Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6Y7_LEIIN

TriTrypDb:

LINF_310028900

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.588
CLV_NRD_NRD_1	192	194	PF00675	0.499
CLV_NRD_NRD_1	204	206	PF00675	0.445
CLV_NRD_NRD_1	212	214	PF00675	0.462
CLV_NRD_NRD_1	260	262	PF00675	0.637
CLV_NRD_NRD_1	28	30	PF00675	0.628
CLV_NRD_NRD_1	57	59	PF00675	0.693
CLV_PCSK_KEX2_1	204	206	PF00082	0.668
CLV_PCSK_KEX2_1	212	214	PF00082	0.447
CLV_PCSK_KEX2_1	260	262	PF00082	0.637
CLV_PCSK_KEX2_1	28	30	PF00082	0.632
CLV_PCSK_KEX2_1	57	59	PF00082	0.616
CLV_PCSK_SKI1_1	205	209	PF00082	0.530
CLV_PCSK_SKI1_1	213	217	PF00082	0.493
CLV_PCSK_SKI1_1	284	288	PF00082	0.563
CLV_PCSK_SKI1_1	291	295	PF00082	0.629
DEG_APCC_DBOX_1	192	200	PF00400	0.523
DEG_SCF_FBW7_1	228	235	PF00400	0.717
DOC_CKS1_1	268	273	PF01111	0.562
DOC_MAPK_gen_1	201	210	PF00069	0.605
DOC_PP4_FxxP_1	163	166	PF00568	0.650
DOC_USP7_MATH_1	125	129	PF00917	0.648
DOC_USP7_MATH_1	148	152	PF00917	0.648
DOC_USP7_MATH_1	262	266	PF00917	0.790
DOC_USP7_MATH_1	27	31	PF00917	0.707
DOC_USP7_MATH_1	273	277	PF00917	0.721
DOC_USP7_MATH_1	322	326	PF00917	0.615
DOC_WW_Pin1_4	140	145	PF00397	0.803
DOC_WW_Pin1_4	146	151	PF00397	0.670
DOC_WW_Pin1_4	19	24	PF00397	0.695
DOC_WW_Pin1_4	228	233	PF00397	0.742
DOC_WW_Pin1_4	267	272	PF00397	0.630
LIG_14-3-3_CanoR_1	18	23	PF00244	0.755
LIG_14-3-3_CanoR_1	205	211	PF00244	0.637
LIG_14-3-3_CanoR_1	28	38	PF00244	0.583
LIG_14-3-3_CanoR_1	291	300	PF00244	0.620
LIG_14-3-3_CanoR_1	335	344	PF00244	0.655
LIG_14-3-3_CanoR_1	47	56	PF00244	0.623
LIG_Clathr_ClatBox_1	286	290	PF01394	0.554
LIG_CtBP_PxDLS_1	124	128	PF00389	0.641
LIG_LIR_Apic_2	161	166	PF02991	0.657
LIG_LIR_Gen_1	180	189	PF02991	0.613
LIG_LIR_Gen_1	242	250	PF02991	0.517
LIG_LIR_Gen_1	290	301	PF02991	0.698
LIG_LIR_Gen_1	309	318	PF02991	0.528
LIG_LIR_Gen_1	65	71	PF02991	0.586
LIG_LIR_Gen_1	96	103	PF02991	0.578
LIG_LIR_Nem_3	180	185	PF02991	0.599
LIG_LIR_Nem_3	242	247	PF02991	0.524
LIG_LIR_Nem_3	290	296	PF02991	0.692
LIG_LIR_Nem_3	309	314	PF02991	0.536
LIG_LIR_Nem_3	65	70	PF02991	0.572
LIG_LIR_Nem_3	96	102	PF02991	0.506
LIG_PCNA_PIPBox_1	184	193	PF02747	0.527
LIG_PCNA_yPIPBox_3	299	312	PF02747	0.599
LIG_PDZ_Class_1	378	383	PF00595	0.682
LIG_Pex14_2	244	248	PF04695	0.554
LIG_Pex14_2	323	327	PF04695	0.551
LIG_SH2_CRK	67	71	PF00017	0.504
LIG_SH2_NCK_1	63	67	PF00017	0.558
LIG_SH2_STAP1	67	71	PF00017	0.697
LIG_SH2_STAT5	162	165	PF00017	0.622
LIG_SH2_STAT5	234	237	PF00017	0.544
LIG_SH2_STAT5	355	358	PF00017	0.593
LIG_SH3_1	358	364	PF00018	0.664
LIG_SH3_3	119	125	PF00018	0.624
LIG_SH3_3	138	144	PF00018	0.702
LIG_SH3_3	265	271	PF00018	0.582
LIG_SH3_3	341	347	PF00018	0.665
LIG_SH3_3	358	364	PF00018	0.511
LIG_SH3_5	158	162	PF00018	0.668
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.500
LIG_SUMO_SIM_par_1	206	211	PF11976	0.594
LIG_TRAF2_1	95	98	PF00917	0.509
MOD_CK1_1	149	155	PF00069	0.698
MOD_CK1_1	177	183	PF00069	0.590
MOD_CK1_1	31	37	PF00069	0.754
MOD_CK1_1	337	343	PF00069	0.550
MOD_CK1_1	50	56	PF00069	0.758
MOD_CK2_1	189	195	PF00069	0.554
MOD_CK2_1	31	37	PF00069	0.601
MOD_CK2_1	335	341	PF00069	0.652
MOD_CMANNOS	327	330	PF00535	0.553
MOD_GlcNHglycan	279	282	PF01048	0.658
MOD_GlcNHglycan	31	34	PF01048	0.652
MOD_GlcNHglycan	324	327	PF01048	0.546
MOD_GlcNHglycan	351	354	PF01048	0.650
MOD_GlcNHglycan	380	383	PF01048	0.658
MOD_GSK3_1	173	180	PF00069	0.639
MOD_GSK3_1	228	235	PF00069	0.733
MOD_GSK3_1	27	34	PF00069	0.736
MOD_GSK3_1	273	280	PF00069	0.590
MOD_GSK3_1	285	292	PF00069	0.609
MOD_GSK3_1	312	319	PF00069	0.607
MOD_LATS_1	26	32	PF00433	0.648
MOD_NEK2_1	173	178	PF00069	0.581
MOD_NEK2_1	277	282	PF00069	0.629
MOD_NEK2_2	115	120	PF00069	0.597
MOD_PIKK_1	180	186	PF00454	0.611
MOD_PIKK_1	248	254	PF00454	0.574
MOD_PIKK_1	50	56	PF00454	0.616
MOD_PKA_1	28	34	PF00069	0.587
MOD_PKA_2	27	33	PF00069	0.633
MOD_PKA_2	334	340	PF00069	0.593
MOD_PKA_2	48	54	PF00069	0.802
MOD_Plk_1	125	131	PF00069	0.580
MOD_Plk_1	289	295	PF00069	0.612
MOD_Plk_4	177	183	PF00069	0.576
MOD_Plk_4	75	81	PF00069	0.494
MOD_ProDKin_1	140	146	PF00069	0.805
MOD_ProDKin_1	19	25	PF00069	0.698
MOD_ProDKin_1	228	234	PF00069	0.738
MOD_ProDKin_1	267	273	PF00069	0.623
MOD_SUMO_rev_2	337	345	PF00179	0.658
TRG_DiLeu_BaEn_2	340	346	PF01217	0.601
TRG_DiLeu_BaEn_3	97	103	PF01217	0.471
TRG_ENDOCYTIC_2	67	70	PF00928	0.508
TRG_ER_diArg_1	185	188	PF00400	0.617
TRG_ER_diArg_1	260	262	PF00400	0.604
TRG_ER_diArg_1	46	49	PF00400	0.772
TRG_ER_diArg_1	56	58	PF00400	0.682
TRG_NES_CRM1_1	239	253	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I674	Leptomonas seymouri	46%	76%
A0A3Q8IGG7	Leishmania donovani	99%	100%
E9B208	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q653	Leishmania major	93%	100%