Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6Z5_LEIIN

TriTrypDb:

LINF_310029800

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	568	572	PF00656	0.689
CLV_C14_Caspase3-7	596	600	PF00656	0.794
CLV_C14_Caspase3-7	615	619	PF00656	0.838
CLV_NRD_NRD_1	106	108	PF00675	0.719
CLV_NRD_NRD_1	166	168	PF00675	0.691
CLV_NRD_NRD_1	180	182	PF00675	0.680
CLV_NRD_NRD_1	269	271	PF00675	0.834
CLV_NRD_NRD_1	34	36	PF00675	0.734
CLV_NRD_NRD_1	443	445	PF00675	0.753
CLV_NRD_NRD_1	532	534	PF00675	0.683
CLV_NRD_NRD_1	574	576	PF00675	0.821
CLV_NRD_NRD_1	696	698	PF00675	0.675
CLV_NRD_NRD_1	85	87	PF00675	0.773
CLV_PCSK_KEX2_1	106	108	PF00082	0.719
CLV_PCSK_KEX2_1	166	168	PF00082	0.691
CLV_PCSK_KEX2_1	180	182	PF00082	0.680
CLV_PCSK_KEX2_1	328	330	PF00082	0.760
CLV_PCSK_KEX2_1	33	35	PF00082	0.829
CLV_PCSK_KEX2_1	443	445	PF00082	0.753
CLV_PCSK_KEX2_1	46	48	PF00082	0.798
CLV_PCSK_KEX2_1	534	536	PF00082	0.783
CLV_PCSK_KEX2_1	574	576	PF00082	0.777
CLV_PCSK_KEX2_1	585	587	PF00082	0.659
CLV_PCSK_KEX2_1	696	698	PF00082	0.784
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.760
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.825
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.798
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.783
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.815
CLV_PCSK_SKI1_1	217	221	PF00082	0.774
CLV_PCSK_SKI1_1	60	64	PF00082	0.624
DEG_Nend_Nbox_1	1	3	PF02207	0.639
DEG_SCF_FBW7_2	580	587	PF00400	0.656
DEG_SPOP_SBC_1	186	190	PF00917	0.803
DEG_SPOP_SBC_1	251	255	PF00917	0.704
DEG_SPOP_SBC_1	499	503	PF00917	0.831
DOC_MAPK_gen_1	533	539	PF00069	0.626
DOC_PP1_RVXF_1	215	222	PF00149	0.729
DOC_PP4_FxxP_1	260	263	PF00568	0.729
DOC_PP4_FxxP_1	285	288	PF00568	0.777
DOC_PP4_FxxP_1	388	391	PF00568	0.787
DOC_PP4_FxxP_1	760	763	PF00568	0.697
DOC_PP4_MxPP_1	291	294	PF00568	0.764
DOC_PP4_MxPP_1	711	714	PF00568	0.768
DOC_SPAK_OSR1_1	314	318	PF12202	0.722
DOC_USP7_MATH_1	134	138	PF00917	0.663
DOC_USP7_MATH_1	140	144	PF00917	0.732
DOC_USP7_MATH_1	186	190	PF00917	0.838
DOC_USP7_MATH_1	23	27	PF00917	0.793
DOC_USP7_MATH_1	356	360	PF00917	0.741
DOC_USP7_MATH_1	430	434	PF00917	0.775
DOC_USP7_MATH_1	498	502	PF00917	0.748
DOC_USP7_MATH_1	593	597	PF00917	0.805
DOC_USP7_MATH_1	672	676	PF00917	0.803
DOC_USP7_MATH_1	707	711	PF00917	0.661
DOC_USP7_MATH_1	783	787	PF00917	0.719
DOC_USP7_UBL2_3	226	230	PF12436	0.786
DOC_USP7_UBL2_3	544	548	PF12436	0.609
DOC_USP7_UBL2_3	60	64	PF12436	0.777
DOC_WW_Pin1_4	11	16	PF00397	0.741
DOC_WW_Pin1_4	132	137	PF00397	0.750
DOC_WW_Pin1_4	221	226	PF00397	0.720
DOC_WW_Pin1_4	235	240	PF00397	0.756
DOC_WW_Pin1_4	278	283	PF00397	0.620
DOC_WW_Pin1_4	349	354	PF00397	0.778
DOC_WW_Pin1_4	39	44	PF00397	0.838
DOC_WW_Pin1_4	392	397	PF00397	0.822
DOC_WW_Pin1_4	426	431	PF00397	0.769
DOC_WW_Pin1_4	500	505	PF00397	0.692
DOC_WW_Pin1_4	576	581	PF00397	0.809
DOC_WW_Pin1_4	686	691	PF00397	0.730
DOC_WW_Pin1_4	703	708	PF00397	0.671
DOC_WW_Pin1_4	709	714	PF00397	0.625
DOC_WW_Pin1_4	741	746	PF00397	0.811
DOC_WW_Pin1_4	771	776	PF00397	0.686
DOC_WW_Pin1_4	814	819	PF00397	0.724
DOC_WW_Pin1_4	89	94	PF00397	0.692
LIG_14-3-3_CanoR_1	142	152	PF00244	0.654
LIG_14-3-3_CanoR_1	180	185	PF00244	0.774
LIG_14-3-3_CanoR_1	195	201	PF00244	0.562
LIG_14-3-3_CanoR_1	243	250	PF00244	0.794
LIG_14-3-3_CanoR_1	297	303	PF00244	0.629
LIG_14-3-3_CanoR_1	369	376	PF00244	0.655
LIG_14-3-3_CanoR_1	389	395	PF00244	0.782
LIG_14-3-3_CanoR_1	401	407	PF00244	0.629
LIG_14-3-3_CanoR_1	449	455	PF00244	0.665
LIG_14-3-3_CanoR_1	47	55	PF00244	0.803
LIG_14-3-3_CanoR_1	528	532	PF00244	0.736
LIG_14-3-3_CanoR_1	533	538	PF00244	0.634
LIG_14-3-3_CanoR_1	574	579	PF00244	0.702
LIG_14-3-3_CanoR_1	696	702	PF00244	0.774
LIG_14-3-3_CanoR_1	708	712	PF00244	0.575
LIG_14-3-3_CanoR_1	792	796	PF00244	0.728
LIG_14-3-3_CanoR_1	86	96	PF00244	0.657
LIG_Actin_WH2_2	387	403	PF00022	0.631
LIG_BRCT_BRCA1_1	13	17	PF00533	0.786
LIG_BRCT_BRCA1_1	371	375	PF00533	0.763
LIG_Clathr_ClatBox_1	803	807	PF01394	0.690
LIG_CtBP_PxDLS_1	391	395	PF00389	0.778
LIG_CtBP_PxDLS_1	740	744	PF00389	0.659
LIG_FHA_1	252	258	PF00498	0.603
LIG_FHA_1	346	352	PF00498	0.613
LIG_FHA_1	456	462	PF00498	0.714
LIG_FHA_1	534	540	PF00498	0.632
LIG_FHA_1	662	668	PF00498	0.808
LIG_FHA_1	777	783	PF00498	0.711
LIG_FHA_2	198	204	PF00498	0.794
LIG_FHA_2	471	477	PF00498	0.656
LIG_HCF-1_HBM_1	514	517	PF13415	0.801
LIG_Integrin_RGD_1	329	331	PF01839	0.708
LIG_LIR_Apic_2	147	153	PF02991	0.727
LIG_LIR_Apic_2	283	288	PF02991	0.772
LIG_LIR_Apic_2	386	391	PF02991	0.784
LIG_LIR_Apic_2	759	763	PF02991	0.700
LIG_LIR_Gen_1	203	212	PF02991	0.672
LIG_LIR_Gen_1	331	340	PF02991	0.773
LIG_LIR_Nem_3	283	289	PF02991	0.773
LIG_LIR_Nem_3	331	335	PF02991	0.769
LIG_LIR_Nem_3	817	823	PF02991	0.720
LIG_LYPXL_S_1	285	289	PF13949	0.778
LIG_LYPXL_yS_3	286	289	PF13949	0.733
LIG_MAD2	638	646	PF02301	0.771
LIG_MLH1_MIPbox_1	13	17	PF16413	0.744
LIG_MLH1_MIPbox_1	372	376	PF16413	0.763
LIG_PCNA_yPIPBox_3	637	650	PF02747	0.621
LIG_PCNA_yPIPBox_3	792	804	PF02747	0.550
LIG_Pex14_1	414	418	PF04695	0.779
LIG_Pex14_2	151	155	PF04695	0.761
LIG_SH2_CRK	2	6	PF00017	0.630
LIG_SH2_CRK	738	742	PF00017	0.761
LIG_SH2_CRK	772	776	PF00017	0.759
LIG_SH2_GRB2like	2	5	PF00017	0.633
LIG_SH2_NCK_1	772	776	PF00017	0.759
LIG_SH2_STAT3	264	267	PF00017	0.775
LIG_SH2_STAT5	150	153	PF00017	0.761
LIG_SH2_STAT5	16	19	PF00017	0.798
LIG_SH2_STAT5	731	734	PF00017	0.708
LIG_SH2_STAT5	772	775	PF00017	0.654
LIG_SH3_1	666	672	PF00018	0.808
LIG_SH3_2	669	674	PF14604	0.809
LIG_SH3_3	37	43	PF00018	0.854
LIG_SH3_3	643	649	PF00018	0.743
LIG_SH3_3	666	672	PF00018	0.823
LIG_SH3_3	812	818	PF00018	0.717
LIG_SH3_3	90	96	PF00018	0.653
LIG_SUMO_SIM_par_1	137	143	PF11976	0.624
LIG_SUMO_SIM_par_1	739	744	PF11976	0.658
LIG_TRAF2_1	657	660	PF00917	0.815
LIG_TRAF2_1	8	11	PF00917	0.782
LIG_UBA3_1	639	645	PF00899	0.773
MOD_CDC14_SPxK_1	92	95	PF00782	0.698
MOD_CDK_SPK_2	221	226	PF00069	0.786
MOD_CDK_SPK_2	39	44	PF00069	0.754
MOD_CDK_SPK_2	580	585	PF00069	0.653
MOD_CDK_SPK_2	703	708	PF00069	0.752
MOD_CDK_SPxK_1	580	586	PF00069	0.656
MOD_CDK_SPxK_1	89	95	PF00069	0.694
MOD_CDK_SPxxK_3	39	46	PF00069	0.811
MOD_CDK_SPxxK_3	814	821	PF00069	0.724
MOD_CK1_1	143	149	PF00069	0.786
MOD_CK1_1	156	162	PF00069	0.570
MOD_CK1_1	235	241	PF00069	0.754
MOD_CK1_1	252	258	PF00069	0.771
MOD_CK1_1	278	284	PF00069	0.619
MOD_CK1_1	367	373	PF00069	0.810
MOD_CK1_1	377	383	PF00069	0.642
MOD_CK1_1	453	459	PF00069	0.666
MOD_CK1_1	49	55	PF00069	0.765
MOD_CK1_1	502	508	PF00069	0.848
MOD_CK1_1	520	526	PF00069	0.802
MOD_CK1_1	579	585	PF00069	0.805
MOD_CK1_1	631	637	PF00069	0.710
MOD_CK1_1	89	95	PF00069	0.764
MOD_CK2_1	143	149	PF00069	0.760
MOD_CK2_1	197	203	PF00069	0.794
MOD_CK2_1	23	29	PF00069	0.798
MOD_CK2_1	5	11	PF00069	0.780
MOD_CK2_1	561	567	PF00069	0.674
MOD_CK2_1	91	97	PF00069	0.761
MOD_Cter_Amidation	326	329	PF01082	0.722
MOD_Cter_Amidation	441	444	PF01082	0.713
MOD_GlcNHglycan	123	126	PF01048	0.684
MOD_GlcNHglycan	235	238	PF01048	0.814
MOD_GlcNHglycan	325	328	PF01048	0.748
MOD_GlcNHglycan	336	339	PF01048	0.622
MOD_GlcNHglycan	372	375	PF01048	0.805
MOD_GlcNHglycan	396	399	PF01048	0.668
MOD_GlcNHglycan	410	413	PF01048	0.619
MOD_GlcNHglycan	432	435	PF01048	0.773
MOD_GlcNHglycan	455	458	PF01048	0.763
MOD_GlcNHglycan	51	54	PF01048	0.759
MOD_GlcNHglycan	520	523	PF01048	0.647
MOD_GlcNHglycan	640	643	PF01048	0.792
MOD_GlcNHglycan	674	677	PF01048	0.805
MOD_GlcNHglycan	79	82	PF01048	0.837
MOD_GlcNHglycan	97	100	PF01048	0.844
MOD_GSK3_1	128	135	PF00069	0.733
MOD_GSK3_1	193	200	PF00069	0.798
MOD_GSK3_1	229	236	PF00069	0.789
MOD_GSK3_1	249	256	PF00069	0.766
MOD_GSK3_1	301	308	PF00069	0.803
MOD_GSK3_1	330	337	PF00069	0.652
MOD_GSK3_1	345	352	PF00069	0.533
MOD_GSK3_1	35	42	PF00069	0.786
MOD_GSK3_1	370	377	PF00069	0.791
MOD_GSK3_1	379	386	PF00069	0.677
MOD_GSK3_1	390	397	PF00069	0.780
MOD_GSK3_1	413	420	PF00069	0.705
MOD_GSK3_1	426	433	PF00069	0.701
MOD_GSK3_1	449	456	PF00069	0.774
MOD_GSK3_1	45	52	PF00069	0.719
MOD_GSK3_1	498	505	PF00069	0.797
MOD_GSK3_1	5	12	PF00069	0.816
MOD_GSK3_1	516	523	PF00069	0.708
MOD_GSK3_1	548	555	PF00069	0.721
MOD_GSK3_1	574	581	PF00069	0.605
MOD_GSK3_1	589	596	PF00069	0.681
MOD_GSK3_1	703	710	PF00069	0.659
MOD_GSK3_1	739	746	PF00069	0.768
MOD_GSK3_1	758	765	PF00069	0.497
MOD_GSK3_1	87	94	PF00069	0.760
MOD_LATS_1	231	237	PF00433	0.750
MOD_LATS_1	483	489	PF00433	0.616
MOD_LATS_1	7	13	PF00433	0.780
MOD_N-GLC_1	186	191	PF02516	0.837
MOD_NEK2_1	128	133	PF00069	0.752
MOD_NEK2_1	17	22	PF00069	0.793
MOD_NEK2_1	205	210	PF00069	0.794
MOD_NEK2_1	250	255	PF00069	0.730
MOD_NEK2_1	343	348	PF00069	0.762
MOD_NEK2_1	375	380	PF00069	0.786
MOD_NEK2_1	400	405	PF00069	0.664
MOD_NEK2_1	45	50	PF00069	0.756
MOD_NEK2_1	543	548	PF00069	0.796
MOD_NEK2_1	791	796	PF00069	0.760
MOD_NEK2_2	396	401	PF00069	0.634
MOD_NEK2_2	450	455	PF00069	0.620
MOD_PIKK_1	140	146	PF00454	0.772
MOD_PIKK_1	212	218	PF00454	0.766
MOD_PIKK_1	243	249	PF00454	0.761
MOD_PIKK_1	628	634	PF00454	0.625
MOD_PIKK_1	661	667	PF00454	0.680
MOD_PK_1	697	703	PF00069	0.780
MOD_PKA_1	180	186	PF00069	0.710
MOD_PKA_1	35	41	PF00069	0.671
MOD_PKA_1	46	52	PF00069	0.751
MOD_PKA_1	533	539	PF00069	0.670
MOD_PKA_1	574	580	PF00069	0.702
MOD_PKA_1	86	92	PF00069	0.772
MOD_PKA_2	165	171	PF00069	0.732
MOD_PKA_2	173	179	PF00069	0.717
MOD_PKA_2	180	186	PF00069	0.613
MOD_PKA_2	194	200	PF00069	0.571
MOD_PKA_2	357	363	PF00069	0.783
MOD_PKA_2	400	406	PF00069	0.784
MOD_PKA_2	408	414	PF00069	0.657
MOD_PKA_2	46	52	PF00069	0.804
MOD_PKA_2	527	533	PF00069	0.725
MOD_PKA_2	574	580	PF00069	0.702
MOD_PKA_2	620	626	PF00069	0.699
MOD_PKA_2	661	667	PF00069	0.744
MOD_PKA_2	678	684	PF00069	0.802
MOD_PKA_2	707	713	PF00069	0.639
MOD_PKA_2	791	797	PF00069	0.726
MOD_Plk_1	153	159	PF00069	0.784
MOD_Plk_1	197	203	PF00069	0.750
MOD_Plk_1	758	764	PF00069	0.646
MOD_Plk_2-3	345	351	PF00069	0.611
MOD_Plk_2-3	610	616	PF00069	0.801
MOD_Plk_4	134	140	PF00069	0.619
MOD_Plk_4	253	259	PF00069	0.751
MOD_Plk_4	383	389	PF00069	0.774
MOD_Plk_4	413	419	PF00069	0.738
MOD_Plk_4	485	491	PF00069	0.769
MOD_ProDKin_1	11	17	PF00069	0.743
MOD_ProDKin_1	132	138	PF00069	0.752
MOD_ProDKin_1	221	227	PF00069	0.719
MOD_ProDKin_1	235	241	PF00069	0.756
MOD_ProDKin_1	278	284	PF00069	0.619
MOD_ProDKin_1	349	355	PF00069	0.778
MOD_ProDKin_1	39	45	PF00069	0.836
MOD_ProDKin_1	392	398	PF00069	0.823
MOD_ProDKin_1	426	432	PF00069	0.770
MOD_ProDKin_1	500	506	PF00069	0.694
MOD_ProDKin_1	576	582	PF00069	0.807
MOD_ProDKin_1	686	692	PF00069	0.729
MOD_ProDKin_1	703	709	PF00069	0.653
MOD_ProDKin_1	741	747	PF00069	0.811
MOD_ProDKin_1	771	777	PF00069	0.684
MOD_ProDKin_1	814	820	PF00069	0.725
MOD_ProDKin_1	89	95	PF00069	0.694
MOD_SUMO_for_1	584	587	PF00179	0.659
MOD_SUMO_rev_2	52	62	PF00179	0.785
MOD_SUMO_rev_2	647	652	PF00179	0.748
TRG_DiLeu_BaEn_4	426	432	PF01217	0.574
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.727
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.580
TRG_ENDOCYTIC_2	2	5	PF00928	0.633
TRG_ENDOCYTIC_2	204	207	PF00928	0.680
TRG_ENDOCYTIC_2	286	289	PF00928	0.777
TRG_ENDOCYTIC_2	490	493	PF00928	0.769
TRG_ENDOCYTIC_2	738	741	PF00928	0.757
TRG_ER_diArg_1	105	107	PF00400	0.784
TRG_ER_diArg_1	165	167	PF00400	0.692
TRG_ER_diArg_1	179	181	PF00400	0.676
TRG_ER_diArg_1	311	314	PF00400	0.764
TRG_ER_diArg_1	696	698	PF00400	0.675
TRG_ER_diArg_1	73	76	PF00400	0.755
TRG_NLS_MonoCore_2	32	37	PF00514	0.622
TRG_NLS_MonoExtN_4	31	37	PF00514	0.817
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.752
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q4	Leishmania donovani	99%	100%
E9B216	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q645	Leishmania major	83%	100%