Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I6Y1_LEIIN

TriTrypDb:

LINF_310028400

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I6Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6Y1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.735
CLV_MEL_PAP_1	7	13	PF00089	0.647
CLV_NRD_NRD_1	106	108	PF00675	0.639
CLV_NRD_NRD_1	301	303	PF00675	0.821
CLV_NRD_NRD_1	41	43	PF00675	0.644
CLV_NRD_NRD_1	472	474	PF00675	0.786
CLV_PCSK_KEX2_1	106	108	PF00082	0.639
CLV_PCSK_KEX2_1	301	303	PF00082	0.821
CLV_PCSK_KEX2_1	41	43	PF00082	0.644
CLV_PCSK_KEX2_1	472	474	PF00082	0.786
CLV_PCSK_PC7_1	468	474	PF00082	0.627
CLV_PCSK_SKI1_1	164	168	PF00082	0.646
CLV_PCSK_SKI1_1	335	339	PF00082	0.679
CLV_PCSK_SKI1_1	369	373	PF00082	0.656
CLV_PCSK_SKI1_1	375	379	PF00082	0.602
CLV_PCSK_SKI1_1	42	46	PF00082	0.722
CLV_PCSK_SKI1_1	492	496	PF00082	0.579
DEG_SPOP_SBC_1	203	207	PF00917	0.785
DOC_CKS1_1	244	249	PF01111	0.635
DOC_CKS1_1	354	359	PF01111	0.736
DOC_CKS1_1	416	421	PF01111	0.690
DOC_CYCLIN_RxL_1	42	55	PF00134	0.780
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.736
DOC_MAPK_gen_1	290	300	PF00069	0.688
DOC_MAPK_gen_1	318	328	PF00069	0.760
DOC_MAPK_gen_1	335	345	PF00069	0.615
DOC_PP1_RVXF_1	367	373	PF00149	0.770
DOC_PP1_SILK_1	30	35	PF00149	0.524
DOC_PP2B_LxvP_1	235	238	PF13499	0.617
DOC_PP2B_LxvP_1	3	6	PF13499	0.740
DOC_PP2B_LxvP_1	343	346	PF13499	0.833
DOC_PP2B_LxvP_1	50	53	PF13499	0.796
DOC_PP2B_LxvP_1	59	62	PF13499	0.675
DOC_PP2B_LxvP_1	67	70	PF13499	0.544
DOC_PP2B_PxIxI_1	273	279	PF00149	0.650
DOC_PP4_FxxP_1	244	247	PF00568	0.670
DOC_USP7_MATH_1	124	128	PF00917	0.665
DOC_USP7_MATH_1	181	185	PF00917	0.744
DOC_USP7_MATH_1	198	202	PF00917	0.601
DOC_USP7_MATH_1	304	308	PF00917	0.745
DOC_USP7_MATH_1	336	340	PF00917	0.751
DOC_USP7_MATH_1	404	408	PF00917	0.640
DOC_USP7_MATH_1	446	450	PF00917	0.794
DOC_USP7_MATH_1	494	498	PF00917	0.572
DOC_USP7_MATH_1	73	77	PF00917	0.719
DOC_USP7_MATH_2	419	425	PF00917	0.683
DOC_WW_Pin1_4	159	164	PF00397	0.655
DOC_WW_Pin1_4	243	248	PF00397	0.678
DOC_WW_Pin1_4	300	305	PF00397	0.775
DOC_WW_Pin1_4	353	358	PF00397	0.632
DOC_WW_Pin1_4	415	420	PF00397	0.639
LIG_14-3-3_CanoR_1	170	180	PF00244	0.747
LIG_14-3-3_CanoR_1	293	298	PF00244	0.800
LIG_14-3-3_CanoR_1	318	324	PF00244	0.708
LIG_14-3-3_CanoR_1	330	337	PF00244	0.649
LIG_14-3-3_CanoR_1	369	377	PF00244	0.660
LIG_Actin_WH2_2	325	340	PF00022	0.815
LIG_AP2alpha_1	372	376	PF02296	0.770
LIG_BRCT_BRCA1_1	198	202	PF00533	0.738
LIG_BRCT_BRCA1_1	486	490	PF00533	0.716
LIG_BRCT_BRCA1_2	486	492	PF00533	0.720
LIG_FHA_1	203	209	PF00498	0.743
LIG_FHA_1	246	252	PF00498	0.789
LIG_FHA_1	327	333	PF00498	0.738
LIG_FHA_1	411	417	PF00498	0.721
LIG_FHA_1	62	68	PF00498	0.825
LIG_FHA_2	205	211	PF00498	0.771
LIG_FHA_2	263	269	PF00498	0.771
LIG_FHA_2	270	276	PF00498	0.656
LIG_FHA_2	416	422	PF00498	0.805
LIG_FHA_2	450	456	PF00498	0.754
LIG_LIR_Apic_2	241	247	PF02991	0.668
LIG_LIR_Gen_1	114	122	PF02991	0.616
LIG_LIR_Gen_1	291	300	PF02991	0.688
LIG_LIR_Gen_1	421	431	PF02991	0.659
LIG_LIR_Nem_3	114	118	PF02991	0.625
LIG_LIR_Nem_3	291	297	PF02991	0.704
LIG_LIR_Nem_3	390	395	PF02991	0.758
LIG_LIR_Nem_3	415	420	PF02991	0.628
LIG_LIR_Nem_3	421	426	PF02991	0.653
LIG_LIR_Nem_3	83	89	PF02991	0.700
LIG_PDZ_Class_1	495	500	PF00595	0.712
LIG_Pex14_2	372	376	PF04695	0.770
LIG_SH2_CRK	4	8	PF00017	0.658
LIG_SH2_SRC	221	224	PF00017	0.818
LIG_SH2_STAP1	115	119	PF00017	0.773
LIG_SH2_STAT5	221	224	PF00017	0.818
LIG_SH2_STAT5	417	420	PF00017	0.728
LIG_SH2_STAT5	485	488	PF00017	0.764
LIG_SH3_3	118	124	PF00018	0.708
LIG_SH3_3	131	137	PF00018	0.595
LIG_SH3_3	219	225	PF00018	0.814
LIG_SH3_3	248	254	PF00018	0.736
LIG_SH3_3	50	56	PF00018	0.779
LIG_SH3_3	82	88	PF00018	0.808
LIG_SUMO_SIM_par_1	223	231	PF11976	0.701
LIG_SUMO_SIM_par_1	356	362	PF11976	0.551
LIG_SUMO_SIM_par_1	411	418	PF11976	0.664
LIG_TRFH_1	283	287	PF08558	0.601
LIG_Vh1_VBS_1	445	463	PF01044	0.724
LIG_WRC_WIRS_1	297	302	PF05994	0.700
MOD_CDK_SPK_2	159	164	PF00069	0.749
MOD_CK1_1	148	154	PF00069	0.693
MOD_CK1_1	158	164	PF00069	0.710
MOD_CK1_1	206	212	PF00069	0.813
MOD_CK1_1	236	242	PF00069	0.675
MOD_CK1_1	279	285	PF00069	0.733
MOD_CK1_1	288	294	PF00069	0.608
MOD_CK1_1	296	302	PF00069	0.585
MOD_CK1_1	305	311	PF00069	0.648
MOD_CK1_1	341	347	PF00069	0.743
MOD_CK1_1	348	354	PF00069	0.692
MOD_CK1_1	398	404	PF00069	0.689
MOD_CK1_1	406	412	PF00069	0.638
MOD_CK1_1	449	455	PF00069	0.654
MOD_CK2_1	125	131	PF00069	0.717
MOD_CK2_1	144	150	PF00069	0.533
MOD_CK2_1	151	157	PF00069	0.650
MOD_CK2_1	204	210	PF00069	0.671
MOD_CK2_1	336	342	PF00069	0.750
MOD_CK2_1	415	421	PF00069	0.705
MOD_CK2_1	449	455	PF00069	0.699
MOD_GlcNHglycan	157	160	PF01048	0.714
MOD_GlcNHglycan	198	201	PF01048	0.745
MOD_GlcNHglycan	214	217	PF01048	0.601
MOD_GlcNHglycan	235	238	PF01048	0.727
MOD_GlcNHglycan	278	281	PF01048	0.667
MOD_GlcNHglycan	304	307	PF01048	0.741
MOD_GlcNHglycan	314	317	PF01048	0.636
MOD_GlcNHglycan	347	350	PF01048	0.825
MOD_GlcNHglycan	351	354	PF01048	0.760
MOD_GlcNHglycan	389	392	PF01048	0.593
MOD_GlcNHglycan	397	400	PF01048	0.604
MOD_GlcNHglycan	486	489	PF01048	0.708
MOD_GSK3_1	125	132	PF00069	0.671
MOD_GSK3_1	144	151	PF00069	0.561
MOD_GSK3_1	155	162	PF00069	0.726
MOD_GSK3_1	166	173	PF00069	0.679
MOD_GSK3_1	198	205	PF00069	0.650
MOD_GSK3_1	227	234	PF00069	0.822
MOD_GSK3_1	281	288	PF00069	0.678
MOD_GSK3_1	289	296	PF00069	0.617
MOD_GSK3_1	300	307	PF00069	0.587
MOD_GSK3_1	308	315	PF00069	0.537
MOD_GSK3_1	324	331	PF00069	0.609
MOD_GSK3_1	337	344	PF00069	0.609
MOD_GSK3_1	345	352	PF00069	0.690
MOD_GSK3_1	380	387	PF00069	0.692
MOD_GSK3_1	400	407	PF00069	0.518
MOD_GSK3_1	480	487	PF00069	0.710
MOD_LATS_1	143	149	PF00433	0.671
MOD_LATS_1	168	174	PF00433	0.650
MOD_N-GLC_1	124	129	PF02516	0.675
MOD_N-GLC_1	203	208	PF02516	0.822
MOD_N-GLC_1	324	329	PF02516	0.643
MOD_N-GLC_1	80	85	PF02516	0.663
MOD_NEK2_1	129	134	PF00069	0.712
MOD_NEK2_1	144	149	PF00069	0.578
MOD_NEK2_1	202	207	PF00069	0.656
MOD_NEK2_1	326	331	PF00069	0.818
MOD_NEK2_1	408	413	PF00069	0.625
MOD_NEK2_1	479	484	PF00069	0.778
MOD_PIKK_1	151	157	PF00454	0.677
MOD_PIKK_1	330	336	PF00454	0.702
MOD_PIKK_1	408	414	PF00454	0.723
MOD_PK_1	28	34	PF00069	0.521
MOD_PKA_2	259	265	PF00069	0.738
MOD_PKA_2	289	295	PF00069	0.735
MOD_PKA_2	467	473	PF00069	0.653
MOD_PKA_2	9	15	PF00069	0.634
MOD_Plk_1	113	119	PF00069	0.775
MOD_Plk_1	181	187	PF00069	0.734
MOD_Plk_1	203	209	PF00069	0.645
MOD_Plk_1	324	330	PF00069	0.742
MOD_Plk_1	341	347	PF00069	0.633
MOD_Plk_1	73	79	PF00069	0.771
MOD_Plk_4	113	119	PF00069	0.771
MOD_Plk_4	125	131	PF00069	0.565
MOD_Plk_4	198	204	PF00069	0.820
MOD_Plk_4	28	34	PF00069	0.531
MOD_Plk_4	293	299	PF00069	0.609
MOD_Plk_4	384	390	PF00069	0.567
MOD_ProDKin_1	159	165	PF00069	0.655
MOD_ProDKin_1	243	249	PF00069	0.679
MOD_ProDKin_1	300	306	PF00069	0.776
MOD_ProDKin_1	353	359	PF00069	0.629
MOD_ProDKin_1	415	421	PF00069	0.640
MOD_SUMO_rev_2	147	154	PF00179	0.663
TRG_ENDOCYTIC_2	115	118	PF00928	0.620
TRG_ENDOCYTIC_2	4	7	PF00928	0.740
TRG_ER_diArg_1	18	21	PF00400	0.675
TRG_ER_diArg_1	23	26	PF00400	0.643
TRG_ER_diArg_1	300	302	PF00400	0.757
TRG_ER_diArg_1	471	473	PF00400	0.790
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4R8	Leishmania donovani	99%	100%
A4HJI6	Leishmania braziliensis	64%	100%
E9B203	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q658	Leishmania major	90%	100%