Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6Z7_LEIIN

TriTrypDb:

LINF_310030000

Length:

903

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Z7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	568	572	PF00656	0.747
CLV_C14_Caspase3-7	792	796	PF00656	0.618
CLV_NRD_NRD_1	128	130	PF00675	0.636
CLV_NRD_NRD_1	151	153	PF00675	0.835
CLV_NRD_NRD_1	195	197	PF00675	0.805
CLV_NRD_NRD_1	323	325	PF00675	0.574
CLV_NRD_NRD_1	351	353	PF00675	0.630
CLV_NRD_NRD_1	37	39	PF00675	0.556
CLV_NRD_NRD_1	444	446	PF00675	0.799
CLV_NRD_NRD_1	467	469	PF00675	0.650
CLV_NRD_NRD_1	494	496	PF00675	0.708
CLV_NRD_NRD_1	501	503	PF00675	0.721
CLV_NRD_NRD_1	530	532	PF00675	0.582
CLV_NRD_NRD_1	54	56	PF00675	0.723
CLV_NRD_NRD_1	581	583	PF00675	0.602
CLV_NRD_NRD_1	622	624	PF00675	0.771
CLV_NRD_NRD_1	79	81	PF00675	0.825
CLV_PCSK_FUR_1	193	197	PF00082	0.796
CLV_PCSK_FUR_1	38	42	PF00082	0.639
CLV_PCSK_FUR_1	618	622	PF00082	0.773
CLV_PCSK_KEX2_1	11	13	PF00082	0.822
CLV_PCSK_KEX2_1	128	130	PF00082	0.636
CLV_PCSK_KEX2_1	151	153	PF00082	0.677
CLV_PCSK_KEX2_1	195	197	PF00082	0.669
CLV_PCSK_KEX2_1	243	245	PF00082	0.688
CLV_PCSK_KEX2_1	350	352	PF00082	0.733
CLV_PCSK_KEX2_1	40	42	PF00082	0.683
CLV_PCSK_KEX2_1	444	446	PF00082	0.726
CLV_PCSK_KEX2_1	494	496	PF00082	0.744
CLV_PCSK_KEX2_1	530	532	PF00082	0.582
CLV_PCSK_KEX2_1	60	62	PF00082	0.523
CLV_PCSK_KEX2_1	620	622	PF00082	0.681
CLV_PCSK_KEX2_1	81	83	PF00082	0.830
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.822
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.688
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.733
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.646
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.521
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.681
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.718
CLV_PCSK_PC7_1	36	42	PF00082	0.629
CLV_PCSK_PC7_1	618	624	PF00082	0.640
CLV_PCSK_SKI1_1	199	203	PF00082	0.653
CLV_PCSK_SKI1_1	21	25	PF00082	0.616
CLV_PCSK_SKI1_1	319	323	PF00082	0.619
CLV_PCSK_SKI1_1	387	391	PF00082	0.592
CLV_PCSK_SKI1_1	686	690	PF00082	0.666
CLV_PCSK_SKI1_1	82	86	PF00082	0.818
CLV_PCSK_SKI1_1	92	96	PF00082	0.677
DEG_SCF_FBW7_1	397	402	PF00400	0.661
DEG_SCF_FBW7_2	710	716	PF00400	0.850
DEG_SPOP_SBC_1	575	579	PF00917	0.749
DEG_SPOP_SBC_1	611	615	PF00917	0.637
DOC_CKS1_1	710	715	PF01111	0.855
DOC_CKS1_1	893	898	PF01111	0.669
DOC_CYCLIN_RxL_1	193	204	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.636
DOC_MAPK_gen_1	193	203	PF00069	0.626
DOC_MAPK_gen_1	224	233	PF00069	0.572
DOC_MAPK_gen_1	701	710	PF00069	0.735
DOC_MAPK_gen_1	814	822	PF00069	0.774
DOC_MAPK_RevD_3	309	325	PF00069	0.588
DOC_PP1_RVXF_1	536	543	PF00149	0.532
DOC_PP1_RVXF_1	684	690	PF00149	0.724
DOC_PP2B_LxvP_1	231	234	PF13499	0.700
DOC_PP2B_LxvP_1	601	604	PF13499	0.634
DOC_PP2B_LxvP_1	95	98	PF13499	0.855
DOC_PP4_FxxP_1	16	19	PF00568	0.770
DOC_PP4_FxxP_1	472	475	PF00568	0.684
DOC_PP4_FxxP_1	743	746	PF00568	0.614
DOC_USP7_MATH_1	168	172	PF00917	0.811
DOC_USP7_MATH_1	367	371	PF00917	0.674
DOC_USP7_MATH_1	377	381	PF00917	0.581
DOC_USP7_MATH_1	453	457	PF00917	0.664
DOC_USP7_MATH_1	462	466	PF00917	0.674
DOC_USP7_MATH_1	575	579	PF00917	0.716
DOC_USP7_MATH_1	585	589	PF00917	0.629
DOC_USP7_MATH_1	611	615	PF00917	0.769
DOC_USP7_MATH_1	717	721	PF00917	0.788
DOC_USP7_MATH_1	749	753	PF00917	0.750
DOC_USP7_MATH_1	90	94	PF00917	0.727
DOC_USP7_MATH_1	96	100	PF00917	0.623
DOC_USP7_UBL2_3	339	343	PF12436	0.746
DOC_USP7_UBL2_3	40	44	PF12436	0.658
DOC_USP7_UBL2_3	56	60	PF12436	0.594
DOC_USP7_UBL2_3	71	75	PF12436	0.741
DOC_WW_Pin1_4	185	190	PF00397	0.817
DOC_WW_Pin1_4	205	210	PF00397	0.528
DOC_WW_Pin1_4	359	364	PF00397	0.708
DOC_WW_Pin1_4	395	400	PF00397	0.805
DOC_WW_Pin1_4	414	419	PF00397	0.546
DOC_WW_Pin1_4	508	513	PF00397	0.606
DOC_WW_Pin1_4	576	581	PF00397	0.745
DOC_WW_Pin1_4	607	612	PF00397	0.763
DOC_WW_Pin1_4	621	626	PF00397	0.601
DOC_WW_Pin1_4	630	635	PF00397	0.650
DOC_WW_Pin1_4	677	682	PF00397	0.702
DOC_WW_Pin1_4	695	700	PF00397	0.514
DOC_WW_Pin1_4	709	714	PF00397	0.855
DOC_WW_Pin1_4	793	798	PF00397	0.797
DOC_WW_Pin1_4	82	87	PF00397	0.819
DOC_WW_Pin1_4	826	831	PF00397	0.763
DOC_WW_Pin1_4	882	887	PF00397	0.722
DOC_WW_Pin1_4	892	897	PF00397	0.748
DOC_WW_Pin1_4	97	102	PF00397	0.775
LIG_14-3-3_CanoR_1	21	30	PF00244	0.602
LIG_14-3-3_CanoR_1	378	383	PF00244	0.734
LIG_14-3-3_CanoR_1	38	48	PF00244	0.472
LIG_14-3-3_CanoR_1	594	601	PF00244	0.681
LIG_14-3-3_CanoR_1	704	711	PF00244	0.724
LIG_14-3-3_CanoR_1	757	762	PF00244	0.820
LIG_14-3-3_CanoR_1	80	85	PF00244	0.772
LIG_14-3-3_CanoR_1	816	821	PF00244	0.776
LIG_BRCT_BRCA1_1	237	241	PF00533	0.634
LIG_BRCT_BRCA1_2	237	243	PF00533	0.638
LIG_eIF4E_1	872	878	PF01652	0.704
LIG_FHA_1	210	216	PF00498	0.724
LIG_FHA_1	217	223	PF00498	0.554
LIG_FHA_1	308	314	PF00498	0.636
LIG_FHA_1	71	77	PF00498	0.712
LIG_FHA_1	737	743	PF00498	0.675
LIG_FHA_2	13	19	PF00498	0.785
LIG_FHA_2	22	28	PF00498	0.542
LIG_FHA_2	336	342	PF00498	0.775
LIG_FHA_2	514	520	PF00498	0.757
LIG_FHA_2	566	572	PF00498	0.736
LIG_FHA_2	781	787	PF00498	0.636
LIG_FHA_2	799	805	PF00498	0.641
LIG_FHA_2	83	89	PF00498	0.627
LIG_FHA_2	865	871	PF00498	0.697
LIG_Integrin_isoDGR_2	629	631	PF01839	0.631
LIG_LIR_Apic_2	15	19	PF02991	0.774
LIG_LIR_Apic_2	869	875	PF02991	0.618
LIG_LIR_Gen_1	29	37	PF02991	0.701
LIG_LIR_Nem_3	380	385	PF02991	0.639
LIG_LYPXL_yS_3	662	665	PF13949	0.736
LIG_MYND_3	308	312	PF01753	0.516
LIG_NRP_CendR_1	901	903	PF00754	0.653
LIG_Pex14_2	472	476	PF04695	0.766
LIG_SH2_GRB2like	31	34	PF00017	0.576
LIG_SH2_NCK_1	791	795	PF00017	0.612
LIG_SH2_PTP2	872	875	PF00017	0.621
LIG_SH2_SRC	744	747	PF00017	0.712
LIG_SH2_STAP1	31	35	PF00017	0.696
LIG_SH2_STAP1	559	563	PF00017	0.604
LIG_SH2_STAT3	525	528	PF00017	0.697
LIG_SH2_STAT5	292	295	PF00017	0.703
LIG_SH2_STAT5	506	509	PF00017	0.757
LIG_SH2_STAT5	525	528	PF00017	0.379
LIG_SH2_STAT5	872	875	PF00017	0.796
LIG_SH3_2	896	901	PF14604	0.616
LIG_SH3_2	98	103	PF14604	0.843
LIG_SH3_3	120	126	PF00018	0.694
LIG_SH3_3	210	216	PF00018	0.660
LIG_SH3_3	413	419	PF00018	0.818
LIG_SH3_3	705	711	PF00018	0.814
LIG_SH3_3	890	896	PF00018	0.637
LIG_SH3_3	95	101	PF00018	0.723
LIG_SUMO_SIM_anti_2	310	315	PF11976	0.627
LIG_SUMO_SIM_par_1	760	767	PF11976	0.746
LIG_TRAF2_1	237	240	PF00917	0.674
LIG_TRAF2_1	338	341	PF00917	0.750
LIG_TRAF2_1	342	345	PF00917	0.733
LIG_TRAF2_1	604	607	PF00917	0.758
LIG_TRAF2_1	748	751	PF00917	0.751
LIG_TRAF2_1	783	786	PF00917	0.629
LIG_UBA3_1	76	81	PF00899	0.713
LIG_WRC_WIRS_1	13	18	PF05994	0.788
LIG_WRC_WIRS_1	735	740	PF05994	0.706
LIG_WW_3	100	104	PF00397	0.833
MOD_CDC14_SPxK_1	100	103	PF00782	0.758
MOD_CDC14_SPxK_1	579	582	PF00782	0.740
MOD_CDC14_SPxK_1	698	701	PF00782	0.714
MOD_CDK_SPK_2	185	190	PF00069	0.763
MOD_CDK_SPK_2	359	364	PF00069	0.708
MOD_CDK_SPK_2	607	612	PF00069	0.724
MOD_CDK_SPxK_1	395	401	PF00069	0.755
MOD_CDK_SPxK_1	576	582	PF00069	0.744
MOD_CDK_SPxK_1	695	701	PF00069	0.718
MOD_CDK_SPxK_1	709	715	PF00069	0.738
MOD_CDK_SPxK_1	97	103	PF00069	0.768
MOD_CDK_SPxxK_3	359	366	PF00069	0.643
MOD_CDK_SPxxK_3	576	583	PF00069	0.744
MOD_CDK_SPxxK_3	621	628	PF00069	0.639
MOD_CK1_1	141	147	PF00069	0.709
MOD_CK1_1	180	186	PF00069	0.820
MOD_CK1_1	247	253	PF00069	0.789
MOD_CK1_1	294	300	PF00069	0.768
MOD_CK1_1	327	333	PF00069	0.686
MOD_CK1_1	359	365	PF00069	0.706
MOD_CK1_1	381	387	PF00069	0.743
MOD_CK1_1	440	446	PF00069	0.779
MOD_CK1_1	456	462	PF00069	0.660
MOD_CK1_1	464	470	PF00069	0.650
MOD_CK1_1	513	519	PF00069	0.765
MOD_CK1_1	564	570	PF00069	0.647
MOD_CK1_1	588	594	PF00069	0.623
MOD_CK1_1	597	603	PF00069	0.611
MOD_CK1_1	610	616	PF00069	0.649
MOD_CK1_1	65	71	PF00069	0.771
MOD_CK1_1	676	682	PF00069	0.675
MOD_CK1_1	752	758	PF00069	0.837
MOD_CK1_1	810	816	PF00069	0.682
MOD_CK1_1	828	834	PF00069	0.624
MOD_CK2_1	180	186	PF00069	0.758
MOD_CK2_1	21	27	PF00069	0.645
MOD_CK2_1	335	341	PF00069	0.704
MOD_CK2_1	404	410	PF00069	0.839
MOD_CK2_1	744	750	PF00069	0.681
MOD_CK2_1	775	781	PF00069	0.836
MOD_CK2_1	798	804	PF00069	0.639
MOD_Cter_Amidation	492	495	PF01082	0.627
MOD_DYRK1A_RPxSP_1	82	86	PF00069	0.774
MOD_GlcNHglycan	110	113	PF01048	0.819
MOD_GlcNHglycan	179	182	PF01048	0.837
MOD_GlcNHglycan	203	206	PF01048	0.741
MOD_GlcNHglycan	253	256	PF01048	0.645
MOD_GlcNHglycan	293	296	PF01048	0.749
MOD_GlcNHglycan	358	361	PF01048	0.824
MOD_GlcNHglycan	369	372	PF01048	0.701
MOD_GlcNHglycan	387	390	PF01048	0.500
MOD_GlcNHglycan	455	458	PF01048	0.648
MOD_GlcNHglycan	512	515	PF01048	0.787
MOD_GlcNHglycan	554	557	PF01048	0.734
MOD_GlcNHglycan	559	562	PF01048	0.807
MOD_GlcNHglycan	563	566	PF01048	0.700
MOD_GlcNHglycan	571	574	PF01048	0.563
MOD_GlcNHglycan	587	590	PF01048	0.580
MOD_GlcNHglycan	596	599	PF01048	0.789
MOD_GlcNHglycan	614	617	PF01048	0.550
MOD_GlcNHglycan	652	655	PF01048	0.715
MOD_GlcNHglycan	681	684	PF01048	0.752
MOD_GlcNHglycan	747	750	PF01048	0.801
MOD_GlcNHglycan	830	833	PF01048	0.712
MOD_GlcNHglycan	842	845	PF01048	0.628
MOD_GlcNHglycan	853	857	PF01048	0.720
MOD_GlcNHglycan	92	95	PF01048	0.703
MOD_GSK3_1	134	141	PF00069	0.682
MOD_GSK3_1	173	180	PF00069	0.741
MOD_GSK3_1	201	208	PF00069	0.794
MOD_GSK3_1	229	236	PF00069	0.694
MOD_GSK3_1	244	251	PF00069	0.609
MOD_GSK3_1	324	331	PF00069	0.701
MOD_GSK3_1	377	384	PF00069	0.724
MOD_GSK3_1	395	402	PF00069	0.681
MOD_GSK3_1	456	463	PF00069	0.637
MOD_GSK3_1	504	511	PF00069	0.805
MOD_GSK3_1	557	564	PF00069	0.704
MOD_GSK3_1	565	572	PF00069	0.800
MOD_GSK3_1	593	600	PF00069	0.649
MOD_GSK3_1	607	614	PF00069	0.621
MOD_GSK3_1	642	649	PF00069	0.753
MOD_GSK3_1	65	72	PF00069	0.668
MOD_GSK3_1	673	680	PF00069	0.754
MOD_GSK3_1	745	752	PF00069	0.714
MOD_GSK3_1	753	760	PF00069	0.675
MOD_GSK3_1	771	778	PF00069	0.552
MOD_GSK3_1	789	796	PF00069	0.714
MOD_GSK3_1	821	828	PF00069	0.787
MOD_GSK3_1	848	855	PF00069	0.734
MOD_LATS_1	592	598	PF00433	0.756
MOD_N-GLC_1	62	67	PF02516	0.636
MOD_N-GLC_1	645	650	PF02516	0.763
MOD_N-GLC_2	769	771	PF02516	0.605
MOD_NEK2_1	201	206	PF00069	0.704
MOD_NEK2_1	385	390	PF00069	0.736
MOD_NEK2_1	563	568	PF00069	0.740
MOD_NEK2_1	852	857	PF00069	0.750
MOD_PIKK_1	141	147	PF00454	0.646
MOD_PIKK_1	21	27	PF00454	0.689
MOD_PIKK_1	235	241	PF00454	0.693
MOD_PIKK_1	345	351	PF00454	0.795
MOD_PIKK_1	372	378	PF00454	0.766
MOD_PIKK_1	39	45	PF00454	0.478
MOD_PIKK_1	504	510	PF00454	0.835
MOD_PK_1	229	235	PF00069	0.596
MOD_PK_1	757	763	PF00069	0.755
MOD_PK_1	816	822	PF00069	0.775
MOD_PKA_1	324	330	PF00069	0.659
MOD_PKA_1	39	45	PF00069	0.659
MOD_PKA_1	80	86	PF00069	0.658
MOD_PKA_2	335	341	PF00069	0.642
MOD_PKA_2	377	383	PF00069	0.637
MOD_PKA_2	593	599	PF00069	0.683
MOD_PKA_2	611	617	PF00069	0.543
MOD_PKA_2	703	709	PF00069	0.723
MOD_PKA_2	834	840	PF00069	0.765
MOD_PKB_1	132	140	PF00069	0.767
MOD_PKB_1	544	552	PF00069	0.689
MOD_PKB_1	650	658	PF00069	0.681
MOD_PKB_1	814	822	PF00069	0.774
MOD_Plk_1	262	268	PF00069	0.769
MOD_Plk_1	749	755	PF00069	0.780
MOD_Plk_1	780	786	PF00069	0.741
MOD_Plk_2-3	775	781	PF00069	0.719
MOD_Plk_4	168	174	PF00069	0.811
MOD_Plk_4	248	254	PF00069	0.732
MOD_Plk_4	381	387	PF00069	0.754
MOD_ProDKin_1	185	191	PF00069	0.816
MOD_ProDKin_1	205	211	PF00069	0.529
MOD_ProDKin_1	359	365	PF00069	0.709
MOD_ProDKin_1	395	401	PF00069	0.809
MOD_ProDKin_1	414	420	PF00069	0.550
MOD_ProDKin_1	508	514	PF00069	0.601
MOD_ProDKin_1	576	582	PF00069	0.744
MOD_ProDKin_1	607	613	PF00069	0.764
MOD_ProDKin_1	621	627	PF00069	0.599
MOD_ProDKin_1	630	636	PF00069	0.650
MOD_ProDKin_1	677	683	PF00069	0.701
MOD_ProDKin_1	695	701	PF00069	0.517
MOD_ProDKin_1	709	715	PF00069	0.855
MOD_ProDKin_1	793	799	PF00069	0.798
MOD_ProDKin_1	82	88	PF00069	0.820
MOD_ProDKin_1	826	832	PF00069	0.764
MOD_ProDKin_1	882	888	PF00069	0.727
MOD_ProDKin_1	892	898	PF00069	0.745
MOD_ProDKin_1	97	103	PF00069	0.775
MOD_SUMO_for_1	342	345	PF00179	0.648
MOD_SUMO_rev_2	271	275	PF00179	0.556
MOD_SUMO_rev_2	532	539	PF00179	0.572
TRG_DiLeu_BaEn_1	535	540	PF01217	0.524
TRG_ENDOCYTIC_2	31	34	PF00928	0.692
TRG_ENDOCYTIC_2	662	665	PF00928	0.736
TRG_ER_diArg_1	150	152	PF00400	0.832
TRG_ER_diArg_1	193	196	PF00400	0.808
TRG_ER_diArg_1	621	623	PF00400	0.643
TRG_ER_diArg_1	721	724	PF00400	0.791
TRG_ER_diArg_1	79	82	PF00400	0.774
TRG_NES_CRM1_1	223	235	PF08389	0.576
TRG_NES_CRM1_1	312	326	PF08389	0.614
TRG_NLS_MonoCore_2	37	42	PF00514	0.634
TRG_NLS_MonoCore_2	619	624	PF00514	0.640
TRG_NLS_MonoExtN_4	36	43	PF00514	0.633
TRG_NLS_MonoExtN_4	618	624	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIP7	Leishmania donovani	99%	100%
A4HJK0	Leishmania braziliensis	48%	100%
E9B218	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	95%
Q4Q643	Leishmania major	81%	100%