LeishMANIAdb
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Transcription factor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transcription factor
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I6Z0_LEIIN
TriTrypDb:
LINF_310029300
Length:
359

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6Z0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Z0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 160 164 PF00656 0.608
CLV_NRD_NRD_1 257 259 PF00675 0.667
CLV_PCSK_KEX2_1 299 301 PF00082 0.578
CLV_PCSK_KEX2_1 320 322 PF00082 0.671
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.578
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.671
CLV_PCSK_SKI1_1 250 254 PF00082 0.722
CLV_PCSK_SKI1_1 343 347 PF00082 0.640
DEG_Nend_Nbox_1 1 3 PF02207 0.587
DOC_CYCLIN_RxL_1 129 137 PF00134 0.654
DOC_USP7_MATH_1 222 226 PF00917 0.679
DOC_USP7_MATH_1 276 280 PF00917 0.618
DOC_USP7_MATH_1 334 338 PF00917 0.643
DOC_USP7_MATH_1 345 349 PF00917 0.584
DOC_WW_Pin1_4 104 109 PF00397 0.583
DOC_WW_Pin1_4 121 126 PF00397 0.584
DOC_WW_Pin1_4 138 143 PF00397 0.747
DOC_WW_Pin1_4 155 160 PF00397 0.536
DOC_WW_Pin1_4 220 225 PF00397 0.815
DOC_WW_Pin1_4 250 255 PF00397 0.799
DOC_WW_Pin1_4 330 335 PF00397 0.707
DOC_WW_Pin1_4 62 67 PF00397 0.637
LIG_14-3-3_CanoR_1 258 265 PF00244 0.615
LIG_14-3-3_CanoR_1 300 307 PF00244 0.739
LIG_BIR_III_4 163 167 PF00653 0.611
LIG_EH1_1 22 30 PF00400 0.502
LIG_FHA_1 251 257 PF00498 0.723
LIG_FHA_1 78 84 PF00498 0.635
LIG_FHA_2 261 267 PF00498 0.557
LIG_LIR_Apic_2 216 222 PF02991 0.708
LIG_LIR_Apic_2 60 66 PF02991 0.723
LIG_SH2_CRK 219 223 PF00017 0.592
LIG_SH2_NCK_1 188 192 PF00017 0.692
LIG_SH2_SRC 188 191 PF00017 0.691
LIG_SH2_STAT3 15 18 PF00017 0.639
LIG_SH3_3 136 142 PF00018 0.694
LIG_SH3_3 328 334 PF00018 0.696
LIG_SH3_3 76 82 PF00018 0.771
LIG_SH3_3 91 97 PF00018 0.664
LIG_SUMO_SIM_par_1 80 88 PF11976 0.576
MOD_CK1_1 124 130 PF00069 0.728
MOD_CK1_1 223 229 PF00069 0.821
MOD_CK1_1 260 266 PF00069 0.728
MOD_CK1_1 270 276 PF00069 0.699
MOD_CK1_1 281 287 PF00069 0.546
MOD_CK1_1 332 338 PF00069 0.646
MOD_CK1_1 72 78 PF00069 0.681
MOD_CK2_1 260 266 PF00069 0.593
MOD_Cter_Amidation 354 357 PF01082 0.711
MOD_GlcNHglycan 185 188 PF01048 0.714
MOD_GlcNHglycan 202 205 PF01048 0.519
MOD_GlcNHglycan 225 228 PF01048 0.649
MOD_GlcNHglycan 260 263 PF01048 0.610
MOD_GlcNHglycan 278 281 PF01048 0.574
MOD_GlcNHglycan 303 306 PF01048 0.621
MOD_GlcNHglycan 316 319 PF01048 0.712
MOD_GlcNHglycan 349 352 PF01048 0.678
MOD_GSK3_1 119 126 PF00069 0.804
MOD_GSK3_1 138 145 PF00069 0.674
MOD_GSK3_1 153 160 PF00069 0.682
MOD_GSK3_1 222 229 PF00069 0.787
MOD_GSK3_1 246 253 PF00069 0.673
MOD_GSK3_1 257 264 PF00069 0.558
MOD_GSK3_1 266 273 PF00069 0.643
MOD_GSK3_1 274 281 PF00069 0.612
MOD_GSK3_1 310 317 PF00069 0.686
MOD_GSK3_1 329 336 PF00069 0.640
MOD_GSK3_1 77 84 PF00069 0.692
MOD_GSK3_1 85 92 PF00069 0.810
MOD_N-GLC_1 102 107 PF02516 0.648
MOD_N-GLC_1 175 180 PF02516 0.667
MOD_N-GLC_1 199 204 PF02516 0.636
MOD_N-GLC_1 213 218 PF02516 0.569
MOD_N-GLC_1 229 234 PF02516 0.546
MOD_N-GLC_1 246 251 PF02516 0.723
MOD_N-GLC_1 301 306 PF02516 0.654
MOD_N-GLC_2 328 330 PF02516 0.631
MOD_NEK2_1 143 148 PF00069 0.729
MOD_NEK2_1 154 159 PF00069 0.670
MOD_NEK2_1 346 351 PF00069 0.692
MOD_NEK2_2 170 175 PF00069 0.628
MOD_PIKK_1 119 125 PF00454 0.652
MOD_PKA_1 258 264 PF00069 0.670
MOD_PKA_1 267 273 PF00069 0.609
MOD_PKA_1 320 326 PF00069 0.637
MOD_PKA_2 257 263 PF00069 0.607
MOD_PKA_2 320 326 PF00069 0.709
MOD_Plk_1 175 181 PF00069 0.738
MOD_Plk_1 213 219 PF00069 0.698
MOD_Plk_4 170 176 PF00069 0.643
MOD_Plk_4 205 211 PF00069 0.597
MOD_Plk_4 214 220 PF00069 0.612
MOD_ProDKin_1 104 110 PF00069 0.584
MOD_ProDKin_1 121 127 PF00069 0.585
MOD_ProDKin_1 138 144 PF00069 0.747
MOD_ProDKin_1 155 161 PF00069 0.534
MOD_ProDKin_1 220 226 PF00069 0.817
MOD_ProDKin_1 250 256 PF00069 0.797
MOD_ProDKin_1 330 336 PF00069 0.705
MOD_ProDKin_1 62 68 PF00069 0.638
MOD_SUMO_rev_2 232 237 PF00179 0.649
MOD_SUMO_rev_2 260 270 PF00179 0.573
TRG_DiLeu_BaEn_1 33 38 PF01217 0.528
TRG_ER_diLys_1 354 359 PF00400 0.655
TRG_Pf-PMV_PEXEL_1 132 137 PF00026 0.654
TRG_Pf-PMV_PEXEL_1 289 293 PF00026 0.571

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILC0 Leptomonas seymouri 33% 86%
A0A3S5H7Q3 Leishmania donovani 100% 100%
A4HJJ2 Leishmania braziliensis 54% 100%
E9AEF6 Leishmania major 90% 100%
E9B211 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS