LeishMANIAdb
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CRAL-TRIO domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL-TRIO domain-containing protein
Gene product:
CRAL/TRIO domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I6Y3_LEIIN
TriTrypDb:
LINF_310028600
Length:
491

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Annotations by Jardim et al.

Transporters, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 34
NetGPI no yes: 0, no: 34
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I6Y3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Y3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 56 60 PF00656 0.539
CLV_NRD_NRD_1 299 301 PF00675 0.298
CLV_NRD_NRD_1 32 34 PF00675 0.443
CLV_PCSK_KEX2_1 34 36 PF00082 0.410
CLV_PCSK_KEX2_1 387 389 PF00082 0.338
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.440
CLV_PCSK_PC1ET2_1 387 389 PF00082 0.409
CLV_PCSK_SKI1_1 125 129 PF00082 0.521
CLV_PCSK_SKI1_1 179 183 PF00082 0.311
CLV_PCSK_SKI1_1 23 27 PF00082 0.442
CLV_PCSK_SKI1_1 232 236 PF00082 0.335
CLV_PCSK_SKI1_1 250 254 PF00082 0.339
CLV_PCSK_SKI1_1 291 295 PF00082 0.384
CLV_PCSK_SKI1_1 387 391 PF00082 0.379
CLV_PCSK_SKI1_1 41 45 PF00082 0.343
CLV_Separin_Metazoa 30 34 PF03568 0.306
DOC_MAPK_gen_1 300 307 PF00069 0.362
DOC_MAPK_gen_1 85 94 PF00069 0.464
DOC_MAPK_HePTP_8 243 255 PF00069 0.298
DOC_MAPK_MEF2A_6 159 167 PF00069 0.328
DOC_MAPK_MEF2A_6 232 240 PF00069 0.360
DOC_MAPK_MEF2A_6 246 255 PF00069 0.442
DOC_MAPK_MEF2A_6 87 96 PF00069 0.442
DOC_PP4_FxxP_1 66 69 PF00568 0.260
DOC_USP7_MATH_1 3 7 PF00917 0.522
DOC_USP7_MATH_1 421 425 PF00917 0.592
DOC_USP7_MATH_1 443 447 PF00917 0.514
DOC_USP7_UBL2_3 246 250 PF12436 0.479
DOC_USP7_UBL2_3 346 350 PF12436 0.476
DOC_WW_Pin1_4 187 192 PF00397 0.298
DOC_WW_Pin1_4 276 281 PF00397 0.293
DOC_WW_Pin1_4 307 312 PF00397 0.360
DOC_WW_Pin1_4 441 446 PF00397 0.556
DOC_WW_Pin1_4 48 53 PF00397 0.539
DOC_WW_Pin1_4 65 70 PF00397 0.265
LIG_14-3-3_CanoR_1 141 149 PF00244 0.441
LIG_14-3-3_CanoR_1 388 393 PF00244 0.379
LIG_14-3-3_CanoR_1 85 90 PF00244 0.419
LIG_Actin_WH2_2 371 389 PF00022 0.325
LIG_deltaCOP1_diTrp_1 82 89 PF00928 0.493
LIG_eIF4E_1 73 79 PF01652 0.444
LIG_FHA_1 149 155 PF00498 0.485
LIG_FHA_1 188 194 PF00498 0.449
LIG_FHA_1 233 239 PF00498 0.308
LIG_FHA_1 357 363 PF00498 0.689
LIG_FHA_1 373 379 PF00498 0.429
LIG_FHA_1 412 418 PF00498 0.401
LIG_FHA_1 425 431 PF00498 0.329
LIG_FHA_2 346 352 PF00498 0.732
LIG_FHA_2 451 457 PF00498 0.397
LIG_FHA_2 54 60 PF00498 0.613
LIG_LIR_Apic_2 413 418 PF02991 0.432
LIG_LIR_Apic_2 65 69 PF02991 0.261
LIG_LIR_Gen_1 397 405 PF02991 0.374
LIG_LIR_Gen_1 457 465 PF02991 0.353
LIG_LIR_Gen_1 88 96 PF02991 0.520
LIG_LIR_Nem_3 12 17 PF02991 0.598
LIG_LIR_Nem_3 147 152 PF02991 0.397
LIG_LIR_Nem_3 244 248 PF02991 0.356
LIG_LIR_Nem_3 262 267 PF02991 0.366
LIG_LIR_Nem_3 397 403 PF02991 0.338
LIG_LIR_Nem_3 409 415 PF02991 0.364
LIG_LIR_Nem_3 457 463 PF02991 0.364
LIG_LIR_Nem_3 65 70 PF02991 0.426
LIG_LYPXL_SIV_4 286 294 PF13949 0.321
LIG_LYPXL_yS_3 14 17 PF13949 0.356
LIG_OCRL_FandH_1 470 482 PF00620 0.292
LIG_PCNA_PIPBox_1 195 204 PF02747 0.269
LIG_PCNA_PIPBox_1 257 266 PF02747 0.198
LIG_Pex14_2 412 416 PF04695 0.324
LIG_Pex14_2 460 464 PF04695 0.219
LIG_PTB_Apo_2 69 76 PF02174 0.234
LIG_PTB_Phospho_1 69 75 PF10480 0.233
LIG_SH2_CRK 287 291 PF00017 0.369
LIG_SH2_CRK 36 40 PF00017 0.465
LIG_SH2_CRK 49 53 PF00017 0.549
LIG_SH2_GRB2like 166 169 PF00017 0.446
LIG_SH2_SRC 341 344 PF00017 0.455
LIG_SH2_STAT5 149 152 PF00017 0.343
LIG_SH2_STAT5 166 169 PF00017 0.280
LIG_SH2_STAT5 322 325 PF00017 0.384
LIG_SH2_STAT5 326 329 PF00017 0.380
LIG_SH2_STAT5 415 418 PF00017 0.388
LIG_SH2_STAT5 438 441 PF00017 0.494
LIG_SH2_STAT5 452 455 PF00017 0.341
LIG_SH2_STAT5 73 76 PF00017 0.348
LIG_SH3_3 128 134 PF00018 0.469
LIG_SH3_3 169 175 PF00018 0.226
LIG_SH3_3 274 280 PF00018 0.363
LIG_SUMO_SIM_par_1 233 239 PF11976 0.354
LIG_SUMO_SIM_par_1 273 279 PF11976 0.212
LIG_TRAF2_1 19 22 PF00917 0.396
LIG_TRAF2_1 382 385 PF00917 0.468
LIG_TYR_ITIM 164 169 PF00017 0.370
LIG_TYR_ITIM 243 248 PF00017 0.401
LIG_UBA3_1 177 182 PF00899 0.405
LIG_UBA3_1 28 34 PF00899 0.526
LIG_UBA3_1 459 467 PF00899 0.232
LIG_WRC_WIRS_1 149 154 PF05994 0.198
LIG_WRC_WIRS_1 63 68 PF05994 0.477
MOD_CDC14_SPxK_1 68 71 PF00782 0.236
MOD_CDK_SPxK_1 65 71 PF00069 0.251
MOD_CK1_1 357 363 PF00069 0.685
MOD_CK1_1 424 430 PF00069 0.466
MOD_CK1_1 441 447 PF00069 0.474
MOD_CK1_1 469 475 PF00069 0.382
MOD_CK2_1 103 109 PF00069 0.527
MOD_CK2_1 168 174 PF00069 0.435
MOD_CK2_1 345 351 PF00069 0.564
MOD_CK2_1 430 436 PF00069 0.457
MOD_CK2_1 441 447 PF00069 0.377
MOD_CK2_1 48 54 PF00069 0.492
MOD_CK2_1 94 100 PF00069 0.298
MOD_GlcNHglycan 111 114 PF01048 0.455
MOD_GlcNHglycan 142 145 PF01048 0.366
MOD_GlcNHglycan 232 235 PF01048 0.198
MOD_GlcNHglycan 351 354 PF01048 0.690
MOD_GlcNHglycan 363 366 PF01048 0.695
MOD_GlcNHglycan 403 406 PF01048 0.445
MOD_GSK3_1 345 352 PF00069 0.646
MOD_GSK3_1 357 364 PF00069 0.641
MOD_GSK3_1 372 379 PF00069 0.480
MOD_GSK3_1 421 428 PF00069 0.384
MOD_GSK3_1 430 437 PF00069 0.486
MOD_GSK3_1 446 453 PF00069 0.371
MOD_GSK3_1 481 488 PF00069 0.409
MOD_N-GLC_2 72 74 PF02516 0.229
MOD_NEK2_1 230 235 PF00069 0.352
MOD_NEK2_1 256 261 PF00069 0.341
MOD_NEK2_1 349 354 PF00069 0.596
MOD_NEK2_1 425 430 PF00069 0.580
MOD_NEK2_1 434 439 PF00069 0.410
MOD_NEK2_1 481 486 PF00069 0.467
MOD_NEK2_1 53 58 PF00069 0.432
MOD_NEK2_1 92 97 PF00069 0.350
MOD_NEK2_2 62 67 PF00069 0.283
MOD_PK_1 394 400 PF00069 0.260
MOD_PKA_2 132 138 PF00069 0.495
MOD_PKA_2 140 146 PF00069 0.371
MOD_Plk_1 376 382 PF00069 0.482
MOD_Plk_4 232 238 PF00069 0.335
MOD_Plk_4 259 265 PF00069 0.426
MOD_Plk_4 394 400 PF00069 0.383
MOD_Plk_4 411 417 PF00069 0.413
MOD_Plk_4 430 436 PF00069 0.483
MOD_Plk_4 466 472 PF00069 0.317
MOD_Plk_4 62 68 PF00069 0.495
MOD_ProDKin_1 187 193 PF00069 0.298
MOD_ProDKin_1 276 282 PF00069 0.293
MOD_ProDKin_1 307 313 PF00069 0.360
MOD_ProDKin_1 441 447 PF00069 0.561
MOD_ProDKin_1 48 54 PF00069 0.554
MOD_ProDKin_1 65 71 PF00069 0.263
MOD_SUMO_for_1 222 225 PF00179 0.198
TRG_DiLeu_BaEn_1 24 29 PF01217 0.380
TRG_ENDOCYTIC_2 14 17 PF00928 0.581
TRG_ENDOCYTIC_2 149 152 PF00928 0.381
TRG_ENDOCYTIC_2 166 169 PF00928 0.342
TRG_ENDOCYTIC_2 212 215 PF00928 0.374
TRG_ENDOCYTIC_2 245 248 PF00928 0.374
TRG_ENDOCYTIC_2 287 290 PF00928 0.378
TRG_ENDOCYTIC_2 36 39 PF00928 0.474
TRG_ENDOCYTIC_2 75 78 PF00928 0.329
TRG_ER_diArg_1 32 35 PF00400 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6D4 Leptomonas seymouri 38% 94%
A0A0N0P991 Leptomonas seymouri 29% 100%
A0A0N0P9K9 Leptomonas seymouri 25% 100%
A0A0N1I2J8 Leptomonas seymouri 42% 100%
A0A0N1PCS4 Leptomonas seymouri 51% 100%
A0A0S4J7N0 Bodo saltans 24% 100%
A0A0S4KJL3 Bodo saltans 28% 100%
A0A1X0NUH5 Trypanosomatidae 26% 84%
A0A1X0NUJ5 Trypanosomatidae 26% 100%
A0A3Q8ICN0 Leishmania donovani 51% 99%
A0A3Q8IGQ2 Leishmania donovani 32% 100%
A0A3R7MUL5 Trypanosoma rangeli 24% 89%
A0A3S7X4P4 Leishmania donovani 41% 94%
A0A3S7X4R1 Leishmania donovani 99% 100%
A0A422P1E3 Trypanosoma rangeli 27% 100%
A4HJI7 Leishmania braziliensis 40% 100%
A4HJI8 Leishmania braziliensis 76% 100%
A4HJI9 Leishmania braziliensis 51% 100%
A4HKB3 Leishmania braziliensis 31% 99%
A4HKB4 Leishmania braziliensis 24% 100%
A4I6Y2 Leishmania infantum 41% 100%
A4I6Y4 Leishmania infantum 51% 100%
A4I7U3 Leishmania infantum 32% 100%
B5MCN3 Homo sapiens 21% 100%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B205 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B206 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 98%
E9B2Q1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 98%
O17907 Caenorhabditis elegans 22% 100%
O76054 Homo sapiens 22% 100%
P58875 Bos taurus 21% 100%
Q03606 Caenorhabditis elegans 23% 68%
Q16KN5 Aedes aegypti 22% 76%
Q4Q5F6 Leishmania major 33% 98%
Q4Q655 Leishmania major 49% 100%
Q4Q656 Leishmania major 94% 100%
Q4Q657 Leishmania major 41% 100%
Q8R0F9 Mus musculus 21% 100%
Q92503 Homo sapiens 22% 69%
Q99J08 Mus musculus 21% 100%
Q99MS0 Rattus norvegicus 22% 100%
Q9UDX3 Homo sapiens 23% 100%
Q9VMD6 Drosophila melanogaster 23% 75%
V5BL84 Trypanosoma cruzi 25% 100%
V5BQT0 Trypanosoma cruzi 25% 89%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS