LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Fungal tRNA ligase phosphodiesterase domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I6Z2_LEIIN
TriTrypDb:
LINF_310029500
Length:
929

Annotations

Annotations by Jardim et al.

tRNA synthetase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6Z2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Z2

Function

Biological processes
Term Name Level Count
GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 8 10
GO:0006139 nucleobase-containing compound metabolic process 3 10
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 9 10
GO:0006396 RNA processing 6 10
GO:0006399 tRNA metabolic process 7 10
GO:0006725 cellular aromatic compound metabolic process 3 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008033 tRNA processing 8 10
GO:0008152 metabolic process 1 10
GO:0008380 RNA splicing 7 10
GO:0009987 cellular process 1 10
GO:0016070 RNA metabolic process 5 10
GO:0034470 ncRNA processing 7 10
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0034660 ncRNA metabolic process 6 10
GO:0043170 macromolecule metabolic process 3 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0046483 heterocycle metabolic process 3 10
GO:0071704 organic substance metabolic process 2 10
GO:0090304 nucleic acid metabolic process 4 10
GO:1901360 organic cyclic compound metabolic process 3 10
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0016310 phosphorylation 5 1
GO:0033554 cellular response to stress 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046939 obsolete nucleotide phosphorylation 6 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0003972 RNA ligase (ATP) activity 5 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0008452 RNA ligase activity 4 10
GO:0016874 ligase activity 2 10
GO:0016886 ligase activity, forming phosphoric ester bonds 3 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:0140098 catalytic activity, acting on RNA 3 10
GO:0140640 catalytic activity, acting on a nucleic acid 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1
GO:0003690 double-stranded DNA binding 5 1
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016791 phosphatase activity 5 1
GO:0019205 nucleobase-containing compound kinase activity 5 1
GO:0042578 phosphoric ester hydrolase activity 4 1
GO:0046403 polynucleotide 3'-phosphatase activity 6 1
GO:0046404 polydeoxyribonucleotide 5'-hydroxyl-kinase activity 7 1
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity 5 1
GO:0051733 polydeoxyribonucleotide kinase activity 6 1
GO:0051734 polynucleotide kinase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 372 376 PF00656 0.697
CLV_C14_Caspase3-7 384 388 PF00656 0.398
CLV_C14_Caspase3-7 547 551 PF00656 0.511
CLV_MEL_PAP_1 242 248 PF00089 0.278
CLV_NRD_NRD_1 150 152 PF00675 0.353
CLV_NRD_NRD_1 16 18 PF00675 0.740
CLV_NRD_NRD_1 213 215 PF00675 0.413
CLV_NRD_NRD_1 430 432 PF00675 0.465
CLV_NRD_NRD_1 520 522 PF00675 0.460
CLV_NRD_NRD_1 534 536 PF00675 0.373
CLV_NRD_NRD_1 713 715 PF00675 0.486
CLV_NRD_NRD_1 867 869 PF00675 0.497
CLV_NRD_NRD_1 886 888 PF00675 0.304
CLV_NRD_NRD_1 910 912 PF00675 0.414
CLV_PCSK_KEX2_1 16 18 PF00082 0.721
CLV_PCSK_KEX2_1 191 193 PF00082 0.602
CLV_PCSK_KEX2_1 213 215 PF00082 0.413
CLV_PCSK_KEX2_1 430 432 PF00082 0.463
CLV_PCSK_KEX2_1 48 50 PF00082 0.605
CLV_PCSK_KEX2_1 520 522 PF00082 0.414
CLV_PCSK_KEX2_1 617 619 PF00082 0.523
CLV_PCSK_KEX2_1 867 869 PF00082 0.391
CLV_PCSK_KEX2_1 910 912 PF00082 0.370
CLV_PCSK_PC1ET2_1 191 193 PF00082 0.602
CLV_PCSK_PC1ET2_1 48 50 PF00082 0.580
CLV_PCSK_PC1ET2_1 617 619 PF00082 0.583
CLV_PCSK_PC1ET2_1 910 912 PF00082 0.429
CLV_PCSK_PC7_1 426 432 PF00082 0.428
CLV_PCSK_SKI1_1 257 261 PF00082 0.451
CLV_PCSK_SKI1_1 292 296 PF00082 0.529
CLV_PCSK_SKI1_1 343 347 PF00082 0.498
CLV_PCSK_SKI1_1 520 524 PF00082 0.499
CLV_PCSK_SKI1_1 626 630 PF00082 0.425
CLV_PCSK_SKI1_1 911 915 PF00082 0.461
DEG_APCC_DBOX_1 527 535 PF00400 0.461
DEG_Nend_UBRbox_1 1 4 PF02207 0.718
DEG_SCF_FBW7_1 135 142 PF00400 0.429
DEG_SPOP_SBC_1 31 35 PF00917 0.651
DOC_ANK_TNKS_1 213 220 PF00023 0.445
DOC_CYCLIN_RxL_1 796 810 PF00134 0.487
DOC_CYCLIN_yClb1_LxF_4 331 337 PF00134 0.474
DOC_CYCLIN_yCln2_LP_2 806 809 PF00134 0.480
DOC_CYCLIN_yCln2_LP_2 84 90 PF00134 0.539
DOC_MAPK_gen_1 120 130 PF00069 0.435
DOC_MAPK_gen_1 535 541 PF00069 0.374
DOC_MAPK_gen_1 617 624 PF00069 0.621
DOC_MAPK_gen_1 78 86 PF00069 0.512
DOC_MAPK_gen_1 910 916 PF00069 0.370
DOC_MAPK_MEF2A_6 385 393 PF00069 0.476
DOC_MAPK_MEF2A_6 724 733 PF00069 0.492
DOC_PP2B_LxvP_1 389 392 PF13499 0.432
DOC_PP2B_LxvP_1 806 809 PF13499 0.480
DOC_PP2B_LxvP_1 84 87 PF13499 0.502
DOC_PP2B_LxvP_1 914 917 PF13499 0.436
DOC_PP2B_PxIxI_1 879 885 PF00149 0.321
DOC_PP4_FxxP_1 185 188 PF00568 0.492
DOC_PP4_FxxP_1 581 584 PF00568 0.468
DOC_PP4_FxxP_1 82 85 PF00568 0.481
DOC_USP7_MATH_1 288 292 PF00917 0.589
DOC_USP7_MATH_1 31 35 PF00917 0.768
DOC_USP7_MATH_1 42 46 PF00917 0.738
DOC_USP7_MATH_1 442 446 PF00917 0.422
DOC_USP7_MATH_1 548 552 PF00917 0.583
DOC_USP7_MATH_1 70 74 PF00917 0.464
DOC_USP7_UBL2_3 152 156 PF12436 0.489
DOC_USP7_UBL2_3 191 195 PF12436 0.483
DOC_WW_Pin1_4 135 140 PF00397 0.581
DOC_WW_Pin1_4 292 297 PF00397 0.476
DOC_WW_Pin1_4 38 43 PF00397 0.750
DOC_WW_Pin1_4 415 420 PF00397 0.548
DOC_WW_Pin1_4 520 525 PF00397 0.559
DOC_WW_Pin1_4 719 724 PF00397 0.563
DOC_WW_Pin1_4 734 739 PF00397 0.540
DOC_WW_Pin1_4 897 902 PF00397 0.393
LIG_14-3-3_CanoR_1 245 252 PF00244 0.436
LIG_14-3-3_CanoR_1 29 38 PF00244 0.811
LIG_14-3-3_CanoR_1 409 413 PF00244 0.431
LIG_14-3-3_CanoR_1 626 635 PF00244 0.537
LIG_14-3-3_CanoR_1 708 713 PF00244 0.443
LIG_Actin_WH2_2 542 558 PF00022 0.427
LIG_APCC_ABBA_1 316 321 PF00400 0.402
LIG_BIR_III_4 443 447 PF00653 0.505
LIG_BIR_III_4 557 561 PF00653 0.454
LIG_BIR_III_4 858 862 PF00653 0.333
LIG_CtBP_PxDLS_1 657 661 PF00389 0.470
LIG_CtBP_PxDLS_1 726 730 PF00389 0.457
LIG_deltaCOP1_diTrp_1 500 508 PF00928 0.393
LIG_deltaCOP1_diTrp_1 537 545 PF00928 0.493
LIG_EH1_1 53 61 PF00400 0.433
LIG_FHA_1 138 144 PF00498 0.575
LIG_FHA_1 517 523 PF00498 0.457
LIG_FHA_1 571 577 PF00498 0.549
LIG_FHA_1 634 640 PF00498 0.416
LIG_FHA_1 734 740 PF00498 0.436
LIG_FHA_1 753 759 PF00498 0.335
LIG_FHA_1 847 853 PF00498 0.470
LIG_FHA_2 50 56 PF00498 0.640
LIG_FHA_2 545 551 PF00498 0.500
LIG_FHA_2 627 633 PF00498 0.527
LIG_FHA_2 696 702 PF00498 0.494
LIG_FHA_2 720 726 PF00498 0.533
LIG_FHA_2 760 766 PF00498 0.512
LIG_LIR_Apic_2 157 163 PF02991 0.463
LIG_LIR_Apic_2 183 188 PF02991 0.469
LIG_LIR_Apic_2 408 413 PF02991 0.421
LIG_LIR_Apic_2 661 667 PF02991 0.384
LIG_LIR_Gen_1 116 126 PF02991 0.452
LIG_LIR_Gen_1 138 147 PF02991 0.445
LIG_LIR_Gen_1 312 319 PF02991 0.322
LIG_LIR_Gen_1 537 545 PF02991 0.460
LIG_LIR_Gen_1 619 628 PF02991 0.532
LIG_LIR_Gen_1 652 660 PF02991 0.416
LIG_LIR_Gen_1 788 794 PF02991 0.475
LIG_LIR_Gen_1 95 103 PF02991 0.360
LIG_LIR_Nem_3 116 121 PF02991 0.470
LIG_LIR_Nem_3 138 144 PF02991 0.468
LIG_LIR_Nem_3 212 218 PF02991 0.392
LIG_LIR_Nem_3 312 318 PF02991 0.342
LIG_LIR_Nem_3 333 339 PF02991 0.350
LIG_LIR_Nem_3 537 541 PF02991 0.488
LIG_LIR_Nem_3 619 624 PF02991 0.540
LIG_LIR_Nem_3 652 656 PF02991 0.408
LIG_LIR_Nem_3 66 72 PF02991 0.386
LIG_LIR_Nem_3 788 792 PF02991 0.484
LIG_LIR_Nem_3 95 99 PF02991 0.355
LIG_NRBOX 595 601 PF00104 0.356
LIG_NRBOX 839 845 PF00104 0.489
LIG_PCNA_PIPBox_1 491 500 PF02747 0.364
LIG_PCNA_yPIPBox_3 796 804 PF02747 0.427
LIG_Pex14_1 311 315 PF04695 0.426
LIG_Pex14_1 508 512 PF04695 0.441
LIG_Pex14_2 315 319 PF04695 0.442
LIG_Pex14_2 65 69 PF04695 0.397
LIG_SH2_CRK 141 145 PF00017 0.579
LIG_SH2_CRK 239 243 PF00017 0.468
LIG_SH2_CRK 410 414 PF00017 0.467
LIG_SH2_CRK 653 657 PF00017 0.525
LIG_SH2_CRK 789 793 PF00017 0.362
LIG_SH2_GRB2like 653 656 PF00017 0.526
LIG_SH2_GRB2like 894 897 PF00017 0.296
LIG_SH2_NCK_1 141 145 PF00017 0.578
LIG_SH2_NCK_1 410 414 PF00017 0.477
LIG_SH2_NCK_1 789 793 PF00017 0.387
LIG_SH2_PTP2 597 600 PF00017 0.366
LIG_SH2_STAP1 337 341 PF00017 0.523
LIG_SH2_STAP1 674 678 PF00017 0.456
LIG_SH2_STAP1 776 780 PF00017 0.398
LIG_SH2_STAP1 894 898 PF00017 0.296
LIG_SH2_STAT5 129 132 PF00017 0.536
LIG_SH2_STAT5 421 424 PF00017 0.528
LIG_SH2_STAT5 597 600 PF00017 0.420
LIG_SH2_STAT5 827 830 PF00017 0.497
LIG_SH3_2 905 910 PF14604 0.393
LIG_SH3_3 183 189 PF00018 0.483
LIG_SH3_3 720 726 PF00018 0.572
LIG_SH3_3 732 738 PF00018 0.523
LIG_SH3_3 781 787 PF00018 0.558
LIG_SH3_3 902 908 PF00018 0.370
LIG_Sin3_3 621 628 PF02671 0.339
LIG_SUMO_SIM_anti_2 575 580 PF11976 0.433
LIG_SUMO_SIM_par_1 656 661 PF11976 0.481
LIG_SUMO_SIM_par_1 728 734 PF11976 0.481
LIG_SUMO_SIM_par_1 847 854 PF11976 0.425
LIG_TRAF2_1 171 174 PF00917 0.531
LIG_TRAF2_1 206 209 PF00917 0.558
LIG_TRAF2_1 698 701 PF00917 0.604
LIG_UBA3_1 531 536 PF00899 0.432
LIG_UBA3_1 639 648 PF00899 0.425
LIG_WW_1 891 894 PF00397 0.411
MOD_CDK_SPK_2 719 724 PF00069 0.455
MOD_CK1_1 199 205 PF00069 0.663
MOD_CK1_1 32 38 PF00069 0.758
MOD_CK1_1 408 414 PF00069 0.474
MOD_CK1_1 41 47 PF00069 0.683
MOD_CK1_1 590 596 PF00069 0.324
MOD_CK1_1 633 639 PF00069 0.510
MOD_CK1_1 737 743 PF00069 0.396
MOD_CK1_1 900 906 PF00069 0.263
MOD_CK2_1 626 632 PF00069 0.515
MOD_CK2_1 695 701 PF00069 0.522
MOD_Cter_Amidation 14 17 PF01082 0.769
MOD_Cter_Amidation 46 49 PF01082 0.597
MOD_Cter_Amidation 615 618 PF01082 0.534
MOD_GlcNHglycan 103 106 PF01048 0.516
MOD_GlcNHglycan 182 185 PF01048 0.423
MOD_GlcNHglycan 280 283 PF01048 0.579
MOD_GlcNHglycan 328 331 PF01048 0.529
MOD_GlcNHglycan 410 413 PF01048 0.408
MOD_GlcNHglycan 44 47 PF01048 0.619
MOD_GlcNHglycan 443 447 PF01048 0.427
MOD_GlcNHglycan 570 573 PF01048 0.624
MOD_GlcNHglycan 8 11 PF01048 0.662
MOD_GSK3_1 1 8 PF00069 0.706
MOD_GSK3_1 135 142 PF00069 0.478
MOD_GSK3_1 288 295 PF00069 0.520
MOD_GSK3_1 351 358 PF00069 0.592
MOD_GSK3_1 38 45 PF00069 0.750
MOD_GSK3_1 516 523 PF00069 0.413
MOD_GSK3_1 544 551 PF00069 0.528
MOD_GSK3_1 626 633 PF00069 0.519
MOD_GSK3_1 656 663 PF00069 0.498
MOD_GSK3_1 704 711 PF00069 0.625
MOD_GSK3_1 733 740 PF00069 0.465
MOD_GSK3_1 844 851 PF00069 0.324
MOD_N-GLC_1 135 140 PF02516 0.559
MOD_N-GLC_1 42 47 PF02516 0.666
MOD_N-GLC_1 695 700 PF02516 0.544
MOD_N-GLC_1 752 757 PF02516 0.522
MOD_N-GLC_1 918 923 PF02516 0.468
MOD_NEK2_1 1 6 PF00069 0.748
MOD_NEK2_1 196 201 PF00069 0.524
MOD_NEK2_1 302 307 PF00069 0.431
MOD_NEK2_1 310 315 PF00069 0.317
MOD_NEK2_1 319 324 PF00069 0.390
MOD_NEK2_1 326 331 PF00069 0.417
MOD_NEK2_1 405 410 PF00069 0.440
MOD_NEK2_1 516 521 PF00069 0.411
MOD_NEK2_1 600 605 PF00069 0.510
MOD_NEK2_1 65 70 PF00069 0.551
MOD_NEK2_1 658 663 PF00069 0.463
MOD_NEK2_1 706 711 PF00069 0.420
MOD_NEK2_1 733 738 PF00069 0.493
MOD_NEK2_1 821 826 PF00069 0.361
MOD_NEK2_1 844 849 PF00069 0.414
MOD_NEK2_2 687 692 PF00069 0.523
MOD_PIKK_1 196 202 PF00454 0.622
MOD_PIKK_1 244 250 PF00454 0.395
MOD_PIKK_1 319 325 PF00454 0.421
MOD_PIKK_1 626 632 PF00454 0.469
MOD_PIKK_1 695 701 PF00454 0.458
MOD_PKA_2 1 7 PF00069 0.803
MOD_PKA_2 244 250 PF00069 0.404
MOD_PKA_2 408 414 PF00069 0.414
MOD_PKA_2 462 468 PF00069 0.449
MOD_Plk_1 156 162 PF00069 0.512
MOD_Plk_1 453 459 PF00069 0.381
MOD_Plk_1 631 637 PF00069 0.536
MOD_Plk_1 65 71 PF00069 0.438
MOD_Plk_1 918 924 PF00069 0.478
MOD_Plk_1 99 105 PF00069 0.384
MOD_Plk_4 139 145 PF00069 0.474
MOD_Plk_4 165 171 PF00069 0.430
MOD_Plk_4 302 308 PF00069 0.402
MOD_Plk_4 55 61 PF00069 0.432
MOD_Plk_4 660 666 PF00069 0.422
MOD_Plk_4 851 857 PF00069 0.363
MOD_Plk_4 918 924 PF00069 0.405
MOD_ProDKin_1 135 141 PF00069 0.571
MOD_ProDKin_1 292 298 PF00069 0.471
MOD_ProDKin_1 38 44 PF00069 0.750
MOD_ProDKin_1 415 421 PF00069 0.542
MOD_ProDKin_1 520 526 PF00069 0.556
MOD_ProDKin_1 719 725 PF00069 0.559
MOD_ProDKin_1 734 740 PF00069 0.536
MOD_ProDKin_1 897 903 PF00069 0.393
MOD_SUMO_rev_2 550 555 PF00179 0.561
MOD_SUMO_rev_2 641 649 PF00179 0.438
MOD_SUMO_rev_2 701 707 PF00179 0.438
TRG_ENDOCYTIC_2 141 144 PF00928 0.440
TRG_ENDOCYTIC_2 215 218 PF00928 0.365
TRG_ENDOCYTIC_2 239 242 PF00928 0.466
TRG_ENDOCYTIC_2 307 310 PF00928 0.455
TRG_ENDOCYTIC_2 597 600 PF00928 0.386
TRG_ENDOCYTIC_2 653 656 PF00928 0.472
TRG_ENDOCYTIC_2 789 792 PF00928 0.445
TRG_ER_diArg_1 213 215 PF00400 0.413
TRG_ER_diArg_1 430 432 PF00400 0.508
TRG_ER_diArg_1 520 522 PF00400 0.438
TRG_ER_diArg_1 866 868 PF00400 0.337
TRG_NLS_MonoExtN_4 908 914 PF00514 0.393
TRG_Pf-PMV_PEXEL_1 744 748 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6S2 Leptomonas seymouri 60% 100%
A0A0S4J4W5 Bodo saltans 35% 100%
A0A1X0NHZ8 Trypanosomatidae 33% 100%
A0A3R7M5Z2 Trypanosoma rangeli 36% 100%
A0A3S7X4Q3 Leishmania donovani 99% 100%
A4HJJ5 Leishmania braziliensis 70% 100%
E9B213 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q648 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS