LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
CRAL/TRIO domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I6Y4_LEIIN
TriTrypDb:
LINF_310028700
Length:
355

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 31
NetGPI no yes: 0, no: 31
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I6Y4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Y4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 181 185 PF00656 0.204
CLV_NRD_NRD_1 11 13 PF00675 0.532
CLV_PCSK_FUR_1 9 13 PF00082 0.388
CLV_PCSK_KEX2_1 11 13 PF00082 0.540
CLV_PCSK_SKI1_1 171 175 PF00082 0.304
CLV_PCSK_SKI1_1 253 257 PF00082 0.321
CLV_PCSK_SKI1_1 283 287 PF00082 0.372
CLV_PCSK_SKI1_1 295 299 PF00082 0.271
CLV_Separin_Metazoa 115 119 PF03568 0.446
DEG_COP1_1 308 318 PF00400 0.252
DEG_SCF_FBW7_1 56 61 PF00400 0.473
DEG_SCF_FBW7_2 14 21 PF00400 0.421
DOC_CYCLIN_yClb5_NLxxxL_5 164 173 PF00134 0.213
DOC_MAPK_gen_1 20 30 PF00069 0.460
DOC_MAPK_gen_1 295 305 PF00069 0.468
DOC_MAPK_MEF2A_6 224 232 PF00069 0.368
DOC_MAPK_MEF2A_6 238 247 PF00069 0.436
DOC_USP7_MATH_1 299 303 PF00917 0.346
DOC_USP7_MATH_1 3 7 PF00917 0.517
DOC_USP7_UBL2_3 238 242 PF12436 0.352
DOC_WW_Pin1_4 14 19 PF00397 0.444
DOC_WW_Pin1_4 46 51 PF00397 0.486
DOC_WW_Pin1_4 54 59 PF00397 0.464
LIG_14-3-3_CanoR_1 224 232 PF00244 0.373
LIG_BIR_II_1 1 5 PF00653 0.615
LIG_eIF4E_1 65 71 PF01652 0.441
LIG_FHA_1 174 180 PF00498 0.473
LIG_FHA_1 224 230 PF00498 0.319
LIG_FHA_1 23 29 PF00498 0.440
LIG_FHA_1 340 346 PF00498 0.669
LIG_FHA_2 49 55 PF00498 0.539
LIG_GBD_Chelix_1 88 96 PF00786 0.281
LIG_LIR_Apic_2 150 155 PF02991 0.237
LIG_LIR_Gen_1 64 71 PF02991 0.421
LIG_LIR_Nem_3 197 203 PF02991 0.351
LIG_LIR_Nem_3 236 240 PF02991 0.364
LIG_LIR_Nem_3 254 259 PF02991 0.392
LIG_LIR_Nem_3 276 282 PF02991 0.336
LIG_LIR_Nem_3 33 38 PF02991 0.480
LIG_LIR_Nem_3 64 70 PF02991 0.459
LIG_NRBOX 190 196 PF00104 0.204
LIG_NRBOX 41 47 PF00104 0.460
LIG_PCNA_PIPBox_1 187 196 PF02747 0.275
LIG_Pex14_1 200 204 PF04695 0.386
LIG_SH2_CRK 152 156 PF00017 0.416
LIG_SH2_CRK 279 283 PF00017 0.353
LIG_SH2_CRK 35 39 PF00017 0.444
LIG_SH2_CRK 67 71 PF00017 0.336
LIG_SH2_STAT3 203 206 PF00017 0.331
LIG_SH2_STAT3 90 93 PF00017 0.459
LIG_SH2_STAT5 13 16 PF00017 0.528
LIG_SH2_STAT5 141 144 PF00017 0.335
LIG_SH2_STAT5 158 161 PF00017 0.288
LIG_SH2_STAT5 314 317 PF00017 0.390
LIG_SH2_STAT5 65 68 PF00017 0.378
LIG_SH3_3 266 272 PF00018 0.380
LIG_SUMO_SIM_anti_2 301 308 PF11976 0.255
LIG_SUMO_SIM_par_1 226 231 PF11976 0.369
LIG_TYR_ITIM 156 161 PF00017 0.408
LIG_UBA3_1 169 174 PF00899 0.393
LIG_WRC_WIRS_1 274 279 PF05994 0.288
MOD_CDK_SPxK_1 14 20 PF00069 0.420
MOD_CK1_1 104 110 PF00069 0.472
MOD_CK1_1 273 279 PF00069 0.429
MOD_CK1_1 340 346 PF00069 0.476
MOD_CK1_1 49 55 PF00069 0.570
MOD_CK2_1 160 166 PF00069 0.428
MOD_CK2_1 349 355 PF00069 0.726
MOD_GlcNHglycan 1 4 PF01048 0.515
MOD_GlcNHglycan 103 106 PF01048 0.446
MOD_GlcNHglycan 196 199 PF01048 0.235
MOD_GlcNHglycan 339 342 PF01048 0.670
MOD_GlcNHglycan 351 354 PF01048 0.711
MOD_GlcNHglycan 5 8 PF01048 0.486
MOD_GSK3_1 247 254 PF00069 0.486
MOD_GSK3_1 337 344 PF00069 0.716
MOD_GSK3_1 54 61 PF00069 0.478
MOD_GSK3_1 97 104 PF00069 0.456
MOD_N-GLC_1 59 64 PF02516 0.452
MOD_NEK2_1 233 238 PF00069 0.347
MOD_NEK2_1 247 252 PF00069 0.341
MOD_NEK2_2 251 256 PF00069 0.194
MOD_PIKK_1 22 28 PF00454 0.455
MOD_PIKK_1 347 353 PF00454 0.494
MOD_PKA_2 124 130 PF00069 0.475
MOD_PKA_2 223 229 PF00069 0.407
MOD_Plk_4 224 230 PF00069 0.354
MOD_Plk_4 251 257 PF00069 0.417
MOD_Plk_4 270 276 PF00069 0.262
MOD_ProDKin_1 14 20 PF00069 0.438
MOD_ProDKin_1 46 52 PF00069 0.492
MOD_ProDKin_1 54 60 PF00069 0.457
MOD_SUMO_for_1 136 139 PF00179 0.235
MOD_SUMO_rev_2 15 25 PF00179 0.426
MOD_SUMO_rev_2 166 176 PF00179 0.351
TRG_DiLeu_BaEn_1 301 306 PF01217 0.322
TRG_ENDOCYTIC_2 13 16 PF00928 0.571
TRG_ENDOCYTIC_2 158 161 PF00928 0.378
TRG_ENDOCYTIC_2 204 207 PF00928 0.404
TRG_ENDOCYTIC_2 237 240 PF00928 0.358
TRG_ENDOCYTIC_2 279 282 PF00928 0.363
TRG_ENDOCYTIC_2 35 38 PF00928 0.456
TRG_ENDOCYTIC_2 67 70 PF00928 0.340
TRG_ER_diArg_1 8 11 PF00400 0.613
TRG_Pf-PMV_PEXEL_1 118 123 PF00026 0.418

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6D4 Leptomonas seymouri 36% 68%
A0A0N0P991 Leptomonas seymouri 30% 74%
A0A0N0P9K9 Leptomonas seymouri 26% 74%
A0A0N1I2J8 Leptomonas seymouri 47% 76%
A0A0N1PCS4 Leptomonas seymouri 66% 76%
A0A0S4J7N0 Bodo saltans 28% 94%
A0A0S4KJL3 Bodo saltans 26% 78%
A0A1X0NUJ5 Trypanosomatidae 29% 75%
A0A3Q8ICN0 Leishmania donovani 99% 71%
A0A3Q8IGQ2 Leishmania donovani 30% 74%
A0A3S7X4P4 Leishmania donovani 39% 68%
A0A3S7X4R1 Leishmania donovani 51% 72%
A0A422P1E3 Trypanosoma rangeli 27% 76%
A4HJI7 Leishmania braziliensis 38% 100%
A4HJI8 Leishmania braziliensis 51% 100%
A4HJI9 Leishmania braziliensis 77% 100%
A4HKB3 Leishmania braziliensis 30% 100%
A4HKB4 Leishmania braziliensis 29% 72%
A4I6Y2 Leishmania infantum 39% 100%
A4I6Y3 Leishmania infantum 51% 100%
A4I7U3 Leishmania infantum 30% 74%
B5MCN3 Homo sapiens 22% 89%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B205 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E9B206 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B2Q1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
F4JYJ3 Arabidopsis thaliana 25% 94%
O76054 Homo sapiens 24% 88%
P58875 Bos taurus 22% 88%
Q4Q5F6 Leishmania major 31% 100%
Q4Q655 Leishmania major 95% 100%
Q4Q656 Leishmania major 51% 100%
Q4Q657 Leishmania major 39% 100%
Q8R0F9 Mus musculus 22% 88%
Q99J08 Mus musculus 23% 88%
Q99MS0 Rattus norvegicus 24% 88%
Q9UDX3 Homo sapiens 22% 87%
Q9UDX4 Homo sapiens 21% 89%
Q9Z1J8 Rattus norvegicus 21% 89%
V5BL84 Trypanosoma cruzi 27% 77%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS