133	143	PF02991	0.613
LIG_LIR_Gen_1	466	475	PF02991	0.615
LIG_LIR_Gen_1	479	490	PF02991	0.561
LIG_LIR_Nem_3	133	139	PF02991	0.641
LIG_LIR_Nem_3	164	169	PF02991	0.555
LIG_LIR_Nem_3	244	249	PF02991	0.724
LIG_LIR_Nem_3	466	472	PF02991	0.609
LIG_LIR_Nem_3	706	712	PF02991	0.639
LIG_LIR_Nem_3	78	83	PF02991	0.593
LIG_MLH1_MIPbox_1	163	167	PF16413	0.644
LIG_MYND_1	124	128	PF01753	0.656
LIG_MYND_1	387	391	PF01753	0.588
LIG_RPA_C_Fungi	738	750	PF08784	0.680
LIG_SH2_CRK	469	473	PF00017	0.514
LIG_SH2_CRK	709	713	PF00017	0.643
LIG_SH2_SRC	512	515	PF00017	0.591
LIG_SH2_STAP1	132	136	PF00017	0.670
LIG_SH2_STAT5	132	135	PF00017	0.608
LIG_SH2_STAT5	166	169	PF00017	0.761
LIG_SH2_STAT5	373	376	PF00017	0.760
LIG_SH3_3	118	124	PF00018	0.659
LIG_SH3_3	186	192	PF00018	0.661
LIG_SH3_3	201	207	PF00018	0.542
LIG_SH3_3	234	240	PF00018	0.694
LIG_SH3_3	242	248	PF00018	0.615
LIG_SH3_3	254	260	PF00018	0.518
LIG_SH3_3	287	293	PF00018	0.801
LIG_SH3_3	385	391	PF00018	0.617
LIG_SH3_3	445	451	PF00018	0.693
LIG_SH3_3	633	639	PF00018	0.635
LIG_SH3_4	755	762	PF00018	0.676
LIG_SUMO_SIM_anti_2	92	100	PF11976	0.598
LIG_SUMO_SIM_par_1	84	90	PF11976	0.572
LIG_TRAF2_2	756	761	PF00917	0.651
LIG_WRC_WIRS_1	77	82	PF05994	0.595
MOD_CDC14_SPxK_1	273	276	PF00782	0.599
MOD_CDK_SPK_2	270	275	PF00069	0.597
MOD_CDK_SPK_2	421	426	PF00069	0.803
MOD_CDK_SPxK_1	270	276	PF00069	0.709
MOD_CDK_SPxK_1	51	57	PF00069	0.664
MOD_CDK_SPxxK_3	188	195	PF00069	0.669
MOD_CDK_SPxxK_3	210	217	PF00069	0.628
MOD_CDK_SPxxK_3	244	251	PF00069	0.583
MOD_CDK_SPxxK_3	640	647	PF00069	0.559
MOD_CDK_SPxxK_3	712	719	PF00069	0.645
MOD_CK1_1	157	163	PF00069	0.707
MOD_CK1_1	165	171	PF00069	0.685
MOD_CK1_1	244	250	PF00069	0.758
MOD_CK1_1	266	272	PF00069	0.715
MOD_CK1_1	421	427	PF00069	0.645
MOD_CK1_1	559	565	PF00069	0.579
MOD_CK1_1	612	618	PF00069	0.679
MOD_CK1_1	634	640	PF00069	0.749
MOD_CK1_1	708	714	PF00069	0.694
MOD_CK1_1	78	84	PF00069	0.667
MOD_CK1_1	89	95	PF00069	0.581
MOD_CK2_1	169	175	PF00069	0.684
MOD_CK2_1	210	216	PF00069	0.705
MOD_CK2_1	264	270	PF00069	0.661
MOD_CK2_1	585	591	PF00069	0.721
MOD_CK2_1	662	668	PF00069	0.729
MOD_CK2_1	712	718	PF00069	0.695
MOD_CK2_1	81	87	PF00069	0.692
MOD_DYRK1A_RPxSP_1	188	192	PF00069	0.663
MOD_GlcNHglycan	104	107	PF01048	0.693
MOD_GlcNHglycan	171	174	PF01048	0.724
MOD_GlcNHglycan	270	273	PF01048	0.686
MOD_GlcNHglycan	323	326	PF01048	0.773
MOD_GlcNHglycan	349	352	PF01048	0.765
MOD_GlcNHglycan	421	424	PF01048	0.589
MOD_GlcNHglycan	435	440	PF01048	0.689
MOD_GlcNHglycan	444	447	PF01048	0.635
MOD_GlcNHglycan	478	481	PF01048	0.748
MOD_GlcNHglycan	498	501	PF01048	0.553
MOD_GlcNHglycan	575	578	PF01048	0.799
MOD_GlcNHglycan	606	609	PF01048	0.728
MOD_GlcNHglycan	611	614	PF01048	0.671
MOD_GlcNHglycan	618	621	PF01048	0.630
MOD_GlcNHglycan	636	639	PF01048	0.749
MOD_GlcNHglycan	673	676	PF01048	0.601
MOD_GSK3_1	113	120	PF00069	0.742
MOD_GSK3_1	12	19	PF00069	0.692
MOD_GSK3_1	154	161	PF00069	0.673
MOD_GSK3_1	165	172	PF00069	0.577
MOD_GSK3_1	196	203	PF00069	0.771
MOD_GSK3_1	264	271	PF00069	0.698
MOD_GSK3_1	315	322	PF00069	0.692
MOD_GSK3_1	371	378	PF00069	0.770
MOD_GSK3_1	435	442	PF00069	0.709
MOD_GSK3_1	476	483	PF00069	0.744
MOD_GSK3_1	490	497	PF00069	0.581
MOD_GSK3_1	548	555	PF00069	0.657
MOD_GSK3_1	556	563	PF00069	0.558
MOD_GSK3_1	583	590	PF00069	0.762
MOD_GSK3_1	612	619	PF00069	0.625
MOD_GSK3_1	656	663	PF00069	0.619
MOD_GSK3_1	704	711	PF00069	0.689
MOD_GSK3_1	86	93	PF00069	0.697
MOD_N-GLC_1	251	256	PF02516	0.677
MOD_N-GLC_1	286	291	PF02516	0.603
MOD_N-GLC_1	490	495	PF02516	0.671
MOD_N-GLC_1	556	561	PF02516	0.638
MOD_N-GLC_1	712	717	PF02516	0.694
MOD_N-GLC_2	263	265	PF02516	0.677
MOD_NEK2_1	113	118	PF00069	0.701
MOD_NEK2_1	167	172	PF00069	0.597
MOD_NEK2_1	382	387	PF00069	0.614
MOD_NEK2_1	529	534	PF00069	0.649
MOD_NEK2_1	578	583	PF00069	0.692
MOD_NEK2_1	604	609	PF00069	0.671
MOD_NEK2_1	693	698	PF00069	0.663
MOD_NEK2_1	703	708	PF00069	0.559
MOD_PIKK_1	291	297	PF00454	0.697
MOD_PIKK_1	382	388	PF00454	0.736
MOD_PIKK_1	490	496	PF00454	0.670
MOD_PIKK_1	524	530	PF00454	0.581
MOD_PIKK_1	680	686	PF00454	0.618
MOD_PK_1	682	688	PF00069	0.630
MOD_PK_1	698	704	PF00069	0.573
MOD_PKA_1	258	264	PF00069	0.680
MOD_PKA_1	341	347	PF00069	0.612
MOD_PKA_1	583	589	PF00069	0.655
MOD_PKA_1	704	710	PF00069	0.692
MOD_PKA_2	162	168	PF00069	0.591
MOD_PKA_2	341	347	PF00069	0.612
MOD_PKA_2	578	584	PF00069	0.684
MOD_PKA_2	625	631	PF00069	0.673
MOD_PKA_2	671	677	PF00069	0.722
MOD_Plk_1	130	136	PF00069	0.679
MOD_Plk_1	398	404	PF00069	0.607
MOD_Plk_1	456	462	PF00069	0.573
MOD_Plk_1	717	723	PF00069	0.666
MOD_Plk_1	734	740	PF00069	0.495
MOD_Plk_1	75	81	PF00069	0.614
MOD_Plk_1	86	92	PF00069	0.591
MOD_Plk_4	162	168	PF00069	0.644
MOD_Plk_4	538	544	PF00069	0.559
MOD_Plk_4	631	637	PF00069	0.711
MOD_Plk_4	698	704	PF00069	0.684
MOD_Plk_4	725	731	PF00069	0.638
MOD_ProDKin_1	104	110	PF00069	0.653
MOD_ProDKin_1	188	194	PF00069	0.676
MOD_ProDKin_1	198	204	PF00069	0.598
MOD_ProDKin_1	210	216	PF00069	0.618
MOD_ProDKin_1	233	239	PF00069	0.651
MOD_ProDKin_1	241	247	PF00069	0.608
MOD_ProDKin_1	270	276	PF00069	0.786
MOD_ProDKin_1	286	292	PF00069	0.645
MOD_ProDKin_1	304	310	PF00069	0.564
MOD_ProDKin_1	421	427	PF00069	0.802
MOD_ProDKin_1	439	445	PF00069	0.535
MOD_ProDKin_1	51	57	PF00069	0.739
MOD_ProDKin_1	62	68	PF00069	0.775
MOD_ProDKin_1	640	646	PF00069	0.679
MOD_ProDKin_1	662	668	PF00069	0.744
MOD_ProDKin_1	712	718	PF00069	0.664
MOD_ProDKin_1	81	87	PF00069	0.480
MOD_SUMO_rev_2	45	50	PF00179	0.646
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.678
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.644
TRG_ENDOCYTIC_2	166	169	PF00928	0.561
TRG_ENDOCYTIC_2	246	249	PF00928	0.667
TRG_ENDOCYTIC_2	469	472	PF00928	0.519
TRG_ENDOCYTIC_2	709	712	PF00928	0.646
TRG_ER_diArg_1	274	276	PF00400	0.687
TRG_ER_diArg_1	300	302	PF00400	0.663
TRG_ER_diArg_1	33	35	PF00400	0.677
TRG_ER_diArg_1	339	342	PF00400	0.688
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFQ0	Leishmania donovani	99%	100%
A4HJK1	Leishmania braziliensis	46%	99%
E9B219	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q642	Leishmania major	85%	100%