LeishMANIAdb
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Prostaglandin f2-alpha synthase/D-arabinose dehydrogenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Prostaglandin f2-alpha synthase/D-arabinose dehydrogenase
Gene product:
prostaglandin f2-alpha synthase/D-arabinose dehydrogenase
Species:
Leishmania infantum
UniProt:
A4I6Z4_LEIIN
TriTrypDb:
LINF_310029700
Length:
284

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, Prostaglandin f2-alpha synthase/D-arabinose dehydrogenase PGFS

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I6Z4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Z4

PDB structure(s): 4f40_A , 4f40_B , 4g5d_A , 4g5d_B

Function

Biological processes
Term Name Level Count
GO:0001516 prostaglandin biosynthetic process 8 5
GO:0006082 organic acid metabolic process 3 5
GO:0006629 lipid metabolic process 3 5
GO:0006631 fatty acid metabolic process 4 5
GO:0006633 fatty acid biosynthetic process 5 5
GO:0006636 unsaturated fatty acid biosynthetic process 6 5
GO:0006690 icosanoid metabolic process 6 5
GO:0006692 prostanoid metabolic process 6 5
GO:0006693 prostaglandin metabolic process 7 5
GO:0008152 metabolic process 1 5
GO:0008610 lipid biosynthetic process 4 5
GO:0009058 biosynthetic process 2 5
GO:0009987 cellular process 1 5
GO:0016053 organic acid biosynthetic process 4 5
GO:0019752 carboxylic acid metabolic process 5 5
GO:0032787 monocarboxylic acid metabolic process 6 5
GO:0033559 unsaturated fatty acid metabolic process 5 5
GO:0043436 oxoacid metabolic process 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0044249 cellular biosynthetic process 3 5
GO:0044255 cellular lipid metabolic process 3 5
GO:0044281 small molecule metabolic process 2 5
GO:0044283 small molecule biosynthetic process 3 5
GO:0046394 carboxylic acid biosynthetic process 5 5
GO:0046456 icosanoid biosynthetic process 6 5
GO:0046457 prostanoid biosynthetic process 7 5
GO:0071704 organic substance metabolic process 2 5
GO:0072330 monocarboxylic acid biosynthetic process 6 5
GO:1901576 organic substance biosynthetic process 3 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0016491 oxidoreductase activity 2 13
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 9
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 9
GO:0036131 prostaglandin D2 11-ketoreductase activity 5 8
GO:0047017 prostaglandin-F synthase activity 5 8
GO:0000166 nucleotide binding 3 1
GO:0005488 binding 1 1
GO:0036094 small molecule binding 2 1
GO:0036130 prostaglandin H2 endoperoxidase reductase activity 5 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 190 194 PF00082 0.377
CLV_PCSK_SKI1_1 38 42 PF00082 0.346
DOC_CYCLIN_yCln2_LP_2 206 212 PF00134 0.384
DOC_MAPK_gen_1 139 148 PF00069 0.424
DOC_MAPK_gen_1 217 227 PF00069 0.463
DOC_USP7_UBL2_3 122 126 PF12436 0.508
DOC_USP7_UBL2_3 240 244 PF12436 0.456
DOC_WW_Pin1_4 163 168 PF00397 0.497
DOC_WW_Pin1_4 195 200 PF00397 0.425
DOC_WW_Pin1_4 24 29 PF00397 0.572
LIG_BIR_II_1 1 5 PF00653 0.424
LIG_CAP-Gly_1 278 284 PF01302 0.408
LIG_CSL_BTD_1 196 199 PF09270 0.425
LIG_deltaCOP1_diTrp_1 129 134 PF00928 0.498
LIG_eIF4E_1 105 111 PF01652 0.462
LIG_FHA_1 164 170 PF00498 0.424
LIG_FHA_1 48 54 PF00498 0.442
LIG_FHA_1 75 81 PF00498 0.462
LIG_LIR_Gen_1 104 111 PF02991 0.472
LIG_LIR_Nem_3 104 108 PF02991 0.472
LIG_LIR_Nem_3 129 134 PF02991 0.462
LIG_LIR_Nem_3 195 200 PF02991 0.462
LIG_SH2_PTP2 105 108 PF00017 0.462
LIG_SH2_SRC 109 112 PF00017 0.462
LIG_SH2_SRC 127 130 PF00017 0.508
LIG_SH2_STAP1 87 91 PF00017 0.460
LIG_SH2_STAT5 105 108 PF00017 0.462
LIG_SH2_STAT5 109 112 PF00017 0.462
LIG_SH2_STAT5 127 130 PF00017 0.495
LIG_SH3_3 12 18 PF00018 0.398
LIG_SUMO_SIM_par_1 7 12 PF11976 0.323
LIG_TRAF2_1 93 96 PF00917 0.450
LIG_TYR_ITIM 103 108 PF00017 0.462
LIG_UBA3_1 210 217 PF00899 0.450
LIG_UBA3_1 235 240 PF00899 0.508
MOD_Cter_Amidation 123 126 PF01082 0.250
MOD_GlcNHglycan 66 69 PF01048 0.270
MOD_GSK3_1 234 241 PF00069 0.425
MOD_N-GLC_1 218 223 PF02516 0.260
MOD_NEK2_1 64 69 PF00069 0.511
MOD_NEK2_1 75 80 PF00069 0.456
MOD_NEK2_1 94 99 PF00069 0.503
MOD_PKA_2 64 70 PF00069 0.508
MOD_Plk_1 56 62 PF00069 0.444
MOD_Plk_1 87 93 PF00069 0.437
MOD_ProDKin_1 163 169 PF00069 0.497
MOD_ProDKin_1 195 201 PF00069 0.425
MOD_ProDKin_1 24 30 PF00069 0.572
MOD_SUMO_for_1 192 195 PF00179 0.450
MOD_SUMO_rev_2 135 143 PF00179 0.462
MOD_SUMO_rev_2 182 192 PF00179 0.517
TRG_ENDOCYTIC_2 105 108 PF00928 0.462
TRG_ENDOCYTIC_2 45 48 PF00928 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4R8 Leptomonas seymouri 28% 75%
A0A0N0P8F4 Leptomonas seymouri 36% 78%
A0A0N1I3R2 Leptomonas seymouri 29% 99%
A0A0N1I9Z1 Leptomonas seymouri 57% 100%
A0A0N1PCR7 Leptomonas seymouri 47% 100%
A0A0S4J2H7 Bodo saltans 33% 100%
A0A0S4J7K9 Bodo saltans 32% 80%
A0A1D5XGW0 Triticum aestivum 35% 90%
A0A1X0NFW0 Trypanosomatidae 34% 84%
A0A1X0NIH1 Trypanosomatidae 32% 90%
A0A1X0NNX8 Trypanosomatidae 66% 100%
A0A1X0P7C2 Trypanosomatidae 56% 100%
A0A1X9QHJ0 Triticum aestivum 35% 90%
A0A2P1GIY9 Catharanthus roseus 36% 88%
A0A3Q8IFG1 Leishmania donovani 99% 100%
A0A3Q8IJ05 Leishmania donovani 58% 100%
A0A3R7NJY8 Trypanosoma rangeli 33% 84%
A0A3S7X124 Leishmania donovani 32% 76%
A0A3S7X518 Leishmania donovani 29% 99%
A0A422N1G0 Trypanosoma rangeli 55% 100%
A0A422N9R4 Trypanosoma rangeli 34% 87%
A0A422NBS6 Trypanosoma rangeli 65% 100%
A0PQ11 Mycobacterium ulcerans (strain Agy99) 42% 100%
A0QJ99 Mycobacterium avium (strain 104) 44% 100%
A0QL30 Mycobacterium avium (strain 104) 44% 99%
A0QV09 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 45% 100%
A0QV10 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 53% 100%
A1CRI1 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 33% 86%
A1D4E3 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 32% 88%
A1KMW6 Mycobacterium bovis (strain BCG / Pasteur 1173P2) 44% 100%
A1T726 Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1) 47% 100%
A1UEC5 Mycobacterium sp. (strain KMS) 43% 100%
A1UEC6 Mycobacterium sp. (strain KMS) 50% 100%
A2Q8B5 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 29% 89%
A3PXS9 Mycobacterium sp. (strain JLS) 43% 100%
A3PXT0 Mycobacterium sp. (strain JLS) 51% 100%
A4HG21 Leishmania braziliensis 32% 100%
A4HJJ7 Leishmania braziliensis 82% 100%
A4HJS6 Leishmania braziliensis 30% 100%
A4HK26 Leishmania braziliensis 56% 100%
A4I342 Leishmania infantum 32% 76%
A4I792 Leishmania infantum 29% 99%
A4I7L0 Leishmania infantum 58% 100%
A4TE41 Mycolicibacterium gilvum (strain PYR-GCK) 49% 100%
A5U6Y1 Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) 44% 100%
B0XNR0 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 32% 90%
B2HIJ9 Mycobacterium marinum (strain ATCC BAA-535 / M) 42% 100%
B4F9A4 Zea mays 36% 90%
B8ASB2 Oryza sativa subsp. indica 23% 81%
B8N195 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 32% 89%
B8ZS00 Mycobacterium leprae (strain Br4923) 42% 100%
B9VRJ2 Papaver somniferum 33% 88%
C5FFQ7 Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) 31% 87%
C6TBN2 Glycine max 23% 82%
C9JRZ8 Homo sapiens 39% 90%
C9ZJL4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 84%
D0A6W5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
D0A735 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 91%
D3ZF77 Rattus norvegicus 40% 88%
E7C196 Erythroxylum coca 34% 87%
E9ACW1 Leishmania major 31% 100%
E9AYA0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AZF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B215 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B287 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B2G7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
F4HPY8 Arabidopsis thaliana 26% 86%
G4MZI3 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 33% 87%
G4N708 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 32% 88%
H9JTG9 Bombyx mori 40% 92%
O08782 Cricetulus griseus 41% 90%
O13283 Candida tropicalis 32% 88%
O13848 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 100%
O14088 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
O32210 Bacillus subtilis (strain 168) 58% 100%
O34678 Bacillus subtilis (strain 168) 57% 100%
O42888 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 87%
O49133 Fragaria ananassa 37% 89%
O59826 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 83%
O60218 Homo sapiens 42% 90%
O69462 Mycobacterium leprae (strain TN) 42% 100%
O70473 Cricetulus griseus 40% 88%
O74237 Candida tenuis 36% 88%
O80944 Arabidopsis thaliana 39% 91%
O94315 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 93%
O94735 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 32% 90%
P02532 Rana temporaria 37% 88%
P05980 Bos taurus 38% 88%
P06632 Corynebacterium sp. (strain ATCC 31090) 45% 100%
P07943 Rattus norvegicus 43% 90%
P14065 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 91%
P14550 Homo sapiens 40% 87%
P15121 Homo sapiens 43% 90%
P15122 Oryctolagus cuniculus 42% 90%
P15339 Corynebacterium sp. (strain SHS752001) 39% 100%
P16116 Bos taurus 44% 90%
P17264 Lithobates catesbeianus 37% 88%
P17516 Homo sapiens 38% 88%
P21300 Mus musculus 40% 90%
P22045 Leishmania major 95% 100%
P23457 Rattus norvegicus 34% 88%
P23901 Hordeum vulgare 39% 89%
P26690 Glycine max 35% 90%
P27800 Sporidiobolus salmonicolor 39% 88%
P28475 Malus domestica 36% 92%
P30863 Escherichia coli (strain K12) 38% 100%
P31210 Rattus norvegicus 37% 87%
P31867 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 36% 89%
P38115 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 83%
P38715 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 87%
P42330 Homo sapiens 37% 88%
P42972 Bacillus subtilis (strain 168) 28% 95%
P45376 Mus musculus 43% 90%
P45377 Mus musculus 41% 90%
P46336 Bacillus subtilis (strain 168) 27% 92%
P46905 Bacillus subtilis (strain 168) 25% 92%
P47137 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P49378 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 32% 86%
P50578 Sus scrofa 41% 87%
P51635 Rattus norvegicus 40% 87%
P51652 Rattus norvegicus 34% 88%
P51857 Homo sapiens 39% 87%
P52895 Homo sapiens 38% 88%
P52897 Bos taurus 38% 88%
P52898 Bos taurus 39% 88%
P54569 Bacillus subtilis (strain 168) 24% 93%
P58744 Salmonella typhi 44% 100%
P70694 Mus musculus 37% 88%
P74308 Synechocystis sp. (strain PCC 6803 / Kazusa) 40% 87%
P76187 Escherichia coli (strain K12) 27% 95%
P76234 Escherichia coli (strain K12) 28% 100%
P77256 Escherichia coli (strain K12) 25% 87%
P77735 Escherichia coli (strain K12) 24% 88%
P78736 Pachysolen tannophilus 33% 89%
P80276 Sus scrofa 44% 90%
P80508 Oryctolagus cuniculus 37% 88%
P82125 Sus scrofa 41% 94%
P82809 Mesocricetus auratus 34% 88%
P87039 Candida tropicalis 32% 88%
P9WQA4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 44% 100%
P9WQA5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 44% 100%
Q01213 Mucor mucedo 32% 88%
Q02198 Pseudomonas putida 44% 96%
Q04828 Homo sapiens 38% 88%
Q07551 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 91%
Q09632 Caenorhabditis elegans 42% 88%
Q0CUL0 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 30% 89%
Q0GYU4 Hypocrea jecorina 38% 89%
Q0GYU5 Hypocrea jecorina 39% 86%
Q0JE32 Oryza sativa subsp. japonica 23% 81%
Q0PCF4 Hordeum vulgare 35% 90%
Q0PGJ6 Arabidopsis thaliana 42% 90%
Q10494 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 88%
Q10PE7 Oryza sativa subsp. japonica 35% 89%
Q12458 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 91%
Q1BAN7 Mycobacterium sp. (strain MCS) 43% 100%
Q1XAA8 Equus caballus 35% 88%
Q28FD1 Xenopus tropicalis 41% 87%
Q2UKD0 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 32% 89%
Q3L181 Rauvolfia serpentina 23% 84%
Q3ZCJ2 Bos taurus 40% 87%
Q3ZFI7 Hypocrea jecorina 37% 92%
Q46857 Escherichia coli (strain K12) 44% 100%
Q4DJ07 Trypanosoma cruzi (strain CL Brener) 59% 100%
Q4Q5N9 Leishmania major 59% 100%
Q4Q5X1 Leishmania major 30% 100%
Q4Q973 Leishmania major 27% 100%
Q4R802 Macaca fascicularis 36% 89%
Q4WJT9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 32% 90%
Q54NZ7 Dictyostelium discoideum 42% 91%
Q55FL3 Dictyostelium discoideum 38% 88%
Q568L5 Danio rerio 41% 88%
Q56Y42 Arabidopsis thaliana 24% 78%
Q5BGA7 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 33% 89%
Q5R5D5 Pongo abelii 40% 87%
Q5R7C9 Pongo abelii 38% 88%
Q5REQ0 Pongo abelii 37% 88%
Q5RJP0 Rattus norvegicus 40% 90%
Q5U1Y4 Rattus norvegicus 40% 94%
Q5ZK84 Gallus gallus 41% 87%
Q6AYQ2 Rattus norvegicus 35% 89%
Q6AZW2 Danio rerio 42% 88%
Q6GMC7 Xenopus laevis 41% 87%
Q6IMN8 Dictyostelium discoideum 42% 96%
Q6W8P9 Equus caballus 36% 88%
Q6Y0Z3 Candida parapsilosis 31% 88%
Q73SC5 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 43% 99%
Q73VK6 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 44% 100%
Q76L36 Candida parapsilosis 37% 93%
Q76L37 Candida parapsilosis 31% 93%
Q7G764 Oryza sativa subsp. japonica 34% 88%
Q7G765 Oryza sativa subsp. japonica 34% 88%
Q7TXI6 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 44% 100%
Q84TF0 Arabidopsis thaliana 43% 90%
Q876L8 Hypocrea jecorina 30% 88%
Q8K023 Mus musculus 34% 88%
Q8SSK6 Encephalitozoon cuniculi (strain GB-M1) 39% 94%
Q8VC28 Mus musculus 36% 88%
Q8VCX1 Mus musculus 41% 87%
Q8X195 Candida boidinii 31% 88%
Q8X7Z7 Escherichia coli O157:H7 39% 100%
Q8XBT6 Escherichia coli O157:H7 44% 100%
Q8Z988 Salmonella typhi 36% 100%
Q8ZH36 Yersinia pestis 35% 100%
Q8ZI40 Yersinia pestis 47% 100%
Q8ZM06 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 45% 100%
Q8ZRM7 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 36% 100%
Q91WR5 Mus musculus 37% 88%
Q94A68 Arabidopsis thaliana 26% 75%
Q95JH4 Macaca fuscata fuscata 39% 88%
Q95JH5 Macaca fascicularis 39% 88%
Q95JH6 Macaca fuscata fuscata 39% 88%
Q95JH7 Macaca fascicularis 39% 88%
Q96JD6 Homo sapiens 37% 89%
Q9C1X5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
Q9DCT1 Mus musculus 40% 94%
Q9GV41 Trypanosoma brucei brucei 61% 100%
Q9JII6 Mus musculus 41% 87%
Q9M338 Arabidopsis thaliana 38% 90%
Q9P430 Scheffersomyces shehatae 37% 88%
Q9P8R5 Aspergillus niger 29% 89%
Q9SQ64 Papaver somniferum 34% 88%
Q9SQ67 Papaver somniferum 33% 88%
Q9SQ68 Papaver somniferum 33% 88%
Q9SQ69 Papaver somniferum 34% 88%
Q9SQ70 Papaver somniferum 33% 88%
Q9TV64 Oryctolagus cuniculus 38% 87%
Q9USV2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 100%
V5B6J8 Trypanosoma cruzi 34% 84%
V5BBS9 Trypanosoma cruzi 58% 100%
V5BR74 Trypanosoma cruzi 33% 88%
W5DYE3 Triticum aestivum 36% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS