Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6Y6_LEIIN

TriTrypDb:

LINF_310028800

Length:

768

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Phosphorylation

Amastigote: 47
Promastigote: 317, 334
Promastigote/Amastigote: 15, 352

Expansion

Sequence features

A4I6Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Y6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.434
CLV_C14_Caspase3-7	239	243	PF00656	0.475
CLV_C14_Caspase3-7	542	546	PF00656	0.544
CLV_C14_Caspase3-7	558	562	PF00656	0.569
CLV_C14_Caspase3-7	611	615	PF00656	0.688
CLV_NRD_NRD_1	10	12	PF00675	0.709
CLV_NRD_NRD_1	410	412	PF00675	0.677
CLV_NRD_NRD_1	426	428	PF00675	0.774
CLV_NRD_NRD_1	564	566	PF00675	0.368
CLV_NRD_NRD_1	571	573	PF00675	0.397
CLV_NRD_NRD_1	577	579	PF00675	0.452
CLV_NRD_NRD_1	604	606	PF00675	0.398
CLV_NRD_NRD_1	63	65	PF00675	0.678
CLV_NRD_NRD_1	761	763	PF00675	0.406
CLV_NRD_NRD_1	98	100	PF00675	0.796
CLV_PCSK_FUR_1	423	427	PF00082	0.755
CLV_PCSK_FUR_1	61	65	PF00082	0.698
CLV_PCSK_KEX2_1	271	273	PF00082	0.734
CLV_PCSK_KEX2_1	410	412	PF00082	0.677
CLV_PCSK_KEX2_1	423	425	PF00082	0.742
CLV_PCSK_KEX2_1	426	428	PF00082	0.773
CLV_PCSK_KEX2_1	564	566	PF00082	0.370
CLV_PCSK_KEX2_1	570	572	PF00082	0.392
CLV_PCSK_KEX2_1	577	579	PF00082	0.456
CLV_PCSK_KEX2_1	63	65	PF00082	0.678
CLV_PCSK_KEX2_1	98	100	PF00082	0.796
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.734
CLV_PCSK_PC7_1	59	65	PF00082	0.698
CLV_PCSK_SKI1_1	136	140	PF00082	0.670
CLV_PCSK_SKI1_1	364	368	PF00082	0.729
CLV_PCSK_SKI1_1	564	568	PF00082	0.360
CLV_PCSK_SKI1_1	577	581	PF00082	0.362
CLV_PCSK_SKI1_1	81	85	PF00082	0.696
DEG_APCC_DBOX_1	159	167	PF00400	0.455
DEG_APCC_DBOX_1	237	245	PF00400	0.464
DEG_SCF_FBW7_1	376	383	PF00400	0.438
DEG_SPOP_SBC_1	109	113	PF00917	0.505
DOC_MAPK_gen_1	440	448	PF00069	0.427
DOC_PP1_RVXF_1	575	582	PF00149	0.581
DOC_PP1_RVXF_1	682	688	PF00149	0.600
DOC_PP2B_LxvP_1	500	503	PF13499	0.523
DOC_PP4_MxPP_1	648	651	PF00568	0.555
DOC_USP7_MATH_1	109	113	PF00917	0.518
DOC_USP7_MATH_1	236	240	PF00917	0.472
DOC_USP7_MATH_1	300	304	PF00917	0.466
DOC_USP7_MATH_1	306	310	PF00917	0.435
DOC_USP7_MATH_1	349	353	PF00917	0.413
DOC_USP7_MATH_1	412	416	PF00917	0.481
DOC_USP7_MATH_1	438	442	PF00917	0.479
DOC_USP7_MATH_1	484	488	PF00917	0.457
DOC_USP7_MATH_1	494	498	PF00917	0.500
DOC_USP7_MATH_1	612	616	PF00917	0.657
DOC_WW_Pin1_4	251	256	PF00397	0.447
DOC_WW_Pin1_4	376	381	PF00397	0.482
DOC_WW_Pin1_4	425	430	PF00397	0.492
DOC_WW_Pin1_4	482	487	PF00397	0.507
DOC_WW_Pin1_4	604	609	PF00397	0.680
DOC_WW_Pin1_4	732	737	PF00397	0.398
DOC_WW_Pin1_4	81	86	PF00397	0.494
LIG_14-3-3_CanoR_1	11	17	PF00244	0.469
LIG_14-3-3_CanoR_1	160	164	PF00244	0.403
LIG_14-3-3_CanoR_1	235	245	PF00244	0.481
LIG_14-3-3_CanoR_1	314	321	PF00244	0.489
LIG_14-3-3_CanoR_1	353	359	PF00244	0.590
LIG_14-3-3_CanoR_1	364	371	PF00244	0.472
LIG_14-3-3_CanoR_1	39	45	PF00244	0.489
LIG_14-3-3_CanoR_1	411	417	PF00244	0.481
LIG_14-3-3_CanoR_1	52	56	PF00244	0.453
LIG_14-3-3_CanoR_1	691	699	PF00244	0.599
LIG_Actin_WH2_2	156	174	PF00022	0.484
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BRCT_BRCA1_1	129	133	PF00533	0.497
LIG_Clathr_ClatBox_1	550	554	PF01394	0.603
LIG_deltaCOP1_diTrp_1	328	335	PF00928	0.469
LIG_eIF4E_1	705	711	PF01652	0.331
LIG_FHA_1	160	166	PF00498	0.475
LIG_FHA_1	280	286	PF00498	0.477
LIG_FHA_1	377	383	PF00498	0.453
LIG_FHA_1	390	396	PF00498	0.361
LIG_FHA_1	400	406	PF00498	0.500
LIG_FHA_1	675	681	PF00498	0.495
LIG_FHA_1	759	765	PF00498	0.481
LIG_FHA_1	82	88	PF00498	0.448
LIG_FHA_2	328	334	PF00498	0.470
LIG_FHA_2	404	410	PF00498	0.453
LIG_FHA_2	609	615	PF00498	0.687
LIG_GBD_Chelix_1	285	293	PF00786	0.686
LIG_KLC1_Yacidic_2	444	449	PF13176	0.423
LIG_LIR_Apic_2	487	493	PF02991	0.449
LIG_LIR_Gen_1	207	217	PF02991	0.449
LIG_LIR_Gen_1	282	292	PF02991	0.446
LIG_LIR_Gen_1	46	55	PF02991	0.533
LIG_LIR_Gen_1	461	470	PF02991	0.392
LIG_LIR_Gen_1	515	526	PF02991	0.343
LIG_LIR_Gen_1	697	707	PF02991	0.517
LIG_LIR_Gen_1	735	746	PF02991	0.289
LIG_LIR_Nem_3	180	185	PF02991	0.419
LIG_LIR_Nem_3	207	213	PF02991	0.454
LIG_LIR_Nem_3	282	287	PF02991	0.488
LIG_LIR_Nem_3	46	51	PF02991	0.499
LIG_LIR_Nem_3	461	465	PF02991	0.399
LIG_LIR_Nem_3	468	473	PF02991	0.381
LIG_LIR_Nem_3	515	521	PF02991	0.343
LIG_LIR_Nem_3	525	531	PF02991	0.335
LIG_LIR_Nem_3	695	701	PF02991	0.588
LIG_LIR_Nem_3	734	740	PF02991	0.383
LIG_LIR_Nem_3	752	757	PF02991	0.201
LIG_NRBOX	288	294	PF00104	0.444
LIG_PDZ_Class_2	763	768	PF00595	0.624
LIG_Pex14_1	331	335	PF04695	0.464
LIG_REV1ctd_RIR_1	14	23	PF16727	0.508
LIG_RPA_C_Fungi	566	578	PF08784	0.419
LIG_SH2_CRK	490	494	PF00017	0.563
LIG_SH2_CRK	528	532	PF00017	0.428
LIG_SH2_CRK	757	761	PF00017	0.331
LIG_SH2_NCK_1	490	494	PF00017	0.563
LIG_SH2_PTP2	284	287	PF00017	0.601
LIG_SH2_PTP2	705	708	PF00017	0.371
LIG_SH2_SRC	447	450	PF00017	0.514
LIG_SH2_SRC	765	768	PF00017	0.529
LIG_SH2_STAP1	131	135	PF00017	0.618
LIG_SH2_STAP1	245	249	PF00017	0.581
LIG_SH2_STAP1	681	685	PF00017	0.402
LIG_SH2_STAT3	475	478	PF00017	0.520
LIG_SH2_STAT5	284	287	PF00017	0.615
LIG_SH2_STAT5	386	389	PF00017	0.523
LIG_SH2_STAT5	447	450	PF00017	0.664
LIG_SH2_STAT5	458	461	PF00017	0.558
LIG_SH2_STAT5	50	53	PF00017	0.692
LIG_SH2_STAT5	530	533	PF00017	0.423
LIG_SH2_STAT5	681	684	PF00017	0.403
LIG_SH2_STAT5	705	708	PF00017	0.357
LIG_SH2_STAT5	759	762	PF00017	0.485
LIG_SH2_STAT5	765	768	PF00017	0.485
LIG_SH3_1	426	432	PF00018	0.618
LIG_SH3_3	187	193	PF00018	0.590
LIG_SH3_3	2	8	PF00018	0.536
LIG_SH3_3	23	29	PF00018	0.629
LIG_SH3_3	275	281	PF00018	0.656
LIG_SH3_3	385	391	PF00018	0.546
LIG_SH3_3	426	432	PF00018	0.668
LIG_SH3_3	483	489	PF00018	0.581
LIG_SH3_3	706	712	PF00018	0.371
LIG_SUMO_SIM_par_1	549	554	PF11976	0.489
LIG_TYR_ITIM	526	531	PF00017	0.287
MOD_CDK_SPxxK_3	251	258	PF00069	0.557
MOD_CDK_SPxxK_3	485	492	PF00069	0.657
MOD_CDK_SPxxK_3	81	88	PF00069	0.621
MOD_CK1_1	110	116	PF00069	0.663
MOD_CK1_1	117	123	PF00069	0.610
MOD_CK1_1	15	21	PF00069	0.596
MOD_CK1_1	313	319	PF00069	0.544
MOD_CK1_1	356	362	PF00069	0.675
MOD_CK1_1	468	474	PF00069	0.602
MOD_CK1_1	480	486	PF00069	0.500
MOD_CK1_1	508	514	PF00069	0.371
MOD_CK1_1	604	610	PF00069	0.629
MOD_CK1_1	616	622	PF00069	0.524
MOD_CK1_1	690	696	PF00069	0.466
MOD_CK1_1	70	76	PF00069	0.660
MOD_CK2_1	314	320	PF00069	0.732
MOD_CK2_1	327	333	PF00069	0.562
MOD_GlcNHglycan	142	145	PF01048	0.616
MOD_GlcNHglycan	148	151	PF01048	0.555
MOD_GlcNHglycan	200	203	PF01048	0.692
MOD_GlcNHglycan	206	209	PF01048	0.546
MOD_GlcNHglycan	298	301	PF01048	0.560
MOD_GlcNHglycan	308	311	PF01048	0.565
MOD_GlcNHglycan	316	319	PF01048	0.635
MOD_GlcNHglycan	359	362	PF01048	0.593
MOD_GlcNHglycan	40	43	PF01048	0.607
MOD_GlcNHglycan	406	409	PF01048	0.602
MOD_GlcNHglycan	414	417	PF01048	0.626
MOD_GlcNHglycan	496	499	PF01048	0.595
MOD_GlcNHglycan	500	503	PF01048	0.596
MOD_GlcNHglycan	505	508	PF01048	0.590
MOD_GlcNHglycan	614	618	PF01048	0.592
MOD_GlcNHglycan	625	628	PF01048	0.588
MOD_GlcNHglycan	630	633	PF01048	0.546
MOD_GSK3_1	104	111	PF00069	0.703
MOD_GSK3_1	112	119	PF00069	0.622
MOD_GSK3_1	146	153	PF00069	0.602
MOD_GSK3_1	155	162	PF00069	0.514
MOD_GSK3_1	215	222	PF00069	0.561
MOD_GSK3_1	266	273	PF00069	0.669
MOD_GSK3_1	288	295	PF00069	0.669
MOD_GSK3_1	296	303	PF00069	0.672
MOD_GSK3_1	306	313	PF00069	0.525
MOD_GSK3_1	327	334	PF00069	0.542
MOD_GSK3_1	349	356	PF00069	0.584
MOD_GSK3_1	376	383	PF00069	0.698
MOD_GSK3_1	389	396	PF00069	0.423
MOD_GSK3_1	399	406	PF00069	0.524
MOD_GSK3_1	480	487	PF00069	0.583
MOD_GSK3_1	494	501	PF00069	0.606
MOD_GSK3_1	508	515	PF00069	0.240
MOD_GSK3_1	517	524	PF00069	0.308
MOD_GSK3_1	604	611	PF00069	0.587
MOD_GSK3_1	612	619	PF00069	0.543
MOD_GSK3_1	67	74	PF00069	0.774
MOD_GSK3_1	675	682	PF00069	0.533
MOD_GSK3_1	685	692	PF00069	0.447
MOD_GSK3_1	711	718	PF00069	0.242
MOD_GSK3_1	732	739	PF00069	0.433
MOD_GSK3_1	745	752	PF00069	0.228
MOD_LATS_1	106	112	PF00433	0.637
MOD_LATS_1	69	75	PF00433	0.661
MOD_N-GLC_1	12	17	PF02516	0.584
MOD_N-GLC_1	31	36	PF02516	0.484
MOD_N-GLC_1	675	680	PF02516	0.396
MOD_N-GLC_1	685	690	PF02516	0.425
MOD_N-GLC_1	731	736	PF02516	0.351
MOD_N-GLC_1	74	79	PF02516	0.653
MOD_N-GLC_1	81	86	PF02516	0.594
MOD_NEK2_1	215	220	PF00069	0.507
MOD_NEK2_1	292	297	PF00069	0.592
MOD_NEK2_1	335	340	PF00069	0.505
MOD_NEK2_1	381	386	PF00069	0.568
MOD_NEK2_1	403	408	PF00069	0.554
MOD_NEK2_1	465	470	PF00069	0.447
MOD_NEK2_1	505	510	PF00069	0.607
MOD_NEK2_1	51	56	PF00069	0.573
MOD_NEK2_1	513	518	PF00069	0.298
MOD_NEK2_1	521	526	PF00069	0.322
MOD_NEK2_1	601	606	PF00069	0.643
MOD_NEK2_1	679	684	PF00069	0.415
MOD_NEK2_1	687	692	PF00069	0.488
MOD_NEK2_2	155	160	PF00069	0.578
MOD_PIKK_1	150	156	PF00454	0.567
MOD_PIKK_1	364	370	PF00454	0.668
MOD_PKA_1	271	277	PF00069	0.641
MOD_PKA_2	107	113	PF00069	0.616
MOD_PKA_2	117	123	PF00069	0.514
MOD_PKA_2	159	165	PF00069	0.582
MOD_PKA_2	237	243	PF00069	0.584
MOD_PKA_2	271	277	PF00069	0.641
MOD_PKA_2	313	319	PF00069	0.605
MOD_PKA_2	38	44	PF00069	0.613
MOD_PKA_2	51	57	PF00069	0.560
MOD_PKA_2	591	597	PF00069	0.512
MOD_PKA_2	612	618	PF00069	0.566
MOD_PKA_2	62	68	PF00069	0.581
MOD_PKA_2	690	696	PF00069	0.489
MOD_PKA_2	70	76	PF00069	0.519
MOD_PKA_2	97	103	PF00069	0.696
MOD_Plk_1	12	18	PF00069	0.588
MOD_Plk_1	127	133	PF00069	0.628
MOD_Plk_1	31	37	PF00069	0.551
MOD_Plk_1	327	333	PF00069	0.589
MOD_Plk_1	675	681	PF00069	0.391
MOD_Plk_2-3	540	546	PF00069	0.425
MOD_Plk_4	12	18	PF00069	0.588
MOD_Plk_4	288	294	PF00069	0.549
MOD_Plk_4	31	37	PF00069	0.551
MOD_Plk_4	381	387	PF00069	0.539
MOD_Plk_4	465	471	PF00069	0.443
MOD_Plk_4	508	514	PF00069	0.388
MOD_Plk_4	517	523	PF00069	0.321
MOD_Plk_4	531	537	PF00069	0.421
MOD_Plk_4	543	549	PF00069	0.396
MOD_Plk_4	637	643	PF00069	0.492
MOD_Plk_4	656	662	PF00069	0.426
MOD_Plk_4	675	681	PF00069	0.332
MOD_Plk_4	697	703	PF00069	0.331
MOD_Plk_4	711	717	PF00069	0.227
MOD_Plk_4	749	755	PF00069	0.331
MOD_ProDKin_1	251	257	PF00069	0.555
MOD_ProDKin_1	376	382	PF00069	0.601
MOD_ProDKin_1	425	431	PF00069	0.616
MOD_ProDKin_1	482	488	PF00069	0.637
MOD_ProDKin_1	604	610	PF00069	0.603
MOD_ProDKin_1	732	738	PF00069	0.482
MOD_ProDKin_1	81	87	PF00069	0.619
TRG_DiLeu_BaEn_1	288	293	PF01217	0.550
TRG_DiLeu_BaEn_4	247	253	PF01217	0.573
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.614
TRG_DiLeu_BaLyEn_6	546	551	PF01217	0.492
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.425
TRG_ENDOCYTIC_2	284	287	PF00928	0.591
TRG_ENDOCYTIC_2	528	531	PF00928	0.434
TRG_ENDOCYTIC_2	698	701	PF00928	0.464
TRG_ENDOCYTIC_2	705	708	PF00928	0.305
TRG_ENDOCYTIC_2	757	760	PF00928	0.331
TRG_ER_diArg_1	423	426	PF00400	0.640
TRG_ER_diArg_1	472	475	PF00400	0.478
TRG_ER_diArg_1	563	565	PF00400	0.449
TRG_ER_diArg_1	569	572	PF00400	0.443
TRG_ER_diArg_1	577	579	PF00400	0.535
TRG_ER_diArg_1	602	605	PF00400	0.458
TRG_ER_diArg_1	61	64	PF00400	0.602
TRG_ER_diArg_1	98	101	PF00400	0.760
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	577	582	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZK3	Leptomonas seymouri	45%	100%
A0A3S7X4P2	Leishmania donovani	99%	100%
A4HJX2	Leishmania braziliensis	60%	100%
E9B207	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q654	Leishmania major	90%	100%