LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
CRAL/TRIO domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I6Y2_LEIIN
TriTrypDb:
LINF_310028500
Length:
520

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Annotations by Jardim et al.

Transporters, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 37
NetGPI no yes: 0, no: 37
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 517, 519

Expansion

Sequence features

A4I6Y2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Y2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 3 7 PF00656 0.519
CLV_NRD_NRD_1 144 146 PF00675 0.478
CLV_NRD_NRD_1 342 344 PF00675 0.399
CLV_NRD_NRD_1 373 375 PF00675 0.374
CLV_NRD_NRD_1 376 378 PF00675 0.452
CLV_NRD_NRD_1 379 381 PF00675 0.434
CLV_NRD_NRD_1 490 492 PF00675 0.390
CLV_NRD_NRD_1 75 77 PF00675 0.718
CLV_PCSK_FUR_1 374 378 PF00082 0.403
CLV_PCSK_FUR_1 488 492 PF00082 0.281
CLV_PCSK_KEX2_1 373 375 PF00082 0.368
CLV_PCSK_KEX2_1 376 378 PF00082 0.447
CLV_PCSK_KEX2_1 379 381 PF00082 0.432
CLV_PCSK_KEX2_1 490 492 PF00082 0.465
CLV_PCSK_KEX2_1 75 77 PF00082 0.709
CLV_PCSK_SKI1_1 174 178 PF00082 0.356
CLV_PCSK_SKI1_1 191 195 PF00082 0.288
CLV_PCSK_SKI1_1 236 240 PF00082 0.485
CLV_PCSK_SKI1_1 264 268 PF00082 0.356
CLV_PCSK_SKI1_1 284 288 PF00082 0.330
CLV_PCSK_SKI1_1 307 311 PF00082 0.395
CLV_PCSK_SKI1_1 314 318 PF00082 0.385
CLV_PCSK_SKI1_1 35 39 PF00082 0.466
CLV_Separin_Metazoa 188 192 PF03568 0.221
DOC_CYCLIN_yCln2_LP_2 54 57 PF00134 0.597
DOC_MAPK_gen_1 171 181 PF00069 0.321
DOC_MAPK_gen_1 29 36 PF00069 0.444
DOC_MAPK_HePTP_8 266 278 PF00069 0.264
DOC_MAPK_MEF2A_6 269 278 PF00069 0.461
DOC_PP1_RVXF_1 321 328 PF00149 0.311
DOC_PP1_RVXF_1 495 502 PF00149 0.336
DOC_PP2B_LxvP_1 54 57 PF13499 0.378
DOC_PP4_FxxP_1 438 441 PF00568 0.365
DOC_USP7_MATH_1 237 241 PF00917 0.412
DOC_USP7_MATH_1 469 473 PF00917 0.488
DOC_USP7_UBL2_3 284 288 PF12436 0.211
DOC_WW_Pin1_4 140 145 PF00397 0.397
DOC_WW_Pin1_4 299 304 PF00397 0.260
LIG_14-3-3_CanoR_1 129 136 PF00244 0.379
LIG_14-3-3_CanoR_1 449 455 PF00244 0.493
LIG_APCC_ABBA_1 276 281 PF00400 0.378
LIG_BIR_II_1 1 5 PF00653 0.703
LIG_BRCT_BRCA1_1 282 286 PF00533 0.202
LIG_BRCT_BRCA1_1 471 475 PF00533 0.595
LIG_BRCT_BRCA1_2 282 288 PF00533 0.184
LIG_deltaCOP1_diTrp_1 94 101 PF00928 0.477
LIG_eIF4E_1 85 91 PF01652 0.438
LIG_FHA_1 131 137 PF00498 0.397
LIG_FHA_1 161 167 PF00498 0.488
LIG_FHA_1 17 23 PF00498 0.659
LIG_FHA_1 216 222 PF00498 0.427
LIG_FHA_1 395 401 PF00498 0.398
LIG_FHA_1 435 441 PF00498 0.354
LIG_FHA_1 85 91 PF00498 0.222
LIG_FHA_2 1 7 PF00498 0.646
LIG_FHA_2 240 246 PF00498 0.469
LIG_FHA_2 337 343 PF00498 0.414
LIG_FHA_2 449 455 PF00498 0.317
LIG_Integrin_isoDGR_2 172 174 PF01839 0.193
LIG_LIR_Apic_2 436 441 PF02991 0.403
LIG_LIR_Gen_1 205 215 PF02991 0.405
LIG_LIR_Gen_1 397 404 PF02991 0.405
LIG_LIR_Gen_1 432 443 PF02991 0.428
LIG_LIR_Gen_1 49 57 PF02991 0.339
LIG_LIR_Nem_3 283 289 PF02991 0.400
LIG_LIR_Nem_3 39 44 PF02991 0.510
LIG_LIR_Nem_3 397 402 PF02991 0.399
LIG_LIR_Nem_3 432 438 PF02991 0.371
LIG_LIR_Nem_3 49 54 PF02991 0.505
LIG_OCRL_FandH_1 493 505 PF00620 0.288
LIG_Pex14_2 122 126 PF04695 0.335
LIG_Pex14_2 435 439 PF04695 0.321
LIG_REV1ctd_RIR_1 284 290 PF16727 0.485
LIG_SH2_CRK 224 228 PF00017 0.355
LIG_SH2_CRK 308 312 PF00017 0.348
LIG_SH2_CRK 41 45 PF00017 0.469
LIG_SH2_PTP2 399 402 PF00017 0.479
LIG_SH2_SRC 345 348 PF00017 0.383
LIG_SH2_STAP1 308 312 PF00017 0.480
LIG_SH2_STAT3 367 370 PF00017 0.301
LIG_SH2_STAT5 345 348 PF00017 0.361
LIG_SH2_STAT5 399 402 PF00017 0.413
LIG_SH2_STAT5 461 464 PF00017 0.490
LIG_SH2_STAT5 51 54 PF00017 0.538
LIG_SH2_STAT5 85 88 PF00017 0.369
LIG_SH3_1 40 46 PF00018 0.301
LIG_SH3_2 369 374 PF14604 0.519
LIG_SH3_3 297 303 PF00018 0.353
LIG_SH3_3 366 372 PF00018 0.496
LIG_SH3_3 40 46 PF00018 0.481
LIG_SH3_3 71 77 PF00018 0.578
LIG_SUMO_SIM_anti_2 202 209 PF11976 0.334
LIG_SUMO_SIM_anti_2 479 486 PF11976 0.388
LIG_SUMO_SIM_par_1 213 220 PF11976 0.257
LIG_TYR_ITIM 176 181 PF00017 0.376
LIG_TYR_ITIM 222 227 PF00017 0.266
LIG_TYR_ITIM 306 311 PF00017 0.435
LIG_UBA3_1 189 194 PF00899 0.385
LIG_WRC_WIRS_1 181 186 PF05994 0.186
LIG_WRC_WIRS_1 435 440 PF05994 0.396
MOD_CDC14_SPxK_1 143 146 PF00782 0.317
MOD_CDK_SPK_2 140 145 PF00069 0.355
MOD_CDK_SPxK_1 140 146 PF00069 0.311
MOD_CK1_1 326 332 PF00069 0.379
MOD_CK1_1 459 465 PF00069 0.430
MOD_CK2_1 180 186 PF00069 0.433
MOD_CK2_1 213 219 PF00069 0.453
MOD_CK2_1 239 245 PF00069 0.484
MOD_CK2_1 448 454 PF00069 0.509
MOD_CK2_1 514 520 PF00069 0.713
MOD_GlcNHglycan 233 236 PF01048 0.402
MOD_GlcNHglycan 328 331 PF01048 0.406
MOD_GlcNHglycan 364 367 PF01048 0.468
MOD_GlcNHglycan 386 390 PF01048 0.721
MOD_GlcNHglycan 445 448 PF01048 0.386
MOD_GlcNHglycan 58 61 PF01048 0.679
MOD_GlcNHglycan 62 65 PF01048 0.720
MOD_GSK3_1 16 23 PF00069 0.612
MOD_GSK3_1 195 202 PF00069 0.414
MOD_GSK3_1 213 220 PF00069 0.432
MOD_GSK3_1 326 333 PF00069 0.336
MOD_GSK3_1 394 401 PF00069 0.474
MOD_GSK3_1 457 464 PF00069 0.420
MOD_GSK3_1 56 63 PF00069 0.586
MOD_GSK3_1 7 14 PF00069 0.516
MOD_GSK3_1 85 92 PF00069 0.390
MOD_N-GLC_1 414 419 PF02516 0.271
MOD_NEK2_1 443 448 PF00069 0.400
MOD_NEK2_1 84 89 PF00069 0.495
MOD_NEK2_2 124 129 PF00069 0.355
MOD_PIKK_1 448 454 PF00454 0.447
MOD_PKA_1 323 329 PF00069 0.361
MOD_PKA_2 372 378 PF00069 0.602
MOD_PKA_2 448 454 PF00069 0.612
MOD_Plk_1 117 123 PF00069 0.455
MOD_Plk_1 406 412 PF00069 0.374
MOD_Plk_4 217 223 PF00069 0.388
MOD_Plk_4 255 261 PF00069 0.333
MOD_Plk_4 301 307 PF00069 0.282
MOD_Plk_4 336 342 PF00069 0.330
MOD_Plk_4 434 440 PF00069 0.401
MOD_Plk_4 47 53 PF00069 0.406
MOD_Plk_4 85 91 PF00069 0.389
MOD_ProDKin_1 140 146 PF00069 0.402
MOD_ProDKin_1 299 305 PF00069 0.260
MOD_SUMO_rev_2 338 346 PF00179 0.271
TRG_DiLeu_BaLyEn_6 50 55 PF01217 0.543
TRG_ENDOCYTIC_2 178 181 PF00928 0.341
TRG_ENDOCYTIC_2 224 227 PF00928 0.359
TRG_ENDOCYTIC_2 308 311 PF00928 0.367
TRG_ENDOCYTIC_2 399 402 PF00928 0.400
TRG_ENDOCYTIC_2 41 44 PF00928 0.479
TRG_ENDOCYTIC_2 51 54 PF00928 0.481
TRG_ER_diArg_1 372 374 PF00400 0.347
TRG_ER_diArg_1 376 379 PF00400 0.439
TRG_ER_diArg_1 487 490 PF00400 0.526
TRG_ER_diArg_1 74 76 PF00400 0.777
TRG_NES_CRM1_1 205 219 PF08389 0.207
TRG_Pf-PMV_PEXEL_1 191 195 PF00026 0.480
TRG_Pf-PMV_PEXEL_1 273 277 PF00026 0.362

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6D4 Leptomonas seymouri 44% 99%
A0A0N0P991 Leptomonas seymouri 26% 100%
A0A0N0P992 Leptomonas seymouri 22% 68%
A0A0N0P9K9 Leptomonas seymouri 27% 100%
A0A0N1I2J8 Leptomonas seymouri 35% 100%
A0A0N1PCS4 Leptomonas seymouri 36% 100%
A0A0S4J7N0 Bodo saltans 26% 100%
A0A0S4KJL3 Bodo saltans 30% 100%
A0A1X0NUH5 Trypanosomatidae 22% 89%
A0A1X0NUJ5 Trypanosomatidae 27% 100%
A0A3Q8ICN0 Leishmania donovani 40% 100%
A0A3Q8IGQ2 Leishmania donovani 29% 100%
A0A3R7MUL5 Trypanosoma rangeli 25% 94%
A0A3S5H7R8 Leishmania donovani 25% 68%
A0A3S7X4P4 Leishmania donovani 99% 100%
A0A3S7X4R1 Leishmania donovani 41% 100%
A0A422P1E3 Trypanosoma rangeli 28% 100%
A4HJI7 Leishmania braziliensis 67% 99%
A4HJI8 Leishmania braziliensis 40% 100%
A4HJI9 Leishmania braziliensis 38% 96%
A4HKB3 Leishmania braziliensis 30% 100%
A4HKB4 Leishmania braziliensis 27% 100%
A4HKB5 Leishmania braziliensis 22% 68%
A4I6Y3 Leishmania infantum 41% 100%
A4I6Y4 Leishmania infantum 39% 100%
A4I7U3 Leishmania infantum 29% 100%
A4I7U4 Leishmania infantum 25% 68%
A8Y5H7 Mus musculus 21% 73%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9B205 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B206 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B2Q1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B2Q2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 68%
O43304 Homo sapiens 22% 75%
O76054 Homo sapiens 22% 100%
P58875 Bos taurus 22% 100%
Q03606 Caenorhabditis elegans 21% 72%
Q0V9N0 Xenopus tropicalis 22% 74%
Q4Q5F5 Leishmania major 24% 68%
Q4Q5F6 Leishmania major 28% 100%
Q4Q655 Leishmania major 39% 100%
Q4Q656 Leishmania major 40% 99%
Q4Q657 Leishmania major 88% 99%
Q92503 Homo sapiens 22% 73%
Q99J08 Mus musculus 22% 100%
Q99MS0 Rattus norvegicus 22% 100%
Q9UDX3 Homo sapiens 21% 100%
V5BL84 Trypanosoma cruzi 27% 100%
V5BQT0 Trypanosoma cruzi 24% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS