LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Mannosyltransferase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mannosyltransferase-like protein
Gene product:
mannosyltransferase-like protein
Species:
Leishmania infantum
UniProt:
A4I6X8_LEIIN
TriTrypDb:
LINF_310026500 *
Length:
857

Annotations

LeishMANIAdb annotations

A complex and fast-evolving family of glycosyltransferases. Their structural innovations and expansion is in accordance with a role in interactions with the environment. Despite the short hydrophobic segment, the N-terminal signal-like stretch is likely to be a signal-anchor as wil all Golgi-resident glycosyltransferases, not a secretory signal. Localization: Golgi (by homology)

Annotations by Jardim et al.

GPI anchor biosynthesis, Mannosyltransferase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 13
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4I6X8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I6X8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0016740 transferase activity 2 15
GO:0016757 glycosyltransferase activity 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 278 282 PF00656 0.418
CLV_NRD_NRD_1 262 264 PF00675 0.441
CLV_NRD_NRD_1 292 294 PF00675 0.484
CLV_NRD_NRD_1 395 397 PF00675 0.438
CLV_NRD_NRD_1 524 526 PF00675 0.587
CLV_NRD_NRD_1 571 573 PF00675 0.530
CLV_NRD_NRD_1 637 639 PF00675 0.426
CLV_NRD_NRD_1 674 676 PF00675 0.435
CLV_NRD_NRD_1 820 822 PF00675 0.369
CLV_NRD_NRD_1 824 826 PF00675 0.345
CLV_PCSK_KEX2_1 262 264 PF00082 0.474
CLV_PCSK_KEX2_1 292 294 PF00082 0.484
CLV_PCSK_KEX2_1 394 396 PF00082 0.440
CLV_PCSK_KEX2_1 523 525 PF00082 0.526
CLV_PCSK_KEX2_1 571 573 PF00082 0.486
CLV_PCSK_KEX2_1 674 676 PF00082 0.435
CLV_PCSK_KEX2_1 820 822 PF00082 0.343
CLV_PCSK_KEX2_1 824 826 PF00082 0.315
CLV_PCSK_PC1ET2_1 523 525 PF00082 0.591
CLV_PCSK_PC7_1 820 826 PF00082 0.383
CLV_PCSK_SKI1_1 109 113 PF00082 0.604
CLV_PCSK_SKI1_1 196 200 PF00082 0.532
CLV_PCSK_SKI1_1 372 376 PF00082 0.557
CLV_PCSK_SKI1_1 483 487 PF00082 0.600
CLV_PCSK_SKI1_1 505 509 PF00082 0.460
CLV_PCSK_SKI1_1 626 630 PF00082 0.436
CLV_PCSK_SKI1_1 69 73 PF00082 0.629
CLV_Separin_Metazoa 807 811 PF03568 0.374
DEG_SCF_FBW7_1 92 97 PF00400 0.643
DOC_ANK_TNKS_1 773 780 PF00023 0.450
DOC_CYCLIN_yClb5_NLxxxL_5 18 27 PF00134 0.521
DOC_CYCLIN_yCln2_LP_2 129 135 PF00134 0.550
DOC_MAPK_gen_1 501 510 PF00069 0.535
DOC_MAPK_gen_1 638 645 PF00069 0.428
DOC_MAPK_gen_1 661 668 PF00069 0.547
DOC_MAPK_MEF2A_6 327 336 PF00069 0.544
DOC_MAPK_MEF2A_6 525 534 PF00069 0.578
DOC_PP1_RVXF_1 624 631 PF00149 0.517
DOC_PP2B_LxvP_1 129 132 PF13499 0.567
DOC_PP2B_PxIxI_1 707 713 PF00149 0.436
DOC_PP4_FxxP_1 432 435 PF00568 0.496
DOC_PP4_FxxP_1 519 522 PF00568 0.518
DOC_PP4_FxxP_1 732 735 PF00568 0.327
DOC_PP4_FxxP_1 773 776 PF00568 0.402
DOC_USP7_MATH_1 366 370 PF00917 0.526
DOC_USP7_MATH_1 493 497 PF00917 0.616
DOC_USP7_MATH_1 58 62 PF00917 0.667
DOC_USP7_MATH_1 601 605 PF00917 0.557
DOC_USP7_MATH_1 798 802 PF00917 0.337
DOC_USP7_MATH_1 94 98 PF00917 0.656
DOC_WW_Pin1_4 488 493 PF00397 0.643
DOC_WW_Pin1_4 573 578 PF00397 0.520
DOC_WW_Pin1_4 674 679 PF00397 0.565
DOC_WW_Pin1_4 781 786 PF00397 0.442
DOC_WW_Pin1_4 90 95 PF00397 0.723
LIG_14-3-3_CanoR_1 126 130 PF00244 0.571
LIG_14-3-3_CanoR_1 171 177 PF00244 0.690
LIG_14-3-3_CanoR_1 229 235 PF00244 0.637
LIG_14-3-3_CanoR_1 273 277 PF00244 0.482
LIG_14-3-3_CanoR_1 37 47 PF00244 0.539
LIG_14-3-3_CanoR_1 372 378 PF00244 0.597
LIG_14-3-3_CanoR_1 380 389 PF00244 0.449
LIG_14-3-3_CanoR_1 427 435 PF00244 0.575
LIG_14-3-3_CanoR_1 464 468 PF00244 0.536
LIG_14-3-3_CanoR_1 615 624 PF00244 0.557
LIG_14-3-3_CanoR_1 663 667 PF00244 0.535
LIG_14-3-3_CanoR_1 69 77 PF00244 0.623
LIG_BIR_III_4 296 300 PF00653 0.553
LIG_deltaCOP1_diTrp_1 557 566 PF00928 0.364
LIG_deltaCOP1_diTrp_1 759 766 PF00928 0.418
LIG_FHA_1 13 19 PF00498 0.618
LIG_FHA_1 138 144 PF00498 0.559
LIG_FHA_1 186 192 PF00498 0.605
LIG_FHA_1 259 265 PF00498 0.529
LIG_FHA_1 413 419 PF00498 0.646
LIG_FHA_1 662 668 PF00498 0.507
LIG_FHA_1 712 718 PF00498 0.421
LIG_FHA_1 803 809 PF00498 0.365
LIG_FHA_2 137 143 PF00498 0.661
LIG_FHA_2 181 187 PF00498 0.686
LIG_FHA_2 229 235 PF00498 0.639
LIG_FHA_2 552 558 PF00498 0.514
LIG_FHA_2 559 565 PF00498 0.485
LIG_FHA_2 617 623 PF00498 0.583
LIG_FHA_2 734 740 PF00498 0.327
LIG_LIR_Apic_2 220 226 PF02991 0.675
LIG_LIR_Apic_2 430 435 PF02991 0.564
LIG_LIR_Apic_2 730 735 PF02991 0.328
LIG_LIR_Apic_2 739 744 PF02991 0.329
LIG_LIR_Apic_2 758 763 PF02991 0.327
LIG_LIR_Apic_2 770 776 PF02991 0.402
LIG_LIR_Gen_1 14 24 PF02991 0.662
LIG_LIR_Gen_1 158 167 PF02991 0.413
LIG_LIR_Gen_1 275 283 PF02991 0.462
LIG_LIR_Gen_1 384 392 PF02991 0.527
LIG_LIR_Gen_1 484 493 PF02991 0.609
LIG_LIR_Gen_1 564 570 PF02991 0.453
LIG_LIR_Nem_3 14 20 PF02991 0.618
LIG_LIR_Nem_3 158 163 PF02991 0.411
LIG_LIR_Nem_3 275 279 PF02991 0.470
LIG_LIR_Nem_3 384 389 PF02991 0.483
LIG_LIR_Nem_3 484 489 PF02991 0.600
LIG_LIR_Nem_3 564 569 PF02991 0.382
LIG_LIR_Nem_3 706 710 PF02991 0.374
LIG_LYPXL_yS_3 707 710 PF13949 0.451
LIG_NRBOX 19 25 PF00104 0.573
LIG_PCNA_yPIPBox_3 371 383 PF02747 0.586
LIG_Pex14_2 629 633 PF04695 0.424
LIG_Pex14_2 688 692 PF04695 0.549
LIG_PTAP_UEV_1 653 658 PF05743 0.506
LIG_REV1ctd_RIR_1 495 505 PF16727 0.598
LIG_SH2_CRK 295 299 PF00017 0.548
LIG_SH2_CRK 386 390 PF00017 0.566
LIG_SH2_CRK 479 483 PF00017 0.617
LIG_SH2_GRB2like 726 729 PF00017 0.471
LIG_SH2_NCK_1 174 178 PF00017 0.694
LIG_SH2_NCK_1 267 271 PF00017 0.557
LIG_SH2_NCK_1 295 299 PF00017 0.548
LIG_SH2_NCK_1 386 390 PF00017 0.503
LIG_SH2_NCK_1 592 596 PF00017 0.573
LIG_SH2_NCK_1 726 730 PF00017 0.471
LIG_SH2_PTP2 17 20 PF00017 0.510
LIG_SH2_PTP2 446 449 PF00017 0.497
LIG_SH2_SRC 592 595 PF00017 0.565
LIG_SH2_SRC 726 729 PF00017 0.471
LIG_SH2_SRC 791 794 PF00017 0.445
LIG_SH2_STAT3 597 600 PF00017 0.593
LIG_SH2_STAT5 17 20 PF00017 0.510
LIG_SH2_STAT5 174 177 PF00017 0.677
LIG_SH2_STAT5 259 262 PF00017 0.455
LIG_SH2_STAT5 446 449 PF00017 0.389
LIG_SH2_STAT5 533 536 PF00017 0.410
LIG_SH2_STAT5 627 630 PF00017 0.496
LIG_SH2_STAT5 811 814 PF00017 0.321
LIG_SH3_3 129 135 PF00018 0.550
LIG_SH3_3 252 258 PF00018 0.669
LIG_SH3_3 394 400 PF00018 0.551
LIG_SH3_3 486 492 PF00018 0.577
LIG_SH3_3 651 657 PF00018 0.377
LIG_SH3_3 782 788 PF00018 0.407
LIG_SH3_3 810 816 PF00018 0.365
LIG_SUMO_SIM_anti_2 125 131 PF11976 0.578
LIG_SUMO_SIM_anti_2 138 146 PF11976 0.321
LIG_SUMO_SIM_par_1 664 670 PF11976 0.521
LIG_SUMO_SIM_par_1 709 714 PF11976 0.404
LIG_SUMO_SIM_par_1 753 759 PF11976 0.372
LIG_TRAF2_1 275 278 PF00917 0.554
LIG_TRAF2_1 619 622 PF00917 0.528
LIG_TYR_ITIM 477 482 PF00017 0.586
LIG_TYR_ITSM 382 389 PF00017 0.452
LIG_WRC_WIRS_1 163 168 PF05994 0.542
LIG_WRC_WIRS_1 630 635 PF05994 0.449
LIG_WW_3 226 230 PF00397 0.541
MOD_CDC14_SPxK_1 576 579 PF00782 0.532
MOD_CDK_SPxK_1 573 579 PF00069 0.517
MOD_CK1_1 11 17 PF00069 0.603
MOD_CK1_1 265 271 PF00069 0.569
MOD_CK1_1 387 393 PF00069 0.584
MOD_CK1_1 408 414 PF00069 0.628
MOD_CK1_1 487 493 PF00069 0.597
MOD_CK1_1 539 545 PF00069 0.392
MOD_CK1_1 608 614 PF00069 0.451
MOD_CK1_1 655 661 PF00069 0.370
MOD_CK1_1 681 687 PF00069 0.493
MOD_CK1_1 784 790 PF00069 0.419
MOD_CK2_1 136 142 PF00069 0.619
MOD_CK2_1 180 186 PF00069 0.771
MOD_CK2_1 228 234 PF00069 0.653
MOD_CK2_1 272 278 PF00069 0.526
MOD_CK2_1 534 540 PF00069 0.407
MOD_CK2_1 614 620 PF00069 0.522
MOD_CK2_1 715 721 PF00069 0.478
MOD_CK2_1 733 739 PF00069 0.192
MOD_CMANNOS 343 346 PF00535 0.434
MOD_CMANNOS 98 101 PF00535 0.461
MOD_Cter_Amidation 822 825 PF01082 0.326
MOD_GlcNHglycan 10 13 PF01048 0.624
MOD_GlcNHglycan 219 222 PF01048 0.638
MOD_GlcNHglycan 264 267 PF01048 0.562
MOD_GlcNHglycan 40 43 PF01048 0.658
MOD_GlcNHglycan 410 413 PF01048 0.646
MOD_GlcNHglycan 431 435 PF01048 0.569
MOD_GlcNHglycan 469 472 PF01048 0.553
MOD_GlcNHglycan 54 57 PF01048 0.634
MOD_GlcNHglycan 654 657 PF01048 0.566
MOD_GlcNHglycan 716 720 PF01048 0.478
MOD_GlcNHglycan 78 81 PF01048 0.620
MOD_GSK3_1 258 265 PF00069 0.558
MOD_GSK3_1 408 415 PF00069 0.697
MOD_GSK3_1 463 470 PF00069 0.547
MOD_GSK3_1 484 491 PF00069 0.613
MOD_GSK3_1 601 608 PF00069 0.464
MOD_GSK3_1 674 681 PF00069 0.496
MOD_GSK3_1 711 718 PF00069 0.428
MOD_GSK3_1 798 805 PF00069 0.361
MOD_GSK3_1 8 15 PF00069 0.661
MOD_GSK3_1 90 97 PF00069 0.620
MOD_N-GLC_1 12 17 PF02516 0.569
MOD_NEK2_1 167 172 PF00069 0.577
MOD_NEK2_1 194 199 PF00069 0.549
MOD_NEK2_1 485 490 PF00069 0.595
MOD_NEK2_1 565 570 PF00069 0.412
MOD_NEK2_1 629 634 PF00069 0.448
MOD_NEK2_1 688 693 PF00069 0.516
MOD_NEK2_1 847 852 PF00069 0.553
MOD_NEK2_2 330 335 PF00069 0.394
MOD_NEK2_2 493 498 PF00069 0.563
MOD_OFUCOSY 606 612 PF10250 0.472
MOD_PIKK_1 196 202 PF00454 0.575
MOD_PIKK_1 655 661 PF00454 0.387
MOD_PK_1 605 611 PF00069 0.437
MOD_PKA_1 262 268 PF00069 0.552
MOD_PKA_2 125 131 PF00069 0.580
MOD_PKA_2 228 234 PF00069 0.651
MOD_PKA_2 262 268 PF00069 0.537
MOD_PKA_2 272 278 PF00069 0.436
MOD_PKA_2 463 469 PF00069 0.575
MOD_PKA_2 614 620 PF00069 0.590
MOD_PKA_2 662 668 PF00069 0.541
MOD_PKA_2 681 687 PF00069 0.266
MOD_PKA_2 768 774 PF00069 0.474
MOD_Plk_1 137 143 PF00069 0.604
MOD_Plk_1 412 418 PF00069 0.588
MOD_Plk_1 661 667 PF00069 0.490
MOD_Plk_2-3 312 318 PF00069 0.711
MOD_Plk_4 125 131 PF00069 0.617
MOD_Plk_4 162 168 PF00069 0.537
MOD_Plk_4 209 215 PF00069 0.417
MOD_Plk_4 384 390 PF00069 0.556
MOD_Plk_4 493 499 PF00069 0.564
MOD_Plk_4 565 571 PF00069 0.473
MOD_Plk_4 59 65 PF00069 0.644
MOD_Plk_4 662 668 PF00069 0.423
MOD_Plk_4 681 687 PF00069 0.300
MOD_Plk_4 847 853 PF00069 0.495
MOD_ProDKin_1 488 494 PF00069 0.637
MOD_ProDKin_1 573 579 PF00069 0.517
MOD_ProDKin_1 674 680 PF00069 0.556
MOD_ProDKin_1 781 787 PF00069 0.442
MOD_ProDKin_1 90 96 PF00069 0.725
MOD_SUMO_for_1 633 636 PF00179 0.364
TRG_DiLeu_BaEn_1 186 191 PF01217 0.611
TRG_DiLeu_BaEn_1 662 667 PF01217 0.546
TRG_ENDOCYTIC_2 17 20 PF00928 0.610
TRG_ENDOCYTIC_2 295 298 PF00928 0.539
TRG_ENDOCYTIC_2 386 389 PF00928 0.569
TRG_ENDOCYTIC_2 479 482 PF00928 0.596
TRG_ENDOCYTIC_2 627 630 PF00928 0.496
TRG_ENDOCYTIC_2 707 710 PF00928 0.459
TRG_ER_diArg_1 149 152 PF00400 0.584
TRG_ER_diArg_1 262 264 PF00400 0.421
TRG_ER_diArg_1 292 294 PF00400 0.532
TRG_ER_diArg_1 394 396 PF00400 0.448
TRG_ER_diArg_1 401 404 PF00400 0.493
TRG_ER_diArg_1 502 505 PF00400 0.507
TRG_ER_diArg_1 524 526 PF00400 0.608
TRG_ER_diArg_1 552 555 PF00400 0.525
TRG_ER_diArg_1 570 572 PF00400 0.401
TRG_ER_diArg_1 674 676 PF00400 0.414
TRG_ER_diArg_1 820 822 PF00400 0.339
TRG_ER_diArg_1 824 827 PF00400 0.312
TRG_NLS_MonoExtC_3 522 528 PF00514 0.487
TRG_NLS_MonoExtN_4 520 527 PF00514 0.472
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.661
TRG_Pf-PMV_PEXEL_1 448 452 PF00026 0.426
TRG_Pf-PMV_PEXEL_1 832 836 PF00026 0.494

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NJI2 Trypanosomatidae 36% 96%
A0A1X0NR25 Trypanosomatidae 31% 83%
A0A3R7NS98 Trypanosoma rangeli 31% 85%
A0A3R7RH60 Trypanosoma rangeli 40% 100%
A0A3S7X4M2 Leishmania donovani 100% 89%
A0A3S7X4P3 Leishmania donovani 100% 89%
A4HJG8 Leishmania braziliensis 77% 100%
E9B1Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B1Y6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B1Y7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q674 Leishmania major 94% 100%
Q4Q675 Leishmania major 94% 100%
V5BEQ4 Trypanosoma cruzi 38% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS